Suresh Sudke - Academia.edu (original) (raw)

Papers by Suresh Sudke

International Journal of Biology, Pharmacy and Allied Sciences, 2021

The current work was a successful attempt to develop a bioadhesive drug delivery system for glicl... more The current work was a successful attempt to develop a bioadhesive drug delivery system for gliclazide, an orally administered anti-diabetic medication, to increase its oral bioavailability and provide long-term drug release. From the results, it can be concluded that gliclazide mucoadhesive drug delivery systems may be made utilizing polymers like guar gum by direct compression method. UV spectrophotometry method of analysis of the drug was developed. In a pH 1.2 buffer (0.1 HCL), gliclazide showed maximum absorption at 226 nm. The regression coefficient (r 2) was determined to be 0.996, indicating that concentration and absorbance have a linear relationship. In the developed formulations, IR spectroscopic tests revealed no drugpolymer interaction. Without capping or chipping, all of the produced tablet formulations were determined to be satisfactory. According to the findings of this study, as the concentration of gum increases, so does the swelling index.

Generally enteric coating is organic solvent based dispersion or solution of polymer which is equ... more Generally enteric coating is organic solvent based dispersion or solution of polymer which is equally hazardous to the environment and operators. Hot-melt coating (HMC) devoid the use of solvents and hence it is cheap, environment friendly, safe and rapid process. The objective of present study was to ensure the suitability of HMC as an enteric coating technique. Aspirin was used as model drug due to its stomach mucosal irritation and ulcerogenic property. Pellets of aspirin prepared by extrusionspheronization technique were used as coating substrate. Stearic acid (SA) and palmitic acid (PA) were evaluated as enteric HMC materials. HMC was carried out in a specially modified coating pan and by applying SA and PA in molten state onto preheated pellets to achieve a coating level of 5-10% w/w. Hotmelt coated pellets were evaluated for disintegration pH and in vitro dissolution in the pH range 1.2 to 6.8, along with basic micromeritics. Scanning electron microscopy (SEM) of coated pelle...

Research Journal of Pharmacy and Technology

The objective of present investigation was to synthesize and assess sub-acute toxicity of novel r... more The objective of present investigation was to synthesize and assess sub-acute toxicity of novel rosin esters using Swiss Albino mice. Assessment of the safety and toxicity of rosin esters is very important step before its use in pharmaceuticals. The solutions of rosin esters were prepared in corn oil to perform acute (28d) oral toxicity study in Swiss Albino mice as animal model of both sexes. The oral administration of rosin esters at the dose of 25 mg/kg of body weight and constant volume was administered to the mice. One group of mice was kept as a control group. Toxicity of the rosin esters was assessed by using various tests like behavioral changes, clinical signs, mortality and morbidity, biochemical tests, haematological tests, relative organ weights and histopathology tests. The body weights and food-water consumption by mice were recorded on weekly basis. The study results revealed that, there were no signs and incidences of toxicity or mortality in mice during the study pe...

Multi-unit dosage forms are becoming popular for providing sustain release of drugs in the gastro... more Multi-unit dosage forms are becoming popular for providing sustain release of drugs in the gastrointestinal (GI) tract as they diminish chances of dose dumping. They usually consist of a drug entrapped in a sustaining matrix or of a drug coated reservoir with a low permeability coating material film. Pellets are one of the multi-unit delivery system and are prepared to obtain sustained drug delivery, to improve bioavailability or stability and to target drug to specific sites. Metoprolol tartarate was used as tracer and transformed into pellets by drug layering technique. Lipids are the materials which can be used to coat the drug in order to control the release. Application of fine layer of coating material in molten state over the substrate is known as hot-melt coating technique. Bees wax and cetyl alcohol are hydrophobic excipients used as a rate-controlling membrane to modulate the drug release from dosage forms. Coating conditions (temperature, speed of pan rotation, air pressu...

Journal of Pharmaceutical Research, 2013

Coatings are widely used to provide drug protection, to increase aesthetic value of product (colo... more Coatings are widely used to provide drug protection, to increase aesthetic value of product (color, taste and texture), to reduces acidity of vitamins, to provide lubrication and modified drug release. Usually, coating agents are dissolved or dispersed in solvents (organic or water) prior to coating and glidants are commonly added to prevent particle agglomeration during coating. Hot-melt coating technique defined as the application of fine layer of coating material in molten state over the substrate. As hot-melt coating devoid of solvent use, therefore solvent disposal, recovery and treatment is not required; as a result powders with very high specific surface areas can be coated rapidly. And also, this process is economic, environment friendly and rapid as compared conventional coating techniques. There are various hot-melt coating techniques, including melt coating (pour/spray coating), direct blending and solid dispersion. Commonly used equipments like fluidized bed coater and p...

Asian Journal of Pharmaceutics, 2017

Aim: The objective of the present investigation involves the design of modified release multiunit... more Aim: The objective of the present investigation involves the design of modified release multiunit drug delivery system for the effective treatment of gastroesophageal diseases (GEDs) using hot-melt coating (HMC) technique. Materials and Methods: Ranitidine hydrochloride (R.HCL) pellets were prepared using extrusion-spheronization and coated with different levels of hydrogenated castor oil (HCO) as HMC agent using pan pour method. To achieve the desirable release profile, R.HCL pellets were coated with a hybrid of HCO and sodium lauryl sulfate as a pore former. The pellets were evaluated for micromeritic properties, physicochemical properties, in vitro buoyancy study, dissolution study, and stability study. Optimized formulation was selected by comparison of the drug release profiles with theoretical release profile (TRP). Results: Formulation R6 with low floating lag time, floating time >12 h, and the drug release profile similar to TRP. Therefore, R6 was selected as optimized fo...

Hot-melt coatings (HMC) are widely used to provide drug protection, to increase aesthetic value o... more Hot-melt coatings (HMC) are widely used to provide drug protection, to increase aesthetic value of products, to reduce acidity if vitamins, to provide lubrication and modified drug release. In hot-melt coating the substrates are coated with molten form of coating materials. Substrates used for coating are beads, capsules, granules, pellets, pills, spherules and tablets. Hot-melt coating devoid of solvent use, solvent disposal, solvent evaporation and solvent treatment is not required; as a result powders with very high specific surface areas can be coated rapidly. HMC technique not only protects the operators from solvent but also protect the environment. Hot-melt coating materials are mostly hydrophilic as well as hydrophobic in nature. Majority of hot-melt coating materials are obtained from natural, semi-synthetic and synthetic sources. Generally, lipids are the smart option to polymer coatings as they need melting before application directly on the substrate and make the techniq...

Aim: The objective of the present investigation was to design curcumin suppositories for the effe... more Aim: The objective of the present investigation was to design curcumin suppositories for the effective treatment of vaginal candidiasis to eliminate side effects that are caused by existing antifungal drugs. Materials and Methods: Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Curcumin suppositories were prepared by fusion method with cow ghee (CG) and combinations of CG and polyethylene glycol 6000 in different ratios. The suppositories were evaluated for their visual, physicochemical, and in vitro release characteristics as well as in vitro antifungal activity. Results and Discussion: Formulation F6 showed all the results within the pharmacopeial and in-house specifications. The antifungal activity of the F6 formulation has demonstrated a significant effect against Candida albicans. Conclusion: The study indicates the possible and effective use of curcumin suppositories for vaginal candidiasis as a promising approach for natural ...

Coatings are widely used to provide drug protection, to increase aesthetic value of product (colo... more Coatings are widely used to provide drug protection, to increase aesthetic value of product (color, taste and texture), to reduces acidity if vitamins, to provide lubrication and modified drug release. Usually, coating agents are dissolved or dispersed in solvents (water or organic) prior to coating and glidants are commonly added to prevent particle agglomeration during coating. Lipids are the smart option to polymer coatings as they need melting before application directly on the substrate. As hot-melt coating (HMC) devoid of solvent use, solvent disposal, solvent evaporation and solvent treatment is not required; as a result powders with very high specific surface areas can be coated rapidly. Different lipids can be used in coating and selection of the right lipid for the application requires knowledge of their physico-chemical properties and its associated effect on drug release.

American Journal of PharmTech Research

The topical drug delivery facilitates a direct entry into the skin as a vital organ for diagnosis... more The topical drug delivery facilitates a direct entry into the skin as a vital organ for diagnosis and cure without any threat of passing through first pass metabolism. Emulgels are nothing but, the combination of emulsion and gel. Emulgel is one of the novel strategy widely employed in acne, fungal infection, arthritis, inflammation, psoriasis and other topical infections. Emulgel for dermatological use has several constructive properties such as being thixotropic, emollient, easily spreadable, easily washable, greaseless, non-staining, water-soluble, greater shelf life, bio-friendly, clear and pleasant appearance. Emulgel is emulsion, either of water in oil or oil in water type, which are gelled by mixing with gelling agent such as HPMC, carbopol etc. However, gels carry a drawback in delivery of hydrophobic drug moiety and thus emulgel can prove a novel topical drug delivery for hydrophobic drugs by incorporating hydrophobic drug into gels using o/w emulsions. Emulgel helps in the incorporation of hydrophobic drugs into the oil phase and then dispersion of oil globules in aqueous phase as a continuous phase, resulting in o/w emulsion and this emulsion can be incorporate into gel base.

International Journal of Pharmaceutical Investigation, 2013

The objective of the present study was to design ferrous fumarate (FF) sustained release (SR) pel... more The objective of the present study was to design ferrous fumarate (FF) sustained release (SR) pellets using of cow ghee (CG) as an important hot-melt coating (HMC) agent. The pellets were coated by HMC technique using CG and ethyl cellulose composition by conventional coating pan without the use of spray system. FF formulated as pellets and characterized with regard to the drug content and physico-chemical properties. Stability studies were carried out on the optimized formulation for a period of 6 months at 40 ± 2°C and 75 ± 5% relative humidity. Pellets with good surface morphology and smooth texture confirmed by stereo micrographs. HMC is easy, efficient, rapid and simple method since virtually no agglomeration seen during coating. In-vitro release from pellets at a given level of coating and for present pellet size was dependent upon the physico-chemical property of the drug and mostly aqueous solubility of the drug. The selection of optimized FF formulation was confirmed by comparing percent cumulative drug release with theoretical release profile. Formulation F2 had difference factor (f 1) and similarity factor (f 2) values was found to be 5 and 66 respectively. F2 showed SR of drug for 8 h with cumulative per cent release of 98.03 ± 4.49%. Release kinetics indicates approximately zero order release pattern. HMC pellets were stable during the course of stability study. By means of HMC using CG and ethyl cellulose, SR pellets containing FF were successfully prepared.

International Journal of Biology, Pharmacy and Allied Sciences, 2021

The current work was a successful attempt to develop a bioadhesive drug delivery system for glicl... more The current work was a successful attempt to develop a bioadhesive drug delivery system for gliclazide, an orally administered anti-diabetic medication, to increase its oral bioavailability and provide long-term drug release. From the results, it can be concluded that gliclazide mucoadhesive drug delivery systems may be made utilizing polymers like guar gum by direct compression method. UV spectrophotometry method of analysis of the drug was developed. In a pH 1.2 buffer (0.1 HCL), gliclazide showed maximum absorption at 226 nm. The regression coefficient (r 2) was determined to be 0.996, indicating that concentration and absorbance have a linear relationship. In the developed formulations, IR spectroscopic tests revealed no drugpolymer interaction. Without capping or chipping, all of the produced tablet formulations were determined to be satisfactory. According to the findings of this study, as the concentration of gum increases, so does the swelling index.

Generally enteric coating is organic solvent based dispersion or solution of polymer which is equ... more Generally enteric coating is organic solvent based dispersion or solution of polymer which is equally hazardous to the environment and operators. Hot-melt coating (HMC) devoid the use of solvents and hence it is cheap, environment friendly, safe and rapid process. The objective of present study was to ensure the suitability of HMC as an enteric coating technique. Aspirin was used as model drug due to its stomach mucosal irritation and ulcerogenic property. Pellets of aspirin prepared by extrusionspheronization technique were used as coating substrate. Stearic acid (SA) and palmitic acid (PA) were evaluated as enteric HMC materials. HMC was carried out in a specially modified coating pan and by applying SA and PA in molten state onto preheated pellets to achieve a coating level of 5-10% w/w. Hotmelt coated pellets were evaluated for disintegration pH and in vitro dissolution in the pH range 1.2 to 6.8, along with basic micromeritics. Scanning electron microscopy (SEM) of coated pelle...

Research Journal of Pharmacy and Technology

The objective of present investigation was to synthesize and assess sub-acute toxicity of novel r... more The objective of present investigation was to synthesize and assess sub-acute toxicity of novel rosin esters using Swiss Albino mice. Assessment of the safety and toxicity of rosin esters is very important step before its use in pharmaceuticals. The solutions of rosin esters were prepared in corn oil to perform acute (28d) oral toxicity study in Swiss Albino mice as animal model of both sexes. The oral administration of rosin esters at the dose of 25 mg/kg of body weight and constant volume was administered to the mice. One group of mice was kept as a control group. Toxicity of the rosin esters was assessed by using various tests like behavioral changes, clinical signs, mortality and morbidity, biochemical tests, haematological tests, relative organ weights and histopathology tests. The body weights and food-water consumption by mice were recorded on weekly basis. The study results revealed that, there were no signs and incidences of toxicity or mortality in mice during the study pe...

Multi-unit dosage forms are becoming popular for providing sustain release of drugs in the gastro... more Multi-unit dosage forms are becoming popular for providing sustain release of drugs in the gastrointestinal (GI) tract as they diminish chances of dose dumping. They usually consist of a drug entrapped in a sustaining matrix or of a drug coated reservoir with a low permeability coating material film. Pellets are one of the multi-unit delivery system and are prepared to obtain sustained drug delivery, to improve bioavailability or stability and to target drug to specific sites. Metoprolol tartarate was used as tracer and transformed into pellets by drug layering technique. Lipids are the materials which can be used to coat the drug in order to control the release. Application of fine layer of coating material in molten state over the substrate is known as hot-melt coating technique. Bees wax and cetyl alcohol are hydrophobic excipients used as a rate-controlling membrane to modulate the drug release from dosage forms. Coating conditions (temperature, speed of pan rotation, air pressu...

Journal of Pharmaceutical Research, 2013

Coatings are widely used to provide drug protection, to increase aesthetic value of product (colo... more Coatings are widely used to provide drug protection, to increase aesthetic value of product (color, taste and texture), to reduces acidity of vitamins, to provide lubrication and modified drug release. Usually, coating agents are dissolved or dispersed in solvents (organic or water) prior to coating and glidants are commonly added to prevent particle agglomeration during coating. Hot-melt coating technique defined as the application of fine layer of coating material in molten state over the substrate. As hot-melt coating devoid of solvent use, therefore solvent disposal, recovery and treatment is not required; as a result powders with very high specific surface areas can be coated rapidly. And also, this process is economic, environment friendly and rapid as compared conventional coating techniques. There are various hot-melt coating techniques, including melt coating (pour/spray coating), direct blending and solid dispersion. Commonly used equipments like fluidized bed coater and p...

Asian Journal of Pharmaceutics, 2017

Aim: The objective of the present investigation involves the design of modified release multiunit... more Aim: The objective of the present investigation involves the design of modified release multiunit drug delivery system for the effective treatment of gastroesophageal diseases (GEDs) using hot-melt coating (HMC) technique. Materials and Methods: Ranitidine hydrochloride (R.HCL) pellets were prepared using extrusion-spheronization and coated with different levels of hydrogenated castor oil (HCO) as HMC agent using pan pour method. To achieve the desirable release profile, R.HCL pellets were coated with a hybrid of HCO and sodium lauryl sulfate as a pore former. The pellets were evaluated for micromeritic properties, physicochemical properties, in vitro buoyancy study, dissolution study, and stability study. Optimized formulation was selected by comparison of the drug release profiles with theoretical release profile (TRP). Results: Formulation R6 with low floating lag time, floating time >12 h, and the drug release profile similar to TRP. Therefore, R6 was selected as optimized fo...

Hot-melt coatings (HMC) are widely used to provide drug protection, to increase aesthetic value o... more Hot-melt coatings (HMC) are widely used to provide drug protection, to increase aesthetic value of products, to reduce acidity if vitamins, to provide lubrication and modified drug release. In hot-melt coating the substrates are coated with molten form of coating materials. Substrates used for coating are beads, capsules, granules, pellets, pills, spherules and tablets. Hot-melt coating devoid of solvent use, solvent disposal, solvent evaporation and solvent treatment is not required; as a result powders with very high specific surface areas can be coated rapidly. HMC technique not only protects the operators from solvent but also protect the environment. Hot-melt coating materials are mostly hydrophilic as well as hydrophobic in nature. Majority of hot-melt coating materials are obtained from natural, semi-synthetic and synthetic sources. Generally, lipids are the smart option to polymer coatings as they need melting before application directly on the substrate and make the techniq...

Aim: The objective of the present investigation was to design curcumin suppositories for the effe... more Aim: The objective of the present investigation was to design curcumin suppositories for the effective treatment of vaginal candidiasis to eliminate side effects that are caused by existing antifungal drugs. Materials and Methods: Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Curcumin suppositories were prepared by fusion method with cow ghee (CG) and combinations of CG and polyethylene glycol 6000 in different ratios. The suppositories were evaluated for their visual, physicochemical, and in vitro release characteristics as well as in vitro antifungal activity. Results and Discussion: Formulation F6 showed all the results within the pharmacopeial and in-house specifications. The antifungal activity of the F6 formulation has demonstrated a significant effect against Candida albicans. Conclusion: The study indicates the possible and effective use of curcumin suppositories for vaginal candidiasis as a promising approach for natural ...

Coatings are widely used to provide drug protection, to increase aesthetic value of product (colo... more Coatings are widely used to provide drug protection, to increase aesthetic value of product (color, taste and texture), to reduces acidity if vitamins, to provide lubrication and modified drug release. Usually, coating agents are dissolved or dispersed in solvents (water or organic) prior to coating and glidants are commonly added to prevent particle agglomeration during coating. Lipids are the smart option to polymer coatings as they need melting before application directly on the substrate. As hot-melt coating (HMC) devoid of solvent use, solvent disposal, solvent evaporation and solvent treatment is not required; as a result powders with very high specific surface areas can be coated rapidly. Different lipids can be used in coating and selection of the right lipid for the application requires knowledge of their physico-chemical properties and its associated effect on drug release.

American Journal of PharmTech Research

The topical drug delivery facilitates a direct entry into the skin as a vital organ for diagnosis... more The topical drug delivery facilitates a direct entry into the skin as a vital organ for diagnosis and cure without any threat of passing through first pass metabolism. Emulgels are nothing but, the combination of emulsion and gel. Emulgel is one of the novel strategy widely employed in acne, fungal infection, arthritis, inflammation, psoriasis and other topical infections. Emulgel for dermatological use has several constructive properties such as being thixotropic, emollient, easily spreadable, easily washable, greaseless, non-staining, water-soluble, greater shelf life, bio-friendly, clear and pleasant appearance. Emulgel is emulsion, either of water in oil or oil in water type, which are gelled by mixing with gelling agent such as HPMC, carbopol etc. However, gels carry a drawback in delivery of hydrophobic drug moiety and thus emulgel can prove a novel topical drug delivery for hydrophobic drugs by incorporating hydrophobic drug into gels using o/w emulsions. Emulgel helps in the incorporation of hydrophobic drugs into the oil phase and then dispersion of oil globules in aqueous phase as a continuous phase, resulting in o/w emulsion and this emulsion can be incorporate into gel base.

International Journal of Pharmaceutical Investigation, 2013

The objective of the present study was to design ferrous fumarate (FF) sustained release (SR) pel... more The objective of the present study was to design ferrous fumarate (FF) sustained release (SR) pellets using of cow ghee (CG) as an important hot-melt coating (HMC) agent. The pellets were coated by HMC technique using CG and ethyl cellulose composition by conventional coating pan without the use of spray system. FF formulated as pellets and characterized with regard to the drug content and physico-chemical properties. Stability studies were carried out on the optimized formulation for a period of 6 months at 40 ± 2°C and 75 ± 5% relative humidity. Pellets with good surface morphology and smooth texture confirmed by stereo micrographs. HMC is easy, efficient, rapid and simple method since virtually no agglomeration seen during coating. In-vitro release from pellets at a given level of coating and for present pellet size was dependent upon the physico-chemical property of the drug and mostly aqueous solubility of the drug. The selection of optimized FF formulation was confirmed by comparing percent cumulative drug release with theoretical release profile. Formulation F2 had difference factor (f 1) and similarity factor (f 2) values was found to be 5 and 66 respectively. F2 showed SR of drug for 8 h with cumulative per cent release of 98.03 ± 4.49%. Release kinetics indicates approximately zero order release pattern. HMC pellets were stable during the course of stability study. By means of HMC using CG and ethyl cellulose, SR pellets containing FF were successfully prepared.