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The present work has been designed to evaluate hepatoprotective&in vivo antioxidant effect of Met... more The present work has been designed to evaluate hepatoprotective&in vivo antioxidant effect of Methanol-Aqueous Extract of whole plant Polygonumglabrumwilld. (MAEP) against carbon tetrachloride(CCl4)induced hepatotoxicity in experimental rats. The levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), uric acid, total protein and total bilirubin were determined. Antioxidant status in liver was determined by measuring the activity of malonaldehyde (MDA), glutathione (GSH), total thiol and catalase (CAT). Total wet weight and histopathological study of isolated liver specimen was also carried out. . The oral pre-treatment with MAEP (200 and 400 mg/kg) showed significant hepatoprotective activity against CCl4 induced hepatotoxicity by decreasing the activities of serum marker enzymes, bilirubin and lipid peroxidation, and significant increase in the levels of uric acid, GSH, Total thiol, Catalase and p...
Journal of Pharmaceutical Research, 2016
The present study was designed to evaluate the Nootropic potential of Ethanolic seed extracts of ... more The present study was designed to evaluate the Nootropic potential of Ethanolic seed extracts of Vigna mungo.Linn.(ESVM). Design/methodology/approach: The objective of the present study was achieved using following methods such as Clonidine induced hypothermia and Haloperidol induced catalepsy. This study was carried out to evaluate the effectiveness of the ethanolic seed extracts of Vigna mungo.Linn.(ESVM) as Nootropic drug. In Clonidine induced hypothermia model, ESVM show significantly increased rectal temperature in animals, showing antagonistic effect of extract. The extract also shows significantly decreased Lithium induced head twitching indicating anti seritonergic properties The results concluded that Vigna mungo Linn plant has nootropic activity which is most useful for patients suffering from dementia.
The present work has been designed to evaluate hepatoprotective&in vivo antioxidant effect of Met... more The present work has been designed to evaluate hepatoprotective&in vivo antioxidant effect of Methanol-Aqueous Extract of whole plant Polygonumglabrumwilld. (MAEP) against carbon tetrachloride(CCl4)induced hepatotoxicity in experimental rats. The levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), uric acid, total protein and total bilirubin were determined. Antioxidant status in liver was determined by measuring the activity of malonaldehyde (MDA), glutathione (GSH), total thiol and catalase (CAT). Total wet weight and histopathological study of isolated liver specimen was also carried out. . The oral pre-treatment with MAEP (200 and 400 mg/kg) showed significant hepatoprotective activity against CCl4 induced hepatotoxicity by decreasing the activities of serum marker enzymes, bilirubin and lipid peroxidation, and significant increase in the levels of uric acid, GSH, Total thiol, Catalase and p...
Journal of Pharmaceutical Research, 2016
The present study was designed to evaluate the Nootropic potential of Ethanolic seed extracts of ... more The present study was designed to evaluate the Nootropic potential of Ethanolic seed extracts of Vigna mungo.Linn.(ESVM). Design/methodology/approach: The objective of the present study was achieved using following methods such as Clonidine induced hypothermia and Haloperidol induced catalepsy. This study was carried out to evaluate the effectiveness of the ethanolic seed extracts of Vigna mungo.Linn.(ESVM) as Nootropic drug. In Clonidine induced hypothermia model, ESVM show significantly increased rectal temperature in animals, showing antagonistic effect of extract. The extract also shows significantly decreased Lithium induced head twitching indicating anti seritonergic properties The results concluded that Vigna mungo Linn plant has nootropic activity which is most useful for patients suffering from dementia.