Tevfik Koçak - Academia.edu (original) (raw)
Papers by Tevfik Koçak
Journal of Translational Medicine, Apr 2, 2023
Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a s... more Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β-cells and/or peripheral insulin resistance, resulting in impaired glucose and lipid metabolism. Genetic, metabolic, multiple lifestyle, and sociodemographic factors are known as related to high T2DM risk. Dietary lipids and lipid metabolism are significant metabolic modulators in T2DM and T2DM-related complications. Besides, accumulated evidence suggests that altered gut microbiota which plays an important role in the metabolic health of the host contributes significantly to T2DM involving impaired or improved glucose and lipid metabolism. At this point, dietary lipids may affect host physiology and health via interaction with the gut microbiota. Besides, increasing evidence in the literature suggests that lipidomics as novel parameters detected with holistic analytical techniques have important roles in the pathogenesis and progression of T2DM, through various mechanisms of action including gut-brain axis modulation. A better understanding of the roles of some nutrients and lipidomics in T2DM through gut microbiota interactions will help develop new strategies for the prevention and treatment of T2DM. However, this issue has not yet been entirely discussed in the literature. The present review provides up-to-date knowledge on the roles of dietary lipids and lipidomics in gut-brain axis in T2DM and some nutritional strategies in T2DM considering lipids-lipidomics and gut microbiota interactions are given. Keywords Lipids, Lipidomics, Type 2 diabetes mellitus, Gut microbiota, Diet Background Type 2 diabetes mellitus (T2DM) is an endocrine metabolic disorder characterized by dysfunctional pancreatic β-cells and peripheral insulin resistance, resulting in abnormalities of glucose metabolism, dyslipidemia, and chronic inflammation [1]. T2DM is commonly associated with poor blood glucose control, dyslipidemia, and obesity, and has become a global public health concern due to the rising prevalence and implications of the disease [2, 3]. In 2021, about 537 million people will be diagnosed with diabetes (DM), and this number is estimated to increase to 643 million by 2030; 90-95 percent of DM diagnoses are T2DM [4, 5]. Genetic, metabolic, lifestyle, and dietary patterns are among the most influential determinants of T2DM [6]. Although ethnicity and family history/genetic
DergiPark (Istanbul University), Dec 31, 2017
Clinical and Experimental Health Sciences, Jun 15, 2023
Objective: The COVID-19 disease, which is caused by the SARS-CoV-2 infectious agent, is the last ... more Objective: The COVID-19 disease, which is caused by the SARS-CoV-2 infectious agent, is the last member of infectious diseases. Factors such as uncertainties about the prognosis of the disease, insufficient control measures, lack of effective therapeutic mechanisms can cause negative effects on individuals' daily living activities and mental health. In this study, it was aimed to evaluate the mood changes and Mediterranean diet adherence of individuals during the COVID-19 pandemic. Methods: The study was carried out between November 2020 and January 2021 with individuals over 18 years of age. The data required for the research were collected with an online questionnaire. The COVID-19 Phobia Scale (C19P-S) and the Coronavirus Anxiety Scale (CAS) were used to assess the emotional state of individuals. The Mediterranean Diet Adherence Screener (MEDAS) was used to examine the adherence to the Mediterranean diet. Results: A total of 6609 individuals between the ages of 18-70 participated in the study and 70% of the participants are female. The median score obtained from the C19P-S in female individuals was found to be significantly higher than in male subjects (p<0.001). A positive relationship was shown between the Mediterranean diet adherence and the COVID-19 Phobia Scale (p<0.001). Conclusion: The COVID-19 related phobia and fear may have positively affected the adherence to the Mediterranean diet of individuals as a coping strategy with this pandemic period.
European journal of environment and public health, Apr 1, 2023
The COVID-19 outbreak was classified as a global epidemic after it emerged in the first quarter o... more The COVID-19 outbreak was classified as a global epidemic after it emerged in the first quarter of 2020 and the virus spread rapidly after only three months. The quarantines implemented during the COVID-19 period, the deterioration of economic income, and the uncertain situation about the future have affected the changes in physical inactivity, mood changes, sleep quality, lifestyle, and eating habits. Our study aimed to investigate the changes in individuals' mood, sleep quality, lifestyle, and eating habits during the COVID-19 pandemic period. Patients and Methods: COVID-19 phobia scale (C19P-S) and coronavirus anxiety scale (CAS) were used to assess the emotional state of individuals. Pittsburgh sleep quality index was used to assess sleep quality. The data required for the research were collected with an online questionnaire. The study was carried out on individuals over 18 years of age between November 2020 and January 2021. Changes in mood, sleep quality and lifestyle with eating habits of individuals during the COVID-19. The data obtained from the studies were analyzed with appropriate statistical methods using the SPSS 22.0 program. Results: A total of 6,609 individuals between the ages of 18-70 participated in the study, and 69.8% of the participants were female. Sleep quality and the mean score obtained from the C19P-S in female individuals (50.4±10.63) were found to be significantly higher than in male individuals (46.9±9.94) (p<0.001). Sleep quality showed a positive and significant relationship with CAS and C19P-S, respectively (r=0.190, r=224) (p<0.001). Before the COVID-19 period, the individuals consumed the highest rate of fruit (68.8%), tea, herbal teas (48.4%), vegetables (50.8%), and milk and yogurt (48.4%), while after the pandemic the highest rate of industrial packaged bakery products (41.0%), sugar or sweeteners (36.2%), processed meat products (34.7%), and sugar-sweetened soft drinks (30.3%) were consumed. Conclusions: The COVID-19 may cause changes in individuals' mood, sleep quality, lifestyle, and eating habits. This is the first study to evaluate these factors together in the Turkish population. We believe that complications related to COVID-19 may have a negative impact on public health in the long term. In the future, we recommend that governments develop policies to improve public health regarding adequate and balanced nutrition, physical activity, and mood management.
Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, Sep 27, 2022
Gazi sağlık bilimleri dergisi, Sep 6, 2020
Yeni koronavius hastalığı "COVID-19" dünyada birçok insanın hayatını tehdit eden ciddi bir halk s... more Yeni koronavius hastalığı "COVID-19" dünyada birçok insanın hayatını tehdit eden ciddi bir halk sağlığı sorunu olmuştur. Bu yeni virüsten korunmada veya hastalık şiddetini hafifletmede, SARS-CoV-2 için halen spesifik bir tedavinin olmadığı da dikkate alındığında, bağışıklık sistemin aktif ve güçlü tutulması önemlidir. Beslenme ve bağışıklık arasında oldukça karmaşık ve güçlü ilişki bulunmaktadır. Epidemiyolojik ve deneysel çalışmalar beslenme, bağışıklık sistemi ve enfeksiyon üçgeninde diyet müdahalelerinin önemine işaret etmektedir. Bu süreçte makro ve mikro besin öğesi gereksinimlerini karşılayacak şekilde yeterli alımını sağlayan bir beslenme planına uyulması, diğer zorunlu tedbirler ile birlikte hastalıktan korunmada etkili olacaktır. Ayrıca hastalığın seyrine uygun olarak yapılan beslenme müdahaleleri tedavinin bir parçası olarak, iyileşme ve sağ kalım oranının artmasında potansiyel etki sağlayacaktır. Bu makalede COVİD-19'da beslenmenin bağışıklık sistemin desteklenmesi üzerindeki etkileri ayrıntılı olarak besin ögesi bazında irdelenmiştir.
European journal of environment and public health, Jul 1, 2023
The molecular biology revolution has emerged with the determination that bone tissue is an endocr... more The molecular biology revolution has emerged with the determination that bone tissue is an endocrine organ that regulates many physiological processes, and osteocalcin (OCN), an osteoblast-derived protein that provides endocrine control, is a hormone that regulates glucose and energy homeostasis. By controlling gene expression in β-cells and adipocytes, OCN improves glucose intolerance, obesity, and insulin expression. In addition, OCN stimulates the secretion of adiponectin, a molecule that increases fatty acid oxidation and insulin secretion and sensitivity in adipose tissue and reduces adipose tissue accumulation. Recent research suggests that serum OCN increases the expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and uncoupling protein-1 (UCP1) genes, which play a role in thermogenesis in brown adipose tissue, it also affects insulin sensitivity by increasing adiponectin expression in white adipose tissue. OCN the target gene of insulin, and resting energy expenditure and mitochondrial biogenesis. With all these effects, OCN is a protein that has recently been found to be associated with diabetes and obesity components. Conclusions: This review aims to present an overview of understanding the interaction of OCN produced by osteoblasts with insulin, glucose metabolism, adipose tissue, skeletal and muscle tissue, and appetite metabolism in understanding the endocrine functions of bone. In addition, it was conducted to examine the role of OCN in energy metabolism and to evaluate the relationship of energy metabolism pathways affected by OCN with noncommunicable chronic diseases such as type 2 diabetes mellitus and obesity.
Rheumatology International, Aug 16, 2023
Clinical and Experimental Health Sciences
Objective: The COVID-19 disease, which is caused by the SARS-CoV-2 infectious agent, is the last ... more Objective: The COVID-19 disease, which is caused by the SARS-CoV-2 infectious agent, is the last member of infectious diseases. Factors such as uncertainties about the prognosis of the disease, insufficient control measures, lack of effective therapeutic mechanisms can cause negative effects on individuals’ daily living activities and mental health. In this study, it was aimed to evaluate the mood changes and Mediterranean diet adherence of individuals during the COVID-19 pandemic. Methods: The study was carried out between November 2020 and January 2021 with individuals over 18 years of age. The data required for the research were collected with an online questionnaire. The COVID-19 Phobia Scale (C19P-S) and the Coronavirus Anxiety Scale (CAS) were used to assess the emotional state of individuals. The Mediterranean Diet Adherence Screener (MEDAS) was used to examine the adherence to the Mediterranean diet. Results: A total of 6609 individuals between the ages of 18-70 participated...
Journal of Translational Medicine
Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a s... more Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β-cells and/or peripheral insulin resistance, resulting in impaired glucose and lipid metabolism. Genetic, metabolic, multiple lifestyle, and sociodemographic factors are known as related to high T2DM risk. Dietary lipids and lipid metabolism are significant metabolic modulators in T2DM and T2DM-related complications. Besides, accumulated evidence suggests that altered gut microbiota which plays an important role in the metabolic health of the host contributes significantly to T2DM involving impaired or improved glucose and lipid metabolism. At this point, dietary lipids may affect host physiology and health via interaction with the gut microbiota. Besides, increasing evidence in the literature suggests that lipidomics as novel parameters detected with holistic analytical techniques have important roles in the pathoge...
European Journal of Environment and Public Health
Objectives: The molecular biology revolution has emerged with the determination that bone tissue ... more Objectives: The molecular biology revolution has emerged with the determination that bone tissue is an endocrine organ that regulates many physiological processes, and osteocalcin (OCN), an osteoblast-derived protein that provides endocrine control, is a hormone that regulates glucose and energy homeostasis. By controlling gene expression in β-cells and adipocytes, OCN improves glucose intolerance, obesity, and insulin expression. In addition, OCN stimulates the secretion of adiponectin, a molecule that increases fatty acid oxidation and insulin secretion and sensitivity in adipose tissue and reduces adipose tissue accumulation. Recent research suggests that serum OCN increases the expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and uncoupling protein-1 (UCP1) genes, which play a role in thermogenesis in brown adipose tissue, it also affects insulin sensitivity by increasing adiponectin expression in white adipose tissue. OCN the target gene of...
European journal of environment and public health, Apr 1, 2023
The COVID-19 outbreak was classified as a global epidemic after it emerged in the first quarter o... more The COVID-19 outbreak was classified as a global epidemic after it emerged in the first quarter of 2020 and the virus spread rapidly after only three months. The quarantines implemented during the COVID-19 period, the deterioration of economic income, and the uncertain situation about the future have affected the changes in physical inactivity, mood changes, sleep quality, lifestyle, and eating habits. Our study aimed to investigate the changes in individuals' mood, sleep quality, lifestyle, and eating habits during the COVID-19 pandemic period. Patients and Methods: COVID-19 phobia scale (C19P-S) and coronavirus anxiety scale (CAS) were used to assess the emotional state of individuals. Pittsburgh sleep quality index was used to assess sleep quality. The data required for the research were collected with an online questionnaire. The study was carried out on individuals over 18 years of age between November 2020 and January 2021. Changes in mood, sleep quality and lifestyle with eating habits of individuals during the COVID-19. The data obtained from the studies were analyzed with appropriate statistical methods using the SPSS 22.0 program. Results: A total of 6,609 individuals between the ages of 18-70 participated in the study, and 69.8% of the participants were female. Sleep quality and the mean score obtained from the C19P-S in female individuals (50.4±10.63) were found to be significantly higher than in male individuals (46.9±9.94) (p<0.001). Sleep quality showed a positive and significant relationship with CAS and C19P-S, respectively (r=0.190, r=224) (p<0.001). Before the COVID-19 period, the individuals consumed the highest rate of fruit (68.8%), tea, herbal teas (48.4%), vegetables (50.8%), and milk and yogurt (48.4%), while after the pandemic the highest rate of industrial packaged bakery products (41.0%), sugar or sweeteners (36.2%), processed meat products (34.7%), and sugar-sweetened soft drinks (30.3%) were consumed. Conclusions: The COVID-19 may cause changes in individuals' mood, sleep quality, lifestyle, and eating habits. This is the first study to evaluate these factors together in the Turkish population. We believe that complications related to COVID-19 may have a negative impact on public health in the long term. In the future, we recommend that governments develop policies to improve public health regarding adequate and balanced nutrition, physical activity, and mood management.
Foods
Fermentation is one of the oldest known production processes and the most technologically valuabl... more Fermentation is one of the oldest known production processes and the most technologically valuable in terms of the food industry. In recent years, increasing nutrition and health awareness has also changed what is expected from fermentation technology, and the production of healthier foods has started to come a little more forward rather than increasing the shelf life and organoleptic properties of foods. Therefore, in addition to traditional microorganisms, a new generation of (novel) microorganisms has been discovered and research has shifted to this point. Novel microorganisms are known as either newly isolated genera and species from natural sources or bacterial strains derived from existing bacteria. Although novel microorganisms are mostly studied for their use in novel food production in terms of gut-microbiota modulation, recent innovative food research highlights their fermentative effects and usability, especially in food modifications. Herein, Clostridium butyricum, Bacte...
Bu çalışma, Tip 2 diyabetli bireyler ile yaş ve beden kütle indeksi benzer olan sağlıklı bireyler... more Bu çalışma, Tip 2 diyabetli bireyler ile yaş ve beden kütle indeksi benzer olan sağlıklı bireylerin diyet enerji yoğunlukları, beslenme durumları ve yaşam tarzı değişkenlerinin karşılaştırılması ve glisemik kontrol ile ilişkisinin değerlendirilmesi amacıyla planlanmış ve yürütülmüştür. Çalışmaya yaşları 45-65 yıl aralığında olan 44 Tip 2 diyabetli 44 sağlıklı olmak üzere toplam 88 gönüllü kadın birey alınmıştır. Bireylerin genel özellikleri, sağlık ve hastalık bilgileri, stres durumu ve sirkadiyen ritim düzeni ile fiziksel aktivite düzeyleri sorgulanmıştır. Bireylerin antropometrik ölçümleri ve vücut bileşimleri alınmış, bazı biyokimyasal bulguları (HbA1c, açlık plazma glukozu, insülin, total kolesterol, HDL-K ve LDL-K trigliserid, C-peptid ve 1,5 anhidroglusitol) analiz edilmiş, besin alımları ve beslenme alışkanlıkları 3 günlük besin tüketim kaydı ile sorgulanmıştır. Tip 2 diyabetli bireylerin HbA1c, açlık plazma glukozu, insülin, HDL kolesterol, trigliserit ve HOMA-IR düzeyleri k...
Ecology of Food and Nutrition
Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi
Prostate cancer (PCa) is the second most common type of cancer for men. Nutrition plays an import... more Prostate cancer (PCa) is the second most common type of cancer for men. Nutrition plays an important role in the development and progression of prostate cancer. Dietary components in PCa cells; showed that high intake of energy, saturated fat, refined carbohydrates and animal protein, as well as insufficient intake of fresh vegetables and fruits, whole grains, essential minerals and phytochemicals, were associated with the etiology and treatment of PCa. A literature search was conducted using electronic databases supported by a manual review of the reference list of articles from PubMed, Web of Science, Scopus, and Google Scholar until March 2022. The following key terms are used: Pub-Med, Web of Science, Scopus, and Google Scholar: ("Prostate Cancer" OR "Diet" OR "Nutrition" OR "Nutrient Intake" OR "Dietary Patterns" OR "Diet Patterns") terms are used. Different nutritional patterns can have different positive or negative ...
Yeni koronavius hastaligi “COVID-19” dunyada bircok insanin hayatini tehdit eden ciddi bir halk s... more Yeni koronavius hastaligi “COVID-19” dunyada bircok insanin hayatini tehdit eden ciddi bir halk sagligi sorunu olmustur. Bu yeni virusten korunmada veya hastalik siddetini hafifletmede, SARS-CoV-2 icin halen spesifik bir tedavinin olmadigi da dikkate alindiginda, bagisiklik sistemin aktif ve guclu tutulmasi onemlidir. Beslenme ve bagisiklik arasinda oldukca karmasik ve guclu iliski bulunmaktadir. Epidemiyolojik ve deneysel calismalar beslenme, bagisiklik sistemi ve enfeksiyon ucgeninde diyet mudahalelerinin onemine isaret etmektedir. Bu surecte makro ve mikro besin ogesi gereksinimlerini karsilayacak sekilde yeterli alimini saglayan bir beslenme planina uyulmasi, diger zorunlu tedbirler ile birlikte hastaliktan korunmada etkili olacaktir. Ayrica hastaligin seyrine uygun olarak yapilan beslenme mudahaleleri tedavinin bir parcasi olarak, iyilesme ve sag kalim oraninin artmasinda potansiyel etki saglayacaktir. Bu makalede COVID-19’da beslenmenin bagisiklik sistemin desteklenmesi uzerin...
Insan intestinal mikrobiyotasi yaklasik 10¹³-10¹ 4 degisen sayida mikroorganizmadan meydana gele... more Insan intestinal mikrobiyotasi yaklasik 10¹³-10¹ 4 degisen sayida mikroorganizmadan meydana gelen super organizma olarak tanimlanmaktadir. Insan organizmasindaki mikroorganizma sayisi toplam insan hucre sayisindan 10 kat daha fazla olup, intestinal mikrobiyotayi meydana getiren genom insan organizmasini meydana getiren genomun yaklasik 150 kat buyuklugundedir. Bu kadar cok sayida bileseniolan mikrobiyota fetal hayattan yasliliga kadar bircok etkenin etkisiyle degisime ugramakta olup beslenmenin rolu goz ardi edilmemelidir. intestinal mikrobiyota; besinlerle alinan polisakkaritlerinin fermantasyonu, esansiyel amino asitler ve vitaminlerin sentezi ve ksenobiyotik ilaclarin metabolizmasi gibi bircok fonksiyonel ozellige sahiptir. Mikro besin ogeleri insan metabolizmasini ve organ fonksiyonlarini ya dogrudan emilim ve hedef hucreye etki mekanizmasiyla ya da intestinal mikrobiyota vasitasiyla dolayli olarak etkilemektedir. Ayrica enerji metabolizmasi, hucresel buyume ve farklilasma, or...
Journal of Translational Medicine, Apr 2, 2023
Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a s... more Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β-cells and/or peripheral insulin resistance, resulting in impaired glucose and lipid metabolism. Genetic, metabolic, multiple lifestyle, and sociodemographic factors are known as related to high T2DM risk. Dietary lipids and lipid metabolism are significant metabolic modulators in T2DM and T2DM-related complications. Besides, accumulated evidence suggests that altered gut microbiota which plays an important role in the metabolic health of the host contributes significantly to T2DM involving impaired or improved glucose and lipid metabolism. At this point, dietary lipids may affect host physiology and health via interaction with the gut microbiota. Besides, increasing evidence in the literature suggests that lipidomics as novel parameters detected with holistic analytical techniques have important roles in the pathogenesis and progression of T2DM, through various mechanisms of action including gut-brain axis modulation. A better understanding of the roles of some nutrients and lipidomics in T2DM through gut microbiota interactions will help develop new strategies for the prevention and treatment of T2DM. However, this issue has not yet been entirely discussed in the literature. The present review provides up-to-date knowledge on the roles of dietary lipids and lipidomics in gut-brain axis in T2DM and some nutritional strategies in T2DM considering lipids-lipidomics and gut microbiota interactions are given. Keywords Lipids, Lipidomics, Type 2 diabetes mellitus, Gut microbiota, Diet Background Type 2 diabetes mellitus (T2DM) is an endocrine metabolic disorder characterized by dysfunctional pancreatic β-cells and peripheral insulin resistance, resulting in abnormalities of glucose metabolism, dyslipidemia, and chronic inflammation [1]. T2DM is commonly associated with poor blood glucose control, dyslipidemia, and obesity, and has become a global public health concern due to the rising prevalence and implications of the disease [2, 3]. In 2021, about 537 million people will be diagnosed with diabetes (DM), and this number is estimated to increase to 643 million by 2030; 90-95 percent of DM diagnoses are T2DM [4, 5]. Genetic, metabolic, lifestyle, and dietary patterns are among the most influential determinants of T2DM [6]. Although ethnicity and family history/genetic
DergiPark (Istanbul University), Dec 31, 2017
Clinical and Experimental Health Sciences, Jun 15, 2023
Objective: The COVID-19 disease, which is caused by the SARS-CoV-2 infectious agent, is the last ... more Objective: The COVID-19 disease, which is caused by the SARS-CoV-2 infectious agent, is the last member of infectious diseases. Factors such as uncertainties about the prognosis of the disease, insufficient control measures, lack of effective therapeutic mechanisms can cause negative effects on individuals' daily living activities and mental health. In this study, it was aimed to evaluate the mood changes and Mediterranean diet adherence of individuals during the COVID-19 pandemic. Methods: The study was carried out between November 2020 and January 2021 with individuals over 18 years of age. The data required for the research were collected with an online questionnaire. The COVID-19 Phobia Scale (C19P-S) and the Coronavirus Anxiety Scale (CAS) were used to assess the emotional state of individuals. The Mediterranean Diet Adherence Screener (MEDAS) was used to examine the adherence to the Mediterranean diet. Results: A total of 6609 individuals between the ages of 18-70 participated in the study and 70% of the participants are female. The median score obtained from the C19P-S in female individuals was found to be significantly higher than in male subjects (p<0.001). A positive relationship was shown between the Mediterranean diet adherence and the COVID-19 Phobia Scale (p<0.001). Conclusion: The COVID-19 related phobia and fear may have positively affected the adherence to the Mediterranean diet of individuals as a coping strategy with this pandemic period.
European journal of environment and public health, Apr 1, 2023
The COVID-19 outbreak was classified as a global epidemic after it emerged in the first quarter o... more The COVID-19 outbreak was classified as a global epidemic after it emerged in the first quarter of 2020 and the virus spread rapidly after only three months. The quarantines implemented during the COVID-19 period, the deterioration of economic income, and the uncertain situation about the future have affected the changes in physical inactivity, mood changes, sleep quality, lifestyle, and eating habits. Our study aimed to investigate the changes in individuals' mood, sleep quality, lifestyle, and eating habits during the COVID-19 pandemic period. Patients and Methods: COVID-19 phobia scale (C19P-S) and coronavirus anxiety scale (CAS) were used to assess the emotional state of individuals. Pittsburgh sleep quality index was used to assess sleep quality. The data required for the research were collected with an online questionnaire. The study was carried out on individuals over 18 years of age between November 2020 and January 2021. Changes in mood, sleep quality and lifestyle with eating habits of individuals during the COVID-19. The data obtained from the studies were analyzed with appropriate statistical methods using the SPSS 22.0 program. Results: A total of 6,609 individuals between the ages of 18-70 participated in the study, and 69.8% of the participants were female. Sleep quality and the mean score obtained from the C19P-S in female individuals (50.4±10.63) were found to be significantly higher than in male individuals (46.9±9.94) (p<0.001). Sleep quality showed a positive and significant relationship with CAS and C19P-S, respectively (r=0.190, r=224) (p<0.001). Before the COVID-19 period, the individuals consumed the highest rate of fruit (68.8%), tea, herbal teas (48.4%), vegetables (50.8%), and milk and yogurt (48.4%), while after the pandemic the highest rate of industrial packaged bakery products (41.0%), sugar or sweeteners (36.2%), processed meat products (34.7%), and sugar-sweetened soft drinks (30.3%) were consumed. Conclusions: The COVID-19 may cause changes in individuals' mood, sleep quality, lifestyle, and eating habits. This is the first study to evaluate these factors together in the Turkish population. We believe that complications related to COVID-19 may have a negative impact on public health in the long term. In the future, we recommend that governments develop policies to improve public health regarding adequate and balanced nutrition, physical activity, and mood management.
Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, Sep 27, 2022
Gazi sağlık bilimleri dergisi, Sep 6, 2020
Yeni koronavius hastalığı "COVID-19" dünyada birçok insanın hayatını tehdit eden ciddi bir halk s... more Yeni koronavius hastalığı "COVID-19" dünyada birçok insanın hayatını tehdit eden ciddi bir halk sağlığı sorunu olmuştur. Bu yeni virüsten korunmada veya hastalık şiddetini hafifletmede, SARS-CoV-2 için halen spesifik bir tedavinin olmadığı da dikkate alındığında, bağışıklık sistemin aktif ve güçlü tutulması önemlidir. Beslenme ve bağışıklık arasında oldukça karmaşık ve güçlü ilişki bulunmaktadır. Epidemiyolojik ve deneysel çalışmalar beslenme, bağışıklık sistemi ve enfeksiyon üçgeninde diyet müdahalelerinin önemine işaret etmektedir. Bu süreçte makro ve mikro besin öğesi gereksinimlerini karşılayacak şekilde yeterli alımını sağlayan bir beslenme planına uyulması, diğer zorunlu tedbirler ile birlikte hastalıktan korunmada etkili olacaktır. Ayrıca hastalığın seyrine uygun olarak yapılan beslenme müdahaleleri tedavinin bir parçası olarak, iyileşme ve sağ kalım oranının artmasında potansiyel etki sağlayacaktır. Bu makalede COVİD-19'da beslenmenin bağışıklık sistemin desteklenmesi üzerindeki etkileri ayrıntılı olarak besin ögesi bazında irdelenmiştir.
European journal of environment and public health, Jul 1, 2023
The molecular biology revolution has emerged with the determination that bone tissue is an endocr... more The molecular biology revolution has emerged with the determination that bone tissue is an endocrine organ that regulates many physiological processes, and osteocalcin (OCN), an osteoblast-derived protein that provides endocrine control, is a hormone that regulates glucose and energy homeostasis. By controlling gene expression in β-cells and adipocytes, OCN improves glucose intolerance, obesity, and insulin expression. In addition, OCN stimulates the secretion of adiponectin, a molecule that increases fatty acid oxidation and insulin secretion and sensitivity in adipose tissue and reduces adipose tissue accumulation. Recent research suggests that serum OCN increases the expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and uncoupling protein-1 (UCP1) genes, which play a role in thermogenesis in brown adipose tissue, it also affects insulin sensitivity by increasing adiponectin expression in white adipose tissue. OCN the target gene of insulin, and resting energy expenditure and mitochondrial biogenesis. With all these effects, OCN is a protein that has recently been found to be associated with diabetes and obesity components. Conclusions: This review aims to present an overview of understanding the interaction of OCN produced by osteoblasts with insulin, glucose metabolism, adipose tissue, skeletal and muscle tissue, and appetite metabolism in understanding the endocrine functions of bone. In addition, it was conducted to examine the role of OCN in energy metabolism and to evaluate the relationship of energy metabolism pathways affected by OCN with noncommunicable chronic diseases such as type 2 diabetes mellitus and obesity.
Rheumatology International, Aug 16, 2023
Clinical and Experimental Health Sciences
Objective: The COVID-19 disease, which is caused by the SARS-CoV-2 infectious agent, is the last ... more Objective: The COVID-19 disease, which is caused by the SARS-CoV-2 infectious agent, is the last member of infectious diseases. Factors such as uncertainties about the prognosis of the disease, insufficient control measures, lack of effective therapeutic mechanisms can cause negative effects on individuals’ daily living activities and mental health. In this study, it was aimed to evaluate the mood changes and Mediterranean diet adherence of individuals during the COVID-19 pandemic. Methods: The study was carried out between November 2020 and January 2021 with individuals over 18 years of age. The data required for the research were collected with an online questionnaire. The COVID-19 Phobia Scale (C19P-S) and the Coronavirus Anxiety Scale (CAS) were used to assess the emotional state of individuals. The Mediterranean Diet Adherence Screener (MEDAS) was used to examine the adherence to the Mediterranean diet. Results: A total of 6609 individuals between the ages of 18-70 participated...
Journal of Translational Medicine
Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a s... more Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β-cells and/or peripheral insulin resistance, resulting in impaired glucose and lipid metabolism. Genetic, metabolic, multiple lifestyle, and sociodemographic factors are known as related to high T2DM risk. Dietary lipids and lipid metabolism are significant metabolic modulators in T2DM and T2DM-related complications. Besides, accumulated evidence suggests that altered gut microbiota which plays an important role in the metabolic health of the host contributes significantly to T2DM involving impaired or improved glucose and lipid metabolism. At this point, dietary lipids may affect host physiology and health via interaction with the gut microbiota. Besides, increasing evidence in the literature suggests that lipidomics as novel parameters detected with holistic analytical techniques have important roles in the pathoge...
European Journal of Environment and Public Health
Objectives: The molecular biology revolution has emerged with the determination that bone tissue ... more Objectives: The molecular biology revolution has emerged with the determination that bone tissue is an endocrine organ that regulates many physiological processes, and osteocalcin (OCN), an osteoblast-derived protein that provides endocrine control, is a hormone that regulates glucose and energy homeostasis. By controlling gene expression in β-cells and adipocytes, OCN improves glucose intolerance, obesity, and insulin expression. In addition, OCN stimulates the secretion of adiponectin, a molecule that increases fatty acid oxidation and insulin secretion and sensitivity in adipose tissue and reduces adipose tissue accumulation. Recent research suggests that serum OCN increases the expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and uncoupling protein-1 (UCP1) genes, which play a role in thermogenesis in brown adipose tissue, it also affects insulin sensitivity by increasing adiponectin expression in white adipose tissue. OCN the target gene of...
European journal of environment and public health, Apr 1, 2023
The COVID-19 outbreak was classified as a global epidemic after it emerged in the first quarter o... more The COVID-19 outbreak was classified as a global epidemic after it emerged in the first quarter of 2020 and the virus spread rapidly after only three months. The quarantines implemented during the COVID-19 period, the deterioration of economic income, and the uncertain situation about the future have affected the changes in physical inactivity, mood changes, sleep quality, lifestyle, and eating habits. Our study aimed to investigate the changes in individuals' mood, sleep quality, lifestyle, and eating habits during the COVID-19 pandemic period. Patients and Methods: COVID-19 phobia scale (C19P-S) and coronavirus anxiety scale (CAS) were used to assess the emotional state of individuals. Pittsburgh sleep quality index was used to assess sleep quality. The data required for the research were collected with an online questionnaire. The study was carried out on individuals over 18 years of age between November 2020 and January 2021. Changes in mood, sleep quality and lifestyle with eating habits of individuals during the COVID-19. The data obtained from the studies were analyzed with appropriate statistical methods using the SPSS 22.0 program. Results: A total of 6,609 individuals between the ages of 18-70 participated in the study, and 69.8% of the participants were female. Sleep quality and the mean score obtained from the C19P-S in female individuals (50.4±10.63) were found to be significantly higher than in male individuals (46.9±9.94) (p<0.001). Sleep quality showed a positive and significant relationship with CAS and C19P-S, respectively (r=0.190, r=224) (p<0.001). Before the COVID-19 period, the individuals consumed the highest rate of fruit (68.8%), tea, herbal teas (48.4%), vegetables (50.8%), and milk and yogurt (48.4%), while after the pandemic the highest rate of industrial packaged bakery products (41.0%), sugar or sweeteners (36.2%), processed meat products (34.7%), and sugar-sweetened soft drinks (30.3%) were consumed. Conclusions: The COVID-19 may cause changes in individuals' mood, sleep quality, lifestyle, and eating habits. This is the first study to evaluate these factors together in the Turkish population. We believe that complications related to COVID-19 may have a negative impact on public health in the long term. In the future, we recommend that governments develop policies to improve public health regarding adequate and balanced nutrition, physical activity, and mood management.
Foods
Fermentation is one of the oldest known production processes and the most technologically valuabl... more Fermentation is one of the oldest known production processes and the most technologically valuable in terms of the food industry. In recent years, increasing nutrition and health awareness has also changed what is expected from fermentation technology, and the production of healthier foods has started to come a little more forward rather than increasing the shelf life and organoleptic properties of foods. Therefore, in addition to traditional microorganisms, a new generation of (novel) microorganisms has been discovered and research has shifted to this point. Novel microorganisms are known as either newly isolated genera and species from natural sources or bacterial strains derived from existing bacteria. Although novel microorganisms are mostly studied for their use in novel food production in terms of gut-microbiota modulation, recent innovative food research highlights their fermentative effects and usability, especially in food modifications. Herein, Clostridium butyricum, Bacte...
Bu çalışma, Tip 2 diyabetli bireyler ile yaş ve beden kütle indeksi benzer olan sağlıklı bireyler... more Bu çalışma, Tip 2 diyabetli bireyler ile yaş ve beden kütle indeksi benzer olan sağlıklı bireylerin diyet enerji yoğunlukları, beslenme durumları ve yaşam tarzı değişkenlerinin karşılaştırılması ve glisemik kontrol ile ilişkisinin değerlendirilmesi amacıyla planlanmış ve yürütülmüştür. Çalışmaya yaşları 45-65 yıl aralığında olan 44 Tip 2 diyabetli 44 sağlıklı olmak üzere toplam 88 gönüllü kadın birey alınmıştır. Bireylerin genel özellikleri, sağlık ve hastalık bilgileri, stres durumu ve sirkadiyen ritim düzeni ile fiziksel aktivite düzeyleri sorgulanmıştır. Bireylerin antropometrik ölçümleri ve vücut bileşimleri alınmış, bazı biyokimyasal bulguları (HbA1c, açlık plazma glukozu, insülin, total kolesterol, HDL-K ve LDL-K trigliserid, C-peptid ve 1,5 anhidroglusitol) analiz edilmiş, besin alımları ve beslenme alışkanlıkları 3 günlük besin tüketim kaydı ile sorgulanmıştır. Tip 2 diyabetli bireylerin HbA1c, açlık plazma glukozu, insülin, HDL kolesterol, trigliserit ve HOMA-IR düzeyleri k...
Ecology of Food and Nutrition
Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi
Prostate cancer (PCa) is the second most common type of cancer for men. Nutrition plays an import... more Prostate cancer (PCa) is the second most common type of cancer for men. Nutrition plays an important role in the development and progression of prostate cancer. Dietary components in PCa cells; showed that high intake of energy, saturated fat, refined carbohydrates and animal protein, as well as insufficient intake of fresh vegetables and fruits, whole grains, essential minerals and phytochemicals, were associated with the etiology and treatment of PCa. A literature search was conducted using electronic databases supported by a manual review of the reference list of articles from PubMed, Web of Science, Scopus, and Google Scholar until March 2022. The following key terms are used: Pub-Med, Web of Science, Scopus, and Google Scholar: ("Prostate Cancer" OR "Diet" OR "Nutrition" OR "Nutrient Intake" OR "Dietary Patterns" OR "Diet Patterns") terms are used. Different nutritional patterns can have different positive or negative ...
Yeni koronavius hastaligi “COVID-19” dunyada bircok insanin hayatini tehdit eden ciddi bir halk s... more Yeni koronavius hastaligi “COVID-19” dunyada bircok insanin hayatini tehdit eden ciddi bir halk sagligi sorunu olmustur. Bu yeni virusten korunmada veya hastalik siddetini hafifletmede, SARS-CoV-2 icin halen spesifik bir tedavinin olmadigi da dikkate alindiginda, bagisiklik sistemin aktif ve guclu tutulmasi onemlidir. Beslenme ve bagisiklik arasinda oldukca karmasik ve guclu iliski bulunmaktadir. Epidemiyolojik ve deneysel calismalar beslenme, bagisiklik sistemi ve enfeksiyon ucgeninde diyet mudahalelerinin onemine isaret etmektedir. Bu surecte makro ve mikro besin ogesi gereksinimlerini karsilayacak sekilde yeterli alimini saglayan bir beslenme planina uyulmasi, diger zorunlu tedbirler ile birlikte hastaliktan korunmada etkili olacaktir. Ayrica hastaligin seyrine uygun olarak yapilan beslenme mudahaleleri tedavinin bir parcasi olarak, iyilesme ve sag kalim oraninin artmasinda potansiyel etki saglayacaktir. Bu makalede COVID-19’da beslenmenin bagisiklik sistemin desteklenmesi uzerin...
Insan intestinal mikrobiyotasi yaklasik 10¹³-10¹ 4 degisen sayida mikroorganizmadan meydana gele... more Insan intestinal mikrobiyotasi yaklasik 10¹³-10¹ 4 degisen sayida mikroorganizmadan meydana gelen super organizma olarak tanimlanmaktadir. Insan organizmasindaki mikroorganizma sayisi toplam insan hucre sayisindan 10 kat daha fazla olup, intestinal mikrobiyotayi meydana getiren genom insan organizmasini meydana getiren genomun yaklasik 150 kat buyuklugundedir. Bu kadar cok sayida bileseniolan mikrobiyota fetal hayattan yasliliga kadar bircok etkenin etkisiyle degisime ugramakta olup beslenmenin rolu goz ardi edilmemelidir. intestinal mikrobiyota; besinlerle alinan polisakkaritlerinin fermantasyonu, esansiyel amino asitler ve vitaminlerin sentezi ve ksenobiyotik ilaclarin metabolizmasi gibi bircok fonksiyonel ozellige sahiptir. Mikro besin ogeleri insan metabolizmasini ve organ fonksiyonlarini ya dogrudan emilim ve hedef hucreye etki mekanizmasiyla ya da intestinal mikrobiyota vasitasiyla dolayli olarak etkilemektedir. Ayrica enerji metabolizmasi, hucresel buyume ve farklilasma, or...