Vipin Singh - Academia.edu (original) (raw)

Papers by Vipin Singh

PLoS ONE, 2012

Background: The central Indian state Madhya Pradesh is often called as 'heart of India' and has a... more Background: The central Indian state Madhya Pradesh is often called as 'heart of India' and has always been an important region functioning as a trinexus belt for three major language families (Indo-European, Dravidian and Austroasiatic). There are less detailed genetic studies on the populations inhabited in this region. Therefore, this study is an attempt for extensive characterization of genetic ancestries of three tribal populations, namely; Bharia, Bhil and Sahariya, inhabiting this region using haploid and diploid DNA markers. Methodology/Principal Findings: Mitochondrial DNA analysis showed high diversity, including some of the older sublineages of M haplogroup and prominent R lineages in all the three tribes. Y-chromosomal biallelic markers revealed high frequency of Austroasiatic-specific M95-O2a haplogroup in Bharia and Sahariya, M82-H1a in Bhil and M17-R1a in Bhil and Sahariya. The results obtained by haploid as well as diploid genetic markers revealed strong genetic affinity of Bharia (a Dravidian speaking tribe) with the Austroasiatic (Munda) group. The gene flow from Austroasiatic group is further confirmed by their Y-STRs haplotype sharing analysis, where we determined their founder haplotype from the North Munda speaking tribe, while, autosomal analysis was largely in concordant with the haploid DNA results. Conclusions/Significance: Bhil exhibited largely Indo-European specific ancestry, while Sahariya and Bharia showed admixed genetic package of Indo-European and Austroasiatic populations. Hence, in a landscape like India, linguistic label doesn't unequivocally follow the genetic footprints.

The FASEB Journal

Platelet mitochondria possess remarkable plasticity for oxidation of energy substrates, where met... more Platelet mitochondria possess remarkable plasticity for oxidation of energy substrates, where metabolic dependency on glucose or fatty acids is higher than glutamine. Since platelets metabolize nearly the entire pool of glucose to lactate rather than fluxing through mitochondrial tricarboxylic acid cycle, we posit that majority of mitochondrial ATP, which is essential for platelet granule secretion and thrombus formation, is sourced from oxidation of fatty acids. We performed a comprehensive analysis of bioenergetics and function of stimulated platelets in the presence of etomoxir, trimetazidine and oxfenicine, three pharmacologically distinct inhibitors of β‐oxidation. Each of them significantly impaired oxidative phosphorylation in unstimulated as well as thrombin‐stimulated platelets leading to a small but consistent drop in ATP level in activated cells due to a lack of compensation from glycolytic ATP. Trimetazidine and oxfenicine attenuated platelet aggregation, P‐selectin exte...

Southwest Journal of Pulmonary, Critical Care & Sleep

Background: Delirium is common in critically ill intensive care unit (ICU) patients and has been ... more Background: Delirium is common in critically ill intensive care unit (ICU) patients and has been documented in up to 87 percent of patients. Sleep deprivation and delirium have been associated. Alteration of melatonin production has been associated with delirium. Melatonin acts via melatonin receptors present in the suprachiasmatic nuclei (SCN) and promotes sleep by attenuating the wake-promoting signal from the SCN. Objective: To determine the relationship between exogenous melatonin and the incidence of delirium and its association of with severity of illness, measured in term of APACHE II, procalcitonin level at the time of admission and daily SOFA score. Patients and Methods: Design: Randomised placebo-control study. Setting: the study was conducted in critical care setting in a tertiary level ICU. Participants: Postoperative patients age between 20-60 years who are going to be ventilated more than 48 hours without any contraindication to enteral medications. Interventions: Stud...

Water and Environment Journal

This study characterises the sewage sludge from 26 sewage treatment plants in India, which demons... more This study characterises the sewage sludge from 26 sewage treatment plants in India, which demonstrates the nutrient potential and highlights the associated challenges in using the sludge. The dry sludge had 2.35%–4.2% N, 2.46–3.2% phosphorus (P2O5) and 0.83%–1.24% potassium oxide (K2O), whereas sludge ash contains ~13.6% and 2.7%, P2O5 and K2O, respectively. Total nutrient potential from the sludge of the existing sewage treatment facility was 97.5 × 103 tonne/year, which is equivalent to 0.92% urea or 0.19% NPK used presently as conventional fertilisers in India. However, pre‐treatment may be required for this sludge before using it in agricultural fields as heavy metals, such as Zn, Cu, Ni, Cd, and Cr, were found higher than the compost standards. This study would be useful for the researchers and policymakers globally and would motivate them to make policies and deploy suitable technologies towards the nutrient utilisation from sewage sludge.

IoT-Based Smart Waste Management for Environmental Sustainability

SSRN Electronic Journal, 2022

Highlights H4K16ac deacetylation during hyperthermia is conserved in human, Drosophila, and yeast... more Highlights H4K16ac deacetylation during hyperthermia is conserved in human, Drosophila, and yeast Dynamic regulation of the chromatin functions during hyperthermia is SIRT1-dependent SIRT1 function is negatively impacted by SMARCAD1 Hyperthermia increases replication stress and impacts DNA resection, impairing DSB repair

Recent Trends in Communication and Electronics, 2021

Code reuse attacks use snippets of code (called gadgets) from the target program. Software divers... more Code reuse attacks use snippets of code (called gadgets) from the target program. Software diversity aims to thwart code reuse attacks by increasing the uncertainty regarding the target program. The current practice is to quantify the security impact of software diversity algorithms via the number/percentage of the surviving gadgets. Recent attacks prove that only reducing the number of surviving gadgets does not add any security against code reuse attacks. We propose the use of the count/percentage of usable and surviving gadgets as the metric to quantify the security impact of software diversity algorithms. We present a novel software diversity algorithm, named NOP4Gadgets, that leaves 0.012% and 14.35% surviving and usable gadgets, respectively. NOP4Gadgets performs targeted diversification, concentrated around the potential Return Oriented Programming (ROP) gadgets. The performance overhead of NOP4Gadgets is 1% for the SPEC CPU2006 benchmark suite. Keywords–Software diversity, R...

International Journal of Advance Research, Ideas and Innovations in Technology, 2019

This thesis studies the impact of reinforcement detailing on the behaviour of a reinforced concre... more This thesis studies the impact of reinforcement detailing on the behaviour of a reinforced concrete structure. Using a retaining wall as a case-study, the performance of two commonly used alternative reinforcement layouts (of which one is wrong) are studied and compared. Reinforcement Layout 1 had the main reinforcement (from the wall) bent towards the heel in the base slab. For Reinforcement Layout 2, the reinforcement was bent towards the toe. This study focused on the reinforcement details used in the D-region, and on how it impacts the capacity, joint efficiency and failure mode of the structure.

The effect of ten chosen Density Functional Theory (DFT) methods at various basis sets for predic... more The effect of ten chosen Density Functional Theory (DFT) methods at various basis sets for predicting he molecular structure, vibrational frequencies and infrared int e sities of pyrimidine molecule has been investigat ed. The exchange functionals DFT employed in this study inc lude local (SVWN), Gradient corrected (BLYP, PW91PW 91, mPWPW91, G96LYP, PBEPBE) and hybrid (B3LYP, B3PW91, mPW1LYP, mPW1PW91) and basis sets include Pople basis sets 6-311G(d,p), 6-311++G(d,p), 6-311G (2d,2p), 6-311++G(2d,2p), 6-311G(3d,3p) 6311++G(3d,3p), 6-311G(2df,2pd) 6-311++G(2df,2pd), 6 -311G(3df,3pd), 6-311++G(3df,3pd) and Dunning's correlation-consistent basis sets cc-pVDZ, aug-cc-p VDZ, cc-pVTZ and aug-cc-pVTZ. The results are compa red with the available experimental data in the gas phase. B ond distances and bond angles computed at the PBEPB E/6-311G (3df, 3pd) level are in good agreement with the ava il ble experimental data. The results also indicate that for the vibrational spectrum of pyri...

International Journal of Orthopaedics Sciences, 2020

Ct aided morphometric measurements of various pedicle parameters in different age groups of India... more Ct aided morphometric measurements of various pedicle parameters in different age groups of Indian population

Cell Death & Disease, 2020

The major challenge in chemotherapy lies in the gain of therapeutic resistance properties of canc... more The major challenge in chemotherapy lies in the gain of therapeutic resistance properties of cancer cells. The relatively small fraction of chemo-resistant cancer cells outgrows and are responsible for tumor relapse, with acquired invasiveness and stemness. We demonstrate that zinc-finger MYND type-8 (ZMYND8), a putative chromatin reader, suppresses stemness, drug resistance, and tumor-promoting genes, which are hallmarks of cancer. Reinstating ZMYND8 suppresses chemotherapeutic drug doxorubicin-induced tumorigenic potential (at a sublethal dose) and drug resistance, thereby resetting the transcriptional program of cells to the epithelial state. The ability of ZMYND8 to chemo-sensitize doxorubicin-treated metastatic breast cancer cells by downregulating tumor-associated genes was further confirmed by transcriptome analysis. Interestingly, we observed that ZMYND8 overexpression in doxorubicin-treated cells stimulated those involved in a good prognosis in breast cancer. Consistently, ...

Journal of Cleaner Production, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

RSC Advances, 2020

Tandem conjugate addition, decarboxylation and esterification/amidation of coumarin 3-carboxylic ... more Tandem conjugate addition, decarboxylation and esterification/amidation of coumarin 3-carboxylic acid derivatives with pyrazolones have been developed.

MedPulse International Journal of ENT, 2019

ChemistrySelect, 2019

Concise and stereoselective synthesis of Hagen's Gland Lactones is achieved by employing vinylogo... more Concise and stereoselective synthesis of Hagen's Gland Lactones is achieved by employing vinylogous Mukaiyama type reaction, Epimerization followed by oxy-Michael addition reaction to form bicyclic lactone as key steps with 54% overall yield. The synthetic route is economical and scalable within 5 steps without use of any toxic metals. The methodology could be useful for the synthesis of natural products containing bicyclic lactones and tetra substituted THF ring. Figure 3. Retrosynthetic analysis of Hagen's gland lactones. Scheme 1. Synthesis of Hagen's gland Lactones.

Biocontrol Science and Technology, 2018

Present study assessed if semiochemical cues left by an aphidophagous beetle, M. sexmaculatus inf... more Present study assessed if semiochemical cues left by an aphidophagous beetle, M. sexmaculatus influenced foraging behaviour of a phytophagous beetle, Z. bicolorata on noxious weed, P. hysterophorus. The lower predation attributes of Z. bicolorata in presence of M. sexmaculatus semiochemical footprints confirms they interfere with weed biological control.

Water and Environment Journal, 2017

Greenhouse gas (GHG) emissions generated from municipal wastewater treatment plants in India is e... more Greenhouse gas (GHG) emissions generated from municipal wastewater treatment plants in India is estimated in this study. The emissions from the wastewater treatment process as well as from the electricity used during the treatment process are estimated by using the methodology of Intergovernmental Panel on Climate Change. The present treatment plants of capacity 15 997 million litres per day (MLD) contributes towards GHG emissions of 7.3 Mt of CO2‐eq/year. The future GHG emissions would depend upon the treatment technology used for treating 34 109 MLD of untreated wastewater. The highest GHG emissions would occur if all new wastewater treatment plants are based on upflow anaerobic sludge blanket technology, 19.66 Mt CO2‐eq/year and lowest if sequential batch reactor technology is adopted, 2.93 MtCO2‐eq/year.

Environmental Challenges and Solutions, 2016

Conventional measures of national income and wealth do not account for environmental and social c... more Conventional measures of national income and wealth do not account for environmental and social costs of development. Therefore, they may mislead long-term economic forecasts for an economy. It is therefore necessary to develop a system of accounting of natural resources, which is likely to provide ample support to design the economic system, in such way that it is possible to attain economic growth without destroying natural resources. Hence, the concept of green accounting has increasingly been accepted and promoted by national and international organizations. This system of greening our accounts would provide an improved parameter of measuring development as compared to GDP growth alone. Green GDP shall measure sustainability of development and would be an appropriate and valuable decision-making aid in economic planning. The study discusses the accounting framework for forestry accounting in the context of SEEA and provides the framework and methodology for compilation of forestry accounts. It attempts on economic valuation of few ecosystem services, viz. carbon sequestration, soil conservation, water recharge, water purification and pollination and seed dispersal services from the forests of Karnataka, India. The study also highlights the ‘glaring lack of data’, ‘standardized methodologies’ and ‘standardized accounting units’ for ascribing an economic value to intangible services deriving from forest resource as the main reason for it not being included in the accounting part of conventional GDP.