Amare Wolide - Academia.edu (original) (raw)
Papers by Amare Wolide
Additional file 1: Table S1. Practice on chronic kidney disease stratified by sex among Health Sc... more Additional file 1: Table S1. Practice on chronic kidney disease stratified by sex among Health Science Students of Jimma University; Nâ =â 395 (2018).
Ethiopian Journal of Health Sciences, 2018
Non-alcoholic Fatty Liver Disease (NAFLD) among type 2 diabetic patients is completely ignored in... more Non-alcoholic Fatty Liver Disease (NAFLD) among type 2 diabetic patients is completely ignored in developing regions like Africa paving the way for public health and economic burden in the region. Therefore, the main objective of this research was to evaluate non-alcoholic fatty liver disease and associated factors among type 2 diabetic patients in Southwestern Ethiopia attending Diabetic Clinic of Jimma University Specialized Hospital (JUSH). Facility based cross-sectional study design was used. Anthropometry, fatty liver (using utrasonography), liver enzymes, and lipid profiles were measured among type 2 diabetic patients who fulfilled the inclusion criteria. Socio-demographic and clinical characteristics were assessed using standard questionnaires. Ninety-six (96) type 2 diabetic patients were enrolled and non-alcoholic fatty liver disease prevalence was 73%. Of non-alcoholic fatty Liver disease documented patients, 35.4%, 31.3% and 6.3% exhibited mild, moderate and severe fatty ...
Background: Long-term hyperglycemia promotes development of complications and suboptimal wellbein... more Background: Long-term hyperglycemia promotes development of complications and suboptimal wellbeing in patients with diabetes. A stringent glycemic control is a worldwide standard of diabetes care recommended in order to reduce such adverse health outcomes. The current study was aimed to undertake glycosylated hemoglobin (HbA1c) assay and assess the quality of glycemic control in Ethiopian diabetes care and identify simple patient related factors associated with poor control. Methods: Hospital-based cross-sectional study with longitudinal components was conducted from October 20 to December 15, 2015 among systematically selected adult ambulatory diabetic patients at the outpatient clinic of Jimma University Medical Center, Southwest Ethiopia. At recruitment, blood samples for HbA1C determination and sociodemographic characteristics were collected from each patient. In addition, patient charts were reviewed for recorded anthropometric data, diabetic duration and blood pressure. Based ...
Fluoride in excess is a toxic chemical to the kidney function. Studies implicated that aggravatin... more Fluoride in excess is a toxic chemical to the kidney function. Studies implicated that aggravating oxidative stress and inhibiting body antioxidative systems is the main route of damage. Moringa stenopetala is rich in antioxidants and has a potent anti-oxidative effect. The study aimed to determine the effect of sub-chronic exposure to fluoride and the effect of Moringa stenopetala crude extract on body weight and kidney function. Randomized control study was conducted using 2 months old, 24 adult Swiss Albino mice. All animals were allowed free access to standard pellet diet ad libitum and distilled water. The mice were randomly divided into six groups of four animals, taking different doses of fluoride and the crude extract. After 3 months of exposure, the mice were anesthetized and sacrificed under anesthesia for sample collection. There was a statistically significant difference in renal function test (plasma urea) between the treated and the control groups in high dose fluoride...
php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (h... more php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2019:12 391–399 Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Dovepress
Title: Association of trace metal elements with lipid profiles in type 2 diabetes mellitus patien... more Title: Association of trace metal elements with lipid profiles in type 2 diabetes mellitus patients. a cross sectional study Authors: Amare Wolide (amaju2002@yahoo.com) Belay Zawdie (bellzolla2000@gmail.com) Tilahun Alemayehu (tilalemnig2012@gmail.com) Samuel Tadesse (sami2tadi@gmail.com) Version: 1 Date: 01 Jun 2017 Author’s response to reviews: Point-by-point responses to the reviewer’s comments on the manuscript submitted to BMC Endocrine Disorders.
BMC Public Health
Background Chronic kidney disease (CKD) is a common and growing health problem that requires adeq... more Background Chronic kidney disease (CKD) is a common and growing health problem that requires adequate Knowledge by health care providers to reduce the progress of the disease. Thus, this study aimed to assess the care provider’s Knowledge, attitude, and practices toward CKD. Method A cross-sectional study conducted among 326 care providers at Jimma University Specialized hospital and three medium to higher clinics found in Jimma Town. Collected data entered into Epi-Data version 3.1 and exported to SPSS version 21 for windows for data analysis. Descriptive statistics and generalized linear modal used to analyze the data. Result The mean age and service year of the participants were 29.68(±4.877) and 4.28(±4.561), respectively. The overall weighted Knowledge, attitude, and practice score of the study participant were 9.0971(8.77, 9.42), 2.53(2.4, 2.65), 10.14(9.94, 10.33) respectively. Over half of the care providers had the awareness to use eGFR to assess kidney function and patient...
BMC Public Health
Background The lack of organ donors has become a limiting factor for the development of organ tra... more Background The lack of organ donors has become a limiting factor for the development of organ transplantation programs. Many countries are currently facing a severe shortage of organs for transplantation. Medical students, as future doctors can engage in the role of promoting organ donation by creating awareness and motivating the community to donate their organs besides their voluntary organ donation. The aim of this study is to assess the knowledge, attitude and willingness of undergraduate medical students’ towards organ donation at Jimma University. Methods A cross-sectional study was conducted among 320 medical students from year I to internship using questionnaire in order to assess their knowledge, attitude and willingness regarding organ donation. Data collected was entered using epidata and analyzed using Statistical Package for Social Sciences (SPSS) software version 20. Results Mean (±SD = standard deviation) age of participants was 23.48 ± 17.025 years. 57.8% of the stud...
Transplant Research and Risk Management, 2020
Background: Donated organs and tissues are necessary for transplantation to treat irreparable org... more Background: Donated organs and tissues are necessary for transplantation to treat irreparable organ failure. This study aimed to assess the knowledge and attitude of undergraduate health science students' toward organ donation at Jimma University. Methods: The study was conducted in Jimma University, College of Health Sciences from February 1, 2018 to April 25, 2018, Gregorian calendar. Data was entered into Epi-Data version 3.1 and exported to SPSS version 23 for analysis. A descriptive and generalized linear model was applied to present the results. Results: The overall knowledge and attitude scores of the students were 3.844 (2.98, 4.712) and 6.3914 (5.93, 6.85) respectively. The results showed that students had good knowledge of and a positive attitude toward organ donation. Male students had a higher mean knowledge score than female students, however, the difference was not significant. Dental medicine and medicine students had a higher mean knowledge score than any other health science students in the faculty. Students showed knowledge difference yearly. A significant number of students 290 (73.4%) and 313 (79.2%) knew the importance of live and cadaveric organ donation to treat permanently failed organs, respectively. Also, about 238 (60.3%) students had the awareness of disease transmission and 358 (90.6%) of them knew the involvement of tissue rejection when inappropriate organ transplantation is done to the recipients. Furthermore, likewise, more than half of the students expressed positive beliefs toward the different questions of organ donation-ethics, religion, and willingness for organ donation. Conclusion: Students showed good knowledge and a positive attitude toward organ donation and this should be translated to the public to increase the rate of organ donations.
Journal of Public Health and Epidemiology, Nov 30, 2017
Cognitive impairment is the major health problem particularly in elderly with type 2 diabetes mel... more Cognitive impairment is the major health problem particularly in elderly with type 2 diabetes mellitus. The aim of this study was to determine the magnitude of cognitive impairment and associated factors among type 2 diabetics in Jimma University Specialized Hospital, 2016. Comparative cross sectional study was employed among 105 type 2 diabetes mellitus patients and 105 matched healthy individuals at Jimma University Specialized Hospital using consecutive sampling technique. Mini-mental state examination scale was used to measure cognitive function. Frequency, independent t-test, and logistic regression were carried to present data. Variables with p≤0.05 were considered as significant association between dependent and outcome variables. Prevalence of cognitive impairment among type 2 diabetes mellitus was higher than healthy individuals (53.3%). Age, occupations, fasting blood glucose level, and type of treatment options for diabetics were the predictors of cognitive impairment among type 2 diabetes mellitus patients. The prevalence of cognitive impairment among type 2 diabetes mellitus patients was significantly higher than non-diabetes study participants. This study was intended to offer information on cognitive impairment and associated factors among type 2 diabetes mellitus patients to concerned bodies in designing diagnosis and management strategies particularly focusing on counseling in preventing risk factors.
Transplantation Proceedings
INTRODUCTION Ethiopia is a country in sub-Saharan Africa with a population of 100 million people.... more INTRODUCTION Ethiopia is a country in sub-Saharan Africa with a population of 100 million people. The incidence and prevalence of end-stage organ failure seems to be a growing health problem in the country. Transplant legislation was drafted years ago by the federal minster of health in Ethiopia, but the number of donors is still low. Thus, we aimed to assess care providers' knowledge and attitude toward organ donation so they will be volunteer advocates for the public to increase organ donation in the country. METHOD A cross-sectional survey was conducted at 3 main higher private clinics and at Jimma University Specialized Hospital (JUSH) in Ethiopia from February 25, 2018, to June 21, 2018. Knowledge measuring questions had 2 possible answers (yes or no). The attitudes domain was measured with an "Agree" and "Disagree" categorical response scale. Data was entered to Epi-Data version 3.1 and exported to SPSS version 21 for Windows (IBM-SPSS Statistics 21, IBM, Armonk, NY) for data analysis. Descriptive statistics and a generalized linear model were used to analyze the data. RESULTS In total, 326 care providers were involved in the study. The mean age and service year of the participants were 29.68 (± 4.877) and 4.28 (± 4.561), respectively. The overall weighted knowledge and practices scores were 4.344 (4.214, 4.473) and 5.64 (5.39, 5.89), respectively. Majority care providers had an understanding about brain death and the definition of organ donation. Over half of the care providers agreed to donate organs in the future; additionally, they believed there was no strict association between religion and organ donation. Furthermore, many care providers believed in the advertisement and promotion of organ donation to raise public awareness. CONCLUSION Care providers showed good knowledge and attitudes toward organ donation. The findings may encourage health care workers to provide better counseling to improve organ donation.
Although insulin resistance often leads to Type 2 Diabetes Mellitus (T2D), its early stages remai... more Although insulin resistance often leads to Type 2 Diabetes Mellitus (T2D), its early stages remain often unrecognized thus reducing the probability of successful prevention and intervention. Moreover, treatment efficacy is affected by the genetics of the individual patient. To identify potential candidate genes for the prediction of diabetes risk and intervention response we linked genetic expression profiles of human skeletal muscle and intermuscular adipose tissue (IMAT) to fasting glucose (FG) and glucose infusion rate (GIR). We found that genes with a strong association to these measures clustered into three distinct expression patterns. Their predictive values for insulin resistance varied strongly between muscle and IMAT. Moreover, we discovered that individual genetic expression based classifications may differ from those classifications based predominantly on clinical parameters indicating a potential incomplete patient stratification. Out of the 15 top hit candidate genes, ...
Additional file 1: Table S1. Practice on chronic kidney disease stratified by sex among Health Sc... more Additional file 1: Table S1. Practice on chronic kidney disease stratified by sex among Health Science Students of Jimma University; Nâ =â 395 (2018).
Ethiopian Journal of Health Sciences, 2018
Non-alcoholic Fatty Liver Disease (NAFLD) among type 2 diabetic patients is completely ignored in... more Non-alcoholic Fatty Liver Disease (NAFLD) among type 2 diabetic patients is completely ignored in developing regions like Africa paving the way for public health and economic burden in the region. Therefore, the main objective of this research was to evaluate non-alcoholic fatty liver disease and associated factors among type 2 diabetic patients in Southwestern Ethiopia attending Diabetic Clinic of Jimma University Specialized Hospital (JUSH). Facility based cross-sectional study design was used. Anthropometry, fatty liver (using utrasonography), liver enzymes, and lipid profiles were measured among type 2 diabetic patients who fulfilled the inclusion criteria. Socio-demographic and clinical characteristics were assessed using standard questionnaires. Ninety-six (96) type 2 diabetic patients were enrolled and non-alcoholic fatty liver disease prevalence was 73%. Of non-alcoholic fatty Liver disease documented patients, 35.4%, 31.3% and 6.3% exhibited mild, moderate and severe fatty ...
Background: Long-term hyperglycemia promotes development of complications and suboptimal wellbein... more Background: Long-term hyperglycemia promotes development of complications and suboptimal wellbeing in patients with diabetes. A stringent glycemic control is a worldwide standard of diabetes care recommended in order to reduce such adverse health outcomes. The current study was aimed to undertake glycosylated hemoglobin (HbA1c) assay and assess the quality of glycemic control in Ethiopian diabetes care and identify simple patient related factors associated with poor control. Methods: Hospital-based cross-sectional study with longitudinal components was conducted from October 20 to December 15, 2015 among systematically selected adult ambulatory diabetic patients at the outpatient clinic of Jimma University Medical Center, Southwest Ethiopia. At recruitment, blood samples for HbA1C determination and sociodemographic characteristics were collected from each patient. In addition, patient charts were reviewed for recorded anthropometric data, diabetic duration and blood pressure. Based ...
Fluoride in excess is a toxic chemical to the kidney function. Studies implicated that aggravatin... more Fluoride in excess is a toxic chemical to the kidney function. Studies implicated that aggravating oxidative stress and inhibiting body antioxidative systems is the main route of damage. Moringa stenopetala is rich in antioxidants and has a potent anti-oxidative effect. The study aimed to determine the effect of sub-chronic exposure to fluoride and the effect of Moringa stenopetala crude extract on body weight and kidney function. Randomized control study was conducted using 2 months old, 24 adult Swiss Albino mice. All animals were allowed free access to standard pellet diet ad libitum and distilled water. The mice were randomly divided into six groups of four animals, taking different doses of fluoride and the crude extract. After 3 months of exposure, the mice were anesthetized and sacrificed under anesthesia for sample collection. There was a statistically significant difference in renal function test (plasma urea) between the treated and the control groups in high dose fluoride...
php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (h... more php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2019:12 391–399 Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Dovepress
Title: Association of trace metal elements with lipid profiles in type 2 diabetes mellitus patien... more Title: Association of trace metal elements with lipid profiles in type 2 diabetes mellitus patients. a cross sectional study Authors: Amare Wolide (amaju2002@yahoo.com) Belay Zawdie (bellzolla2000@gmail.com) Tilahun Alemayehu (tilalemnig2012@gmail.com) Samuel Tadesse (sami2tadi@gmail.com) Version: 1 Date: 01 Jun 2017 Author’s response to reviews: Point-by-point responses to the reviewer’s comments on the manuscript submitted to BMC Endocrine Disorders.
BMC Public Health
Background Chronic kidney disease (CKD) is a common and growing health problem that requires adeq... more Background Chronic kidney disease (CKD) is a common and growing health problem that requires adequate Knowledge by health care providers to reduce the progress of the disease. Thus, this study aimed to assess the care provider’s Knowledge, attitude, and practices toward CKD. Method A cross-sectional study conducted among 326 care providers at Jimma University Specialized hospital and three medium to higher clinics found in Jimma Town. Collected data entered into Epi-Data version 3.1 and exported to SPSS version 21 for windows for data analysis. Descriptive statistics and generalized linear modal used to analyze the data. Result The mean age and service year of the participants were 29.68(±4.877) and 4.28(±4.561), respectively. The overall weighted Knowledge, attitude, and practice score of the study participant were 9.0971(8.77, 9.42), 2.53(2.4, 2.65), 10.14(9.94, 10.33) respectively. Over half of the care providers had the awareness to use eGFR to assess kidney function and patient...
BMC Public Health
Background The lack of organ donors has become a limiting factor for the development of organ tra... more Background The lack of organ donors has become a limiting factor for the development of organ transplantation programs. Many countries are currently facing a severe shortage of organs for transplantation. Medical students, as future doctors can engage in the role of promoting organ donation by creating awareness and motivating the community to donate their organs besides their voluntary organ donation. The aim of this study is to assess the knowledge, attitude and willingness of undergraduate medical students’ towards organ donation at Jimma University. Methods A cross-sectional study was conducted among 320 medical students from year I to internship using questionnaire in order to assess their knowledge, attitude and willingness regarding organ donation. Data collected was entered using epidata and analyzed using Statistical Package for Social Sciences (SPSS) software version 20. Results Mean (±SD = standard deviation) age of participants was 23.48 ± 17.025 years. 57.8% of the stud...
Transplant Research and Risk Management, 2020
Background: Donated organs and tissues are necessary for transplantation to treat irreparable org... more Background: Donated organs and tissues are necessary for transplantation to treat irreparable organ failure. This study aimed to assess the knowledge and attitude of undergraduate health science students' toward organ donation at Jimma University. Methods: The study was conducted in Jimma University, College of Health Sciences from February 1, 2018 to April 25, 2018, Gregorian calendar. Data was entered into Epi-Data version 3.1 and exported to SPSS version 23 for analysis. A descriptive and generalized linear model was applied to present the results. Results: The overall knowledge and attitude scores of the students were 3.844 (2.98, 4.712) and 6.3914 (5.93, 6.85) respectively. The results showed that students had good knowledge of and a positive attitude toward organ donation. Male students had a higher mean knowledge score than female students, however, the difference was not significant. Dental medicine and medicine students had a higher mean knowledge score than any other health science students in the faculty. Students showed knowledge difference yearly. A significant number of students 290 (73.4%) and 313 (79.2%) knew the importance of live and cadaveric organ donation to treat permanently failed organs, respectively. Also, about 238 (60.3%) students had the awareness of disease transmission and 358 (90.6%) of them knew the involvement of tissue rejection when inappropriate organ transplantation is done to the recipients. Furthermore, likewise, more than half of the students expressed positive beliefs toward the different questions of organ donation-ethics, religion, and willingness for organ donation. Conclusion: Students showed good knowledge and a positive attitude toward organ donation and this should be translated to the public to increase the rate of organ donations.
Journal of Public Health and Epidemiology, Nov 30, 2017
Cognitive impairment is the major health problem particularly in elderly with type 2 diabetes mel... more Cognitive impairment is the major health problem particularly in elderly with type 2 diabetes mellitus. The aim of this study was to determine the magnitude of cognitive impairment and associated factors among type 2 diabetics in Jimma University Specialized Hospital, 2016. Comparative cross sectional study was employed among 105 type 2 diabetes mellitus patients and 105 matched healthy individuals at Jimma University Specialized Hospital using consecutive sampling technique. Mini-mental state examination scale was used to measure cognitive function. Frequency, independent t-test, and logistic regression were carried to present data. Variables with p≤0.05 were considered as significant association between dependent and outcome variables. Prevalence of cognitive impairment among type 2 diabetes mellitus was higher than healthy individuals (53.3%). Age, occupations, fasting blood glucose level, and type of treatment options for diabetics were the predictors of cognitive impairment among type 2 diabetes mellitus patients. The prevalence of cognitive impairment among type 2 diabetes mellitus patients was significantly higher than non-diabetes study participants. This study was intended to offer information on cognitive impairment and associated factors among type 2 diabetes mellitus patients to concerned bodies in designing diagnosis and management strategies particularly focusing on counseling in preventing risk factors.
Transplantation Proceedings
INTRODUCTION Ethiopia is a country in sub-Saharan Africa with a population of 100 million people.... more INTRODUCTION Ethiopia is a country in sub-Saharan Africa with a population of 100 million people. The incidence and prevalence of end-stage organ failure seems to be a growing health problem in the country. Transplant legislation was drafted years ago by the federal minster of health in Ethiopia, but the number of donors is still low. Thus, we aimed to assess care providers' knowledge and attitude toward organ donation so they will be volunteer advocates for the public to increase organ donation in the country. METHOD A cross-sectional survey was conducted at 3 main higher private clinics and at Jimma University Specialized Hospital (JUSH) in Ethiopia from February 25, 2018, to June 21, 2018. Knowledge measuring questions had 2 possible answers (yes or no). The attitudes domain was measured with an "Agree" and "Disagree" categorical response scale. Data was entered to Epi-Data version 3.1 and exported to SPSS version 21 for Windows (IBM-SPSS Statistics 21, IBM, Armonk, NY) for data analysis. Descriptive statistics and a generalized linear model were used to analyze the data. RESULTS In total, 326 care providers were involved in the study. The mean age and service year of the participants were 29.68 (± 4.877) and 4.28 (± 4.561), respectively. The overall weighted knowledge and practices scores were 4.344 (4.214, 4.473) and 5.64 (5.39, 5.89), respectively. Majority care providers had an understanding about brain death and the definition of organ donation. Over half of the care providers agreed to donate organs in the future; additionally, they believed there was no strict association between religion and organ donation. Furthermore, many care providers believed in the advertisement and promotion of organ donation to raise public awareness. CONCLUSION Care providers showed good knowledge and attitudes toward organ donation. The findings may encourage health care workers to provide better counseling to improve organ donation.
Although insulin resistance often leads to Type 2 Diabetes Mellitus (T2D), its early stages remai... more Although insulin resistance often leads to Type 2 Diabetes Mellitus (T2D), its early stages remain often unrecognized thus reducing the probability of successful prevention and intervention. Moreover, treatment efficacy is affected by the genetics of the individual patient. To identify potential candidate genes for the prediction of diabetes risk and intervention response we linked genetic expression profiles of human skeletal muscle and intermuscular adipose tissue (IMAT) to fasting glucose (FG) and glucose infusion rate (GIR). We found that genes with a strong association to these measures clustered into three distinct expression patterns. Their predictive values for insulin resistance varied strongly between muscle and IMAT. Moreover, we discovered that individual genetic expression based classifications may differ from those classifications based predominantly on clinical parameters indicating a potential incomplete patient stratification. Out of the 15 top hit candidate genes, ...