Ulfat Imran - Academia.edu (original) (raw)
Papers by Ulfat Imran
Pakistan Journal of Physiology, Jun 30, 2023
Introduction: Class attendance is traditionally taken as a very important factor to earn better a... more Introduction: Class attendance is traditionally taken as a very important factor to earn better academic grades. However, with the emphasis on student-centered learning and due to advancement in information technology, its role must be reassessed. Objective: To correlate class attendance of Pharmacology students of Rehman Medical College with their academic performance. Materials & Methods: An institution-based cross-sectional correlational study was conducted in the Department of Pharmacology, Rehman Medical College, Peshawar, from May to August 2017 on students of academic session 2014-15. Academic performance of students in different internal examinations was evaluated and correlated with their attendance. Students were divided into two groups; Group I, with 75% or more class attendance and Group II, with less than 75% attendance. Data were analyzed by SPSS 20 for descriptive statistics; group comparisons were done using Chi Square Test for frequencies and Student’s T test for Means and SD; correlation was determined by Pearson’s Correlation r . In all cases, a p≤0.05 denoted significance. Results: Group I students performed better academically than Group II students (p=0.007). However, class attendance was not the only factor responsible for the good academic performance of those students who scored in higher academic categories (marks more than 75%). Conclusion: Class attendance has a positive impact on students’ academic performance, even in this technological age. However, other factors may affect academic performance of high-scoring students. Keywords: Class attendance; Academic performance; Pharmacology; Multiple Choice Questions; Short Essay Questions.
Journal of Rehman Medical Institute, 2018
Journal of Postgraduate Medical Institute, May 20, 2015
Objective: To determine the effect of thymoquinone and methotrexate on lung in pristine induced i... more Objective: To determine the effect of thymoquinone and methotrexate on lung in pristine induced inflammation in rats. Methodology: It was a comparative study which was carried out at Post Graduate Medical Institute Lahore. Rats were divided into four equal groups each consisting of 8 rats (n=8); group A served as healthy control, group B was taken as positive control, group C was treated with thymoquinone and group D with methotrexate. Arthritis developed within two weeks after a single pristane injection which is assessed through total leukocyte count. Total leukocyte count was taken at day 0, 15 and 30 while lung tissue for histopathology was taken at the time of dissection (day 30). Results: The result of this study indicated that development of arthritis was accompanied by significant raise in total leukocyte count and the presence of inflammatory cells in lung histopathological sections as compared to healthy control groups. Both thymoquinone and methotrexate significantly reduced total leukocyte count and number of inflammatory cells as compared to positive control group of arthritic rats. Conclusion: Evaluation of results supported the beneficial effects of both thymoquinone and Methotrexate in lung inflammation produced by murine model of rheumatoid arthritis. Thus thymoquinone can be a potential therapy for rheumatoid lung and needs further evaluation in human models.
Journal of pharmaceutical research international, Dec 30, 2021
Aim: To find out the prevalence and susceptibility of MDR klebsiella isolates in Karachi. Study D... more Aim: To find out the prevalence and susceptibility of MDR klebsiella isolates in Karachi. Study Design: Pre-clinical in-vitro study. Place and Duration of Study: Study was conducted at the microbiology lab of the tertiary care hospital of Karachi, Pakistan during May to October 2021. Methodology: About 550 samples of blood, urine and wound swab were inoculated on blood agar and MacConkey agar and incubated at 37° Celsius for 24 hours. The antibiotic susceptibility was identified by Kirby Bauer's disc diffusion method. Antibiotic disc of amoxicillin-clavulanate 20 µg, Fosfomycin 200 µg, Ciprofloxacin 5 μg, Moxifloxacin µg, Gentamicin 10 μg and Ceftolozane/tazobactam (30/10 μg) were placed on agar plate and then incubated at 35°C for 16-24 hours. Data was analyzed by using Statistical Package for Social Sciences (SPSS) version 20. Results: Out of total 550 strains of Klebsiella 35% were multidrug resistant while 64% were not. Sensitivity and resistance pattern of multiple antibiotics against Klebsiella showed that majority of antibiotics were resistant to Klebsiella. The highest resistance was noted with amoxicillin that was 90%, followed by amoxiclave, nitrofurantoin, doxycycline, ceftazidime and ciprofloxacin with Original Research Article
Journal of pharmaceutical research international, Feb 17, 2022
Background: Flax seeds has health-potentiating medicinal benefits due to the presence of a remark... more Background: Flax seeds has health-potentiating medicinal benefits due to the presence of a remarkable amount of bioactive compounds. The antibacterial activity of ethanolic extract of flax seeds against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae has been documented. Therefore, the current study current aims to investigated the antibacterial activity flax seeds extract rinse against Streptococcus mutans colonies Methodology: It was a preclinical experimental study and sample size was n = 60. The participants were given an envelope for group randomization. Film of plaque from labial surface of teeth of study participants was collected on sterile strips that was transported to laboratory for culture in sterile containers. For culture S. mutant samples were inoculated in Columbia Agar. The flax seeds extract was diluted in distilled water in 1:4 (Extract: Distilled water) concentration. And participants were divided into 3 groups. (negative control, positive control, flax seed extract group). Diluted flax seed extract was given to experimental group for rinses, distilled water was given to negative control Original Research Article
Global Pharmaceutical Sciences Review
Computers are vital, but in banking, they are essential. Long-term computer screen exposure harms... more Computers are vital, but in banking, they are essential. Long-term computer screen exposure harms the eyes. This study examined CVS prevalence and associated variables in Peshawar City Bank employees. This descriptive-analytical investigation was done across Peshawar city. Commuter bankers were the study population. This multistage study attracted 289 people. A complete tailored questionnaire using SPSS version 24 analyses collected data. Time exposure and CVS were examined. The chi-square test determined significance. A sample of 289 bank workers (mean age 32.72 ± 7.02 years) included 266 (92.0%) men and 23 (8.0%) women. 24.2% of employees had yes illnesses and 77.2% had CVS. Most of them had simple eye health issues due to computer screen overexposure. These symptoms included eye strain, pain, headache (68.9%), blurriness (67.5%), dryness (49.1%), blinking (46.7%), redness and irritations (44.3%). The prevalence of diagnosed eye diseases was high at 24.2% while CVS was positive in...
Journal of Pharmaceutical Research International
Background: The reason behind the poor outcomes in treating bacterial infections is mainly the li... more Background: The reason behind the poor outcomes in treating bacterial infections is mainly the limited treatment options. The strains of ESBL are generally resistant to broad-spectrum penicillin, monobactams, and third-generation cephalosporins. Literature is currently highlighting the efficacy of herbs against many resistant organisms. Hence, the study aims to identify the sensitivity pattern and zone of inhibition of Fenugreek seed extract and Nigella sativa Extract against ESBL E. Coli. Methodology: The calculated sample size was n = 40. The ESBL E. coli growth plate samples were recruited from an associated lab which were identified by performing biochemical tests on appropriate media i.e. Mueller-Hinton agar was used. Agar dilution methods were performed to examine the antibacterial effects of fenugreek seed extract (FGSE) and Nigella sativa seed extract (NGSE) against ESBL E. coli. wells of 8mm diameter were punched in the inoculated plates by using sterile cork borer, 100μl ...
Pakistan Journal of Medical and Health Sciences, 2022
Aim: To find out possible to determine effect of C. reflexa extract on spontaneous contractions o... more Aim: To find out possible to determine effect of C. reflexa extract on spontaneous contractions of rabbit jejunum. Methods: Animal experimental in vitro study from 1st October 2017 to 30 September 2018 at Pharmacology experimental lab, Wah Medical College Wah Cantt. Study model was Isolated pieces of rabbit jejunum and ileum. Sampling Technique used was Simple Random. Tissue considered fit for experiment after initial equilibration and stabilization. Result: Three increasing concentrations (0.1mg/ml, 0.2mg/ml and 0.4mg/ml) of C. reflexa extract decreased the response to 3.83±0.40, 2.33±0.33 and 1.33± 0.21mm. Decrease in response was significant with p- value 0.04, 0.008 and 0.003 respectively. Conclusion: Freshly prepared aqueous solution of crude extract of C. reflexa decreases the amplitude of spontaneous contractions of isolated rabbit jejunum. Keywords: Rabbit jejunum, effect of drug
Journal of Rehman Medical Institute, 2018
Introduction: Class attendance is traditionally taken as a very important factor to earn better a... more Introduction: Class attendance is traditionally taken as a very important factor to earn better academic grades. However, with the emphasis on student-centered learning and due to advancement in information technology, its role must be reassessed. Objective: To correlate class attendance of Pharmacology students of Rehman Medical College with their academic performance. Materials & Methods: An institution-based cross-sectional correlational study was conducted in the Department of Pharmacology, Rehman Medical College, Peshawar, from May to August 2017 on students of academic session 2014-15. Academic performance of students in different internal examinations was evaluated and correlated with their attendance. Students were divided into two groups; Group I, with 75% or more class attendance and Group II, with less than 75% attendance. Data were analyzed by SPSS 20 for descriptive statistics; group comparisons were done using Chi Square Test for frequencies and Student’s T test for Me...
Pakistan Journal of Public Health, 2021
Background: Diabetes mainly depends on social determinants of health. Addressing the social deter... more Background: Diabetes mainly depends on social determinants of health. Addressing the social determinants, and attitude toward disease management is an important step toward the prognosis, and control of diabetes. The objective of the study was to determine the contributing role of social Determinants in diabetes development and evaluation of diabetes parameters affecting the prognosis and management among the diabetic patients of NESH and RMI. Methods: This was comparative hospital based case control study carried out from the duration of March to December 2016. A total 174 patients, 87 diabetics and 87 non diabetics were included in the study. After taking written consent, a predesigned questionnaire was filled from each patient. Data were collected and analyzed by using SPSS version 16. Results: A total 174 study subjects, 87 diabetic (Cases) and non-diabetic (control) each from two different hospitals with equal distribution were included in the study. Out of 174 study subjects 5...
Khyber Medical University Journal, 2016
OBJECTIVES: To isolate total flavonoids from Achillea Wilhelmsii andTeucrium Stocksianum and scre... more OBJECTIVES: To isolate total flavonoids from Achillea Wilhelmsii andTeucrium Stocksianum and screen them for possible analgesic activityand to determine the safe dose range of total flavonoids for preclinicalstudies in mice.METHODS: Acute toxicity studies were performed in mice to determineits safe dose range for total flavonoids of Achillea wilhelmsii and Teucriumstocksianum. Writhing tests were performed in mice for possibleanalgesic activity. Tail immersion method was used in rats for possibleanalgesic activity.RESULTS: Respective LD50 for crude flavonoids of Achillea wilhelmsii(CFA) and crude flavonoids of Teucrium stocksianum (CFT) are1312±12.76 mg/kg and 1248 ±29.6 mg/kg. In acetic acid inducedwrithing, analgesic effect of CFA and CFT in dose 10 mg/kg is almostcomparable with standard acetylsalicylic acid (p≤0.05). Similarly, in tailimmersion method, reaction time was significantly prolonged in testdoses of 5 and 10 mg/kg (both for CFA and CFT) suggesting supraspinalanalgesic ...
Khyber Medical University Journal, 2020
To evaluate the saponins rich fraction of Dioscorea deltoidea (D. deltoidea) for possible antinoc... more To evaluate the saponins rich fraction of Dioscorea deltoidea (D. deltoidea) for possible antinociceptive activity. METHODS: Saponins were extracted from the crude methanolic extract of D. deltoidea (Wall). Presence of saponins was confirmed through phytochemical screenings. Acute toxicity test was performed to determine safe dose range of the saponins rich fraction (n-butanol fraction) using balb C Mice. The saponins rich fraction was assessed for possible antinociceptive activity using acetic acid induced writhing method and hot plate method. Data was analyzed using Graph Pad Prism 6. ANOVA was used to determine the significance of test samples versus positive control at 95% CI with p<0.05. RESULTS: The results showed that crude saponin rich fraction was safe up to test dose of 1000 mg/kg administered orally. In acetic acid induced writhing method, its test samples in doses of 10 and 50 mg/kg showed respectively 75.51% and 85.71% inhibition of writhing, while diclofenac sodium showed 74.4% inhibition of writhing. Percent inhibition of latency time of test samples increased from 87.87% to 133.6% in test doses of 10 mg/kg to 100 mg/kg dose, respectively, while Tramadol showed latency time of 85.12% within 30 minutes of its administration. CONCLUSION: Saponins rich n-butanol fraction of Dioscorea deltoidea (D.deltoidea) showed significant antinociceptive activity.
SSRN Electronic Journal, 2019
This Research examines the frequency of trade affects the fund performance and design the fund tu... more This Research examines the frequency of trade affects the fund performance and design the fund turnover in the existence of time-varying profit possibilities. Our design predicts positive regard between an active fund’s returns and its major standard modified return. We also find such some relative regards for value common resources. This time-series regards revenues as well as is more powerful than the cross-sectional regards, as the design forecasts.<br><br>Also, as expected, the turnover-performance regards are more powerful for stocks trading less-liquid shares and assets likely to acquire greater expertise. Turnover is associated across mutual stocks. The common part of returns is favorably associated with proxy servers for stock mispricing. Turnover of similar resources helps estimate a fund’s efficiency and performance.<br>
Journal of Pharmaceutical Research International, 2022
Background: Flax seeds has health-potentiating medicinal benefits due to the presence of a remark... more Background: Flax seeds has health-potentiating medicinal benefits due to the presence of a remarkable amount of bioactive compounds. The antibacterial activity of ethanolic extract of flax seeds against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae has been documented. Therefore, the current study current aims to investigated the antibacterial activity flax seeds extract rinse against Streptococcus mutans colonies Methodology: It was a preclinical experimental study and sample size was n = 60. The participants were given an envelope for group randomization. Film of plaque from labial surface of teeth of study participants was collected on sterile strips that was transported to laboratory for culture in sterile containers. For culture S. mutant samples were inoculated in Columbia Agar. The flax seeds extract was diluted in distilled water in 1:4 (Extract: Distilled water) concentration. And participants were divided into 3 groups. (negative ...
Journal of Postgraduate Medical Institute, 2015
Objective: To determine the effect of thymoquinone and methotrexate onlung in pristine induced in... more Objective: To determine the effect of thymoquinone and methotrexate onlung in pristine induced inflammation in rats. Methodology: It was a comparative study which was carried out at PostGraduate Medical Institute Lahore. Rats were divided into four equal groupseach consisting of 8 rats (n=8); group A served as healthy control, group B wastaken as positive control, group C was treated with thymoquinone and groupD with methotrexate. Arthritis developed within two weeks after a single pristane injection which is assessed through total leukocyte count. Total leukocyte count was taken at day 0, 15 and 30 while lung tissue for histopathology wastaken at the time of dissection (day 30). Results: The result of this study indicated that development of arthritis was accompanied by significant raise in total leukocyte count and the presence of inflammatory cells in lung histopathological sections as compared to healthy control groups. Both thymoquinone and methotrexate significantly reduced to...
Pakistan Journal of Physiology, Jun 30, 2023
Introduction: Class attendance is traditionally taken as a very important factor to earn better a... more Introduction: Class attendance is traditionally taken as a very important factor to earn better academic grades. However, with the emphasis on student-centered learning and due to advancement in information technology, its role must be reassessed. Objective: To correlate class attendance of Pharmacology students of Rehman Medical College with their academic performance. Materials & Methods: An institution-based cross-sectional correlational study was conducted in the Department of Pharmacology, Rehman Medical College, Peshawar, from May to August 2017 on students of academic session 2014-15. Academic performance of students in different internal examinations was evaluated and correlated with their attendance. Students were divided into two groups; Group I, with 75% or more class attendance and Group II, with less than 75% attendance. Data were analyzed by SPSS 20 for descriptive statistics; group comparisons were done using Chi Square Test for frequencies and Student’s T test for Means and SD; correlation was determined by Pearson’s Correlation r . In all cases, a p≤0.05 denoted significance. Results: Group I students performed better academically than Group II students (p=0.007). However, class attendance was not the only factor responsible for the good academic performance of those students who scored in higher academic categories (marks more than 75%). Conclusion: Class attendance has a positive impact on students’ academic performance, even in this technological age. However, other factors may affect academic performance of high-scoring students. Keywords: Class attendance; Academic performance; Pharmacology; Multiple Choice Questions; Short Essay Questions.
Journal of Rehman Medical Institute, 2018
Journal of Postgraduate Medical Institute, May 20, 2015
Objective: To determine the effect of thymoquinone and methotrexate on lung in pristine induced i... more Objective: To determine the effect of thymoquinone and methotrexate on lung in pristine induced inflammation in rats. Methodology: It was a comparative study which was carried out at Post Graduate Medical Institute Lahore. Rats were divided into four equal groups each consisting of 8 rats (n=8); group A served as healthy control, group B was taken as positive control, group C was treated with thymoquinone and group D with methotrexate. Arthritis developed within two weeks after a single pristane injection which is assessed through total leukocyte count. Total leukocyte count was taken at day 0, 15 and 30 while lung tissue for histopathology was taken at the time of dissection (day 30). Results: The result of this study indicated that development of arthritis was accompanied by significant raise in total leukocyte count and the presence of inflammatory cells in lung histopathological sections as compared to healthy control groups. Both thymoquinone and methotrexate significantly reduced total leukocyte count and number of inflammatory cells as compared to positive control group of arthritic rats. Conclusion: Evaluation of results supported the beneficial effects of both thymoquinone and Methotrexate in lung inflammation produced by murine model of rheumatoid arthritis. Thus thymoquinone can be a potential therapy for rheumatoid lung and needs further evaluation in human models.
Journal of pharmaceutical research international, Dec 30, 2021
Aim: To find out the prevalence and susceptibility of MDR klebsiella isolates in Karachi. Study D... more Aim: To find out the prevalence and susceptibility of MDR klebsiella isolates in Karachi. Study Design: Pre-clinical in-vitro study. Place and Duration of Study: Study was conducted at the microbiology lab of the tertiary care hospital of Karachi, Pakistan during May to October 2021. Methodology: About 550 samples of blood, urine and wound swab were inoculated on blood agar and MacConkey agar and incubated at 37° Celsius for 24 hours. The antibiotic susceptibility was identified by Kirby Bauer's disc diffusion method. Antibiotic disc of amoxicillin-clavulanate 20 µg, Fosfomycin 200 µg, Ciprofloxacin 5 μg, Moxifloxacin µg, Gentamicin 10 μg and Ceftolozane/tazobactam (30/10 μg) were placed on agar plate and then incubated at 35°C for 16-24 hours. Data was analyzed by using Statistical Package for Social Sciences (SPSS) version 20. Results: Out of total 550 strains of Klebsiella 35% were multidrug resistant while 64% were not. Sensitivity and resistance pattern of multiple antibiotics against Klebsiella showed that majority of antibiotics were resistant to Klebsiella. The highest resistance was noted with amoxicillin that was 90%, followed by amoxiclave, nitrofurantoin, doxycycline, ceftazidime and ciprofloxacin with Original Research Article
Journal of pharmaceutical research international, Feb 17, 2022
Background: Flax seeds has health-potentiating medicinal benefits due to the presence of a remark... more Background: Flax seeds has health-potentiating medicinal benefits due to the presence of a remarkable amount of bioactive compounds. The antibacterial activity of ethanolic extract of flax seeds against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae has been documented. Therefore, the current study current aims to investigated the antibacterial activity flax seeds extract rinse against Streptococcus mutans colonies Methodology: It was a preclinical experimental study and sample size was n = 60. The participants were given an envelope for group randomization. Film of plaque from labial surface of teeth of study participants was collected on sterile strips that was transported to laboratory for culture in sterile containers. For culture S. mutant samples were inoculated in Columbia Agar. The flax seeds extract was diluted in distilled water in 1:4 (Extract: Distilled water) concentration. And participants were divided into 3 groups. (negative control, positive control, flax seed extract group). Diluted flax seed extract was given to experimental group for rinses, distilled water was given to negative control Original Research Article
Global Pharmaceutical Sciences Review
Computers are vital, but in banking, they are essential. Long-term computer screen exposure harms... more Computers are vital, but in banking, they are essential. Long-term computer screen exposure harms the eyes. This study examined CVS prevalence and associated variables in Peshawar City Bank employees. This descriptive-analytical investigation was done across Peshawar city. Commuter bankers were the study population. This multistage study attracted 289 people. A complete tailored questionnaire using SPSS version 24 analyses collected data. Time exposure and CVS were examined. The chi-square test determined significance. A sample of 289 bank workers (mean age 32.72 ± 7.02 years) included 266 (92.0%) men and 23 (8.0%) women. 24.2% of employees had yes illnesses and 77.2% had CVS. Most of them had simple eye health issues due to computer screen overexposure. These symptoms included eye strain, pain, headache (68.9%), blurriness (67.5%), dryness (49.1%), blinking (46.7%), redness and irritations (44.3%). The prevalence of diagnosed eye diseases was high at 24.2% while CVS was positive in...
Journal of Pharmaceutical Research International
Background: The reason behind the poor outcomes in treating bacterial infections is mainly the li... more Background: The reason behind the poor outcomes in treating bacterial infections is mainly the limited treatment options. The strains of ESBL are generally resistant to broad-spectrum penicillin, monobactams, and third-generation cephalosporins. Literature is currently highlighting the efficacy of herbs against many resistant organisms. Hence, the study aims to identify the sensitivity pattern and zone of inhibition of Fenugreek seed extract and Nigella sativa Extract against ESBL E. Coli. Methodology: The calculated sample size was n = 40. The ESBL E. coli growth plate samples were recruited from an associated lab which were identified by performing biochemical tests on appropriate media i.e. Mueller-Hinton agar was used. Agar dilution methods were performed to examine the antibacterial effects of fenugreek seed extract (FGSE) and Nigella sativa seed extract (NGSE) against ESBL E. coli. wells of 8mm diameter were punched in the inoculated plates by using sterile cork borer, 100μl ...
Pakistan Journal of Medical and Health Sciences, 2022
Aim: To find out possible to determine effect of C. reflexa extract on spontaneous contractions o... more Aim: To find out possible to determine effect of C. reflexa extract on spontaneous contractions of rabbit jejunum. Methods: Animal experimental in vitro study from 1st October 2017 to 30 September 2018 at Pharmacology experimental lab, Wah Medical College Wah Cantt. Study model was Isolated pieces of rabbit jejunum and ileum. Sampling Technique used was Simple Random. Tissue considered fit for experiment after initial equilibration and stabilization. Result: Three increasing concentrations (0.1mg/ml, 0.2mg/ml and 0.4mg/ml) of C. reflexa extract decreased the response to 3.83±0.40, 2.33±0.33 and 1.33± 0.21mm. Decrease in response was significant with p- value 0.04, 0.008 and 0.003 respectively. Conclusion: Freshly prepared aqueous solution of crude extract of C. reflexa decreases the amplitude of spontaneous contractions of isolated rabbit jejunum. Keywords: Rabbit jejunum, effect of drug
Journal of Rehman Medical Institute, 2018
Introduction: Class attendance is traditionally taken as a very important factor to earn better a... more Introduction: Class attendance is traditionally taken as a very important factor to earn better academic grades. However, with the emphasis on student-centered learning and due to advancement in information technology, its role must be reassessed. Objective: To correlate class attendance of Pharmacology students of Rehman Medical College with their academic performance. Materials & Methods: An institution-based cross-sectional correlational study was conducted in the Department of Pharmacology, Rehman Medical College, Peshawar, from May to August 2017 on students of academic session 2014-15. Academic performance of students in different internal examinations was evaluated and correlated with their attendance. Students were divided into two groups; Group I, with 75% or more class attendance and Group II, with less than 75% attendance. Data were analyzed by SPSS 20 for descriptive statistics; group comparisons were done using Chi Square Test for frequencies and Student’s T test for Me...
Pakistan Journal of Public Health, 2021
Background: Diabetes mainly depends on social determinants of health. Addressing the social deter... more Background: Diabetes mainly depends on social determinants of health. Addressing the social determinants, and attitude toward disease management is an important step toward the prognosis, and control of diabetes. The objective of the study was to determine the contributing role of social Determinants in diabetes development and evaluation of diabetes parameters affecting the prognosis and management among the diabetic patients of NESH and RMI. Methods: This was comparative hospital based case control study carried out from the duration of March to December 2016. A total 174 patients, 87 diabetics and 87 non diabetics were included in the study. After taking written consent, a predesigned questionnaire was filled from each patient. Data were collected and analyzed by using SPSS version 16. Results: A total 174 study subjects, 87 diabetic (Cases) and non-diabetic (control) each from two different hospitals with equal distribution were included in the study. Out of 174 study subjects 5...
Khyber Medical University Journal, 2016
OBJECTIVES: To isolate total flavonoids from Achillea Wilhelmsii andTeucrium Stocksianum and scre... more OBJECTIVES: To isolate total flavonoids from Achillea Wilhelmsii andTeucrium Stocksianum and screen them for possible analgesic activityand to determine the safe dose range of total flavonoids for preclinicalstudies in mice.METHODS: Acute toxicity studies were performed in mice to determineits safe dose range for total flavonoids of Achillea wilhelmsii and Teucriumstocksianum. Writhing tests were performed in mice for possibleanalgesic activity. Tail immersion method was used in rats for possibleanalgesic activity.RESULTS: Respective LD50 for crude flavonoids of Achillea wilhelmsii(CFA) and crude flavonoids of Teucrium stocksianum (CFT) are1312±12.76 mg/kg and 1248 ±29.6 mg/kg. In acetic acid inducedwrithing, analgesic effect of CFA and CFT in dose 10 mg/kg is almostcomparable with standard acetylsalicylic acid (p≤0.05). Similarly, in tailimmersion method, reaction time was significantly prolonged in testdoses of 5 and 10 mg/kg (both for CFA and CFT) suggesting supraspinalanalgesic ...
Khyber Medical University Journal, 2020
To evaluate the saponins rich fraction of Dioscorea deltoidea (D. deltoidea) for possible antinoc... more To evaluate the saponins rich fraction of Dioscorea deltoidea (D. deltoidea) for possible antinociceptive activity. METHODS: Saponins were extracted from the crude methanolic extract of D. deltoidea (Wall). Presence of saponins was confirmed through phytochemical screenings. Acute toxicity test was performed to determine safe dose range of the saponins rich fraction (n-butanol fraction) using balb C Mice. The saponins rich fraction was assessed for possible antinociceptive activity using acetic acid induced writhing method and hot plate method. Data was analyzed using Graph Pad Prism 6. ANOVA was used to determine the significance of test samples versus positive control at 95% CI with p<0.05. RESULTS: The results showed that crude saponin rich fraction was safe up to test dose of 1000 mg/kg administered orally. In acetic acid induced writhing method, its test samples in doses of 10 and 50 mg/kg showed respectively 75.51% and 85.71% inhibition of writhing, while diclofenac sodium showed 74.4% inhibition of writhing. Percent inhibition of latency time of test samples increased from 87.87% to 133.6% in test doses of 10 mg/kg to 100 mg/kg dose, respectively, while Tramadol showed latency time of 85.12% within 30 minutes of its administration. CONCLUSION: Saponins rich n-butanol fraction of Dioscorea deltoidea (D.deltoidea) showed significant antinociceptive activity.
SSRN Electronic Journal, 2019
This Research examines the frequency of trade affects the fund performance and design the fund tu... more This Research examines the frequency of trade affects the fund performance and design the fund turnover in the existence of time-varying profit possibilities. Our design predicts positive regard between an active fund’s returns and its major standard modified return. We also find such some relative regards for value common resources. This time-series regards revenues as well as is more powerful than the cross-sectional regards, as the design forecasts.<br><br>Also, as expected, the turnover-performance regards are more powerful for stocks trading less-liquid shares and assets likely to acquire greater expertise. Turnover is associated across mutual stocks. The common part of returns is favorably associated with proxy servers for stock mispricing. Turnover of similar resources helps estimate a fund’s efficiency and performance.<br>
Journal of Pharmaceutical Research International, 2022
Background: Flax seeds has health-potentiating medicinal benefits due to the presence of a remark... more Background: Flax seeds has health-potentiating medicinal benefits due to the presence of a remarkable amount of bioactive compounds. The antibacterial activity of ethanolic extract of flax seeds against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae has been documented. Therefore, the current study current aims to investigated the antibacterial activity flax seeds extract rinse against Streptococcus mutans colonies Methodology: It was a preclinical experimental study and sample size was n = 60. The participants were given an envelope for group randomization. Film of plaque from labial surface of teeth of study participants was collected on sterile strips that was transported to laboratory for culture in sterile containers. For culture S. mutant samples were inoculated in Columbia Agar. The flax seeds extract was diluted in distilled water in 1:4 (Extract: Distilled water) concentration. And participants were divided into 3 groups. (negative ...
Journal of Postgraduate Medical Institute, 2015
Objective: To determine the effect of thymoquinone and methotrexate onlung in pristine induced in... more Objective: To determine the effect of thymoquinone and methotrexate onlung in pristine induced inflammation in rats. Methodology: It was a comparative study which was carried out at PostGraduate Medical Institute Lahore. Rats were divided into four equal groupseach consisting of 8 rats (n=8); group A served as healthy control, group B wastaken as positive control, group C was treated with thymoquinone and groupD with methotrexate. Arthritis developed within two weeks after a single pristane injection which is assessed through total leukocyte count. Total leukocyte count was taken at day 0, 15 and 30 while lung tissue for histopathology wastaken at the time of dissection (day 30). Results: The result of this study indicated that development of arthritis was accompanied by significant raise in total leukocyte count and the presence of inflammatory cells in lung histopathological sections as compared to healthy control groups. Both thymoquinone and methotrexate significantly reduced to...