W. Boyce - Academia.edu (original) (raw)
Papers by W. Boyce
Psychosomatic Medicine, 1995
Psychological stress is thought to undermine host resistance to infection through neuroendocrine-... more Psychological stress is thought to undermine host resistance to infection through neuroendocrine-mediated changes in immune competence. Associations between stress and infection have been modest in magnitude, however, suggesting individual variability in stress response. We therefore studied environmental stressors, psychobiologic reactivity to stress, and respiratory illness incidence in two studies of 236 preschool children. In Study 1,137 3-to 5-year-old children from four childcare centers underwent a laboratory-based assessment of cardiovascular reactivity (changes in heart rate and mean arterial pressure) during a series of developmentally challenging tasks. Environmental stress was evaluated with two measures of stressors in the childcare setting. The incidence of respiratory illnesses was ascertained over 6 months using weekly respiratory tract examinations by a nurse. In Study 2, 99 5-year-old children were assessed for immune reactivity (changes in CD4+, CD8 + , and CD19+ cell numbers, lymphocyte mitogenesis, and antibody response to pneumococcal vaccine) during the normative stressor of entering school. Blood for immune measures was sampled 1 week before and after kindergarten entry. Environmental stress was indexed with parent reports of family stressors, and a 12-week respiratory illness incidence was measured with biweekly, parent-completed symptom checklists. The two studies produced remarkably similar findings. Although environmental stress was not independently associated with respiratory illnesses in either study, the incidence of illness was related to an interaction between childcare stress and mean arterial pressure reactivity (/3 = .35, p < .05) in Study 1 and to an interaction between stressful life events and CD19+ reactivity (/3 = .51, p < .05) in Study 2. In both studies, reactive children sustained higher illness rates under high-stress conditions, but lower rates in low-stress conditions, compared with less reactive peers. Stress was associated with increased rates of illnesses, but only among psychobiologically reactive children. Less reactive children experienced no escalation in illness incidence under stressful conditions, suggesting that only a subset of individuals may be susceptible to the health-altering effects of stressors and adversity.
NeuroToxicology, 2011
Background: Organophosphate pesticides (OP), because of their effects on cholinergic fibers, may ... more Background: Organophosphate pesticides (OP), because of their effects on cholinergic fibers, may interfere with the functions of the autonomic nervous system (ANS). We conducted a study to assess the relation of in utero and child OP pesticide exposures and children's autonomic nervous system (ANS) dysregulation under resting and challenge conditions. We hypothesized that children with high OP levels would show parasympathetic activation and no sympathetic activation during rest and concomitant parasympathetic and sympathetic activation during challenging conditions. Methods: OP exposures were assessed by measuring urinary dialkylphosphate metabolites (DAPs, total diethyls-DEs, and total dimethyls-DMs) in maternal and children's spot urine samples. ANS regulation was examined in relation to maternal and child DAPs in 149 children at 6 months and 1 year, 97 at 3 1/2 years and 274 at 5 years. We assessed resting and reactivity (i.e., challenge minus rest) measures using heart rate (HR), respiratory sinus arrhythmia (RSA), and preejection period (PEP) during the administration of a standardized protocol. Cross-sectional (at each age) and longitudinal regression models were conducted to assess OP and ANS associations. To estimate cumulative exposure at 5 years, we used an area-under-the-concentration-time-curve (AUC) methodology. We also evaluated whether children with consistently high versus low DAP concentrations had significantly different mean ANS scores at 5 years. Results: Child DMs and DAPs were significantly negatively associated with resting RSA at 6 months and maternal DMs and child DEs were significantly positively associated with resting PEP at 1 year. No associations with resting were observed in 3 1/2-or 5-year-old children nor with reactivity at any age. There was no significant relationship between the reactivity profiles and maternal or child DAPs. Cumulative maternal total DEs were associated with low HR (À3.19 bpm decrease; 95% CI: À6.29 to À0.09, p = 0.04) only at 5 years. In addition, there were no significant differences in ANS measures for 5year-olds with consistently high versus low DAPs. Conclusion: Although we observe some evidence of ANS dysregulation in infancy, we report no consistent associations of maternal and child OP pesticide exposure, as measured by urinary DAPs, on children's ANS (HR, RSA, and PEP) regulation during resting and challenging conditions up to age 5 years. ß
Journal of the American Academy of Child & Adolescent Psychiatry, 2006
To study how early father involvement and children&amp;amp;amp;amp;amp;amp;amp;amp;amp;am... more To study how early father involvement and children&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s biobehavioral sensitivity to social contexts interactively predict mental health symptoms in middle childhood. Fathers&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; involvement in infant care and maternal symptoms of depression were prospectively ascertained in a community-based study of child health and development in Madison and Milwaukee, WI. In a subsample of 120 children, behavioral, autonomic, and adrenocortical reactivity to standardized challenges were measured as indicators of biobehavioral sensitivity to social context during a 4-hour home assessment in 1998, when the children were 7 years of age. Mental health symptoms were evaluated at age 9 years using parent, child, and teacher reports. Early father involvement and children&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s biobehavioral sensitivity to context significantly and interactively predicted symptom severity. Among children experiencing low father involvement in infancy, behavioral, autonomic, and adrenocortical reactivity became risk factors for later mental health symptoms. The highest symptom severity scores were found for children with high autonomic reactivity that, as infants, had experienced low father involvement and mothers with symptoms of depression. Among children experiencing minimal paternal caretaking in infancy, heightened biobehavioral sensitivity to social contexts may be an important predisposing factor for the emergence of mental health symptoms in middle childhood. Such predispositions may be exacerbated by the presence of maternal depression.
Journal of the American Academy of Child & Adolescent Psychiatry, 1996
To examine the effects of child temperament and stressful family functioning on child behavior pr... more To examine the effects of child temperament and stressful family functioning on child behavior problems among preschool children. One hundred forty-five preschool children, aged 2 to 5 years, were evaluated by teachers, mothers, and independent observers. Teachers reported on child temperament; from these ratings, two dimensions of temperament were derived: difficult/easy and approachability. Mothers reported on two dimensions of family functioning: conflict and expressiveness. Both teachers and independent observers rated child behavior problems. Children with more difficult temperaments who were in high-conflict families had the most internalizing and externalizing behavior problems, while children with easy temperaments had fewer such problems, regardless of levels of family conflict. Difficult children whose families were highly expressive engaged in the most observed aggression. Results suggest that temperament is involved in both protective and vulnerability processes. A difficult temperament operates as a vulnerability factor for internalizing and externalizing behavior problems and observed aggression, while an easy temperament functions as a protective mechanism for these outcomes.
Journal of Experimental Child Psychology, 2011
Current methods of assessing children's physiological ''stress reactivity'' may be confounded by ... more Current methods of assessing children's physiological ''stress reactivity'' may be confounded by psychomotor activity, biasing estimates of the relation between reactivity and health. We examined the joint and independent contributions of psychomotor activity and challenge reactivity during a protocol for 5-and 6-year-old children (N = 338). Measures of parasympathetic reactivity (respiratory sinus arrhythmia [RSA]) and sympathetic reactivity (preejection period [PEP]) were calculated for social, cognitive, sensory, and emotional challenge tasks. Reactivity was calculated relative to both resting and a paired comparison task that accounted for psychomotor activity effects during each challenge. Results indicated that comparison tasks themselves elicited RSA and PEP responses, and reactivity adjusted for psychomotor activity was incongruent with reactivity calculated using rest. Findings demonstrate the importance of accounting for confounding psychomotor activity effects on physiological reactivity.
Journal of Developmental & Behavioral Pediatrics, 2010
To evaluate whether autonomic nervous system (ANS) reactivity modifies the relation between famil... more To evaluate whether autonomic nervous system (ANS) reactivity modifies the relation between family stress, and physical and mental health, and functional impairment for children with sickle cell disease. Thirty-eight 5-to 8-year old children with sickle cell disease completed a 20-minute ANS reactivity protocol measuring respiratory sinus arrhythmia and pre-ejection period during comparison and challenge tasks in social, cognitive, sensory, and emotion domains. Domain-specific reactivity was calculated as the difference between challenge and comparison tasks; overall reactivity was calculated across domains as the mean of the difference scores. ANS profile scores combined the overall respiratory sinus arrhythmia and pre-ejection period reactivity scores. Caregivers completed measures of family stress, child physical and mental health symptoms, and functional impairment. Family stress was associated with child functional impairment whereas overall and cognitive ANS reactivity was associated with co-morbid internalizing and externalizing mental health symptoms. Interaction models showed that children with the classic ANS profile (parasympathetic inhibition and sympathetic activation) in the cognitive and emotion domains were most vulnerable to the effects of stress, with more functional impairment and injuries when family stress was high, controlling for age, sex, and parent education. The costs to patients and families in diminished quality of life and to the health care system could be reduced by further exploration of strategies to identify children with sickle cell disease who are most vulnerable under conditions of high family stress and heightened psychobiologic reactivity.
Journal of Developmental & Behavioral Pediatrics, 2007
Objective: Behavioral inhibition (BI) to the unfamiliar represents the temperamental tendency to ... more Objective: Behavioral inhibition (BI) to the unfamiliar represents the temperamental tendency to exhibit fearfulness, reticence, or restraint when faced with unfamiliar people or situations. It has been hypothesized to be a risk factor for anxiety disorders. In this prospective longitudinal study, we compared the psychiatric outcomes in middle childhood of children evaluated at preschool age for BI. Method: The baseline sample consisted of 284 children ages 21 months to 6 years, including offspring at risk for anxiety (children of parents with panic disorder and/or major depression) and comparison offspring of parents without mood or major anxiety disorders. They had been assessed for BI using age-specific laboratory protocols. We reassessed 215 of the children (76.5%) at 5-year follow-up at a mean age of 9.6 years using structured diagnostic interviews. Results: BI specifically predicted onset of social anxiety. The rate of lifetime social anxiety (DSM-IV social phobia or DSM-III-R avoidant disorder) was 28% versus 14% (odds ratio [OR] ؍ 2.37; 95% confidence interval [CI]: 1.10 -5.10) in inhibited versus noninhibited children. BI significantly predicted new onset of social phobia among children unaffected at baseline (22.2% vs 8.0% in inhibited versus noninhibited children (OR ؍ 3.15, 95% CI: 1.16 -8.57). No other anxiety disorders were associated with BI. Conclusion: BI appears to be a temperamental antecedent to subsequent social anxiety in middle childhood. Children presenting with BI should be monitored for symptoms of social anxiety and may be good candidates for preventive cognitive behavioral strategies.
Developmental Psychobiology, 2000
Although there are general assumptions that physiological and behavioral indices of emotion are i... more Although there are general assumptions that physiological and behavioral indices of emotion are interrelated, empirical research has revealed inconsistent findings with regard to their degree of association, particularly in children. Two studies were conducted to examine the relations between cardiovascular reactivity and emotional behavior. In the first study, 3- to 6-year-olds completed challenging tasks during which measures of their physiological responses and facial expressions were obtained. With age, children's heart rate decreased, vagal tone increased, and facial expressions became slightly more exaggerated. However, children's physiologic reactions were unrelated to their concurrent facial expression when all children were considered, when only boys were considered, and when children extreme in their physiologic reactions were considered. Only among girls was physiologic reactivity moderately associated with concurrent negative expressiveness. In the second study, 4- and 5-year-olds' physiologic reactivity was examined as a predictor of later overt emotional reaction to venipuncture episodes. Children's overt emotional reactions were consistent across repeated venipunctures, and girls were more visibly distressed than boys. As in the first study, physiologic reactivity was generally unrelated to children's behavioral responses. Findings have implications for assumptions about the degree of coupling between biological and behavioral emotional systems in childhood.
Developmental Psychobiology, 2006
Although numerous studies have examined the relations between stress and memory in children, few ... more Although numerous studies have examined the relations between stress and memory in children, few studies have investigated physiological responses as predictors of children's memory for stressful events. In this study, 4-to 8-year-olds completed laboratory challenges and experienced a fire-alarm incident while their sympathetic and parasympathetic reactions were monitored. Shortly afterward, children's memory of the alarm incident was tested. As children's age and family income increased, memory performance improved. High sympathetic activation during the laboratory challenges was associated with enhanced memory. Also, a trend indicated that, among older children, greater general parasympathetic withdrawal was associated with poorer memory, but among younger children, parasympathetic withdrawal was unrelated to memory. Findings highlight the need to measure both sympathetic and parasympathetic responses when evaluating children's memory for mild stressors and to include a wide age range so that developmental changes in the relations between stress and memory in childhood can be identified.
Developmental Psychobiology, 2003
Studies of cardiovascular reactivity in young children have generally employed integrated, physio... more Studies of cardiovascular reactivity in young children have generally employed integrated, physiologically complex measures, such as heart rate and blood pressure, which are subject to the multiple influences of factors such as blood volume, hematologic status, thermoregulation, and autonomic nervous system (ANS) tone. Reactivity studies in children have rarely employed more differentiated, proximal measures of autonomic function capable of discerning the independent effects of sympathetic and parasympathetic responses. We describe 1) the development, validity, and reliability of a psychobiology protocol assessing autonomic reactivity to challenge in 3-to 8-year-old children; 2) the influences of age, gender, and study context on autonomic measures; and 3) the distributions of reactivity measures in a normative sample of children and the prevalences of discrete autonomic profiles. Preejection period (PEP) and respiratory sinus arrythmia (RSA) were measured as indices of sympathetic and parasympathetic nervous system reactivity, respectively, and autonomic profiles were created to offer summative indices of PEP and RSA response. Results confirmed the protocol's validity and reliability, and showed differences in autonomic reactivity by age and study context, but not by gender. The studies' findings offer guidelines for future research on autonomic reactivity in middle childhood and support the feasibility of examining sympathetic and parasympathetic responses to challenge in 3-to 8-yearold children. ß 2003 Wiley Periodicals, Inc. Dev Psychobiol 42: 64-78, 2003.
Developmental Psychobiology, 2006
The purpose of this study was to develop a standardized protocol to measure preejection period (P... more The purpose of this study was to develop a standardized protocol to measure preejection period (PEP), a measure of sympathetic nervous system, and respiratory sinus arrhythmia (RSA), a measure of parasympathetic nervous system, during resting and challenging states for 6-and 12-month-old infants and to determine developmental changes and individual stability of these measures. A 7-min reactivity protocol was administered to Latino infants at 6 months (n ¼ 194) and 12 months (n ¼ 181). Results showed: (1) it is feasible to measure PEP and RSA in infants, (2) the protocol elicited significant autonomic changes, (3) individual resting autonomic measures were moderately stable from 6 to 12 months, but reactivity measures were not stable, and (4) heart rate and RSA resting and challenge group means changed significantly from 6 to 12 months. Findings suggest that although infants' autonomic responses show developmental changes, individuals' rank order is stable from 6 to 12 months of age. ß 2006 Wiley Periodicals, Inc. Dev Psychobiol 48: 197-208, 2006.
Clinical Autonomic Research, 2005
Individual differences in autonomic nervous system reactivity have been studied in relation to ph... more Individual differences in autonomic nervous system reactivity have been studied in relation to physical and mental health outcomes, but rarely among children with chronic disease. The purpose of this study was to examine the associations among autonomic reactivity, clinical severity, family stressors, and mental health symptoms in children with homozygous sickle cell disease. Nineteen children with homozygous sickle cell disease participated in a cross-sectional study involving parent-completed measures, medical record reviews and laboratory-based measures of autonomic nervous system responses to social, cognitive, physical and emotional challenges. Autonomic reactivity was significantly associated with both clinical severity and externalizing behavior symptoms. Children with greater parasympathetic withdrawal during challenges compared to rest had significantly more severe disease (r = -0.45, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05); greater sympathetic activation during challenges compared to rest was associated with more externalizing behavior symptoms ( r= 0.44, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). Children experiencing major family stressors had internalizing behavior symptoms but no difference in autonomic reactivity or clinical severity compared to children experiencing fewer family stressors. Individual differences in autonomic reactivity may offer a new, biologically plausible account for observed variation in painful episodes, other physical complications and behavioral symptoms among children with sickle cell disease.
Child Development, 2002
Previous research in both humans and nonhuman primates suggests that subtle asymmetries in tympan... more Previous research in both humans and nonhuman primates suggests that subtle asymmetries in tympanic membrane (TM) temperatures may be related to aspects of cognition and socioaffective behavior. Such associations could plausibly reflect lateralities in cerebral blood flow that support side-to-side differences in regional cortical activation. Asymmetries in activation of the left and right frontal cortex, for example, are correlates of temperamental differences in child behavior and markers of risk status for affective and anxiety disorders. Tympanic membrane temperatures might thus reflect the neural asymmetries that subserve individual differences in temperament and behavior. This report merged findings from four geographically and demographically distinctive studies, which utilized identical thermometry methods to examine associations between TM temperature asymmetries and biobehavioral attributes of 4-to 8-year-old children . The four studies produced shared patterns of associations that linked TM temperature lateralities to individual differences in behavior and socioaffective difficulties. Warmer left TMs were associated with "surgent," affectively positive behaviors, whereas warmer right TMs were related to problematic, affectively negative behaviors. Taken together, these findings suggest that asymmetries in TM temperatures could be associated with behavior problems that signal risk for developmental psychopathology.
Archives of Pediatrics & Adolescent Medicine, 1999
Archives of Pediatrics &amp;amp;amp;amp; Adolescent Medicine, a monthly professional medi... more Archives of Pediatrics &amp;amp;amp;amp; Adolescent Medicine, a monthly professional medical journal published by the American Medical Association, publishes original, peer-reviewed clinical and basic research articles.
Annals of Behavioral Medicine, 1995
Individual differences in children's physiologic responses to environmental stressors may... more Individual differences in children's physiologic responses to environmental stressors may be responsible for significant, but modest, associations found in past studies between stress and various morbidities. Because no standardized approach currently exists for eliciting and measuring cardiovascular reactivity (CVR) to laboratory stressors in preschool children, we developed a laboratory-based reactivity protocol that derives three dimensions of CVR-intensity, variability, and attenuation-and collected reliability data for each. A sample of 137 children between the ages of three and five years completed a series of seven devel-opmentally challenging tasks, comprising interpersonal, cognitive, and fine motor problems. Pulse rate (PR), diastolic blood pressure (DBP), systolic blood pressure (SBP), and mean arterial blood pressure (MAP) were measured at twelve standardized points using a Dinamap oscillometric blood pressure monitor. CVR scores were calculated for each of the four cardiovascular measures using: (a) a difference score; (b) a standardized residual score; and (c) three scores characterizing the dimensions of intensity, variability, and attenuation. Four to six weeks following initial testing, the protocol was readministered to ascertain temporal stability of reactivity measures.All four cardiovascular measures were responsive to the presented tasks (p>.001), and extensive variability was found in the character of cardiovascular responses. Subjects less than four years of age showed higher task PRs and lower DBPs, SBPs, and MAPs compared to older peers, but no gender differences were found. Difference scores were highly correlated with standardized residual scores (r's=.94 and .79,p>.001 for PR and MAP, respectively), but the three reactivity dimension scores showed a lack of intercorrelation and were independent of both difference and residual scores. Only the intensity and variability dimension scores showed modest and significant test-retest reliability (r's=.25 to .50,P>.01). Although previous CVR research has generally utilized difference or residual scores, dimensional scores reflecting the intensity and variability of CVR may achieve greater reliability in preschool childen.
Childhood obesity (Print), 2014
To understand whether the relationship between young children's autonomic nervous system (ANS... more To understand whether the relationship between young children's autonomic nervous system (ANS) responses predicted their BMI, or vice versa, the association between standardized BMI (zBMI) at 2, 3.5, and 5 years of age and ANS reactivity at 3.5-5 years of age, and whether zBMI predicts later ANS reactivity or whether early ANS reactivity predicts later zBMI, was studied. Low-income, primarily Latino children (n=112) were part of a larger cohort study of mothers recruited during early pregnancy. Study measures included maternal prenatal weight, children's health behaviors (i.e., time watching television, fast food consumption, and time playing outdoors), children's height and weight at 2, 3.5, and 5 years, and children's ANS reactivity at 3.5 and 5 years. ANS measures of sympathetic nervous system (i.e., pre-ejection period) and parasympathetic nervous system (i.e., respiratory sinus arrhythmia) activity were monitored during rest and four challenges. Reactivity was c...
Psychosomatic Medicine, 1995
Psychological stress is thought to undermine host resistance to infection through neuroendocrine-... more Psychological stress is thought to undermine host resistance to infection through neuroendocrine-mediated changes in immune competence. Associations between stress and infection have been modest in magnitude, however, suggesting individual variability in stress response. We therefore studied environmental stressors, psychobiologic reactivity to stress, and respiratory illness incidence in two studies of 236 preschool children. In Study 1,137 3-to 5-year-old children from four childcare centers underwent a laboratory-based assessment of cardiovascular reactivity (changes in heart rate and mean arterial pressure) during a series of developmentally challenging tasks. Environmental stress was evaluated with two measures of stressors in the childcare setting. The incidence of respiratory illnesses was ascertained over 6 months using weekly respiratory tract examinations by a nurse. In Study 2, 99 5-year-old children were assessed for immune reactivity (changes in CD4+, CD8 + , and CD19+ cell numbers, lymphocyte mitogenesis, and antibody response to pneumococcal vaccine) during the normative stressor of entering school. Blood for immune measures was sampled 1 week before and after kindergarten entry. Environmental stress was indexed with parent reports of family stressors, and a 12-week respiratory illness incidence was measured with biweekly, parent-completed symptom checklists. The two studies produced remarkably similar findings. Although environmental stress was not independently associated with respiratory illnesses in either study, the incidence of illness was related to an interaction between childcare stress and mean arterial pressure reactivity (/3 = .35, p < .05) in Study 1 and to an interaction between stressful life events and CD19+ reactivity (/3 = .51, p < .05) in Study 2. In both studies, reactive children sustained higher illness rates under high-stress conditions, but lower rates in low-stress conditions, compared with less reactive peers. Stress was associated with increased rates of illnesses, but only among psychobiologically reactive children. Less reactive children experienced no escalation in illness incidence under stressful conditions, suggesting that only a subset of individuals may be susceptible to the health-altering effects of stressors and adversity.
NeuroToxicology, 2011
Background: Organophosphate pesticides (OP), because of their effects on cholinergic fibers, may ... more Background: Organophosphate pesticides (OP), because of their effects on cholinergic fibers, may interfere with the functions of the autonomic nervous system (ANS). We conducted a study to assess the relation of in utero and child OP pesticide exposures and children's autonomic nervous system (ANS) dysregulation under resting and challenge conditions. We hypothesized that children with high OP levels would show parasympathetic activation and no sympathetic activation during rest and concomitant parasympathetic and sympathetic activation during challenging conditions. Methods: OP exposures were assessed by measuring urinary dialkylphosphate metabolites (DAPs, total diethyls-DEs, and total dimethyls-DMs) in maternal and children's spot urine samples. ANS regulation was examined in relation to maternal and child DAPs in 149 children at 6 months and 1 year, 97 at 3 1/2 years and 274 at 5 years. We assessed resting and reactivity (i.e., challenge minus rest) measures using heart rate (HR), respiratory sinus arrhythmia (RSA), and preejection period (PEP) during the administration of a standardized protocol. Cross-sectional (at each age) and longitudinal regression models were conducted to assess OP and ANS associations. To estimate cumulative exposure at 5 years, we used an area-under-the-concentration-time-curve (AUC) methodology. We also evaluated whether children with consistently high versus low DAP concentrations had significantly different mean ANS scores at 5 years. Results: Child DMs and DAPs were significantly negatively associated with resting RSA at 6 months and maternal DMs and child DEs were significantly positively associated with resting PEP at 1 year. No associations with resting were observed in 3 1/2-or 5-year-old children nor with reactivity at any age. There was no significant relationship between the reactivity profiles and maternal or child DAPs. Cumulative maternal total DEs were associated with low HR (À3.19 bpm decrease; 95% CI: À6.29 to À0.09, p = 0.04) only at 5 years. In addition, there were no significant differences in ANS measures for 5year-olds with consistently high versus low DAPs. Conclusion: Although we observe some evidence of ANS dysregulation in infancy, we report no consistent associations of maternal and child OP pesticide exposure, as measured by urinary DAPs, on children's ANS (HR, RSA, and PEP) regulation during resting and challenging conditions up to age 5 years. ß
Journal of the American Academy of Child & Adolescent Psychiatry, 2006
To study how early father involvement and children&amp;amp;amp;amp;amp;amp;amp;amp;amp;am... more To study how early father involvement and children&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s biobehavioral sensitivity to social contexts interactively predict mental health symptoms in middle childhood. Fathers&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; involvement in infant care and maternal symptoms of depression were prospectively ascertained in a community-based study of child health and development in Madison and Milwaukee, WI. In a subsample of 120 children, behavioral, autonomic, and adrenocortical reactivity to standardized challenges were measured as indicators of biobehavioral sensitivity to social context during a 4-hour home assessment in 1998, when the children were 7 years of age. Mental health symptoms were evaluated at age 9 years using parent, child, and teacher reports. Early father involvement and children&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s biobehavioral sensitivity to context significantly and interactively predicted symptom severity. Among children experiencing low father involvement in infancy, behavioral, autonomic, and adrenocortical reactivity became risk factors for later mental health symptoms. The highest symptom severity scores were found for children with high autonomic reactivity that, as infants, had experienced low father involvement and mothers with symptoms of depression. Among children experiencing minimal paternal caretaking in infancy, heightened biobehavioral sensitivity to social contexts may be an important predisposing factor for the emergence of mental health symptoms in middle childhood. Such predispositions may be exacerbated by the presence of maternal depression.
Journal of the American Academy of Child & Adolescent Psychiatry, 1996
To examine the effects of child temperament and stressful family functioning on child behavior pr... more To examine the effects of child temperament and stressful family functioning on child behavior problems among preschool children. One hundred forty-five preschool children, aged 2 to 5 years, were evaluated by teachers, mothers, and independent observers. Teachers reported on child temperament; from these ratings, two dimensions of temperament were derived: difficult/easy and approachability. Mothers reported on two dimensions of family functioning: conflict and expressiveness. Both teachers and independent observers rated child behavior problems. Children with more difficult temperaments who were in high-conflict families had the most internalizing and externalizing behavior problems, while children with easy temperaments had fewer such problems, regardless of levels of family conflict. Difficult children whose families were highly expressive engaged in the most observed aggression. Results suggest that temperament is involved in both protective and vulnerability processes. A difficult temperament operates as a vulnerability factor for internalizing and externalizing behavior problems and observed aggression, while an easy temperament functions as a protective mechanism for these outcomes.
Journal of Experimental Child Psychology, 2011
Current methods of assessing children's physiological ''stress reactivity'' may be confounded by ... more Current methods of assessing children's physiological ''stress reactivity'' may be confounded by psychomotor activity, biasing estimates of the relation between reactivity and health. We examined the joint and independent contributions of psychomotor activity and challenge reactivity during a protocol for 5-and 6-year-old children (N = 338). Measures of parasympathetic reactivity (respiratory sinus arrhythmia [RSA]) and sympathetic reactivity (preejection period [PEP]) were calculated for social, cognitive, sensory, and emotional challenge tasks. Reactivity was calculated relative to both resting and a paired comparison task that accounted for psychomotor activity effects during each challenge. Results indicated that comparison tasks themselves elicited RSA and PEP responses, and reactivity adjusted for psychomotor activity was incongruent with reactivity calculated using rest. Findings demonstrate the importance of accounting for confounding psychomotor activity effects on physiological reactivity.
Journal of Developmental & Behavioral Pediatrics, 2010
To evaluate whether autonomic nervous system (ANS) reactivity modifies the relation between famil... more To evaluate whether autonomic nervous system (ANS) reactivity modifies the relation between family stress, and physical and mental health, and functional impairment for children with sickle cell disease. Thirty-eight 5-to 8-year old children with sickle cell disease completed a 20-minute ANS reactivity protocol measuring respiratory sinus arrhythmia and pre-ejection period during comparison and challenge tasks in social, cognitive, sensory, and emotion domains. Domain-specific reactivity was calculated as the difference between challenge and comparison tasks; overall reactivity was calculated across domains as the mean of the difference scores. ANS profile scores combined the overall respiratory sinus arrhythmia and pre-ejection period reactivity scores. Caregivers completed measures of family stress, child physical and mental health symptoms, and functional impairment. Family stress was associated with child functional impairment whereas overall and cognitive ANS reactivity was associated with co-morbid internalizing and externalizing mental health symptoms. Interaction models showed that children with the classic ANS profile (parasympathetic inhibition and sympathetic activation) in the cognitive and emotion domains were most vulnerable to the effects of stress, with more functional impairment and injuries when family stress was high, controlling for age, sex, and parent education. The costs to patients and families in diminished quality of life and to the health care system could be reduced by further exploration of strategies to identify children with sickle cell disease who are most vulnerable under conditions of high family stress and heightened psychobiologic reactivity.
Journal of Developmental & Behavioral Pediatrics, 2007
Objective: Behavioral inhibition (BI) to the unfamiliar represents the temperamental tendency to ... more Objective: Behavioral inhibition (BI) to the unfamiliar represents the temperamental tendency to exhibit fearfulness, reticence, or restraint when faced with unfamiliar people or situations. It has been hypothesized to be a risk factor for anxiety disorders. In this prospective longitudinal study, we compared the psychiatric outcomes in middle childhood of children evaluated at preschool age for BI. Method: The baseline sample consisted of 284 children ages 21 months to 6 years, including offspring at risk for anxiety (children of parents with panic disorder and/or major depression) and comparison offspring of parents without mood or major anxiety disorders. They had been assessed for BI using age-specific laboratory protocols. We reassessed 215 of the children (76.5%) at 5-year follow-up at a mean age of 9.6 years using structured diagnostic interviews. Results: BI specifically predicted onset of social anxiety. The rate of lifetime social anxiety (DSM-IV social phobia or DSM-III-R avoidant disorder) was 28% versus 14% (odds ratio [OR] ؍ 2.37; 95% confidence interval [CI]: 1.10 -5.10) in inhibited versus noninhibited children. BI significantly predicted new onset of social phobia among children unaffected at baseline (22.2% vs 8.0% in inhibited versus noninhibited children (OR ؍ 3.15, 95% CI: 1.16 -8.57). No other anxiety disorders were associated with BI. Conclusion: BI appears to be a temperamental antecedent to subsequent social anxiety in middle childhood. Children presenting with BI should be monitored for symptoms of social anxiety and may be good candidates for preventive cognitive behavioral strategies.
Developmental Psychobiology, 2000
Although there are general assumptions that physiological and behavioral indices of emotion are i... more Although there are general assumptions that physiological and behavioral indices of emotion are interrelated, empirical research has revealed inconsistent findings with regard to their degree of association, particularly in children. Two studies were conducted to examine the relations between cardiovascular reactivity and emotional behavior. In the first study, 3- to 6-year-olds completed challenging tasks during which measures of their physiological responses and facial expressions were obtained. With age, children's heart rate decreased, vagal tone increased, and facial expressions became slightly more exaggerated. However, children's physiologic reactions were unrelated to their concurrent facial expression when all children were considered, when only boys were considered, and when children extreme in their physiologic reactions were considered. Only among girls was physiologic reactivity moderately associated with concurrent negative expressiveness. In the second study, 4- and 5-year-olds' physiologic reactivity was examined as a predictor of later overt emotional reaction to venipuncture episodes. Children's overt emotional reactions were consistent across repeated venipunctures, and girls were more visibly distressed than boys. As in the first study, physiologic reactivity was generally unrelated to children's behavioral responses. Findings have implications for assumptions about the degree of coupling between biological and behavioral emotional systems in childhood.
Developmental Psychobiology, 2006
Although numerous studies have examined the relations between stress and memory in children, few ... more Although numerous studies have examined the relations between stress and memory in children, few studies have investigated physiological responses as predictors of children's memory for stressful events. In this study, 4-to 8-year-olds completed laboratory challenges and experienced a fire-alarm incident while their sympathetic and parasympathetic reactions were monitored. Shortly afterward, children's memory of the alarm incident was tested. As children's age and family income increased, memory performance improved. High sympathetic activation during the laboratory challenges was associated with enhanced memory. Also, a trend indicated that, among older children, greater general parasympathetic withdrawal was associated with poorer memory, but among younger children, parasympathetic withdrawal was unrelated to memory. Findings highlight the need to measure both sympathetic and parasympathetic responses when evaluating children's memory for mild stressors and to include a wide age range so that developmental changes in the relations between stress and memory in childhood can be identified.
Developmental Psychobiology, 2003
Studies of cardiovascular reactivity in young children have generally employed integrated, physio... more Studies of cardiovascular reactivity in young children have generally employed integrated, physiologically complex measures, such as heart rate and blood pressure, which are subject to the multiple influences of factors such as blood volume, hematologic status, thermoregulation, and autonomic nervous system (ANS) tone. Reactivity studies in children have rarely employed more differentiated, proximal measures of autonomic function capable of discerning the independent effects of sympathetic and parasympathetic responses. We describe 1) the development, validity, and reliability of a psychobiology protocol assessing autonomic reactivity to challenge in 3-to 8-year-old children; 2) the influences of age, gender, and study context on autonomic measures; and 3) the distributions of reactivity measures in a normative sample of children and the prevalences of discrete autonomic profiles. Preejection period (PEP) and respiratory sinus arrythmia (RSA) were measured as indices of sympathetic and parasympathetic nervous system reactivity, respectively, and autonomic profiles were created to offer summative indices of PEP and RSA response. Results confirmed the protocol's validity and reliability, and showed differences in autonomic reactivity by age and study context, but not by gender. The studies' findings offer guidelines for future research on autonomic reactivity in middle childhood and support the feasibility of examining sympathetic and parasympathetic responses to challenge in 3-to 8-yearold children. ß 2003 Wiley Periodicals, Inc. Dev Psychobiol 42: 64-78, 2003.
Developmental Psychobiology, 2006
The purpose of this study was to develop a standardized protocol to measure preejection period (P... more The purpose of this study was to develop a standardized protocol to measure preejection period (PEP), a measure of sympathetic nervous system, and respiratory sinus arrhythmia (RSA), a measure of parasympathetic nervous system, during resting and challenging states for 6-and 12-month-old infants and to determine developmental changes and individual stability of these measures. A 7-min reactivity protocol was administered to Latino infants at 6 months (n ¼ 194) and 12 months (n ¼ 181). Results showed: (1) it is feasible to measure PEP and RSA in infants, (2) the protocol elicited significant autonomic changes, (3) individual resting autonomic measures were moderately stable from 6 to 12 months, but reactivity measures were not stable, and (4) heart rate and RSA resting and challenge group means changed significantly from 6 to 12 months. Findings suggest that although infants' autonomic responses show developmental changes, individuals' rank order is stable from 6 to 12 months of age. ß 2006 Wiley Periodicals, Inc. Dev Psychobiol 48: 197-208, 2006.
Clinical Autonomic Research, 2005
Individual differences in autonomic nervous system reactivity have been studied in relation to ph... more Individual differences in autonomic nervous system reactivity have been studied in relation to physical and mental health outcomes, but rarely among children with chronic disease. The purpose of this study was to examine the associations among autonomic reactivity, clinical severity, family stressors, and mental health symptoms in children with homozygous sickle cell disease. Nineteen children with homozygous sickle cell disease participated in a cross-sectional study involving parent-completed measures, medical record reviews and laboratory-based measures of autonomic nervous system responses to social, cognitive, physical and emotional challenges. Autonomic reactivity was significantly associated with both clinical severity and externalizing behavior symptoms. Children with greater parasympathetic withdrawal during challenges compared to rest had significantly more severe disease (r = -0.45, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05); greater sympathetic activation during challenges compared to rest was associated with more externalizing behavior symptoms ( r= 0.44, p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). Children experiencing major family stressors had internalizing behavior symptoms but no difference in autonomic reactivity or clinical severity compared to children experiencing fewer family stressors. Individual differences in autonomic reactivity may offer a new, biologically plausible account for observed variation in painful episodes, other physical complications and behavioral symptoms among children with sickle cell disease.
Child Development, 2002
Previous research in both humans and nonhuman primates suggests that subtle asymmetries in tympan... more Previous research in both humans and nonhuman primates suggests that subtle asymmetries in tympanic membrane (TM) temperatures may be related to aspects of cognition and socioaffective behavior. Such associations could plausibly reflect lateralities in cerebral blood flow that support side-to-side differences in regional cortical activation. Asymmetries in activation of the left and right frontal cortex, for example, are correlates of temperamental differences in child behavior and markers of risk status for affective and anxiety disorders. Tympanic membrane temperatures might thus reflect the neural asymmetries that subserve individual differences in temperament and behavior. This report merged findings from four geographically and demographically distinctive studies, which utilized identical thermometry methods to examine associations between TM temperature asymmetries and biobehavioral attributes of 4-to 8-year-old children . The four studies produced shared patterns of associations that linked TM temperature lateralities to individual differences in behavior and socioaffective difficulties. Warmer left TMs were associated with "surgent," affectively positive behaviors, whereas warmer right TMs were related to problematic, affectively negative behaviors. Taken together, these findings suggest that asymmetries in TM temperatures could be associated with behavior problems that signal risk for developmental psychopathology.
Archives of Pediatrics & Adolescent Medicine, 1999
Archives of Pediatrics &amp;amp;amp;amp; Adolescent Medicine, a monthly professional medi... more Archives of Pediatrics &amp;amp;amp;amp; Adolescent Medicine, a monthly professional medical journal published by the American Medical Association, publishes original, peer-reviewed clinical and basic research articles.
Annals of Behavioral Medicine, 1995
Individual differences in children's physiologic responses to environmental stressors may... more Individual differences in children's physiologic responses to environmental stressors may be responsible for significant, but modest, associations found in past studies between stress and various morbidities. Because no standardized approach currently exists for eliciting and measuring cardiovascular reactivity (CVR) to laboratory stressors in preschool children, we developed a laboratory-based reactivity protocol that derives three dimensions of CVR-intensity, variability, and attenuation-and collected reliability data for each. A sample of 137 children between the ages of three and five years completed a series of seven devel-opmentally challenging tasks, comprising interpersonal, cognitive, and fine motor problems. Pulse rate (PR), diastolic blood pressure (DBP), systolic blood pressure (SBP), and mean arterial blood pressure (MAP) were measured at twelve standardized points using a Dinamap oscillometric blood pressure monitor. CVR scores were calculated for each of the four cardiovascular measures using: (a) a difference score; (b) a standardized residual score; and (c) three scores characterizing the dimensions of intensity, variability, and attenuation. Four to six weeks following initial testing, the protocol was readministered to ascertain temporal stability of reactivity measures.All four cardiovascular measures were responsive to the presented tasks (p>.001), and extensive variability was found in the character of cardiovascular responses. Subjects less than four years of age showed higher task PRs and lower DBPs, SBPs, and MAPs compared to older peers, but no gender differences were found. Difference scores were highly correlated with standardized residual scores (r's=.94 and .79,p>.001 for PR and MAP, respectively), but the three reactivity dimension scores showed a lack of intercorrelation and were independent of both difference and residual scores. Only the intensity and variability dimension scores showed modest and significant test-retest reliability (r's=.25 to .50,P>.01). Although previous CVR research has generally utilized difference or residual scores, dimensional scores reflecting the intensity and variability of CVR may achieve greater reliability in preschool childen.
Childhood obesity (Print), 2014
To understand whether the relationship between young children's autonomic nervous system (ANS... more To understand whether the relationship between young children's autonomic nervous system (ANS) responses predicted their BMI, or vice versa, the association between standardized BMI (zBMI) at 2, 3.5, and 5 years of age and ANS reactivity at 3.5-5 years of age, and whether zBMI predicts later ANS reactivity or whether early ANS reactivity predicts later zBMI, was studied. Low-income, primarily Latino children (n=112) were part of a larger cohort study of mothers recruited during early pregnancy. Study measures included maternal prenatal weight, children's health behaviors (i.e., time watching television, fast food consumption, and time playing outdoors), children's height and weight at 2, 3.5, and 5 years, and children's ANS reactivity at 3.5 and 5 years. ANS measures of sympathetic nervous system (i.e., pre-ejection period) and parasympathetic nervous system (i.e., respiratory sinus arrhythmia) activity were monitored during rest and four challenges. Reactivity was c...