YUNYANG DENG - Academia.edu (original) (raw)

Papers by YUNYANG DENG

Prostate Cancer and Prostatic Diseases

European Journal of Nutrition

Journal of Digestive Diseases

Clinical Gastroenterology

Cancer Control

Background This study aimed to evaluate the updated burden and temporal trends of cancer incidenc... more Background This study aimed to evaluate the updated burden and temporal trends of cancer incidence and mortality in Asian countries. Methodology The data used in this study were retrieved from the Global Cancer Observatory, Cancer Incidence in Five Continents volumes I-XI, and the World Health Organization mortality database. These data were used to calculate the Average Annual Percentage Change (AAPC), with a 95% confidence interval (CI) by joinpoint regression analysis to determine the epidemiological trend in the past decade. Results In 2020, the cancer incidence in Asia was 169.1 per 1 00 000, accounting for 49.3% of the global cancer incidence. The most common cancers included lung (13.8%), breast (10.8%) and colorectal (10.6%) cancers. Its mortality was 101.6 per 1 00 000 (58.3% of the global cancer death) with lung (19.2%), liver (10.5%) and stomach (9.9%) cancers being the most common causes of cancer death. The cancer incidence had been increasing in female population, with...

Hepatology Communications

BMJ Open

ObjectivesTo perform a systematic review on the characteristics of participants who attended scre... more ObjectivesTo perform a systematic review on the characteristics of participants who attended screening programmes with blood glucose tests, lipid profiles or a combination of them, respectively.DesignSystematic review following the Meta-analysis Of Observational Studies in Epidemiology checklist.Data sourcesPubMed and Medline databases for English literature from 1 January 2000 to 1 April 2020.Eligibility criteriaOriginal observational studies that reported baseline characteristics of apparently healthy adult participants screening for diabetes and lipid disorders were included in this review.Data extractionWe examined their sociodemographic characteristics, including age, gender, body mass index (BMI) and lifestyle habits. The quality of the included articles was evaluated by the Appraisal of Cross-sectional Studies.ResultsA total of 33 articles involving 38 studies in 22 countries were included and analysed in this systematic review. Overall, there was a higher participation rate ...

Gastrointestinal Endoscopy

Background and Aims: This systematic review and meta-analysis aims to compare the pooled diagnost... more Background and Aims: This systematic review and meta-analysis aims to compare the pooled diagnostic accuracy of the currently available esophageal squamous cell carcinoma (ESCC) screening tests. Methods: A comprehensive literature search of Embase and Medline (up to October 31, 2020) was performed to identify eligible studies. We pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio for ESCC screening tools using a bivariate random-effects model. The summary receiver operating characteristic curves with area under the curve (AUC) were plotted for each screening test. Results: We included 161 studies conducted in 81 research articles involving 32,209 subjects. The pooled sensitivity, specificity, and AUC of the major screening tools were respectively as follows: endoscopy (peroral endoscopy): .

Chest, 2022

Lung cancer ranked second for cancer incidence and first for cancer mortality. The investigation ... more Lung cancer ranked second for cancer incidence and first for cancer mortality. The investigation on its risk factors and epidemiologic trends could help describe geographical distribution and identify high-risk population groups. What is the global incidence, mortality, associated risk factors, and temporal trends of lung cancer by sex, age, and country? Data on incidence and mortality were retrieved from the Global Cancer Observatory (GLOBOCAN), Cancer Incidence in Five Continents series I-X (CI5), WHO mortality database, the Nordic Cancer Registries (NORDCAN), and the Surveillance, Epidemiology, and End Results Program (SEER). We searched the WHO Global Health Observatory data repository for age-adjusted prevalence of current smoking. The Average Annual Percentage Change (AAPC) of the trends were obtained by Joinpoint Regression. The age-standardized rate of incidence and mortality were 22.4 and 18.0 per 100,000 globally. The lung cancer incidence and mortality were associated with Human Development Index (HDI), Gross Domestics Products (GDP), and prevalence of smoking. For incidence, more countries had increasing trends in females but decreasing trends in males (AAPC: 1.06 to 6.43 for female; -3.53 to -0.64 for male). Similar pattern was found in those ≥50 years, while those aged <50 years had declining incidence trends in both sexes in most countries. For mortality, similar to incidence, 17/48 countries showed decreasing trends in males and increasing trends in females (AAPC: -3.28 to -1.32 for male, 0.63 to 3.96 for female). Most countries had increasing trends in females but decreasing trends in males and in lung cancer incidence and mortality. Tobacco related measures and screening should be implemented to control the increasing trends of lung cancer in females, and in regions identified as having these trends. Future studies may explore the reasons behind these epidemiological transitions.

Journal of Public Health and Emergency, 2021

Scientific Reports, 2019

Body composition and bone strength are closely associated. How lean mass (LM) and fat mass (FM) c... more Body composition and bone strength are closely associated. How lean mass (LM) and fat mass (FM) contribute to bone strength remains ambiguous. We investigated the associations of total body LM and FM with changes in predicted hip bone strength over a period of 3 years in 1,743 postmenopausal Chinese women from the communities of Guangzhou, China. the body compositions of the women were obtained with dual-energy X-ray absorptiometry. We used the hip structure analysis program to obtain the bone parameters at the femoral neck region, including the bone mineral density (BMD), cross-sectional area (CsA), cortical thickness (Ct), section modulus (sM) and buckling ratio (BR). We found the FM and LM were positive predictors for hip bone strength (β > 0, P < 0.05). The LM had a larger contribution to the BMD, CsA, Ct, sM and/or their annual percent changes (β LM > β FM), while the contribution of FM to the BR and its annual percent change was higher than LM (|β FM | > |β LM |). Further analysis found that the associations of FM and LM with bone parameters were stronger in the underweight and normal weight participants (|β BMI1 | > |β BMI2 |). overall, FM and LM had positive but differential effects on predicted hip bone strength, with a higher impact in the thinner participants.

Gynecologic Oncology, 2021

OBJECTIVES This study aimed to evaluate the most updated worldwide distribution, risk factors, an... more OBJECTIVES This study aimed to evaluate the most updated worldwide distribution, risk factors, and temporal trends of cervical cancer for different countries and age groups. METHODS The Global Cancer Observatory database was retrieved for the age-standardized rates (ASRs, per 100,000 persons) for incidence and mortality of cervical cancer in 2018. The associations with risk factors were examined by multivariable regression analysis, adjusting for human development index (HDI) and gross domestic products (GDP) per capita. Joinpoint regression analysis was used to calculate the 10-year annual average percent change (AAPC) for incidence and mortality. RESULTS A total of 568,847 new cases (ASR, 13.1) and 311,365 deaths (ASR, 6.9) of cervical cancer were reported globally in 2018. The highest incidence and mortality were observed in Southern Africa (ASRs, 43.1 and 20.0) and countries with low HDI (ASRs, 29.8 and 23.0). Countries with higher incidence and mortality had lower HDI (β = -8.19, 95% CI -11.32 to -5.06, p < 0.001; β = -7.66, CI -9.82 to -5.50; p < 0.001) but higher alcohol consumption (β = 1.89, 95% CI 0.59 to 3.19, p = 0.005; β = 0.98, CI 0.08 to 1.88; p = 0.033). An increasing trend of incidence was also observed in younger populations, with Cyprus (AAPC, 6.96), Sweden (AAPC, 4.88), and Norway (AAPC, 3.80) showing the most prominent. CONCLUSIONS The burden of cervical cancer was highest in regions with low and medium HDI and was associated with higher prevalence of alcohol consumption. There was an overall decreasing burden of cervical cancer; however, an increase in incidence and mortality was observed in some populations. More intensive preventive strategies are recommended for these populations.