Suvamoy Datta - Academia.edu (original) (raw)

Papers by Suvamoy Datta

Haryana Veterinarian, 2013

Haryana Veterinarian, 2014

Journal of medical sciences, Jun 15, 2013

Proceedings of Anticancer Research

Cancer is one of the most prevalent diseases worldwide, which causes significant morbidity and mo... more Cancer is one of the most prevalent diseases worldwide, which causes significant morbidity and mortality. Designing and developing a potential anti-cancer drug is an active field of research worldwide. Microorganisms have been considered a potential source of anti-cancer drugs. One such microbe-derived compound is surfactin, which shows potential anti-cancer activities. In this study, we evaluated the binding potential of surfactin with several cancer cell ligands via an in-silico approach. Hence, molecular docking studies were performed to test the binding potential of surfactin against four targets. The analyses revealed that surfactin from Bacillus sp. can bind with the targeted ligands (coenzyme A, D-leucine, glycerol, and (R)-3-hydroxytetradecanal) with significant affinity. Surfactin showed the highest binding affinity (-7.7 kcal mol-1) to coenzyme A among the targeted ligands. These results may be useful for developing anti-cancer drugs. Nevertheless, further experimental stu...

British Journal of Medicine and Medical Research, 2016

International Journal of Scientific Research in Science and Technology

Hospitalizations due to urinary tract infections are among the most commonly observed condition t... more Hospitalizations due to urinary tract infections are among the most commonly observed condition throughout the world. The study conducted among a total of 200 positive urine samples comprising male and female patients of different age showed E. coli (120), Klebsiella spp. (56) and Proteus spp. (24). Based on antibiotic susceptibility testing, It was revealed that E. coli showed lowest resistance to cefotaxime (35%) and highest resistance to levofloxacin (60%), whereas, Klebsiella spp. showed resistance to ceftriaxone (30.59%) and amoxicillin (88.33%). Likewise, Proteus spp. observed to have 29.16% (azithromycin) and 70.83% (ciprofloxacin) resistance. Cefotaxime was found to be the best drug for the treatment of E. coli related infections with 66.67% sensitivity. Ceftriaxone (69.41%) sensitive) was also found to be the best drug for the treatment of Klebsiella spp., whereas Proteus spp. could be effectively treated by Azithromycin (70.83% sensitive). Thirty-six (36) Multi drug resist...

Annals of Clinical Microbiology and Antimicrobials, 2013

Background: Staphylococcus aureus infections are increasingly reported from both health instituti... more Background: Staphylococcus aureus infections are increasingly reported from both health institutions and communities around the world. In particular, infections due to methicillin-resistant Staphylococcus aureus (MRSA) strains have been detected worldwide. If MRSA becomes the most common form of S. aureus in a community, it makes the treatment of common infections much more difficult. But, report on the current status of community acquired MRSA in the study area is scanty. Methods: Community-based cross sectional study was conducted to evaluate the current prevalence and antibiotic susceptibility pattern of MRSA among primary school children and prisoners in Jimma town. MRSA was detected using Cefoxitin (30μg) disc; and epidemiologic risk factors were assessed using pre-designed questionnaires distributed to the children's parents and prisoners. A total of 354 nasal swabs were collected from primary school children and prisoners from December 2010 to March 2011 following standards microbiological methods. Results: A total of 169 S. aureus isolates were recovered. The overall prevalence of MRSA among the study population was 23.08 % (39/169). Specifically, the prevalence of MRSA among primary school children and prisoners were 18.8% (27/144) and 48% (12/25), respectively. The isolated S. aureus and MRSA displayed multiple drug resistance (MDR) to 2 to 10 antibiotics. The most frequent MDR was Amp/Bac/Ery/Pen/Fox (resistance to Ampicillin, Bacitracin, Erythromycin, Penicillin, and Cefoxitin). Conclusion: The present study revealed that MRSA could be prevalent in the healthy community, transmitted from hospital to the community. The high distribution of MRSA could be favored by potential risk factors. Thus, for comprehensive evaluation of the current prevalence of MRSA and design control measures, consideration need to be given to the healthy community besides data coming from health institutions.

Journal of Pure and Applied Microbiology

Urinary tract infection (UTI) is the leading cause of death among patients and majority of people... more Urinary tract infection (UTI) is the leading cause of death among patients and majority of people visiting the hospital worldwide. In the current quantitative study, urine samples were obtained using sterile method and 100 isolates, including 60 Escherichia coli, 28 Klebsiella sp., and 12 Proteus sp., were investigated in a laboratory. Current study showed that E. coli 60/100 (60%) was the most common cause of UTI followed by Klebsiella sp. 28/100 (28%) and Proteus sp. 12/100 (12%). Cefotaxime (86.67% sensitive) was found to be the best drug for treating infections with E. coli, ceftazidime (100% sensitive) for infections with Klebsiella sp., and imipenem and levofloxacin (100% sensitive) for infections with Proteus sp. Overall, 51% of the isolated strains showed high multidrug resistance (MDR). Because of the alarming increase in extensively drug-resistant and MDR uropathogens, which is a concern in public health, the rational use of antimicrobial therapy should be implemented.

Campylobacter jejuni by PCR in strains isolated from humans, poultry meat and broiler and bovine ... more Campylobacter jejuni by PCR in strains isolated from humans, poultry meat and broiler and bovine faeces

UTIs during pregnancy are a common cause of serious maternal and perinatal morbidity. Pregnancy-r... more UTIs during pregnancy are a common cause of serious maternal and perinatal morbidity. Pregnancy-related physiological changes increases risk of UTI, which more frequently progresses to pyelonephritis. We aimed to examine the common etiology of UTI in obstetrics and its correlation with the age of patients. A total of 300 urine samples were collected from obstetric patients at their third trimester of pregnancy attended at an urban hospital in Dhaka, Bangladesh. Mid stream urine samples were processed for culture. Isolates were identified and antimicrobial drug susceptibility was found out. Obstetric patients had higher prevalence of UTI, found in 23% of the patients in the study. Among the UTI cases, 59% developed purulent infection. Pregnancies in both lower and higher age are more vulnerable to UTI infections. Mostly isolated etiological agents were E. coli and Klebsiella spp. among the Gram negative bacteria. Staphylococcus spp. and Enterococcus spp. were isolated among the Gram ...

Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis. It is an ... more Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis. It is an airborne infection which spreads through the air. Not all people who have been infected with TB germs are infectious in their turn however. In fact, only people who have TB in their lungs are infectious. When a person with TB in their lungs coughs or sneezes, or even talks or spits, this expels TB germs, into the air around them. To become infected, a person simply needs to inhale these airborne bacilli. This study was conducted to assess the diagnostic accuracy of Xpert for rifampicin resistance detection where Xpert was used as the initial test, replacing conventional solid culture-based drug susceptibility test. Total of 80 TB patients sputum sample were collected from NIDCH (Indoor and Outdoor) and were comparatively investigated with the new molecular-based Gene Xpert MTB/RIF assay system and conventional solid culture methods. The samples were collected among different age group. A...

Ayurveda is possibly the most ancient system of medicine in India with a well-defined formulary a... more Ayurveda is possibly the most ancient system of medicine in India with a well-defined formulary and a philosophy which gives an explanation for the occurrence of various diseases. Ayurvedic medicine is one of the oldest systems of medicine in the world. Ayurveda or Ayurvedic medicine is a system of traditional medicine native to the Indian subcontinent and a form of alternative medicine. Ayurveda stresses the use of plant-based medicines and treatments. Hundreds of plant-based medicines are employed, including cardamom and cinnamon. The World Health Organization (WHO) has recognized the Unani System of Medicine (USM) as an alternative system to cater the health care needs of human population. Two Ayurvedic (Lauhashob and Saribadyarisht) and two Unani (Safi and Fevnil) medicines were used for this experiment. It was found that the Ayurvedic medicine Lauhashob worked better against the selected microorganisms. It created larger and better zones of inhibition than other medicines. Sari...

Tuberculosis is a chronic communicable disease. Infections are initially asymptomatic and latent ... more Tuberculosis is a chronic communicable disease. Infections are initially asymptomatic and latent but eventually progresses to active disease, which, if left untreated, may have ≥50% mortality. In 2011, an anti-tuberculosis drug resistance survey in Narsingdi, Bangladesh enrolled both new and retreatment patients. In the study, a number of villages were randomly selected and 152 extra pulmonary tuberculosis (EPTB) patients were identified. All the patients received treatment with standardized first-line drug (FLD) regimens and were investigated to document treatment efficiency. Among the patients, 34 were reported in lower income, 112 in medium income and only 06 in higher income group. Farmers (16.4%) in low income group, and female housewives (41.4%) in medium income group were mostly infected. Silicosis and malnutrition were assumed responsible for high EPTB cases in farmers and housewives respectively. The working youth group (25-34) were found most vulnerable. Extra Pulmonary TB...

Sri Lankan Journal of Infectious Diseases, 2012

The aim of this study was to determine the antibiotic sensitivity pattern of Staphylococcus aureu... more The aim of this study was to determine the antibiotic sensitivity pattern of Staphylococcus aureus in a tertiary care hospital of Sri Lanka. S aureus isolated from patient samples received during the period April to December 2010 were identified by standard methods. The antimicrobial susceptibility testing was performed using the standard disc diffusion method recommended by the Clinical and Laboratory Standards Institute 2008. Of 431 S aureus isolates from all specimens received during this period, 203(47%) were methicillin resistant (MRSA), 45 of which were from screening swabs. Of the 210 methicillin sensitive S aureus (MSSA) isolates tested for penicillin sensitivity, 83% were resistant. Erythromycin and clindamycin sensitivity were tested in 149 isolates with 30.9% and 17.5% resistance respectively. Resistance to ciprofloxacin was 12% in 108 isolates tested. Erythromycin, clindamycin and ciprofloxacin were not tested for all the isolates due to non-availability of antibiotic discs. Erythromycin and clindamycin resistance in 164 MRSA isolates was 79% and 72% respectively. Ciprofloxacin resistance in 125 MRSA isolates tested was 54%. Gentamicin resistance of 44% (n=127 isolates) and cotrimoxazole resistance of 48% (n=158 isolates) was noted. All MRSA isolates were sensitive to vancomycin ,teicoplanin and linezolid. 14 Of the 45 strains isolated from screening swabs, 18% were MRSA. As a high proportion of S aureus is MRSA in this hospital setting, it is important to do culture and sensitivity of relevant specimens when S aureus infection is suspected. The results of this study suggest that MRSA cover may need to be considered in empirical therapy of possible S aureus infections.

Microbiology Research Journal International, 2018

Aims: To find out the prevalence of multi-drug resistance pattern of Escherichia coli in urinary ... more Aims: To find out the prevalence of multi-drug resistance pattern of Escherichia coli in urinary tract infected patients in Dhaka, Bangladesh. Study Design: The study was influenced by recurrent urinary tract infections (UTIs) and presence of high multi-drug resistant (MDR) E. coli.