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Papers by Tippawan Siritientong

Research paper thumbnail of A high-protein peptide-based enteral formula improves diarrhea in tube-fed patients: A prospective multicenter study

Nutrition and Health, Nov 29, 2022

Background: Diarrhea is a common problem in tube-fed patients. The relevant guidelines suggest us... more Background: Diarrhea is a common problem in tube-fed patients. The relevant guidelines suggest using a peptide-based enteral formula in patients with diarrhea; however, sufficient evidence to support this recommendation is currently lacking. Aim: This study aimed to evaluate the effects of a high-protein peptide-based formula on gastrointestinal intolerance, mainly focusing on diarrhea symptoms in patients who were intolerant to polymeric formula feeding. Methods: This prospective, single-arm, open-label, multicenter study was conducted from March 2021 to March 2022 at two tertiary-care hospitals. Patients who presented with diarrhea during tube feeding with polymeric formula were assigned to receive a high-protein peptide-based formula for ≤7 days. Stool weight and frequency were monitored at baseline, on day 3, and on day 7 (or end of the study) as the primary outcomes. Results: Twenty-eight tube-fed patients with diarrhea were recruited. After switching their feeding formula from polymeric to peptide based, significant improvements in stool frequency and stool weight were observed on day 3 and day 7 compared with the baseline (median [IQR] stool frequency: 5 (2), 2.5 (3.5), and 3 (3) times/day, respectively, p <0.001; median stool weight: 500 (370), 170 (285), and 275 (385) gram/day, respectively, p = 0.015). Stool consistency was assessed using the Bristol Stool Score and showed significant improvement with time. No serious adverse events were reported. Conclusion: A high-protein peptidebased enteral formula was effective in reducing stool weight and frequency in patients who experienced diarrhea during tube feeding with a polymeric formula. Trial registration: TCTR20210302006

Research paper thumbnail of Compatibility of calcium and sodium glycerophosphate in parenteral nutrition solutions

Keywords: sodium glycerophosphate; calcium; phosphate; parenteral nutrition; neonate Objectives:... more Keywords: sodium glycerophosphate; calcium; phosphate; parenteral nutrition; neonate Objectives: Preterm infants need high amounts of calcium and phosphorus for bone mineralization and growth, which is difficult to obtain with parenteral feeding due to its low solubility. The purpose of this study was to test the compatibility of sodium glycerophosphate (NaGP) with calcium gluconate in pediatric parenteral nutrition (PN) solutions. Methods : Ten PN admixtures formulas for neonatal use were aseptically prepared. Standard formula consisted of 10%dextrose and 2%amino acid according to Ramathibodi Hospital pediatric PN prescription. In this study, calcium at the concentrations of 0, 20, 30 mmol/L and phosphate at the concentrations of 0, 20, 50 mmol/L, were orderly mixed into the standard formula. Each admixture separately tested according to 4 following conditions; after mixing, 30°C for 1 day, 4°C for 1 day and 4°C for 7 days. Visual inspections against a black and white contrast ba...

Research paper thumbnail of Nutritional Support with Omega-3 Fatty Acids in Burn Patients: A Systematic Review with Meta-Analysis of Randomized Controlled Trials

Nutrients

Background: In burn patients, the profound effect of nutritional support on improved wound healin... more Background: In burn patients, the profound effect of nutritional support on improved wound healing and a reduced rate of hospitalization and mortality has been documented. Fish oil as a primary source of omega-3 fatty acids in nutritional support may attenuate the inflammatory response and enhance immune function; however, unclear effects on the improvement of clinical outcomes in burn patients remain. Methods: The systematic literature review was conducted by searching the electronic databases: Cochrane Library, PubMed, ScienceDirect, and Scopus to assess the randomized controlled trials of nutritional support with omega-3 fatty acids compared to control diets in patients that presented with burns from any causes. Results: Seven trials were included in this meta-analysis. We found no significant differences in length of stay (LOS) (p = 0.59), mortality (p = 0.86), ventilation days (p = 0.16), gastrointestinal complications—e.g., constipation and diarrhea (p = 0.73)—or infectious co...

Research paper thumbnail of Proton pump inhibitors use in short bowel patients at a Thai tertiary hospital; a 10-year retrospective observational study

Thai Journal of Pharmaceutical Sciences (TJPS), Dec 15, 2020

Research paper thumbnail of Nutritional assessment in the HIV-infected older population receiving antiretroviral therapy

Aids Reviews, Dec 22, 2021

Malnutrition is a pronounced public health issue which often seems underestimated in the older pe... more Malnutrition is a pronounced public health issue which often seems underestimated in the older people living with HIV (PLWH) virus infection. PLWH are highly vulnerable to nutritional problems resulting from agingrelated deterioration, disease itself, and adverse effects of antiretroviral therapy (ART). The comprehensive nutritional assessments are necessary to perform routinely in this population to monitor and provide appropriate interventions to reduce comorbid conditions. In this review, we focus on the untoward impacts of malnutrition and nutritional assessments on the morbidity and mortality in the older PLWH. Some predictive factors of nutritional status in this group of patients are discussed. We propose the important components for nutrition assessment tool for older PLWH on ART. Highlighted issue is the need for developing uniform standardized tools for the early diagnosis of malnutrition in this population. Applications of the nutritional assessments, proper nutritional interventions, and regular monitoring of nutritional status in older PLWH liv-ing in every clinical setting may help the patients get better well-being.

Research paper thumbnail of Effectiveness of Web-Based Nutrition Education for Chronic Kidney Disease Patients

Journal of Pharmacy and Nutrition Sciences, 2018

Background: In the early stages of chronic kidney disease (CKD), encouraging health behaviors can... more Background: In the early stages of chronic kidney disease (CKD), encouraging health behaviors can help prevent the progression of kidney disease leading to eventual kidney failure. The studies of health education using computer technology have been greatly developed, especially web-based nutrition education.Objective: To determine the effectiveness of a nutrition education website for CKD patients.Method: The design of this quasi-experimental research was a group pre-test/post-test. The participants were pre-dialysis CKD patients who were enrolled on the developed website www.banraktai.com. The participants were required to complete an eating behavior questionnaire and knowledge test. They accessed the website for eight weeks, and at week 8, they completed the eating behavior questionnaire and knowledge test again. The main outcomes were the changes in scores of nutrition knowledge and eating behavior that were compared between the baseline and after the intervention using the paire...

Research paper thumbnail of Carbohydrate content of the medications for epileptic children treated with ketogenic diet at King Chulalongkorn memorial hospital

The purposes of this study were to establish a database of the carbohydrate content of medication... more The purposes of this study were to establish a database of the carbohydrate content of medications and investigate carbohydrate content of medications in epileptic children treated with ketogenic diet (KD) at King Chulalongkorn Memorial Hospital. One hundred sixty-nine KD order forms in 3 events (KD initiation, follow-up visit, and hospital re-admission) for epileptic children whose aged younger than 18 years old during 2009-2017 were selected. Clinical and nutritional data were obtained from medical records and KD order forms from the pediatric nutrition unit. The study showed that oral liquid dosage forms had the highest carbohydrate content in the formulations as 0.52 (0.13-1.78) g/dosage unit. In the event of hospital re-admission, children were at risk of excessively received carbohydrate content of medications because of the increased number of medications for treating illnesses. However, there was no significant difference between carbohydrate content in the prescribed diet a...

Research paper thumbnail of Preliminary Characterization of Genipin-Cross-Linked Silk Sericin/Poly(vinyl alcohol) Films as Two-Dimensional Wound Dressings for the Healing of Superficial Wounds

BioMed Research International, 2013

The genipin-cross-linked silk sericin/poly(vinyl alcohol) (PVA) films were developed aiming to be... more The genipin-cross-linked silk sericin/poly(vinyl alcohol) (PVA) films were developed aiming to be applied as two-dimensional wound dressings for the treatment of superficial wounds. The effects of genipin cross-linking concentration on the physical and biological properties of the films were investigated. The genipin-cross-linked silk sericin/PVA films showed the increased surface density, tensile strength, and percentage of elongation, but decreased percentage of light transmission, water vapor transmission rate, and water swelling, compared to the non-cross-linked films. This explained that the cross-linking bonds between genipin and silk sericin would reduce the mobility of molecular chains within the films, resulting in the more rigid molecular structure. Silk sericin was released from the genipin-cross-linked films in a sustained manner. In addition, either L929 mouse fibroblast or HaCat keratinocyte cells showed high percentage of viability when cultured on the silk sericin/PV...

Research paper thumbnail of Clinical Potential of a Silk Sericin-Releasing Bioactive Wound Dressing for the Treatment of Split-Thickness Skin Graft Donor Sites

Pharmaceutical Research, 2013

An ethyl alcohol-precipitated silk sericin/PVA scaffold that controlled the release of silk seric... more An ethyl alcohol-precipitated silk sericin/PVA scaffold that controlled the release of silk sericin was previously developed and applied for the treatment of full-thickness wounds in rats and demonstrated efficient healing. In this study, we aimed to further evaluate the clinical potential of this scaffold, hereafter called &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;silk sericin-releasing wound dressing&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;, for the treatment of split-thickness skin graft donor sites by comparison with the clinically available wound dressing known as &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;Bactigras®&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;. In vitro characterization and in vivo evaluation for safety of the wound dressings were performed. A clinical trial of the wound dressings was conducted according to standard protocols. The sericin released from the wound dressing was not toxic to HaCat human keratinocytes. A peel test indicated that the silk sericin-releasing wound dressing was less adhesive than Bactigras®, potentially reducing trauma and the risk of repeated injury upon removal. There was no evidence of skin irritation upon treatment with either wound dressing. When tested in patients with split-thickness skin graft donor sites, the wounds treated with the silk sericin-releasing wound dressing exhibited complete healing at 12 ± 5.0 days, whereas those treated with Bactigras® were completely healed at 14 ± 5.2 days (p = 1.99 × 10(-4)). In addition, treatment with the silk sericin-releasing wound dressing significantly reduced pain compared with Bactigras® particularly during the first 4 postoperative days (p = 2.70 × 10(-5) on day 1). We introduce this novel silk sericin-releasing wound dressing as an alternative treatment for split-thickness skin graft donor sites.

Research paper thumbnail of Pharmacokinetic Outcomes of the Interactions of Antiretroviral Agents with Food and Supplements: A Systematic Review and Meta-Analysis

Nutrients

Because pharmacokinetic changes in antiretroviral drugs (ARV), due to their concurrent administra... more Because pharmacokinetic changes in antiretroviral drugs (ARV), due to their concurrent administration with food or nutritional products, have become a clinical challenge, it is necessary to monitor the therapeutic efficacy of ARV in people living with the human immunodeficiency virus (PLWH). A systematic review and meta-analysis were conducted to clarify the pharmacokinetic outcomes of the interaction between supplements such as food, dietary supplements, and nutrients, and ARV. Twenty-four articles in both healthy subjects and PLWH were included in the qualitative analysis, of which five studies were included in the meta-analysis. Food–drug coadministration significantly increased the time to reach maximum concentration (tmax) (p < 0.00001) of ARV including abacavir, amprenavir, darunavir, emtricitabine, lamivudine, zidovudine, ritonavir, and tenofovir alafenamide. In addition, the increased maximum plasma concentration (Cmax) of ARV, such as darunavir, under fed conditions was ...

Research paper thumbnail of หลักฐานเชิงประจักษ์ของการใช้การแพทย์เสริมและการแพทย์ทางเลือกสำหรับอาการนอนไม่หลับ (Evidence-Based Complementary and Alternative Medicine for Insomnia)

อาการนอนไมหลบเปนความผดปกตของการนอนททำใหเกดปญหาสขภาพเรอรงอนได การรกษาอาการนอนไมหลบโดยการแพทยเสรมแล... more อาการนอนไมหลบเปนความผดปกตของการนอนททำใหเกดปญหาสขภาพเรอรงอนได การรกษาอาการนอนไมหลบโดยการแพทยเสรมและการแพทยทางเลอก ไดแก การรบประทานอาหารทอดมดวยกรดอะมโน ทรปโตเฟน การฝงเขม การเจรญสตภาวนาและการใชสมนไพรบางชนด เชน valerian, kava, German chamomile, Wuling, พทราจน, ขเหลก เปนตน ซงผลตภณฑดงกลาวมการจดจำหนายในทองตลาดมากมาย รายงานการวจยระดบคลนกถงประสทธภาพในการบรรเทาอาการนอนไมหลบของการแพทยเสรมและการแพทยทางเลอกยงมจำกด พบความแตกตางกนระหวางการศกษา ไดแก ขนาดของสารสำคญ ลกษณะและปญหานอนไมหลบของผเขารวมการวจย เปนตน การศกษายงมจำนวนผเขารวมการวจยนอยและระยะเวลาการศกษาคอนขางสน อกทงยงไมทราบกลไกการออกฤทธทางเภสชวทยาแนชดของสารสำคญในสมนไพร และมรายงานอาการไมพงประสงครนแรง เชน ภาวะตบอกเสบรนแรงจากการใชผลตภณฑทมสวนผสมของ kava หรอผลตภณฑจากขเหลก ดงนนแมการแพทยเสรมและการแพทยทางเลอกอาจมแนวโนมบรรเทาอาการนอนไมหลบได แตยงตองการการศกษาทมคณภาพถงประสทธภาพและความปลอดภยทางคลนกในระยะยาวตอไป Insomnia is a sleep disorder that causes chronic health problems as a consequence. The choices of complementary and alternative medicines (CAM) fo...

Research paper thumbnail of Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies

The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunod... more The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ...

Research paper thumbnail of The preliminary study of Ganoderma lucidum broken spores on immunoglobulin levels and its safety in cancer patients after completion of chemotherapy

Ganoderma lucidum (GL), known as ‘Lingzhi’ has immunomodulatory effect to stimulate immune cells,... more Ganoderma lucidum (GL), known as ‘Lingzhi’ has immunomodulatory effect to stimulate immune cells, such as B cell, immunoglobulin (Ig). The duration of those cells’ recovery after chemotherapy completion was longer than 9 months. The objectives of our preliminary study were to evaluate the effect of GL broken spores (GLBS) on immunoglobulin levels and its safety in patients after chemotherapy completion. Fifteen cancer patients after completion of chemotherapy were informed to take 750 mg of GLBS per day divided into three doses before meals for 8 weeks. The results showed IgG, IgM, IgA and IgE levels were not significantly difference compared before and after this study (p-value: 0.34, 0.53 and 0.95, respectively). Mild adverse events such as dry mouth, headache, pain, oral wound, and constipation were found. No significant changes of renal and liver functions were observed. The results suggested that consuming GLBS at 750 mg per day might not be effective for increasing immunoglobu...

Research paper thumbnail of Are there maximum compatible concentrations of calcium gluconate and sodium glycerophosphate in infant parenteral nutrition solutions?

Background: Calcium gluconate and sodium glycerophosphate (NaGP) were claimed to reduce risk of p... more Background: Calcium gluconate and sodium glycerophosphate (NaGP) were claimed to reduce risk of precipitation in infant parenteral nutrition (PN) solutions which contained high amounts of calcium and phosphorus. Objective: To determine the compatibility of calcium gluconate and NaGP at high concentrations in PN solutions with different amino acid concentrations and storage conditions. Methods: PN solutions consisted of 1.5-2.5% amino acid, 0-100 mM/l calcium gluconate and 0-150 mM/l NaGP in constant amounts of dextrose, sodium chloride, and magnesium sulfate. The solutions were kept under 3 conditions; 30°C for 1 d, 4°C for 1 d and 4°C for 7 d. Compatibility initially evaluated by pH measurement and visual inspection. Solutions were then measured turbidity and further observed under a light microscope for microscopic particle count test. PN solution was determined to be compatible if particle counts of three replicates were under USP criteria. Results: PN solutions containing 1.5% a...

Research paper thumbnail of Mutagenicity and antimutagenicity of water extracts from gac fruit (Momordica cochinchinensis Spreng)

Journal of Health Research, 2016

Background: Gac fruit (Momordica cochinchinensis Spreng) was used as food, colourant and medicine... more Background: Gac fruit (Momordica cochinchinensis Spreng) was used as food, colourant and medicine for a period of time. Moreover, several in vitro and in vivo studies showed that gac fruit contained many phytochemicals and exerted bioactive effects, including pro-vitamin A, antioxidant and antitumor activity. This study aimed to investigate the mutagenicity and the antimutagenicity against a standard mutagen; nitrite treated 1-aminopyrene (1-AP) of gac fruit. Method: The water extracts from unripe pulp, half-ripe pulp, fully ripe pulp and aril of gac fruit were treated with and without nitrite and investigated for their mutagenicity using Ames test with modified pre-incubation method on Salmonella typhimurium strain TA98 and TA100 without enzymatic activation. The antimutagenicity against nitrite treated 1-AP of these fruit extracts was also evaluated. Results: The results showed that none of them showed mutagenicity on both strains of S. typhimurium either with or without nitrite t...

Research paper thumbnail of Alu repetitive sequence CpG methylation changes in burn scars

Research paper thumbnail of Deterioration of nutritional status and its negative association with depression among older HIV-infected Asian population: a four-year longitudinal study

AIDS Research and Human Retroviruses

Research paper thumbnail of The carbohydrate content of medications prescribed to children treated with a ketogenic diet

Journal of Pharmacy Practice and Research

Research paper thumbnail of Sodium glycerophosphate and prescribed calcium concentrations in pediatric parenteral nutrition: a retrospective observational study and economic evaluation

Asian Biomedicine

Background The risk of precipitation limits calcium and phosphate concentrations that can be admi... more Background The risk of precipitation limits calcium and phosphate concentrations that can be administered parenterally to pediatric patients. As an alternative to dipotassium phosphate, sodium glycerophosphate (NaGlyP) is claimed to reduce the risk of precipitation in solutions for parenteral administration. Objectives To determine the calcium concentrations, NaGlyP, and dipotassium phosphate prescribed in pediatric parenteral nutrition orders and the cost–benefit of the organic phosphate. Methods We retrospectively collected cross-sectional data for parenteral nutrition orders from September 2014 to August 2015 for pediatric patients including neonates and children aged <18 years who were admitted to King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Calcium concentration, calcium concentration adjustments, and costs of phosphate used per bag were analyzed. Results Of 2,192 parenteral nutrition orders, NaGlyP was used in 2,128 (97.1%) with calcium concentrations in the ran...

Research paper thumbnail of Mutagenic modification effect of pomegranate juice in nitrite treated aminopyrene using Ames test (LB640)

The Faseb Journal, Apr 1, 2014

Research paper thumbnail of A high-protein peptide-based enteral formula improves diarrhea in tube-fed patients: A prospective multicenter study

Nutrition and Health, Nov 29, 2022

Background: Diarrhea is a common problem in tube-fed patients. The relevant guidelines suggest us... more Background: Diarrhea is a common problem in tube-fed patients. The relevant guidelines suggest using a peptide-based enteral formula in patients with diarrhea; however, sufficient evidence to support this recommendation is currently lacking. Aim: This study aimed to evaluate the effects of a high-protein peptide-based formula on gastrointestinal intolerance, mainly focusing on diarrhea symptoms in patients who were intolerant to polymeric formula feeding. Methods: This prospective, single-arm, open-label, multicenter study was conducted from March 2021 to March 2022 at two tertiary-care hospitals. Patients who presented with diarrhea during tube feeding with polymeric formula were assigned to receive a high-protein peptide-based formula for ≤7 days. Stool weight and frequency were monitored at baseline, on day 3, and on day 7 (or end of the study) as the primary outcomes. Results: Twenty-eight tube-fed patients with diarrhea were recruited. After switching their feeding formula from polymeric to peptide based, significant improvements in stool frequency and stool weight were observed on day 3 and day 7 compared with the baseline (median [IQR] stool frequency: 5 (2), 2.5 (3.5), and 3 (3) times/day, respectively, p <0.001; median stool weight: 500 (370), 170 (285), and 275 (385) gram/day, respectively, p = 0.015). Stool consistency was assessed using the Bristol Stool Score and showed significant improvement with time. No serious adverse events were reported. Conclusion: A high-protein peptidebased enteral formula was effective in reducing stool weight and frequency in patients who experienced diarrhea during tube feeding with a polymeric formula. Trial registration: TCTR20210302006

Research paper thumbnail of Compatibility of calcium and sodium glycerophosphate in parenteral nutrition solutions

Keywords: sodium glycerophosphate; calcium; phosphate; parenteral nutrition; neonate Objectives:... more Keywords: sodium glycerophosphate; calcium; phosphate; parenteral nutrition; neonate Objectives: Preterm infants need high amounts of calcium and phosphorus for bone mineralization and growth, which is difficult to obtain with parenteral feeding due to its low solubility. The purpose of this study was to test the compatibility of sodium glycerophosphate (NaGP) with calcium gluconate in pediatric parenteral nutrition (PN) solutions. Methods : Ten PN admixtures formulas for neonatal use were aseptically prepared. Standard formula consisted of 10%dextrose and 2%amino acid according to Ramathibodi Hospital pediatric PN prescription. In this study, calcium at the concentrations of 0, 20, 30 mmol/L and phosphate at the concentrations of 0, 20, 50 mmol/L, were orderly mixed into the standard formula. Each admixture separately tested according to 4 following conditions; after mixing, 30°C for 1 day, 4°C for 1 day and 4°C for 7 days. Visual inspections against a black and white contrast ba...

Research paper thumbnail of Nutritional Support with Omega-3 Fatty Acids in Burn Patients: A Systematic Review with Meta-Analysis of Randomized Controlled Trials

Nutrients

Background: In burn patients, the profound effect of nutritional support on improved wound healin... more Background: In burn patients, the profound effect of nutritional support on improved wound healing and a reduced rate of hospitalization and mortality has been documented. Fish oil as a primary source of omega-3 fatty acids in nutritional support may attenuate the inflammatory response and enhance immune function; however, unclear effects on the improvement of clinical outcomes in burn patients remain. Methods: The systematic literature review was conducted by searching the electronic databases: Cochrane Library, PubMed, ScienceDirect, and Scopus to assess the randomized controlled trials of nutritional support with omega-3 fatty acids compared to control diets in patients that presented with burns from any causes. Results: Seven trials were included in this meta-analysis. We found no significant differences in length of stay (LOS) (p = 0.59), mortality (p = 0.86), ventilation days (p = 0.16), gastrointestinal complications—e.g., constipation and diarrhea (p = 0.73)—or infectious co...

Research paper thumbnail of Proton pump inhibitors use in short bowel patients at a Thai tertiary hospital; a 10-year retrospective observational study

Thai Journal of Pharmaceutical Sciences (TJPS), Dec 15, 2020

Research paper thumbnail of Nutritional assessment in the HIV-infected older population receiving antiretroviral therapy

Aids Reviews, Dec 22, 2021

Malnutrition is a pronounced public health issue which often seems underestimated in the older pe... more Malnutrition is a pronounced public health issue which often seems underestimated in the older people living with HIV (PLWH) virus infection. PLWH are highly vulnerable to nutritional problems resulting from agingrelated deterioration, disease itself, and adverse effects of antiretroviral therapy (ART). The comprehensive nutritional assessments are necessary to perform routinely in this population to monitor and provide appropriate interventions to reduce comorbid conditions. In this review, we focus on the untoward impacts of malnutrition and nutritional assessments on the morbidity and mortality in the older PLWH. Some predictive factors of nutritional status in this group of patients are discussed. We propose the important components for nutrition assessment tool for older PLWH on ART. Highlighted issue is the need for developing uniform standardized tools for the early diagnosis of malnutrition in this population. Applications of the nutritional assessments, proper nutritional interventions, and regular monitoring of nutritional status in older PLWH liv-ing in every clinical setting may help the patients get better well-being.

Research paper thumbnail of Effectiveness of Web-Based Nutrition Education for Chronic Kidney Disease Patients

Journal of Pharmacy and Nutrition Sciences, 2018

Background: In the early stages of chronic kidney disease (CKD), encouraging health behaviors can... more Background: In the early stages of chronic kidney disease (CKD), encouraging health behaviors can help prevent the progression of kidney disease leading to eventual kidney failure. The studies of health education using computer technology have been greatly developed, especially web-based nutrition education.Objective: To determine the effectiveness of a nutrition education website for CKD patients.Method: The design of this quasi-experimental research was a group pre-test/post-test. The participants were pre-dialysis CKD patients who were enrolled on the developed website www.banraktai.com. The participants were required to complete an eating behavior questionnaire and knowledge test. They accessed the website for eight weeks, and at week 8, they completed the eating behavior questionnaire and knowledge test again. The main outcomes were the changes in scores of nutrition knowledge and eating behavior that were compared between the baseline and after the intervention using the paire...

Research paper thumbnail of Carbohydrate content of the medications for epileptic children treated with ketogenic diet at King Chulalongkorn memorial hospital

The purposes of this study were to establish a database of the carbohydrate content of medication... more The purposes of this study were to establish a database of the carbohydrate content of medications and investigate carbohydrate content of medications in epileptic children treated with ketogenic diet (KD) at King Chulalongkorn Memorial Hospital. One hundred sixty-nine KD order forms in 3 events (KD initiation, follow-up visit, and hospital re-admission) for epileptic children whose aged younger than 18 years old during 2009-2017 were selected. Clinical and nutritional data were obtained from medical records and KD order forms from the pediatric nutrition unit. The study showed that oral liquid dosage forms had the highest carbohydrate content in the formulations as 0.52 (0.13-1.78) g/dosage unit. In the event of hospital re-admission, children were at risk of excessively received carbohydrate content of medications because of the increased number of medications for treating illnesses. However, there was no significant difference between carbohydrate content in the prescribed diet a...

Research paper thumbnail of Preliminary Characterization of Genipin-Cross-Linked Silk Sericin/Poly(vinyl alcohol) Films as Two-Dimensional Wound Dressings for the Healing of Superficial Wounds

BioMed Research International, 2013

The genipin-cross-linked silk sericin/poly(vinyl alcohol) (PVA) films were developed aiming to be... more The genipin-cross-linked silk sericin/poly(vinyl alcohol) (PVA) films were developed aiming to be applied as two-dimensional wound dressings for the treatment of superficial wounds. The effects of genipin cross-linking concentration on the physical and biological properties of the films were investigated. The genipin-cross-linked silk sericin/PVA films showed the increased surface density, tensile strength, and percentage of elongation, but decreased percentage of light transmission, water vapor transmission rate, and water swelling, compared to the non-cross-linked films. This explained that the cross-linking bonds between genipin and silk sericin would reduce the mobility of molecular chains within the films, resulting in the more rigid molecular structure. Silk sericin was released from the genipin-cross-linked films in a sustained manner. In addition, either L929 mouse fibroblast or HaCat keratinocyte cells showed high percentage of viability when cultured on the silk sericin/PV...

Research paper thumbnail of Clinical Potential of a Silk Sericin-Releasing Bioactive Wound Dressing for the Treatment of Split-Thickness Skin Graft Donor Sites

Pharmaceutical Research, 2013

An ethyl alcohol-precipitated silk sericin/PVA scaffold that controlled the release of silk seric... more An ethyl alcohol-precipitated silk sericin/PVA scaffold that controlled the release of silk sericin was previously developed and applied for the treatment of full-thickness wounds in rats and demonstrated efficient healing. In this study, we aimed to further evaluate the clinical potential of this scaffold, hereafter called &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;silk sericin-releasing wound dressing&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;, for the treatment of split-thickness skin graft donor sites by comparison with the clinically available wound dressing known as &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;Bactigras®&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;. In vitro characterization and in vivo evaluation for safety of the wound dressings were performed. A clinical trial of the wound dressings was conducted according to standard protocols. The sericin released from the wound dressing was not toxic to HaCat human keratinocytes. A peel test indicated that the silk sericin-releasing wound dressing was less adhesive than Bactigras®, potentially reducing trauma and the risk of repeated injury upon removal. There was no evidence of skin irritation upon treatment with either wound dressing. When tested in patients with split-thickness skin graft donor sites, the wounds treated with the silk sericin-releasing wound dressing exhibited complete healing at 12 ± 5.0 days, whereas those treated with Bactigras® were completely healed at 14 ± 5.2 days (p = 1.99 × 10(-4)). In addition, treatment with the silk sericin-releasing wound dressing significantly reduced pain compared with Bactigras® particularly during the first 4 postoperative days (p = 2.70 × 10(-5) on day 1). We introduce this novel silk sericin-releasing wound dressing as an alternative treatment for split-thickness skin graft donor sites.

Research paper thumbnail of Pharmacokinetic Outcomes of the Interactions of Antiretroviral Agents with Food and Supplements: A Systematic Review and Meta-Analysis

Nutrients

Because pharmacokinetic changes in antiretroviral drugs (ARV), due to their concurrent administra... more Because pharmacokinetic changes in antiretroviral drugs (ARV), due to their concurrent administration with food or nutritional products, have become a clinical challenge, it is necessary to monitor the therapeutic efficacy of ARV in people living with the human immunodeficiency virus (PLWH). A systematic review and meta-analysis were conducted to clarify the pharmacokinetic outcomes of the interaction between supplements such as food, dietary supplements, and nutrients, and ARV. Twenty-four articles in both healthy subjects and PLWH were included in the qualitative analysis, of which five studies were included in the meta-analysis. Food–drug coadministration significantly increased the time to reach maximum concentration (tmax) (p < 0.00001) of ARV including abacavir, amprenavir, darunavir, emtricitabine, lamivudine, zidovudine, ritonavir, and tenofovir alafenamide. In addition, the increased maximum plasma concentration (Cmax) of ARV, such as darunavir, under fed conditions was ...

Research paper thumbnail of หลักฐานเชิงประจักษ์ของการใช้การแพทย์เสริมและการแพทย์ทางเลือกสำหรับอาการนอนไม่หลับ (Evidence-Based Complementary and Alternative Medicine for Insomnia)

อาการนอนไมหลบเปนความผดปกตของการนอนททำใหเกดปญหาสขภาพเรอรงอนได การรกษาอาการนอนไมหลบโดยการแพทยเสรมแล... more อาการนอนไมหลบเปนความผดปกตของการนอนททำใหเกดปญหาสขภาพเรอรงอนได การรกษาอาการนอนไมหลบโดยการแพทยเสรมและการแพทยทางเลอก ไดแก การรบประทานอาหารทอดมดวยกรดอะมโน ทรปโตเฟน การฝงเขม การเจรญสตภาวนาและการใชสมนไพรบางชนด เชน valerian, kava, German chamomile, Wuling, พทราจน, ขเหลก เปนตน ซงผลตภณฑดงกลาวมการจดจำหนายในทองตลาดมากมาย รายงานการวจยระดบคลนกถงประสทธภาพในการบรรเทาอาการนอนไมหลบของการแพทยเสรมและการแพทยทางเลอกยงมจำกด พบความแตกตางกนระหวางการศกษา ไดแก ขนาดของสารสำคญ ลกษณะและปญหานอนไมหลบของผเขารวมการวจย เปนตน การศกษายงมจำนวนผเขารวมการวจยนอยและระยะเวลาการศกษาคอนขางสน อกทงยงไมทราบกลไกการออกฤทธทางเภสชวทยาแนชดของสารสำคญในสมนไพร และมรายงานอาการไมพงประสงครนแรง เชน ภาวะตบอกเสบรนแรงจากการใชผลตภณฑทมสวนผสมของ kava หรอผลตภณฑจากขเหลก ดงนนแมการแพทยเสรมและการแพทยทางเลอกอาจมแนวโนมบรรเทาอาการนอนไมหลบได แตยงตองการการศกษาทมคณภาพถงประสทธภาพและความปลอดภยทางคลนกในระยะยาวตอไป Insomnia is a sleep disorder that causes chronic health problems as a consequence. The choices of complementary and alternative medicines (CAM) fo...

Research paper thumbnail of Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies

The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunod... more The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ...

Research paper thumbnail of The preliminary study of Ganoderma lucidum broken spores on immunoglobulin levels and its safety in cancer patients after completion of chemotherapy

Ganoderma lucidum (GL), known as ‘Lingzhi’ has immunomodulatory effect to stimulate immune cells,... more Ganoderma lucidum (GL), known as ‘Lingzhi’ has immunomodulatory effect to stimulate immune cells, such as B cell, immunoglobulin (Ig). The duration of those cells’ recovery after chemotherapy completion was longer than 9 months. The objectives of our preliminary study were to evaluate the effect of GL broken spores (GLBS) on immunoglobulin levels and its safety in patients after chemotherapy completion. Fifteen cancer patients after completion of chemotherapy were informed to take 750 mg of GLBS per day divided into three doses before meals for 8 weeks. The results showed IgG, IgM, IgA and IgE levels were not significantly difference compared before and after this study (p-value: 0.34, 0.53 and 0.95, respectively). Mild adverse events such as dry mouth, headache, pain, oral wound, and constipation were found. No significant changes of renal and liver functions were observed. The results suggested that consuming GLBS at 750 mg per day might not be effective for increasing immunoglobu...

Research paper thumbnail of Are there maximum compatible concentrations of calcium gluconate and sodium glycerophosphate in infant parenteral nutrition solutions?

Background: Calcium gluconate and sodium glycerophosphate (NaGP) were claimed to reduce risk of p... more Background: Calcium gluconate and sodium glycerophosphate (NaGP) were claimed to reduce risk of precipitation in infant parenteral nutrition (PN) solutions which contained high amounts of calcium and phosphorus. Objective: To determine the compatibility of calcium gluconate and NaGP at high concentrations in PN solutions with different amino acid concentrations and storage conditions. Methods: PN solutions consisted of 1.5-2.5% amino acid, 0-100 mM/l calcium gluconate and 0-150 mM/l NaGP in constant amounts of dextrose, sodium chloride, and magnesium sulfate. The solutions were kept under 3 conditions; 30°C for 1 d, 4°C for 1 d and 4°C for 7 d. Compatibility initially evaluated by pH measurement and visual inspection. Solutions were then measured turbidity and further observed under a light microscope for microscopic particle count test. PN solution was determined to be compatible if particle counts of three replicates were under USP criteria. Results: PN solutions containing 1.5% a...

Research paper thumbnail of Mutagenicity and antimutagenicity of water extracts from gac fruit (Momordica cochinchinensis Spreng)

Journal of Health Research, 2016

Background: Gac fruit (Momordica cochinchinensis Spreng) was used as food, colourant and medicine... more Background: Gac fruit (Momordica cochinchinensis Spreng) was used as food, colourant and medicine for a period of time. Moreover, several in vitro and in vivo studies showed that gac fruit contained many phytochemicals and exerted bioactive effects, including pro-vitamin A, antioxidant and antitumor activity. This study aimed to investigate the mutagenicity and the antimutagenicity against a standard mutagen; nitrite treated 1-aminopyrene (1-AP) of gac fruit. Method: The water extracts from unripe pulp, half-ripe pulp, fully ripe pulp and aril of gac fruit were treated with and without nitrite and investigated for their mutagenicity using Ames test with modified pre-incubation method on Salmonella typhimurium strain TA98 and TA100 without enzymatic activation. The antimutagenicity against nitrite treated 1-AP of these fruit extracts was also evaluated. Results: The results showed that none of them showed mutagenicity on both strains of S. typhimurium either with or without nitrite t...

Research paper thumbnail of Alu repetitive sequence CpG methylation changes in burn scars

Research paper thumbnail of Deterioration of nutritional status and its negative association with depression among older HIV-infected Asian population: a four-year longitudinal study

AIDS Research and Human Retroviruses

Research paper thumbnail of The carbohydrate content of medications prescribed to children treated with a ketogenic diet

Journal of Pharmacy Practice and Research

Research paper thumbnail of Sodium glycerophosphate and prescribed calcium concentrations in pediatric parenteral nutrition: a retrospective observational study and economic evaluation

Asian Biomedicine

Background The risk of precipitation limits calcium and phosphate concentrations that can be admi... more Background The risk of precipitation limits calcium and phosphate concentrations that can be administered parenterally to pediatric patients. As an alternative to dipotassium phosphate, sodium glycerophosphate (NaGlyP) is claimed to reduce the risk of precipitation in solutions for parenteral administration. Objectives To determine the calcium concentrations, NaGlyP, and dipotassium phosphate prescribed in pediatric parenteral nutrition orders and the cost–benefit of the organic phosphate. Methods We retrospectively collected cross-sectional data for parenteral nutrition orders from September 2014 to August 2015 for pediatric patients including neonates and children aged <18 years who were admitted to King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Calcium concentration, calcium concentration adjustments, and costs of phosphate used per bag were analyzed. Results Of 2,192 parenteral nutrition orders, NaGlyP was used in 2,128 (97.1%) with calcium concentrations in the ran...

Research paper thumbnail of Mutagenic modification effect of pomegranate juice in nitrite treated aminopyrene using Ames test (LB640)

The Faseb Journal, Apr 1, 2014