Takao Kiyoi - Academia.edu (original) (raw)
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University of Maryland School of Medicine
Beckman Research Institute of City of Hope
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Papers by Takao Kiyoi
Bioorg Medicinal Chem Letter, 1998
Journal of Synthetic Organic Chemistry, Japan, 1998
J Am Chem Soc, 1988
J. Am. Chem. SOC. demonstrate the successful nature of competition between substitution and elimi... more J. Am. Chem. SOC. demonstrate the successful nature of competition between substitution and elimination channels for gas-phase anion-molecule reactions. 110,[8570][8571][8572] aldehydes 2 to bicyclic a-pyrans 3 (eq 1).
Journal of the American Chemical Society, 1988
J. Am. Chem. SOC. demonstrate the successful nature of competition between substitution and elimi... more J. Am. Chem. SOC. demonstrate the successful nature of competition between substitution and elimination channels for gas-phase anion-molecule reactions. 110,[8570][8571][8572] aldehydes 2 to bicyclic a-pyrans 3 (eq 1).
The Journal of Organic Chemistry, 1990
The Journal of Organic Chemistry, 1990
The Journal of Organic Chemistry, 1986
Progress in Medicinal Chemistry, 2006
This chapter gives a good impression of the rate at which cannabinoid research is progressing. Th... more This chapter gives a good impression of the rate at which cannabinoid research is progressing. The past decade has seen a rapid growth in cannabinoid research, which looks set to continue. The therapeutic potential of cannabinoid agonists has long been acknowledged through the use of cannabis for medicinal purposes. However, the accompanying psychotropic effects have restricted the usefulness of this approach. Some of the benefits of cannabinoids can be realized without central nervous system side effects through strategies, such as peripheral restriction of compounds, CB2 subtype selectivity and subtle modulation of the endocannabinoid system. Improved drug delivery systems are also proving beneficial in this regard.
![Research paper thumbnail of Synthesis of hexahydro[2]benzopyrano[4,3-c]pyridines as serotonin 5-HT2C receptor agonists via intramolecular hetero Diels―Alder reactions](https://attachments.academia-assets.com/50414730/thumbnails/1.jpg)
](Tetrahedron Letters, 2011
a b s t r a c t Hexahydro[2]benzopyrano[4,pyridines were synthesized by an intramolecular hetero ... more a b s t r a c t Hexahydro[2]benzopyrano[4,pyridines were synthesized by an intramolecular hetero Diels-Alder reaction. The reaction was applicable to a range of substrates and the products could be easily converted into serotonin 5-HT 2C receptor agonists.
J Med Chem, 1998
Studies on Selection Blockers. 5. Design, Synthesis, and Biological Profile of Sialyl Lewis X Mim... more Studies on Selection Blockers. 5. Design, Synthesis, and Biological Profile of Sialyl Lewis X Mimetics Based on Modified Serine-Glutamic Acid Dipeptides.
![Research paper thumbnail of Synthesis of hexahydro[2]benzopyrano[3,4-c]pyrroles as serotonin 5-HT2C receptor agonists via intramolecular hetero Diels―Alder reactions](https://attachments.academia-assets.com/50414728/thumbnails/1.jpg)
](Tetrahedron Letters, 2011
[2]Benzopyrano[3,4-c]pyrroles were synthesized via an intramolecular hetero Diels-Alder reaction.... more [2]Benzopyrano[3,4-c]pyrroles were synthesized via an intramolecular hetero Diels-Alder reaction. The reaction was applicable to a wide range of substrates and the products could be easily converted into serotonin 5-HT 2C receptor agonists.
J Org Chem, 1993
In the course of our studies of a practical synthesis of the antihypertensive drug 1, a general a... more In the course of our studies of a practical synthesis of the antihypertensive drug 1, a general and convenient preparation of N,"-disubstituted carbodiimides 2 was achieved by the nickel(I1)-catalyzed reaction of isocyanides with primary amines, using oxygen gas as an oxidant. A palladium(O)/oxygen catalytic system was also useful, giving 2 in good yield, although palladium(I1) was inert. A variety of metal oxides and organic peroxides were not effective as the oxidant in the carbodiimide synthesis, with the exception of Ag2O and HgO. The present synthesis of carbodiimides was applicable to the preparation of N-(3-chloro-Bcyanophenyl)-N'-tert-pentylcarbodiimide (2a), a precursor of the antihypertensive drug 1.
Medicinal Chemistry Communication, 2010
Bioorg Medicinal Chem Letter, 1998
Journal of Synthetic Organic Chemistry, Japan, 1998
J Am Chem Soc, 1988
J. Am. Chem. SOC. demonstrate the successful nature of competition between substitution and elimi... more J. Am. Chem. SOC. demonstrate the successful nature of competition between substitution and elimination channels for gas-phase anion-molecule reactions. 110,[8570][8571][8572] aldehydes 2 to bicyclic a-pyrans 3 (eq 1).
Journal of the American Chemical Society, 1988
J. Am. Chem. SOC. demonstrate the successful nature of competition between substitution and elimi... more J. Am. Chem. SOC. demonstrate the successful nature of competition between substitution and elimination channels for gas-phase anion-molecule reactions. 110,[8570][8571][8572] aldehydes 2 to bicyclic a-pyrans 3 (eq 1).
The Journal of Organic Chemistry, 1990
The Journal of Organic Chemistry, 1990
The Journal of Organic Chemistry, 1986
Progress in Medicinal Chemistry, 2006
This chapter gives a good impression of the rate at which cannabinoid research is progressing. Th... more This chapter gives a good impression of the rate at which cannabinoid research is progressing. The past decade has seen a rapid growth in cannabinoid research, which looks set to continue. The therapeutic potential of cannabinoid agonists has long been acknowledged through the use of cannabis for medicinal purposes. However, the accompanying psychotropic effects have restricted the usefulness of this approach. Some of the benefits of cannabinoids can be realized without central nervous system side effects through strategies, such as peripheral restriction of compounds, CB2 subtype selectivity and subtle modulation of the endocannabinoid system. Improved drug delivery systems are also proving beneficial in this regard.
Tetrahedron Letters, 2011
a b s t r a c t Hexahydro[2]benzopyrano[4,pyridines were synthesized by an intramolecular hetero ... more a b s t r a c t Hexahydro[2]benzopyrano[4,pyridines were synthesized by an intramolecular hetero Diels-Alder reaction. The reaction was applicable to a range of substrates and the products could be easily converted into serotonin 5-HT 2C receptor agonists.
J Med Chem, 1998
Studies on Selection Blockers. 5. Design, Synthesis, and Biological Profile of Sialyl Lewis X Mim... more Studies on Selection Blockers. 5. Design, Synthesis, and Biological Profile of Sialyl Lewis X Mimetics Based on Modified Serine-Glutamic Acid Dipeptides.
Tetrahedron Letters, 2011
[2]Benzopyrano[3,4-c]pyrroles were synthesized via an intramolecular hetero Diels-Alder reaction.... more [2]Benzopyrano[3,4-c]pyrroles were synthesized via an intramolecular hetero Diels-Alder reaction. The reaction was applicable to a wide range of substrates and the products could be easily converted into serotonin 5-HT 2C receptor agonists.
J Org Chem, 1993
In the course of our studies of a practical synthesis of the antihypertensive drug 1, a general a... more In the course of our studies of a practical synthesis of the antihypertensive drug 1, a general and convenient preparation of N,"-disubstituted carbodiimides 2 was achieved by the nickel(I1)-catalyzed reaction of isocyanides with primary amines, using oxygen gas as an oxidant. A palladium(O)/oxygen catalytic system was also useful, giving 2 in good yield, although palladium(I1) was inert. A variety of metal oxides and organic peroxides were not effective as the oxidant in the carbodiimide synthesis, with the exception of Ag2O and HgO. The present synthesis of carbodiimides was applicable to the preparation of N-(3-chloro-Bcyanophenyl)-N'-tert-pentylcarbodiimide (2a), a precursor of the antihypertensive drug 1.
Medicinal Chemistry Communication, 2010