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Papers by Vicente MARTÍN SÁNCHEZ

European journal of nutrition, Jan 11, 2018

Studies attempting to link dietary non-enzymatic antioxidant activity (NEAC) and colorectal cance... more Studies attempting to link dietary non-enzymatic antioxidant activity (NEAC) and colorectal cancer (CRC) risk have reported mixed results. We examined this association in the Spanish Multicase-Control Study considering the likely influence of coffee and other dietary factors. 1718 CRC cases and 3312 matched-controls provided information about diet through a validated 140-item food frequency questionnaire. Dietary NEAC was estimated for three methods [total radical-trapping antioxidant parameters (TRAP), ferric reducing/antioxidant power (FRAP) and TEAC-ABTS] using published values of NEAC content in food, with and without coffee's NEAC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated through unconditional logistic regression models adjusted for lifestyle and dietary factors. Overall dietary intake of NEAC was significantly lower in cases compared to controls and associated with a significantly reduced CRC risk, in both men (OR = 0.67, 95% CI 0.47-0.96 for FR...

International Journal of Epidemiology, 2018

Journal of Advanced Nursing, 2010

Effectiveness of a course on the prevention and control of the smoking habit on its prevalence an... more Effectiveness of a course on the prevention and control of the smoking habit on its prevalence and incidence among students of health sciences.

Aims The aim of this study was to evaluate the association of diabetes and diabetes treatment wit... more Aims The aim of this study was to evaluate the association of diabetes and diabetes treatment with risk of postmenopausal breast cancer. Methods Histologically confirmed incident cases of postmenopausal breast (N = 916) cancer were recruited from 23 Spanish public hospitals. Population-based controls (N = 1094) were randomly selected from primary care center lists within the catchment areas of the participant hospitals. ORs (95 % CI) were estimated using mixed-effects logistic regression models, using the recruitment center as a random effect term. Breast tumors were classified into hormone receptor positive (ER? or PR?), HER2? and triple negative (TN). Results Diabetes was not associated with the overall risk of breast cancer (OR 1.09; 95 % CI 0.82-1.45), and it was only linked to the risk of developing TN tumors: Among 91 women with TN tumors, 18.7 % were diabetic, while the corresponding figure among controls was 9.9 % (OR 2.25; 95 % CI 1.22-4.15). Regarding treatment, results showed that insulin use was more prevalent among diabetic cases (2.5 %) as compared to diabetic controls (0.7 %); OR 2.98; 95 % CI 1.26-7.01. They also showed that, among diabetics, the risk of developing HR?/HER2-tumors decreased with longer metformin use (OR per year 0.89; 95 % CI 0.81-0.99; based on 24 cases and 43 controls). Conclusion This study reinforces the need to correctly classify breast cancers when studying their association with diabetes. Given the low survival rates in women diagnosed with TN breast tumors and the potential impact of diabetes control on breast cancer prevention, more studies are needed to better characterize this association.

Cómo citar este artículo: Dávila-Batista V, et al. Escala colorimétrica del porcentaje de grasa c... more Cómo citar este artículo: Dávila-Batista V, et al. Escala colorimétrica del porcentaje de grasa corporal según el estimador de adiposidad CUN-BAE. Aten Primaria. 2015. http://dx.

Objectives: To describe levels of nitrate and trace elements in drinking water from the study are... more Objectives: To describe levels of nitrate and trace elements in drinking water from the study areas of a multicase-control study of cancer in Spain (MCC-Spain). Methods: A total of 227 tap water samples were randomly collected from 67 municipalities in 11 provinces and the nine most frequently consumed bottled water brands were sampled to measure levels of nitrate, arsenic, nickel, chromium, cadmium, lead, selenium and zinc. Results: The median nitrate level was 4.2 mg/l (range < 1-29.0), with similar levels in rural and urban municipalities (p = 0.86). Trace elements were unquantifiable in 94% of tap water samples. Differences between areas were significant for nitrate (p < 0.001) and arsenic (p = 0.03). Only nitrate was quantifiable in bottled water (range 2.3-15.6 mg/l). Conclusions: Nitrate levels in municipal water differed between regions and were below the regulatory limit in all samples, including bottled water. Trace element levels were low and mainly unquantifiable in tap and bottled water.

Objective. To evaluate trends in seasonal influenza vaccination coverage in primary healthcare wo... more Objective. To evaluate trends in seasonal influenza vaccination coverage in primary healthcare workers (PHCWs) in Spain between 2008 and 2011.

A pilot programme of hepatit& B vacc&ation was set up in three prisons to assess the feasibility ... more A pilot programme of hepatit& B vacc&ation was set up in three prisons to assess the feasibility and results of this method of reachin9 a high-risk population. Hepatitis B vaccine was offered to all inmates who lacked serological markers for hepatitis B virus. The antibody response was assessed in those who received two or three doses of vaccine. Candidates for vaccination were 41% of 1755 imprisoned men (20% of intravenous dru9 users ( IVDU) and 63% of non-IVDU), but complete vaccination could be 9iven to only 33% of candidates. A further 29% received two doses. Seroconversion to anti-HBs ( titres > 10 IU l-1) occurred in 33% ofvaccinees after two doses and in 76% after three doses. The overall rate of susceptible inmates who became protected for hepatitis B was 34%. The seroconversion rate was higher when the interval between the first two doses was shorter than 3 weeks (91%), than in cases with an interval of 3-6 weeks (79%) or longer than 6 weeks (33%). Age 9reater than 35 years and history of lVDU were associated with a lower response to the vaccine, while anti-HIV seropositivity did not influence the response. In conclusion, vaccination of prisoners susceptible to HB V may achieve protection in at least a third of cases. Shortenin9 intervals between the primin9 doses of vaccine may improve compliance and increases the response.

Background. In most seasons, the influenza vaccine is effective in preventing influenza, but it i... more Background. In most seasons, the influenza vaccine is effective in preventing influenza, but it is not clear whether it is equally effective in preventing mild and severe cases. We designed a case-control study to compare the effectiveness of the influenza vaccine in preventing outpatient, inpatient, and severe or fatal cases of laboratory-confirmed influenza.

The objective of this paper was to develop a prognostic index for severe complications among hosp... more The objective of this paper was to develop a prognostic index for severe complications among hospitalized patients with influenza A (H1N1) 2009 virus infection. We conducted a prospective observational cohort study of 618 inpatients with 2009 H1N1 virus infection admitted to 36 Spanish hospitals between July 2009 and February 2010. Risk factors evaluated included host-related factors and clinical data at admission. We developed a composite index of severe in-hospital complications (SIHC), which included: mortality, mechanical ventilation, septic shock, acute respiratory distress syndrome, and requirement for resuscitation maneuvers. Six factors were independently associated with SIHC: age >45 years, male sex, number of comorbidities, pneumonia, dyspnea, and confusion. From the β parameter obtained in the multivariate model, a weight was assigned to each factor to compute the individual influenza risk score. The score shows an area under the receiver operating characteristic (ROC) curve of 0.77. The SIHC rate was 1.9 % in the low-risk group, 10.3 % in the intermediate-risk group, and 29.6 % in the high-risk group. The odds ratio for complications was 21.8 for the high-risk group compared with the low-risk group. This easy-to-score influenza A

Recibido el 8-7-1999; aceptado para su publicación el 15-7-1999 Med Clin (Barc) 1999; 113: 710-71... more Recibido el 8-7-1999; aceptado para su publicación el 15-7-1999 Med Clin (Barc) 1999; 113: 710-715 análisis coste-efectividad; antirretrovirales; centro de salud; comorbilidad; control de enfermedades transmisibles; cumplimiento de la prescripción; estudios epidemiológicos; etambutol; factores sociosanitarios; incidencia; infecciones por VIH Documento descargado de http://www.elsevier.es el 26/02/2013. Copia para uso personal, se prohíbe la transmisión de este documento por cualquier medio o formato.

Systemic lupus erythematosus (SLE) is a rheumatic disease characterized by a variety of symptoms,... more Systemic lupus erythematosus (SLE) is a rheumatic disease characterized by a variety of symptoms, especially fatigue, pain and reduced quality of life. Physical exercise is a useful tool for improving cardiovascular fitness, reducing metabolic abnormalities and fatigue and improving quality of life. However, very few studies have focused on the relationship between SLE and physical exercise. This paper reviews the main SLE symptoms that can be alleviated by exercising, as well as the results of studies seeking to analyse the exercise capacity and physical training possibilities of SLE patients. Considerations for future research are also discussed. Lupus (2007) 16, 5-9.

European journal of nutrition, Jan 11, 2018

Studies attempting to link dietary non-enzymatic antioxidant activity (NEAC) and colorectal cance... more Studies attempting to link dietary non-enzymatic antioxidant activity (NEAC) and colorectal cancer (CRC) risk have reported mixed results. We examined this association in the Spanish Multicase-Control Study considering the likely influence of coffee and other dietary factors. 1718 CRC cases and 3312 matched-controls provided information about diet through a validated 140-item food frequency questionnaire. Dietary NEAC was estimated for three methods [total radical-trapping antioxidant parameters (TRAP), ferric reducing/antioxidant power (FRAP) and TEAC-ABTS] using published values of NEAC content in food, with and without coffee's NEAC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated through unconditional logistic regression models adjusted for lifestyle and dietary factors. Overall dietary intake of NEAC was significantly lower in cases compared to controls and associated with a significantly reduced CRC risk, in both men (OR = 0.67, 95% CI 0.47-0.96 for FR...

International Journal of Epidemiology, 2018

Journal of Advanced Nursing, 2010

Effectiveness of a course on the prevention and control of the smoking habit on its prevalence an... more Effectiveness of a course on the prevention and control of the smoking habit on its prevalence and incidence among students of health sciences.

Aims The aim of this study was to evaluate the association of diabetes and diabetes treatment wit... more Aims The aim of this study was to evaluate the association of diabetes and diabetes treatment with risk of postmenopausal breast cancer. Methods Histologically confirmed incident cases of postmenopausal breast (N = 916) cancer were recruited from 23 Spanish public hospitals. Population-based controls (N = 1094) were randomly selected from primary care center lists within the catchment areas of the participant hospitals. ORs (95 % CI) were estimated using mixed-effects logistic regression models, using the recruitment center as a random effect term. Breast tumors were classified into hormone receptor positive (ER? or PR?), HER2? and triple negative (TN). Results Diabetes was not associated with the overall risk of breast cancer (OR 1.09; 95 % CI 0.82-1.45), and it was only linked to the risk of developing TN tumors: Among 91 women with TN tumors, 18.7 % were diabetic, while the corresponding figure among controls was 9.9 % (OR 2.25; 95 % CI 1.22-4.15). Regarding treatment, results showed that insulin use was more prevalent among diabetic cases (2.5 %) as compared to diabetic controls (0.7 %); OR 2.98; 95 % CI 1.26-7.01. They also showed that, among diabetics, the risk of developing HR?/HER2-tumors decreased with longer metformin use (OR per year 0.89; 95 % CI 0.81-0.99; based on 24 cases and 43 controls). Conclusion This study reinforces the need to correctly classify breast cancers when studying their association with diabetes. Given the low survival rates in women diagnosed with TN breast tumors and the potential impact of diabetes control on breast cancer prevention, more studies are needed to better characterize this association.

Cómo citar este artículo: Dávila-Batista V, et al. Escala colorimétrica del porcentaje de grasa c... more Cómo citar este artículo: Dávila-Batista V, et al. Escala colorimétrica del porcentaje de grasa corporal según el estimador de adiposidad CUN-BAE. Aten Primaria. 2015. http://dx.

Objectives: To describe levels of nitrate and trace elements in drinking water from the study are... more Objectives: To describe levels of nitrate and trace elements in drinking water from the study areas of a multicase-control study of cancer in Spain (MCC-Spain). Methods: A total of 227 tap water samples were randomly collected from 67 municipalities in 11 provinces and the nine most frequently consumed bottled water brands were sampled to measure levels of nitrate, arsenic, nickel, chromium, cadmium, lead, selenium and zinc. Results: The median nitrate level was 4.2 mg/l (range < 1-29.0), with similar levels in rural and urban municipalities (p = 0.86). Trace elements were unquantifiable in 94% of tap water samples. Differences between areas were significant for nitrate (p < 0.001) and arsenic (p = 0.03). Only nitrate was quantifiable in bottled water (range 2.3-15.6 mg/l). Conclusions: Nitrate levels in municipal water differed between regions and were below the regulatory limit in all samples, including bottled water. Trace element levels were low and mainly unquantifiable in tap and bottled water.

Objective. To evaluate trends in seasonal influenza vaccination coverage in primary healthcare wo... more Objective. To evaluate trends in seasonal influenza vaccination coverage in primary healthcare workers (PHCWs) in Spain between 2008 and 2011.

A pilot programme of hepatit& B vacc&ation was set up in three prisons to assess the feasibility ... more A pilot programme of hepatit& B vacc&ation was set up in three prisons to assess the feasibility and results of this method of reachin9 a high-risk population. Hepatitis B vaccine was offered to all inmates who lacked serological markers for hepatitis B virus. The antibody response was assessed in those who received two or three doses of vaccine. Candidates for vaccination were 41% of 1755 imprisoned men (20% of intravenous dru9 users ( IVDU) and 63% of non-IVDU), but complete vaccination could be 9iven to only 33% of candidates. A further 29% received two doses. Seroconversion to anti-HBs ( titres > 10 IU l-1) occurred in 33% ofvaccinees after two doses and in 76% after three doses. The overall rate of susceptible inmates who became protected for hepatitis B was 34%. The seroconversion rate was higher when the interval between the first two doses was shorter than 3 weeks (91%), than in cases with an interval of 3-6 weeks (79%) or longer than 6 weeks (33%). Age 9reater than 35 years and history of lVDU were associated with a lower response to the vaccine, while anti-HIV seropositivity did not influence the response. In conclusion, vaccination of prisoners susceptible to HB V may achieve protection in at least a third of cases. Shortenin9 intervals between the primin9 doses of vaccine may improve compliance and increases the response.

Background. In most seasons, the influenza vaccine is effective in preventing influenza, but it i... more Background. In most seasons, the influenza vaccine is effective in preventing influenza, but it is not clear whether it is equally effective in preventing mild and severe cases. We designed a case-control study to compare the effectiveness of the influenza vaccine in preventing outpatient, inpatient, and severe or fatal cases of laboratory-confirmed influenza.

The objective of this paper was to develop a prognostic index for severe complications among hosp... more The objective of this paper was to develop a prognostic index for severe complications among hospitalized patients with influenza A (H1N1) 2009 virus infection. We conducted a prospective observational cohort study of 618 inpatients with 2009 H1N1 virus infection admitted to 36 Spanish hospitals between July 2009 and February 2010. Risk factors evaluated included host-related factors and clinical data at admission. We developed a composite index of severe in-hospital complications (SIHC), which included: mortality, mechanical ventilation, septic shock, acute respiratory distress syndrome, and requirement for resuscitation maneuvers. Six factors were independently associated with SIHC: age >45 years, male sex, number of comorbidities, pneumonia, dyspnea, and confusion. From the β parameter obtained in the multivariate model, a weight was assigned to each factor to compute the individual influenza risk score. The score shows an area under the receiver operating characteristic (ROC) curve of 0.77. The SIHC rate was 1.9 % in the low-risk group, 10.3 % in the intermediate-risk group, and 29.6 % in the high-risk group. The odds ratio for complications was 21.8 for the high-risk group compared with the low-risk group. This easy-to-score influenza A

Recibido el 8-7-1999; aceptado para su publicación el 15-7-1999 Med Clin (Barc) 1999; 113: 710-71... more Recibido el 8-7-1999; aceptado para su publicación el 15-7-1999 Med Clin (Barc) 1999; 113: 710-715 análisis coste-efectividad; antirretrovirales; centro de salud; comorbilidad; control de enfermedades transmisibles; cumplimiento de la prescripción; estudios epidemiológicos; etambutol; factores sociosanitarios; incidencia; infecciones por VIH Documento descargado de http://www.elsevier.es el 26/02/2013. Copia para uso personal, se prohíbe la transmisión de este documento por cualquier medio o formato.

Systemic lupus erythematosus (SLE) is a rheumatic disease characterized by a variety of symptoms,... more Systemic lupus erythematosus (SLE) is a rheumatic disease characterized by a variety of symptoms, especially fatigue, pain and reduced quality of life. Physical exercise is a useful tool for improving cardiovascular fitness, reducing metabolic abnormalities and fatigue and improving quality of life. However, very few studies have focused on the relationship between SLE and physical exercise. This paper reviews the main SLE symptoms that can be alleviated by exercising, as well as the results of studies seeking to analyse the exercise capacity and physical training possibilities of SLE patients. Considerations for future research are also discussed. Lupus (2007) 16, 5-9.