Vincenzo Carnevale - Academia.edu (original) (raw)
Papers by Vincenzo Carnevale
The American Journal of the Medical Sciences, 1996
Whipple's disease is a rare systemic illness, with the main clinical feature bein... more Whipple's disease is a rare systemic illness, with the main clinical feature being severe malabsorption syndrome. Bone involvement in the disease has rarely been described in previous articles. The authors report a case in which an extensive skeletal evaluation was carried out. Even though osteomalacia is generally considered the most typical metabolic bone disease of malabsorption syndromes, bone biopsy demonstrated that osteoporosis was the prominent histologic feature in this patient. On the basis of serial bone mineral density measurements, antibiotic treatment was able to reverse the initial reduced bone mass.
European Radiology, 1999
The purpose of this study was to evaluate the diagnostic sensitivity of phalangeal bone ultrasoun... more The purpose of this study was to evaluate the diagnostic sensitivity of phalangeal bone ultrasound velocity of the hand in the diagnosis of osteoporosis and to compare this technique to bone mineral density (BMD) measurement at the lumbar spine assessed by dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). We investigated US velocity at the distal metaphysis of the proximal phalanx and spinal BMD in 101 women. Fifty-nine were healthy (mean age 50 +/- 11.6 years) and 42 were osteoporotic (mean age 65 +/- 6.6 years) with documented vertebral fractures. In the healthy population the relation with age was, respectively, r = -0.73 (p < 0. 0001) for quantitative US (QUS), r = -0.74 (p < 0.0001) for QCT and r = -0.48 (p < 0.01) for DXA. Both US and DXA were correlated with QCT: r = 0.74 and r = 0.77 (p < 0.0001), respectively. Correlation of QUS and DXA was r = 0.56 (p < 0.0001). Phalangeal US velocity and spinal BMD (QCT and DXA) values discriminate healthy from osteoporotic women. Age-adjusted logistic regression analysis of the data showed standardized odds ratios (OR) for vertebral fracture to be similar for US and DXA (OR = 1.8 and 1.5, respectively) and stronger for QCT (OR = 2.9). Phalangeal US velocity reflects age-related bone loss and differentiates between healthy and osteoporotic subjects.
The Journal of Clinical Endocrinology & Metabolism, 2010
Context: Effects of vitamin D repletion in young people with low vitamin D status have not been i... more Context: Effects of vitamin D repletion in young people with low vitamin D status have not been investigated so far. Objective: We evaluated the effect of a single massive dose of cholecalciferol on calcium metabolism at 3, 15, and 30 d, compared to baseline. Design and Setting: We conducted a prospective intervention study in an ambulatory care setting. Participants: Forty-eight young subjects with vitamin D deficiency participated in the study. Intervention: A single oral dose of 600,000 IU of cholecalciferol was administered to each subject. Main Outcome Measures: We evaluated serum changes of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D, calcium, and PTH induced by a single load of cholecalciferol. Results: The 25(OH)D level was 15.8 ± 6.5 ng/ml at baseline and became 77.2 ± 30.5 ng/ml at 3 d (P < 0.001) and 62.4 ± 26.1 ng/ml at 30 d (P < 0.001). PTH levels concomitantly decreased from 53.0 ± 20.1 to 38.6 ± 17.2 pg/ml at 3 d and to 43.4 ± 14.0 pg/ml at 30 d (P &l...
Biophysical Journal, 2015
Our group has previously demonstrated that cardiomyocytes express ChAT (choline acetyltransferase... more Our group has previously demonstrated that cardiomyocytes express ChAT (choline acetyltransferase), VAChT (vesicular acetylcholine transporter) and ChT-1 (choline high affinity transporter), proteins involved in the synthesis, release and reuptake of acetylcholine. Additionally, we have shown that this cardiomyocyte intrinsic cholinergic machinery has an important role in preventing deleterious effects of adrenergic signaling in vitro and in vivo. To address the role of this non-neuronal acetylcholine for heart function, a new mouse lineage was generated with deletion of VAChT (vesicular acetylcholine transporter) only in cardiac myocytes (cVAChT-ko). These mice are characterized by heart hypertrophy, calcium signaling dysfunction and increased reactive oxygen species levels. In order to better understand how impairment in acetylcholine released from cardiomyocytes could impact heart function, we subjected these mice to transverse aortic constriction (TAC) and evaluated left ventricular hypertrophy at 3 and 14 days after surgery.
Endocrine, 2016
Your article is protected by copyright and all rights are held exclusively by Springer Science +B... more Your article is protected by copyright and all rights are held exclusively by Springer Science +Business Media New York. This e-offprint is for personal use only and shall not be selfarchived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website. You may further deposit the accepted manuscript version in any repository, provided it is only made publicly available 12 months after official publication or later and provided acknowledgement is given to the original source of publication and a link is inserted to the published article on Springer's website. The link must be accompanied by the following text: "The final publication is available at link.springer.com".
European Radiol, 1999
The purpose of this study was to evaluate the diagnostic sensitivity of phalangeal bone ultrasoun... more The purpose of this study was to evaluate the diagnostic sensitivity of phalangeal bone ultrasound velocity of the hand in the diagnosis of osteoporosis and to compare this technique to bone mineral density (BMD) measurement at the lumbar spine assessed by dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). We investigated US velocity at the distal metaphysis of the proximal phalanx and spinal BMD in 101 women. Fifty-nine were healthy (mean age 50 +/- 11.6 years) and 42 were osteoporotic (mean age 65 +/- 6.6 years) with documented vertebral fractures. In the healthy population the relation with age was, respectively, r = -0.73 (p < 0. 0001) for quantitative US (QUS), r = -0.74 (p < 0.0001) for QCT and r = -0.48 (p < 0.01) for DXA. Both US and DXA were correlated with QCT: r = 0.74 and r = 0.77 (p < 0.0001), respectively. Correlation of QUS and DXA was r = 0.56 (p < 0.0001). Phalangeal US velocity and spinal BMD (QCT and DXA) values discriminate healthy from osteoporotic women. Age-adjusted logistic regression analysis of the data showed standardized odds ratios (OR) for vertebral fracture to be similar for US and DXA (OR = 1.8 and 1.5, respectively) and stronger for QCT (OR = 2.9). Phalangeal US velocity reflects age-related bone loss and differentiates between healthy and osteoporotic subjects.
Osteoporosis International, 2001
Journal of Endocrinological Investigation, 2001
Journal of Bone and Mineral Research, 1997
Bone involvement is a common clinical feature in acromegalic patients, though previous studies ga... more Bone involvement is a common clinical feature in acromegalic patients, though previous studies gave divergent results possibly because of the different gonadal status of the patients studied. To study the influence of estrogen milieu in these patients, we evaluated 23 acromegalic patients with active disease, subdivided into two groups: menstruating and amenorrheal patients, comparable for duration and activity of disease. Forty-two matched women served as controls. Skeletal involvement was studied by measuring: (a) the main biomarkers of bone turnover: serum alkaline phosphatase total activity (AP), bone GLA protein (BGP), serum carboxy-terminal propeptide of type I collagen (PICP), serum type I cross-linked N-telopeptide (ICTP), and urinary pyridinoline and deoxypyridinoline corrected for creatinine (Pyr/Cr, D-Pyr/Cr) and urinary calcium/creatinine ratio (Ca/Cr); (b) bone mineral density (BMD), as measured by quantitative computed tomography both at lumbar spine and distal radius, and by dual X-ray absorptiometry both at lumbar spine and at three femoral sites (Ward's triangle, femoral neck, and great trochanter). AP, BGP, ICTP, Pyr/Cr, D-Pyr/Cr were significantly higher in patients than in controls, independent of the menstrual pattern. Higher PICP levels were found in the whole group and in menstruating acromegalics when compared with control women; no difference was found in amenorrheal patients, who in turn showed higher urinary Ca/Cr values. When patients were considered all together, BMD at spine, femoral neck, and trochanter was higher than in controls. In contrast, when the gonadal status was taking into account and, menstruating and amenorrheal subjects were considered separately, BMD at spine, but not in other sites, was significantly higher in menstruating patients than in controls. In contrast, no difference of BMD values at any site was observed between amenorrheal patients and controls. The mean BMD Z scores allowed us to detect an unequal involvement of different skeletal sites. Our results show that bone turnover is increased in acromegalic women and suggest that GH anabolic effect on bone is more evident in the presence of estrogens and that different skeletal sites may be affected differently by hormone excess.
Clinical …, 2003
It has been known for over 50 years that acromegaly affects bone (Albright & Reifeinstein, 1948).... more It has been known for over 50 years that acromegaly affects bone (Albright & Reifeinstein, 1948). However, data on bone mineral density (BMD) in these patients are still conflicting. Seeman et al. (1982) detected increased spinal BMD in seven patients with active acromegaly. ...
HORMONES, 2013
with PHPt took erroneously 2,400,000U (300,000 U/day for 8 days) and 4,500,000U (300,000 U/day fo... more with PHPt took erroneously 2,400,000U (300,000 U/day for 8 days) and 4,500,000U (300,000 U/day for 15 days) of cholecalciferol, respectively. they were followed for 4 months and ionized calcium, creatinine, PtH, 25 hydroxy-vitamin D, 1,25(OH)2D and urinary calcium/creatinine levels were measured. Finally, the patients were operated on and a parathyroid adenoma was removed in both. rEsULts: One week after the last dose of vitamin D, serum ionized calcium (ica) rose from 1.35 to 1.41 mMol/L (n.r. 1.14-1.31) for patient A, and from 1.43 to 1.62 for patient b, while fasting urinary calcium/creatinine (uca/cr) augmented from 0.31 to 0.50 mg/ mg, and from 0.32 to 0.55, respectively. During the follow-up, the average levels of ica were 1.37 ± 0.03 and 1.48 ± 0.07 mMol/L, while those of uca/cr were 0.29 ± 0.13 and 0.32 ± 0.13, both ica and uca/cr levels returning to baseline values within 4 months. cONcLUsIONs: the unintentional over-supplementation of vitamin D in the two PHPt patients caused a moderate and temporary increase of hypercalcemia and hypercalciuria and was not associated with clinical signs of toxicity.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 2018
The American journal of medicine, Jan 12, 2017
BMC Medical Imaging
Background: Chest X-ray (CXR) is the primary diagnostic tool for community-acquired pneumonia (CA... more Background: Chest X-ray (CXR) is the primary diagnostic tool for community-acquired pneumonia (CAP). Some authors recently proposed that thoracic ultrasound (TUS) could valuably flank or even reliably substitute CXR in the diagnosis and follow-up of CAP. We investigated the clinical utility of TUS in a large sample of patients with CAP, to challenge the hypothesis that it may be a substitute for CXR.
European journal of endocrinology, Jan 8, 2017
Patients with primary aldosteronism (PA) have a high prevalence of osteoporosis (OP) and fracture... more Patients with primary aldosteronism (PA) have a high prevalence of osteoporosis (OP) and fractures (Fx). We evaluated the presence of PA in patients admitted to our metabolic bone disease outpatient clinic. Study conducted on an in- and outpatient basis in a referral Italian endocrinology unit. A total of 2632 patients were evaluated. 2310 were excluded because they were taking drugs known to affect bone or mineralocorticoids metabolism, or were diagnosed to have a secondary cause of osteoporosis. The remaining 322 subjects (304 females, 18 males) took part in the study. Bone mineral density (BMD) and thoracic and lumbar spine vertebral morphometry were performed by dual X-ray absorptiometry. All patients were screened for PA with aldosterone-to-renin ratio. In those who had positive results, confirmatory tests were performed. Among 322 subjects, 213 were osteoporotics and 109 were not. PA was diagnosed in eleven out of 213 osteoporotic patients (5.2%) and one out of 109 non osteopo...
Thorax, 2016
We investigated if contrast-enhanced ultrasound (CEUS) may differentiate community acquired pneum... more We investigated if contrast-enhanced ultrasound (CEUS) may differentiate community acquired pneumonia (CAP) from lung cancer (LC). Among 1374 patients admitted in a 5-year period for lung opacities, 728 (329 CAP and 399 LC) were investigated by CEUS, comparing the time of appearance, disappearance, duration and pattern of distribution of contrast enhancement (CE). The patients with CAP and LC did not differ in terms of age, time of CE appearance, disappearance and duration or CE distribution. Our data show that the timing and pattern of CE detected by chest CEUS does not distinguish between CAP and LC and overly optimistic beliefs on this matter should be abandoned.
Eur J Clin Invest, 2010
Purpose The aim of this study was to investigate the clinical applicability of transthoracic ultr... more Purpose The aim of this study was to investigate the clinical applicability of transthoracic ultrasound (TUS) in the diagnosis and follow-up of community acquired pneumonia (CAP).
The American Journal of the Medical Sciences, 1996
Whipple&amp;#39;s disease is a rare systemic illness, with the main clinical feature bein... more Whipple&amp;#39;s disease is a rare systemic illness, with the main clinical feature being severe malabsorption syndrome. Bone involvement in the disease has rarely been described in previous articles. The authors report a case in which an extensive skeletal evaluation was carried out. Even though osteomalacia is generally considered the most typical metabolic bone disease of malabsorption syndromes, bone biopsy demonstrated that osteoporosis was the prominent histologic feature in this patient. On the basis of serial bone mineral density measurements, antibiotic treatment was able to reverse the initial reduced bone mass.
European Radiology, 1999
The purpose of this study was to evaluate the diagnostic sensitivity of phalangeal bone ultrasoun... more The purpose of this study was to evaluate the diagnostic sensitivity of phalangeal bone ultrasound velocity of the hand in the diagnosis of osteoporosis and to compare this technique to bone mineral density (BMD) measurement at the lumbar spine assessed by dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). We investigated US velocity at the distal metaphysis of the proximal phalanx and spinal BMD in 101 women. Fifty-nine were healthy (mean age 50 +/- 11.6 years) and 42 were osteoporotic (mean age 65 +/- 6.6 years) with documented vertebral fractures. In the healthy population the relation with age was, respectively, r = -0.73 (p < 0. 0001) for quantitative US (QUS), r = -0.74 (p < 0.0001) for QCT and r = -0.48 (p < 0.01) for DXA. Both US and DXA were correlated with QCT: r = 0.74 and r = 0.77 (p < 0.0001), respectively. Correlation of QUS and DXA was r = 0.56 (p < 0.0001). Phalangeal US velocity and spinal BMD (QCT and DXA) values discriminate healthy from osteoporotic women. Age-adjusted logistic regression analysis of the data showed standardized odds ratios (OR) for vertebral fracture to be similar for US and DXA (OR = 1.8 and 1.5, respectively) and stronger for QCT (OR = 2.9). Phalangeal US velocity reflects age-related bone loss and differentiates between healthy and osteoporotic subjects.
The Journal of Clinical Endocrinology & Metabolism, 2010
Context: Effects of vitamin D repletion in young people with low vitamin D status have not been i... more Context: Effects of vitamin D repletion in young people with low vitamin D status have not been investigated so far. Objective: We evaluated the effect of a single massive dose of cholecalciferol on calcium metabolism at 3, 15, and 30 d, compared to baseline. Design and Setting: We conducted a prospective intervention study in an ambulatory care setting. Participants: Forty-eight young subjects with vitamin D deficiency participated in the study. Intervention: A single oral dose of 600,000 IU of cholecalciferol was administered to each subject. Main Outcome Measures: We evaluated serum changes of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D, calcium, and PTH induced by a single load of cholecalciferol. Results: The 25(OH)D level was 15.8 ± 6.5 ng/ml at baseline and became 77.2 ± 30.5 ng/ml at 3 d (P < 0.001) and 62.4 ± 26.1 ng/ml at 30 d (P < 0.001). PTH levels concomitantly decreased from 53.0 ± 20.1 to 38.6 ± 17.2 pg/ml at 3 d and to 43.4 ± 14.0 pg/ml at 30 d (P &l...
Biophysical Journal, 2015
Our group has previously demonstrated that cardiomyocytes express ChAT (choline acetyltransferase... more Our group has previously demonstrated that cardiomyocytes express ChAT (choline acetyltransferase), VAChT (vesicular acetylcholine transporter) and ChT-1 (choline high affinity transporter), proteins involved in the synthesis, release and reuptake of acetylcholine. Additionally, we have shown that this cardiomyocyte intrinsic cholinergic machinery has an important role in preventing deleterious effects of adrenergic signaling in vitro and in vivo. To address the role of this non-neuronal acetylcholine for heart function, a new mouse lineage was generated with deletion of VAChT (vesicular acetylcholine transporter) only in cardiac myocytes (cVAChT-ko). These mice are characterized by heart hypertrophy, calcium signaling dysfunction and increased reactive oxygen species levels. In order to better understand how impairment in acetylcholine released from cardiomyocytes could impact heart function, we subjected these mice to transverse aortic constriction (TAC) and evaluated left ventricular hypertrophy at 3 and 14 days after surgery.
Endocrine, 2016
Your article is protected by copyright and all rights are held exclusively by Springer Science +B... more Your article is protected by copyright and all rights are held exclusively by Springer Science +Business Media New York. This e-offprint is for personal use only and shall not be selfarchived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website. You may further deposit the accepted manuscript version in any repository, provided it is only made publicly available 12 months after official publication or later and provided acknowledgement is given to the original source of publication and a link is inserted to the published article on Springer's website. The link must be accompanied by the following text: "The final publication is available at link.springer.com".
European Radiol, 1999
The purpose of this study was to evaluate the diagnostic sensitivity of phalangeal bone ultrasoun... more The purpose of this study was to evaluate the diagnostic sensitivity of phalangeal bone ultrasound velocity of the hand in the diagnosis of osteoporosis and to compare this technique to bone mineral density (BMD) measurement at the lumbar spine assessed by dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). We investigated US velocity at the distal metaphysis of the proximal phalanx and spinal BMD in 101 women. Fifty-nine were healthy (mean age 50 +/- 11.6 years) and 42 were osteoporotic (mean age 65 +/- 6.6 years) with documented vertebral fractures. In the healthy population the relation with age was, respectively, r = -0.73 (p < 0. 0001) for quantitative US (QUS), r = -0.74 (p < 0.0001) for QCT and r = -0.48 (p < 0.01) for DXA. Both US and DXA were correlated with QCT: r = 0.74 and r = 0.77 (p < 0.0001), respectively. Correlation of QUS and DXA was r = 0.56 (p < 0.0001). Phalangeal US velocity and spinal BMD (QCT and DXA) values discriminate healthy from osteoporotic women. Age-adjusted logistic regression analysis of the data showed standardized odds ratios (OR) for vertebral fracture to be similar for US and DXA (OR = 1.8 and 1.5, respectively) and stronger for QCT (OR = 2.9). Phalangeal US velocity reflects age-related bone loss and differentiates between healthy and osteoporotic subjects.
Osteoporosis International, 2001
Journal of Endocrinological Investigation, 2001
Journal of Bone and Mineral Research, 1997
Bone involvement is a common clinical feature in acromegalic patients, though previous studies ga... more Bone involvement is a common clinical feature in acromegalic patients, though previous studies gave divergent results possibly because of the different gonadal status of the patients studied. To study the influence of estrogen milieu in these patients, we evaluated 23 acromegalic patients with active disease, subdivided into two groups: menstruating and amenorrheal patients, comparable for duration and activity of disease. Forty-two matched women served as controls. Skeletal involvement was studied by measuring: (a) the main biomarkers of bone turnover: serum alkaline phosphatase total activity (AP), bone GLA protein (BGP), serum carboxy-terminal propeptide of type I collagen (PICP), serum type I cross-linked N-telopeptide (ICTP), and urinary pyridinoline and deoxypyridinoline corrected for creatinine (Pyr/Cr, D-Pyr/Cr) and urinary calcium/creatinine ratio (Ca/Cr); (b) bone mineral density (BMD), as measured by quantitative computed tomography both at lumbar spine and distal radius, and by dual X-ray absorptiometry both at lumbar spine and at three femoral sites (Ward's triangle, femoral neck, and great trochanter). AP, BGP, ICTP, Pyr/Cr, D-Pyr/Cr were significantly higher in patients than in controls, independent of the menstrual pattern. Higher PICP levels were found in the whole group and in menstruating acromegalics when compared with control women; no difference was found in amenorrheal patients, who in turn showed higher urinary Ca/Cr values. When patients were considered all together, BMD at spine, femoral neck, and trochanter was higher than in controls. In contrast, when the gonadal status was taking into account and, menstruating and amenorrheal subjects were considered separately, BMD at spine, but not in other sites, was significantly higher in menstruating patients than in controls. In contrast, no difference of BMD values at any site was observed between amenorrheal patients and controls. The mean BMD Z scores allowed us to detect an unequal involvement of different skeletal sites. Our results show that bone turnover is increased in acromegalic women and suggest that GH anabolic effect on bone is more evident in the presence of estrogens and that different skeletal sites may be affected differently by hormone excess.
Clinical …, 2003
It has been known for over 50 years that acromegaly affects bone (Albright & Reifeinstein, 1948).... more It has been known for over 50 years that acromegaly affects bone (Albright & Reifeinstein, 1948). However, data on bone mineral density (BMD) in these patients are still conflicting. Seeman et al. (1982) detected increased spinal BMD in seven patients with active acromegaly. ...
HORMONES, 2013
with PHPt took erroneously 2,400,000U (300,000 U/day for 8 days) and 4,500,000U (300,000 U/day fo... more with PHPt took erroneously 2,400,000U (300,000 U/day for 8 days) and 4,500,000U (300,000 U/day for 15 days) of cholecalciferol, respectively. they were followed for 4 months and ionized calcium, creatinine, PtH, 25 hydroxy-vitamin D, 1,25(OH)2D and urinary calcium/creatinine levels were measured. Finally, the patients were operated on and a parathyroid adenoma was removed in both. rEsULts: One week after the last dose of vitamin D, serum ionized calcium (ica) rose from 1.35 to 1.41 mMol/L (n.r. 1.14-1.31) for patient A, and from 1.43 to 1.62 for patient b, while fasting urinary calcium/creatinine (uca/cr) augmented from 0.31 to 0.50 mg/ mg, and from 0.32 to 0.55, respectively. During the follow-up, the average levels of ica were 1.37 ± 0.03 and 1.48 ± 0.07 mMol/L, while those of uca/cr were 0.29 ± 0.13 and 0.32 ± 0.13, both ica and uca/cr levels returning to baseline values within 4 months. cONcLUsIONs: the unintentional over-supplementation of vitamin D in the two PHPt patients caused a moderate and temporary increase of hypercalcemia and hypercalciuria and was not associated with clinical signs of toxicity.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 2018
The American journal of medicine, Jan 12, 2017
BMC Medical Imaging
Background: Chest X-ray (CXR) is the primary diagnostic tool for community-acquired pneumonia (CA... more Background: Chest X-ray (CXR) is the primary diagnostic tool for community-acquired pneumonia (CAP). Some authors recently proposed that thoracic ultrasound (TUS) could valuably flank or even reliably substitute CXR in the diagnosis and follow-up of CAP. We investigated the clinical utility of TUS in a large sample of patients with CAP, to challenge the hypothesis that it may be a substitute for CXR.
European journal of endocrinology, Jan 8, 2017
Patients with primary aldosteronism (PA) have a high prevalence of osteoporosis (OP) and fracture... more Patients with primary aldosteronism (PA) have a high prevalence of osteoporosis (OP) and fractures (Fx). We evaluated the presence of PA in patients admitted to our metabolic bone disease outpatient clinic. Study conducted on an in- and outpatient basis in a referral Italian endocrinology unit. A total of 2632 patients were evaluated. 2310 were excluded because they were taking drugs known to affect bone or mineralocorticoids metabolism, or were diagnosed to have a secondary cause of osteoporosis. The remaining 322 subjects (304 females, 18 males) took part in the study. Bone mineral density (BMD) and thoracic and lumbar spine vertebral morphometry were performed by dual X-ray absorptiometry. All patients were screened for PA with aldosterone-to-renin ratio. In those who had positive results, confirmatory tests were performed. Among 322 subjects, 213 were osteoporotics and 109 were not. PA was diagnosed in eleven out of 213 osteoporotic patients (5.2%) and one out of 109 non osteopo...
Thorax, 2016
We investigated if contrast-enhanced ultrasound (CEUS) may differentiate community acquired pneum... more We investigated if contrast-enhanced ultrasound (CEUS) may differentiate community acquired pneumonia (CAP) from lung cancer (LC). Among 1374 patients admitted in a 5-year period for lung opacities, 728 (329 CAP and 399 LC) were investigated by CEUS, comparing the time of appearance, disappearance, duration and pattern of distribution of contrast enhancement (CE). The patients with CAP and LC did not differ in terms of age, time of CE appearance, disappearance and duration or CE distribution. Our data show that the timing and pattern of CE detected by chest CEUS does not distinguish between CAP and LC and overly optimistic beliefs on this matter should be abandoned.
Eur J Clin Invest, 2010
Purpose The aim of this study was to investigate the clinical applicability of transthoracic ultr... more Purpose The aim of this study was to investigate the clinical applicability of transthoracic ultrasound (TUS) in the diagnosis and follow-up of community acquired pneumonia (CAP).