Tatiana Helfenstein - Academia.edu (original) (raw)

Papers by Tatiana Helfenstein

Pubvet, 2018

O objetivo do presente trabalho foi identificar fatores considerados de risco, como raça, idade, ... more O objetivo do presente trabalho foi identificar fatores considerados de risco, como raça, idade, sexo, peso corporal e castração em cães que sofreram ruptura do ligamento cruzado cranial (RLCCr), atendidos no Hovet Universidade Anhembi Morumbi. Foram pesquisadas as fichas dos cães com RLCCr atendidos no período de 2009 a 2015. Neste período foram atendidos 382 animais com RLCCr, dos quais 189 fêmeas e 193 machos. Não houve diferença estatisticamente significativa entre machos e fêmeas com RLCCr, entre idade da ruptura, entre os sexos e entre intervalo da castração e RLCCr, mas houve diferença estatisticamente significativa na idade à ruptura dos animais com peso acima de 20 kg em relação aos demais. Concluiu-se que há influência do peso do animal na ocorrência da RLCCr, pois animais com mais de 20 kg apresentaram a RLCCr com uma idade inferior à dos animais de porte menor. As raças mais acometidas pela RLCCr foram Pitbull, Poodle, Fila Brasileiro, Yorkshire, Rotweiler, Labrador e Lhasa Apso. Como neste estudo não houve atendimento de animais castrados antes da puberdade que apresentaram RLCCr, faz-se necessária a pesquisa da influência da castração em animais pré-púberes na ocorrência de RLCCr.

Atherosclerosis Supplements, 2011

Conclusion: in our patients, the strong association between platelet count and PAD was independen... more Conclusion: in our patients, the strong association between platelet count and PAD was independent of the ferritin levels and the inflammatory background.

Atherosclerosis Supplements, 2005

Universidade Federal de São Paulo, São Paulo, BrazilUniversidade Federal de São Paulo, São Paulo,... more Universidade Federal de São Paulo, São Paulo, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilWeb of Scienc

Atherosclerosis Supplements, 2007

Atherosclerosis Supplements, 2008

Sessions 134 PO29 Nutrition diet and were randomly allocated to receive orlistat 120 mg three tim... more Sessions 134 PO29 Nutrition diet and were randomly allocated to receive orlistat 120 mg three times daily (n=28, O group), micronized fenofibrate 200 mg/day (n=28, F group) or both (n=27, OF group) for 6 months. Plasma visfatin concentrations were measured using an enzyme-linked immunoabsorbent assay (EIA) kit (Phoenix Pharmaceuticals, Belmont, California, USA). Results: All groups experienced a significant weight loss, as well as a significant improvement in lipid profile and parameters of carbohydrate metabolism. Plasma visfatin levels were not changed significantly in the 3 groups [from 29.1 (16.5-46.0) to 28.1 (18.9-47.3) ng/mL in O group, from 29.0 (15.4-46.0) to 26.9 (17.0-51.0) ng/mL in F group and from 28.7 (13.4-43.0) to 27.6 (15.5-48.0) in OF group, all p=NS]. Conclusions: Fenofibrate and orlistat administration, alone or in combination, does not significantly alter plasma visfatin levels in overweight and obese subjects with MetS.

Atherosclerosis Supplements, 2007

Universidade Federal de São Paulo, EPM, São Paulo, SP, BrazilUniversidade Federal de São Paulo, E... more Universidade Federal de São Paulo, EPM, São Paulo, SP, BrazilUniversidade Federal de São Paulo, EPM, São Paulo, SP, BrazilWeb of Scienc

Atherosclerosis Supplements, 2005

Atherosclerosis Supplements, 2008

Background and aims: Metabolic syndrome is considered an inflammatory state associated to endothe... more Background and aims: Metabolic syndrome is considered an inflammatory state associated to endothelial dysfunction. The main objective of the present study was to determine whether soluble and leukocitary cell adhesion molecules were altered in patients with metabolic syndrome in comparison with control subjects. Moreover, other circulating markers of different candidate atherogenic risk factors were also studied. Methods: Thirty one male patients with metabolic syndrome (ATPIII definition) and 56 male controls were studied. We evaluated different markers of insulin resistance, inflammation and atherosclerosis, as well as protective factors: insulin, HOMA, QUICKI, lipoprotein profile, HDL composition, CETP, LpPLA2, VCAM-1, ICAM-1, E-Selectin (ELISA), and leukocitary CD18, CD49d and CD54 (flow cytometry). Results: Patients with metabolic syndrome showed a) hypoadiponectinemia (4551±2302 vs. 5865±2548 ng/ml, respectively; p<0.05), b) an atherogenic lipoprotein profile, c) altered HDL chemical composition, d) higher CETP activity, e) diminished Lp-PLA2 activity (6.5±1.9 vs. 7.3±2.2, p<0.05, respectively), antioxidant enzyme related with LDL oxidation, which was positively associated with QUICKI and negatively with VCAM-1 and lymphocyte CD18, and f) high soluble (VCAM-1: 17±5 vs. 13±4 ng/ml, respectively; p<0.0005) and leukocyte adhesion molecule expression (monocyte CD54: 52±15 vs. 45±12 arbitrary units, respectively; p<0.0005; and lymphocyte CD49d: 312±56 vs. 284±64 arbitrary units, respectively; p<0.05). Conclusions: The increment in soluble and leukocitary cell adhesion molecules, crucial for leukocyte interaction with the endothelium and migration into the artery wall, in combination with the other disorders described above reinforce the presence of a clinical status with high propensity to atherosclerotic cardiovascular disease.

Atherosclerosis Supplements, 2007

Universidade Federal de São Paulo, São Paulo, BrazilUniv São Paulo, BR-05508 São Paulo, BrazilUni... more Universidade Federal de São Paulo, São Paulo, BrazilUniv São Paulo, BR-05508 São Paulo, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilWeb of Scienc

Atherosclerosis Supplements, 2007

Universidade Federal de São Paulo, São Paulo, SP, BrazilUniv São Paulo, São Paulo, SP, BrazilUniv... more Universidade Federal de São Paulo, São Paulo, SP, BrazilUniv São Paulo, São Paulo, SP, BrazilUniversidade Federal de São Paulo, São Paulo, SP, BrazilWeb of Scienc

Journal of Cardiovascular Pharmacology, 2005

Renin-angiotensin system activation is recognized to play an important role in atherosclerosis. T... more Renin-angiotensin system activation is recognized to play an important role in atherosclerosis. This study aimed to verify the antiatherosclerotic effects of ACE inhibition on an experimental model of diabetes and hypercholesterolemia. Diabetes was induced in New Zealand male rabbits with a single dose of alloxan (100 mg/kg, IV), and, according to plasma glucose levels obtained after 1 week, the animals were divided into 2 groups ($250 mg/dL or ,250 mg/dL). Each group was randomly assigned to receive or not quinapril (30 mg/d) added to a 0.5% cholesterol-enriched diet. Animals with high glucose levels at 1 week and that remained high after 12 weeks presented higher triglyceride levels (P , 0.02 versus basal). Those initially hyperglycemic but presenting ,250 mg/dL glucose at the end of study formed an additional group. Plasma ACE activity was lower in quinapril-treated animals (P , 0.01 versus untreated groups). However, aorta intima/media ratio and intima area were lower only in the subgroups of quinapril-treated animals with low glucose levels (P , 0.05). Our results support the hypothesis that high plasma glucose may abolish the antiatherosclerotic effect of ACE inhibitors.

Meio ambiente: Preservação, saúde e sobrevivência 3

Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena... more Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica. A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

The role of soluble fiber intake in patients under

With the increasing prevalence of diabetes mellitus worldwide, new experimental models are requir... more With the increasing prevalence of diabetes mellitus worldwide, new experimental models are required to better understand the pathophysiology of this disease and to offer therapeutic options that can preserve pancreatic beta-cells, protect target organs and attenuate atherosclerosis. Objective: The aims of this study were to develop an experimental model of type 2 diabetes mellitus induced by diet and assess on this model the effects of an angiotensin-converting enzyme inhibitor (ACEI) and an antagonist of the angiotensin II type1 receptor (AT1R) on target organ protection. Methods: New Zealand male white

Rev Soc Cardiol Estado De Sao Paulo, Jun 1, 2004

Atherosclerosis Supplements, 2006

Pl l Opti.~d atherosclerosis management (lst part) 46.8±3.5 vs 55.8±11.2 years p<0.05) and their ... more Pl l Opti.~d atherosclerosis management (lst part) 46.8±3.5 vs 55.8±11.2 years p<0.05) and their systolic blood pressure was significantly lower than in the latter group: 1st ABPM-112.3±11.9 vs 122.9±16.9 mmHg (p<0.03) 2nd ABPM 111.7±11.9 vs 122.5±25.8 mmHg (p< 0.01), respectively, while diastolic blood pressure was similar in these two groups: 1st ABPM-75.3±9.9 and 74.5±10.3 mmHg; 2nd ABPM-78.8±14.1 and 73.9±9.6 mmHg, respectively. ConclusionDipping status may change in up to 20% type 2 diabetes patients as a result of an antihypertensive medication change. At that time the diagnosis of impaired blood pressure variation should be made with caution.

Atherosclerosis Supplements, 2007

Atherosclerosis Supplements, 2008

Prevalence of the metabolic syndrome among hypertensive patients in a community practice in Israe... more Prevalence of the metabolic syndrome among hypertensive patients in a community practice in Israel Background: The metabolic syndrome (MS) is a risk factor for cardiovascular disease and DM.Appropriate treatment can reduce cardiovascular morbidity and mortality. However, family physicians in Israel may not routinely diagnosis the MS. Purpose: To measure the prevalence of the MS among hypertensive patients in a community clinic,to identify the characteristics of this population. Method: A sample of hypertensive patients were invited by mail to an appointment in which they filled out a questionnaire, underwent a physical exam, and appropriate lab tests. Additional information was obtained from the patient files. Results: 200 patients were invited to the clinic, of which 82% participated. The age range of the participants was 28-95 years,48% were men,10% were smokers. 47% reported that they followed a diet and 48% reported doing physical activity Only 4 patients had been diagnosed with metabolic syndrome before the study. 110 additional hypertensives were found to meet the criteria for the syndrome. Significant correlation was found between metabolic syndrome and life style. Patients on a diet had a lower prevalence of MS (58 Patients-p<0.008). Hypertensives without MS smoked less (35 Patients-p=0.024) Conclusions: In this sample,69% of hypertensives suffer from MS but only 2.4% had this diagnosis recorded in their medical file before this intervention. Keeping to good diet is associated with less MS Interventions should be planned to increase the awareness of family physicians in Israel to diagnose and treat the MS

Pubvet, 2018

Atherosclerosis Supplements, 2011

Atherosclerosis Supplements, 2005

Atherosclerosis Supplements, 2007

Atherosclerosis Supplements, 2008

Atherosclerosis Supplements, 2007

Atherosclerosis Supplements, 2005

Atherosclerosis Supplements, 2008

Atherosclerosis Supplements, 2007

Journal of Cardiovascular Pharmacology, 2005

Meio ambiente: Preservação, saúde e sobrevivência 3

The role of soluble fiber intake in patients under

Rev Soc Cardiol Estado De Sao Paulo, Jun 1, 2004

Atherosclerosis Supplements, 2006

Atherosclerosis Supplements, 2007

Atherosclerosis Supplements, 2008