Yasser Gazar - Academia.edu (original) (raw)

Papers by Yasser Gazar

Research paper thumbnail of The Booster Effect of a Single Quarterly Dose of Hyaluronic Acid in Knee Osteoarthritis: Five-Year Results of a Registry-Based Study

Cureus, Nov 16, 2022

Viscosupplementation by hyaluronic acid (HA) is well established non-surgical treatment of knee o... more Viscosupplementation by hyaluronic acid (HA) is well established non-surgical treatment of knee osteoarthritis (KOA). This registry-based study investigated the booster effect of a quarterly intra-articular single knee injection (30mg/2ml) for five years. Methods Sixty patients, including 29 males and 31 females, with a mean ± SD age 61.07 ± 9.15 with Kellgren-Lawrence grade I-III KOA, have been selected from a registry of interventional treatments for musculoskeletal pain conditions. To be eligible, patients had to be treated with a single quarterly intraarticular injection of HA with a follow-up of at least five years and assessed with Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Numeric Rating Scale (NRS) at baseline and after each HA injection in the first 24 months and at 36, 48, and 60 months. Results Sixty of 63 patients enrolled in this study completed the 60 months of follow-up. Patients had a marked improvement in knee function and pain, expressed by the significant reduction in WOMAC (T0 48.62±8.95 vs. T11 10.75±4.36; p<0.0001) and NRS scores (6.38±1.06 vs. T11 0.95±0.89 p<0.0001) from the baseline to the end of the follow-up period. Conclusion A quarterly injection of HA provides a rapid, safe, and stable long-term reduction of pain and improvement of function in elderly people with mild to moderate knee osteoarthritis along a five-year period of treatment and follow-up. Further investigations are necessary to confirm these findings.

Research paper thumbnail of Efficacy of Ultrasound-Guided Injection of Botulinum Toxin, Ozone, and Lidocaine in Piriformis Syndrome

Healthcare

Background: Piriformis syndrome (PS) is a painful musculoskeletal condition characterized by a de... more Background: Piriformis syndrome (PS) is a painful musculoskeletal condition characterized by a deep gluteal pain that may radiate to the posterior thigh and leg. This study was designed to compare the effectiveness of ozone and BTX to lidocaine injection in treating piriformis syndrome that was resistant to medication and/or physical therapy. Study design: Between November 2018 and August 2019, we involved eighty-four subjects diagnosed with piriformis syndrome in a double-blinded, prospective, randomized comparative study to receive an ultrasound-guided injection of lidocaine (control group), botulinum toxin A, or local ozone (28 patients each group) in the belly of the piriformis muscle. Pain condition evaluated by the visual analog score (VAS) was used as a primary outcome, and the Oswestry Disability Index (ODI) as a secondary outcome, before, at one month, two months, three months, and six months following the injection. Results: The majority (58.3%) of patients were male, whil...

Research paper thumbnail of The Booster Effect of a Single Quarterly Dose of Hyaluronic Acid in Knee Osteoarthritis: Five-Year Results of a Registry-Based Study

Cureus

Viscosupplementation by hyaluronic acid (HA) is well established non-surgical treatment of knee o... more Viscosupplementation by hyaluronic acid (HA) is well established non-surgical treatment of knee osteoarthritis (KOA). This registry-based study investigated the booster effect of a quarterly intra-articular single knee injection (30mg/2ml) for five years. Methods Sixty patients, including 29 males and 31 females, with a mean ± SD age 61.07 ± 9.15 with Kellgren-Lawrence grade I-III KOA, have been selected from a registry of interventional treatments for musculoskeletal pain conditions. To be eligible, patients had to be treated with a single quarterly intraarticular injection of HA with a follow-up of at least five years and assessed with Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Numeric Rating Scale (NRS) at baseline and after each HA injection in the first 24 months and at 36, 48, and 60 months. Results Sixty of 63 patients enrolled in this study completed the 60 months of follow-up. Patients had a marked improvement in knee function and pain, expressed by the significant reduction in WOMAC (T0 48.62±8.95 vs. T11 10.75±4.36; p<0.0001) and NRS scores (6.38±1.06 vs. T11 0.95±0.89 p<0.0001) from the baseline to the end of the follow-up period. Conclusion A quarterly injection of HA provides a rapid, safe, and stable long-term reduction of pain and improvement of function in elderly people with mild to moderate knee osteoarthritis along a five-year period of treatment and follow-up. Further investigations are necessary to confirm these findings.

Research paper thumbnail of Nailfold Capillaroscopy in Early Stages of Mixed Connective Tissue Disease in a Sample of Egyptian Patients

Indian Journal of Rheumatology, 2022

Research paper thumbnail of POS1278 THE Prevalence and Clinical Significance of Ultrasonographic Findings of Distal Medial Hamstring Tendons in Patients with Posteromedial Knee Pain

Annals of the Rheumatic Diseases, 2021

Periarticular abnormalities are common ultrasonographic (U/S) findings in individuals with knee p... more Periarticular abnormalities are common ultrasonographic (U/S) findings in individuals with knee pain. Incidental U/S observations, including thickening of the distal hamstring tendons, require explanations for their clinical importance. Tendon thickness may be a good indicator of tendinopathy and tendon dysfunction. Also, it is uncertain whether these tendon changes are correlated with knee pain or not?The aim of this study was to determine U/S findings of distal medial hamstring tendons in patients with posteromedial (PM) knee pain and assess the diagnostic values of tendon thickness in predicting tendinopathy.We studied distal medial hamstring tendons (semimembranosus [SM] and semitendinosus [ST]) of 104 patients (104 knees) with non-traumatic unilateral PM knee pain and 118 healthy controls (236 knees). U/S evaluations included tendon thickness, echogenicity, the presence of intrasubstance tears, calcification, and vascularity.The mean age (standard deviation) of the patients and...

Research paper thumbnail of AB0076 THE Role of Macrophage Migration Inhibitory Factor in Activity and Progression of Ankylosing Spondylitis

Annals of the Rheumatic Diseases, 2021

Background:Ankylosing Spondylitis (AS) is a chronic inflammatory form of arthritis that predomina... more Background:Ankylosing Spondylitis (AS) is a chronic inflammatory form of arthritis that predominantly affects the axial joints and has a global prevalence of 1%. Disease progression is marked by osteoproliferation and bone fusion in the axial joints, causing considerable loss of mobility. Migration Inhibitory Factor (MIF) is a potent pro-inflammatory cytokine implicated in several diseases. Elevated serum MIF levels have been reported in AS the role of MIF in bone formation has been a subject of controversy.Objectives:Detection the level of Migration Inhibitory Factor in Ankylosing Spondylitis patients and correlate the level with disease activity and progression.Methods:This cross-sectional case-control study were concluded upon 70 randomly selected people from internal medicine department in Kobry El-kobba Military Hospital and from rheumatology and rehabilitation department in EL-Hussein university hospital. The population study were divided into two groups: Group A: (50) Patient...

Research paper thumbnail of Bone marrow lesion in advanced osteoarthritis of the knees. Correlation study between histopathological findings and structural damage

Annals of Physical and Rehabilitation Medicine, 2018

Research paper thumbnail of AB0323 Relationshib between serum levels of leptin & homocystein in rheumatoid arthritis patients with or without extra articular manifestations

Rheumatoid arthritis – prognosis, predictors and outcome, 2018

Research paper thumbnail of SAT0553 Detection of serum level changes of matrix metalloprotienase-13 and inter leukin-1 beta during remission and flare-ups of primary osteoarthritis of the knees

Poster Presentations, 2017

improvements over placebo were seen in 0.03 mg and 0.07 mg treatment arms, achieving statistical ... more improvements over placebo were seen in 0.03 mg and 0.07 mg treatment arms, achieving statistical significance for PTGA and MDGA. Further studies to identify relevant sub-populations and evaluate the safety and efficacy of SM04690 are ongoing.

Research paper thumbnail of Bilateral Avascular Necrosis of the Femoral Heads After Covid-19 Infection without Steroid Treatment

Current Rheumatology Reviews

Background: Avascular necrosis (AVN) is a potentially serious multifactorial disease. In COVID-19... more Background: Avascular necrosis (AVN) is a potentially serious multifactorial disease. In COVID-19 patients, AVN of many bones has been reported. Usually, the condition is linked to steroid therapy. In this case report, we describe our experience with bilateral AVN of femoral heads in an elderly patient months after being cured of COVID-19 infection without the use of steroids. Case Presentation: A 68-year-old male was referred to the outpatient clinic of the rheumatology and rehabilitation department for progressive bilateral hip pain starting on the left side 5 months ago. An extensive review of the patient’s medical history identified documented COVID-19 infection that required hospitalization 9 months before presentation. Multiplanar MRI with fat suppression of both hips showed ill-defined areas of abnormal signal intensity affecting the left femoral head, neck and intertrochanteric regions with associated subchondral fissuring and mild joint effusion. A similar smaller area was ...

Research paper thumbnail of Bacterial Compositional Shifts of Gut Microbiomes in Patients with Rheumatoid Arthritis in Association with Disease Activity

Microorganisms

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disabling autoimmune disorder. Li... more Background: Rheumatoid arthritis (RA) is a chronic inflammatory disabling autoimmune disorder. Little is known regarding the association between the gut microbiome and etiopathogenesis of RA. We aimed to dissect the differences in gut microbiomes associated with RA in comparison to healthy individuals and, in addition, to identify the shifts in the bacterial community in association with disease activity; Methods: In order to identify compositional shifts in gut microbiomes of RA patients, V3-V4 hypervariable regions of 16S rRNA were sequenced using Illumina MiSeq. In total, sixty stool samples were collected from 45 patients with RA besides 15 matched healthy subjects; Results: Notably, RA microbiomes were significantly associated with diverse bacterial communities compared with healthy individuals. Likewise, a direct association between bacterial diversity and disease activity was detected in RA patients (Kruskal Wallis; p = 0.00047). In general, genus-level analysis revealed a po...

Research paper thumbnail of Relationship Between Serum Level of Homocysteine, Leptin and Neopterin and Disease Activity in Rheumatoid Arthritis patients with or without Extra-articular Manifestations

Minia Journal of Medical Research

Objectives: this study was aimed to determine serum homocysteine, leptin and neopterin levels in ... more Objectives: this study was aimed to determine serum homocysteine, leptin and neopterin levels in patients with RA and investigate the relationship between clinical and laboratory parameters of disease activity and presence or absence of extra-articular manifestations. Patients and methods: This study included 80 RA patients (16 males, 64 females; mean age 34.5±10.8 years; range 24.5 to 45.3 years) and age and sex-matched 80 healthy controls (16 males, 64 females, mean age 30.8 ± 10.4 range 20 to 65). RA patients were divided into two groups (A&B) depending on the presence or absence of Extra-articular manifestations. Of the patients, there was 40 patients with no Extra-articular while the other 40 with Extra-articular (9 patients with Cutaneous vasculitis, 7 with Nodules, 6 with Neuropathy, 5 with Reynaud's phenomenon ,7 with 2 nd ry. Sjogren, 2 with Fealty's syndrome, 2 with Interstitial nephritis, 2 with Interstitial lung disease). Results: In the RA group (A+B), mean serum Hcy, leptin and neopterin levels were (11.79 + 8.72 μmol/L), (22.43 ± 7.37 ng/ml) & (3.83±1.84 nmol/L) respectively with No statistically significant difference was found between RA and control groups regarding serum Leptin (p=0.674). While a significant difference was found between RA and control groups regarding serum Neopetrin (< 0.001) &Hcy. (< 0.001). Also, In RA groups (A, B) there was a statistically significant difference regarding serum Neopterin (p< 0.03) and DAS 28 ESR (p< 0.05). there was a Positive significant correlation between serum (neopterin-Hcy) and ESR, TNF-α, IL-6, and DAS-28 (p < 0.05) while no significant correlation was found between serum (neopterin-Hcy) and CRP (p > 0.05). Conclusion: Serum leptin cannot be considered of value as an inflammation marker in monitoring RA patients while Serum neopterin can be used as a sensitive marker for assaying background inflammation and disease activity score in RA patients while serum homocysteine can be used as a marker for probability of extra articular complication of RA.

Research paper thumbnail of The Relationship Between Pain Pattern and Disability in Patients with Knee Osteoarthritis

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Early detection of Asymptomatic Myocardial Dysfunctions in Rheumatoid Arthritis Patients: A New Approach

International Journal of Medical Arts, 2022

Research paper thumbnail of Evaluation of Nailfold Capillaroscopy Pattern in patients with Primary Osteoarthritis of the Hands

Al-Azhar International Medical Journal, 2021

Background: Hand osteoarthritis (OA) can be a distressing disorder that impairs a patients' q... more Background: Hand osteoarthritis (OA) can be a distressing disorder that impairs a patients' quality of life. There is a relation between OA and vascular damage, especially atherosclerosis, and OA are both common chronic conditions associated with aging and obesity. Aim of The Work: To examine nailfold microcirculation in individuals with hand OA for early detection and differentiation from other mimics. Patients and Methods: In this cross-sectional, observational study, about 56 patients with hand OA (mean age 56.2 ± 8.4years) were enrolled. All subjects underwent a standard radiology X-Ray examination of the hands, and the Kellgren–Lawrence (K-L) radiographic grading scale has been applied. Nailfold vascular examination was performed. Results: With a mean age of 56 years, 44 (78.6%) of the 56 patients studied were females, and 12 were males. Kellgren and Lawrence scoring was mild (grade II) in one patient (50%) and severe (grade IV) in one patient (50%) in the male patients wit...

Research paper thumbnail of AB0950 EFFECT of Selective Serotonin Reuptake Inhibitors and Serotonin Norepinephrine Reuptake Inhibitors on Bone Mineral Density in Egyption Patients with Primary Fibromyalgia

Annals of the Rheumatic Diseases, 2020

Research paper thumbnail of AB0978 NEUROLOGICAL Manifestations of Pediatric Systemic Lupus Erythemtosus in Egyption Patients

Abstracts Accepted for Publication, 2019

Research paper thumbnail of SAT0542 DETECTION of Subclinical LV Myocardial Dysfunction in Rheumatoid Arthritis Patients by Speckle Tracking

Annals of the Rheumatic Diseases, 2019

Background Patients with rheumatoid arthritis (RA) have shorter life expectancy and their risk of... more Background Patients with rheumatoid arthritis (RA) have shorter life expectancy and their risk of cardiovascular (CV) death is more than 50% higher than the rest of the population. Early myocardial dysfunction may be detectable more precisely and sooner using speckle tracking echocardiography. Objectives This study was designed to assess myocardial (LV) systolic function by STE (speckletracking Echocardiography) strain imaging in patients with RA without known CVD and to correlate the findings with characters of the disease. Methods Cross-sectional observational study enrolled 60 patients with RA (mean age 46.22 ± 8.14 years) without known CVD, and 20 healthy controls. All subjects underwent a standard echocardiographic examination as well as the speckle tracking assessment of left ventricle strains. Results Speckle-tracking assessment of LV systolic function revealed decreased GLS among the patients group (-16.80% vs. -22.35%, P<0.001). There was a negative correlation between t...

Research paper thumbnail of Serum Renalase Level as A Marker of Activity and Severity in Lupus Nephritis Cases

European Journal of Applied Sciences, 2021

- Introduction: Lupus nephritis (LN) is a substantial risk factor for death and morbidity in pa... more - Introduction:
Lupus nephritis (LN) is a substantial risk factor for death and morbidity in patients with Systemic Lupus Erythematosus (SLE) (SLE). Despite excellent immunosuppressive therapy, it nevertheless leads to a disproportionate percentage of persons developing chronic kidney disease (CKD) or end-stage renal disease (ESRD). Renalase is a distinctive cytokine-like protein generated by the kidneys that promote cell survival. It has been recently linked to the etiology of LN and may be an ideal candidate as a sensitive biomarker for flare-ups and LN remission.
-Aim of the work:
The purpose of this study was to evaluate the utility of human serum renalase as a biomarker for assessing disease activity and severity in SLE, as well as to evaluate if it can be used as a sensitive biomarker in this capacity.
-Methods:
This study consists of around 23 healthy controls and 46 individuals with LN. These participants were separated into two equal groups according to disease activity as determined by the SLEDAI (SLE Disease Activity Index): 23 cases with LN who had disease activity and 23 cases who did not. The concentration of human serum Renalase (RNLS) was evaluated using a very sensitive commercial enzyme immunoassay that captures renalase from serum using (RNLS) antibody.
- Results:
Renalase concentrations were significantly greater in LN cases than in healthy controls (P-value <0.001). Additionally, cases with active LN exhibited significantly greater serum renalase concentrations than those with inactive LN (P-value <0.005). Serum renalase concentrations were positively connected with 24-h urine protein excretion, SLEDAI, ESR, CRP, and ds-DNA but were negatively related to serum C3 and the class (particularly in the proliferative type) (Class III, IV, more than class V).
-Conclusion:
Serum renalase levels were associated with disease symptoms in LN and may serve as a biomarker for disease activity in LN.

Research paper thumbnail of Detection of Serum Level Changes of Matrix METALLOPROTIENASE-13 and Inter LEUKIN-1 Beta During Remission and Flare-Ups of Primary Osteoarthritis of the Knees

Research paper thumbnail of The Booster Effect of a Single Quarterly Dose of Hyaluronic Acid in Knee Osteoarthritis: Five-Year Results of a Registry-Based Study

Cureus, Nov 16, 2022

Viscosupplementation by hyaluronic acid (HA) is well established non-surgical treatment of knee o... more Viscosupplementation by hyaluronic acid (HA) is well established non-surgical treatment of knee osteoarthritis (KOA). This registry-based study investigated the booster effect of a quarterly intra-articular single knee injection (30mg/2ml) for five years. Methods Sixty patients, including 29 males and 31 females, with a mean ± SD age 61.07 ± 9.15 with Kellgren-Lawrence grade I-III KOA, have been selected from a registry of interventional treatments for musculoskeletal pain conditions. To be eligible, patients had to be treated with a single quarterly intraarticular injection of HA with a follow-up of at least five years and assessed with Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Numeric Rating Scale (NRS) at baseline and after each HA injection in the first 24 months and at 36, 48, and 60 months. Results Sixty of 63 patients enrolled in this study completed the 60 months of follow-up. Patients had a marked improvement in knee function and pain, expressed by the significant reduction in WOMAC (T0 48.62±8.95 vs. T11 10.75±4.36; p<0.0001) and NRS scores (6.38±1.06 vs. T11 0.95±0.89 p<0.0001) from the baseline to the end of the follow-up period. Conclusion A quarterly injection of HA provides a rapid, safe, and stable long-term reduction of pain and improvement of function in elderly people with mild to moderate knee osteoarthritis along a five-year period of treatment and follow-up. Further investigations are necessary to confirm these findings.

Research paper thumbnail of Efficacy of Ultrasound-Guided Injection of Botulinum Toxin, Ozone, and Lidocaine in Piriformis Syndrome

Healthcare

Background: Piriformis syndrome (PS) is a painful musculoskeletal condition characterized by a de... more Background: Piriformis syndrome (PS) is a painful musculoskeletal condition characterized by a deep gluteal pain that may radiate to the posterior thigh and leg. This study was designed to compare the effectiveness of ozone and BTX to lidocaine injection in treating piriformis syndrome that was resistant to medication and/or physical therapy. Study design: Between November 2018 and August 2019, we involved eighty-four subjects diagnosed with piriformis syndrome in a double-blinded, prospective, randomized comparative study to receive an ultrasound-guided injection of lidocaine (control group), botulinum toxin A, or local ozone (28 patients each group) in the belly of the piriformis muscle. Pain condition evaluated by the visual analog score (VAS) was used as a primary outcome, and the Oswestry Disability Index (ODI) as a secondary outcome, before, at one month, two months, three months, and six months following the injection. Results: The majority (58.3%) of patients were male, whil...

Research paper thumbnail of The Booster Effect of a Single Quarterly Dose of Hyaluronic Acid in Knee Osteoarthritis: Five-Year Results of a Registry-Based Study

Cureus

Viscosupplementation by hyaluronic acid (HA) is well established non-surgical treatment of knee o... more Viscosupplementation by hyaluronic acid (HA) is well established non-surgical treatment of knee osteoarthritis (KOA). This registry-based study investigated the booster effect of a quarterly intra-articular single knee injection (30mg/2ml) for five years. Methods Sixty patients, including 29 males and 31 females, with a mean ± SD age 61.07 ± 9.15 with Kellgren-Lawrence grade I-III KOA, have been selected from a registry of interventional treatments for musculoskeletal pain conditions. To be eligible, patients had to be treated with a single quarterly intraarticular injection of HA with a follow-up of at least five years and assessed with Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Numeric Rating Scale (NRS) at baseline and after each HA injection in the first 24 months and at 36, 48, and 60 months. Results Sixty of 63 patients enrolled in this study completed the 60 months of follow-up. Patients had a marked improvement in knee function and pain, expressed by the significant reduction in WOMAC (T0 48.62±8.95 vs. T11 10.75±4.36; p<0.0001) and NRS scores (6.38±1.06 vs. T11 0.95±0.89 p<0.0001) from the baseline to the end of the follow-up period. Conclusion A quarterly injection of HA provides a rapid, safe, and stable long-term reduction of pain and improvement of function in elderly people with mild to moderate knee osteoarthritis along a five-year period of treatment and follow-up. Further investigations are necessary to confirm these findings.

Research paper thumbnail of Nailfold Capillaroscopy in Early Stages of Mixed Connective Tissue Disease in a Sample of Egyptian Patients

Indian Journal of Rheumatology, 2022

Research paper thumbnail of POS1278 THE Prevalence and Clinical Significance of Ultrasonographic Findings of Distal Medial Hamstring Tendons in Patients with Posteromedial Knee Pain

Annals of the Rheumatic Diseases, 2021

Periarticular abnormalities are common ultrasonographic (U/S) findings in individuals with knee p... more Periarticular abnormalities are common ultrasonographic (U/S) findings in individuals with knee pain. Incidental U/S observations, including thickening of the distal hamstring tendons, require explanations for their clinical importance. Tendon thickness may be a good indicator of tendinopathy and tendon dysfunction. Also, it is uncertain whether these tendon changes are correlated with knee pain or not?The aim of this study was to determine U/S findings of distal medial hamstring tendons in patients with posteromedial (PM) knee pain and assess the diagnostic values of tendon thickness in predicting tendinopathy.We studied distal medial hamstring tendons (semimembranosus [SM] and semitendinosus [ST]) of 104 patients (104 knees) with non-traumatic unilateral PM knee pain and 118 healthy controls (236 knees). U/S evaluations included tendon thickness, echogenicity, the presence of intrasubstance tears, calcification, and vascularity.The mean age (standard deviation) of the patients and...

Research paper thumbnail of AB0076 THE Role of Macrophage Migration Inhibitory Factor in Activity and Progression of Ankylosing Spondylitis

Annals of the Rheumatic Diseases, 2021

Background:Ankylosing Spondylitis (AS) is a chronic inflammatory form of arthritis that predomina... more Background:Ankylosing Spondylitis (AS) is a chronic inflammatory form of arthritis that predominantly affects the axial joints and has a global prevalence of 1%. Disease progression is marked by osteoproliferation and bone fusion in the axial joints, causing considerable loss of mobility. Migration Inhibitory Factor (MIF) is a potent pro-inflammatory cytokine implicated in several diseases. Elevated serum MIF levels have been reported in AS the role of MIF in bone formation has been a subject of controversy.Objectives:Detection the level of Migration Inhibitory Factor in Ankylosing Spondylitis patients and correlate the level with disease activity and progression.Methods:This cross-sectional case-control study were concluded upon 70 randomly selected people from internal medicine department in Kobry El-kobba Military Hospital and from rheumatology and rehabilitation department in EL-Hussein university hospital. The population study were divided into two groups: Group A: (50) Patient...

Research paper thumbnail of Bone marrow lesion in advanced osteoarthritis of the knees. Correlation study between histopathological findings and structural damage

Annals of Physical and Rehabilitation Medicine, 2018

Research paper thumbnail of AB0323 Relationshib between serum levels of leptin & homocystein in rheumatoid arthritis patients with or without extra articular manifestations

Rheumatoid arthritis – prognosis, predictors and outcome, 2018

Research paper thumbnail of SAT0553 Detection of serum level changes of matrix metalloprotienase-13 and inter leukin-1 beta during remission and flare-ups of primary osteoarthritis of the knees

Poster Presentations, 2017

improvements over placebo were seen in 0.03 mg and 0.07 mg treatment arms, achieving statistical ... more improvements over placebo were seen in 0.03 mg and 0.07 mg treatment arms, achieving statistical significance for PTGA and MDGA. Further studies to identify relevant sub-populations and evaluate the safety and efficacy of SM04690 are ongoing.

Research paper thumbnail of Bilateral Avascular Necrosis of the Femoral Heads After Covid-19 Infection without Steroid Treatment

Current Rheumatology Reviews

Background: Avascular necrosis (AVN) is a potentially serious multifactorial disease. In COVID-19... more Background: Avascular necrosis (AVN) is a potentially serious multifactorial disease. In COVID-19 patients, AVN of many bones has been reported. Usually, the condition is linked to steroid therapy. In this case report, we describe our experience with bilateral AVN of femoral heads in an elderly patient months after being cured of COVID-19 infection without the use of steroids. Case Presentation: A 68-year-old male was referred to the outpatient clinic of the rheumatology and rehabilitation department for progressive bilateral hip pain starting on the left side 5 months ago. An extensive review of the patient’s medical history identified documented COVID-19 infection that required hospitalization 9 months before presentation. Multiplanar MRI with fat suppression of both hips showed ill-defined areas of abnormal signal intensity affecting the left femoral head, neck and intertrochanteric regions with associated subchondral fissuring and mild joint effusion. A similar smaller area was ...

Research paper thumbnail of Bacterial Compositional Shifts of Gut Microbiomes in Patients with Rheumatoid Arthritis in Association with Disease Activity

Microorganisms

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disabling autoimmune disorder. Li... more Background: Rheumatoid arthritis (RA) is a chronic inflammatory disabling autoimmune disorder. Little is known regarding the association between the gut microbiome and etiopathogenesis of RA. We aimed to dissect the differences in gut microbiomes associated with RA in comparison to healthy individuals and, in addition, to identify the shifts in the bacterial community in association with disease activity; Methods: In order to identify compositional shifts in gut microbiomes of RA patients, V3-V4 hypervariable regions of 16S rRNA were sequenced using Illumina MiSeq. In total, sixty stool samples were collected from 45 patients with RA besides 15 matched healthy subjects; Results: Notably, RA microbiomes were significantly associated with diverse bacterial communities compared with healthy individuals. Likewise, a direct association between bacterial diversity and disease activity was detected in RA patients (Kruskal Wallis; p = 0.00047). In general, genus-level analysis revealed a po...

Research paper thumbnail of Relationship Between Serum Level of Homocysteine, Leptin and Neopterin and Disease Activity in Rheumatoid Arthritis patients with or without Extra-articular Manifestations

Minia Journal of Medical Research

Objectives: this study was aimed to determine serum homocysteine, leptin and neopterin levels in ... more Objectives: this study was aimed to determine serum homocysteine, leptin and neopterin levels in patients with RA and investigate the relationship between clinical and laboratory parameters of disease activity and presence or absence of extra-articular manifestations. Patients and methods: This study included 80 RA patients (16 males, 64 females; mean age 34.5±10.8 years; range 24.5 to 45.3 years) and age and sex-matched 80 healthy controls (16 males, 64 females, mean age 30.8 ± 10.4 range 20 to 65). RA patients were divided into two groups (A&B) depending on the presence or absence of Extra-articular manifestations. Of the patients, there was 40 patients with no Extra-articular while the other 40 with Extra-articular (9 patients with Cutaneous vasculitis, 7 with Nodules, 6 with Neuropathy, 5 with Reynaud's phenomenon ,7 with 2 nd ry. Sjogren, 2 with Fealty's syndrome, 2 with Interstitial nephritis, 2 with Interstitial lung disease). Results: In the RA group (A+B), mean serum Hcy, leptin and neopterin levels were (11.79 + 8.72 μmol/L), (22.43 ± 7.37 ng/ml) & (3.83±1.84 nmol/L) respectively with No statistically significant difference was found between RA and control groups regarding serum Leptin (p=0.674). While a significant difference was found between RA and control groups regarding serum Neopetrin (< 0.001) &Hcy. (< 0.001). Also, In RA groups (A, B) there was a statistically significant difference regarding serum Neopterin (p< 0.03) and DAS 28 ESR (p< 0.05). there was a Positive significant correlation between serum (neopterin-Hcy) and ESR, TNF-α, IL-6, and DAS-28 (p < 0.05) while no significant correlation was found between serum (neopterin-Hcy) and CRP (p > 0.05). Conclusion: Serum leptin cannot be considered of value as an inflammation marker in monitoring RA patients while Serum neopterin can be used as a sensitive marker for assaying background inflammation and disease activity score in RA patients while serum homocysteine can be used as a marker for probability of extra articular complication of RA.

Research paper thumbnail of The Relationship Between Pain Pattern and Disability in Patients with Knee Osteoarthritis

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Early detection of Asymptomatic Myocardial Dysfunctions in Rheumatoid Arthritis Patients: A New Approach

International Journal of Medical Arts, 2022

Research paper thumbnail of Evaluation of Nailfold Capillaroscopy Pattern in patients with Primary Osteoarthritis of the Hands

Al-Azhar International Medical Journal, 2021

Background: Hand osteoarthritis (OA) can be a distressing disorder that impairs a patients' q... more Background: Hand osteoarthritis (OA) can be a distressing disorder that impairs a patients' quality of life. There is a relation between OA and vascular damage, especially atherosclerosis, and OA are both common chronic conditions associated with aging and obesity. Aim of The Work: To examine nailfold microcirculation in individuals with hand OA for early detection and differentiation from other mimics. Patients and Methods: In this cross-sectional, observational study, about 56 patients with hand OA (mean age 56.2 ± 8.4years) were enrolled. All subjects underwent a standard radiology X-Ray examination of the hands, and the Kellgren–Lawrence (K-L) radiographic grading scale has been applied. Nailfold vascular examination was performed. Results: With a mean age of 56 years, 44 (78.6%) of the 56 patients studied were females, and 12 were males. Kellgren and Lawrence scoring was mild (grade II) in one patient (50%) and severe (grade IV) in one patient (50%) in the male patients wit...

Research paper thumbnail of AB0950 EFFECT of Selective Serotonin Reuptake Inhibitors and Serotonin Norepinephrine Reuptake Inhibitors on Bone Mineral Density in Egyption Patients with Primary Fibromyalgia

Annals of the Rheumatic Diseases, 2020

Research paper thumbnail of AB0978 NEUROLOGICAL Manifestations of Pediatric Systemic Lupus Erythemtosus in Egyption Patients

Abstracts Accepted for Publication, 2019

Research paper thumbnail of SAT0542 DETECTION of Subclinical LV Myocardial Dysfunction in Rheumatoid Arthritis Patients by Speckle Tracking

Annals of the Rheumatic Diseases, 2019

Background Patients with rheumatoid arthritis (RA) have shorter life expectancy and their risk of... more Background Patients with rheumatoid arthritis (RA) have shorter life expectancy and their risk of cardiovascular (CV) death is more than 50% higher than the rest of the population. Early myocardial dysfunction may be detectable more precisely and sooner using speckle tracking echocardiography. Objectives This study was designed to assess myocardial (LV) systolic function by STE (speckletracking Echocardiography) strain imaging in patients with RA without known CVD and to correlate the findings with characters of the disease. Methods Cross-sectional observational study enrolled 60 patients with RA (mean age 46.22 ± 8.14 years) without known CVD, and 20 healthy controls. All subjects underwent a standard echocardiographic examination as well as the speckle tracking assessment of left ventricle strains. Results Speckle-tracking assessment of LV systolic function revealed decreased GLS among the patients group (-16.80% vs. -22.35%, P<0.001). There was a negative correlation between t...

Research paper thumbnail of Serum Renalase Level as A Marker of Activity and Severity in Lupus Nephritis Cases

European Journal of Applied Sciences, 2021

- Introduction: Lupus nephritis (LN) is a substantial risk factor for death and morbidity in pa... more - Introduction:
Lupus nephritis (LN) is a substantial risk factor for death and morbidity in patients with Systemic Lupus Erythematosus (SLE) (SLE). Despite excellent immunosuppressive therapy, it nevertheless leads to a disproportionate percentage of persons developing chronic kidney disease (CKD) or end-stage renal disease (ESRD). Renalase is a distinctive cytokine-like protein generated by the kidneys that promote cell survival. It has been recently linked to the etiology of LN and may be an ideal candidate as a sensitive biomarker for flare-ups and LN remission.
-Aim of the work:
The purpose of this study was to evaluate the utility of human serum renalase as a biomarker for assessing disease activity and severity in SLE, as well as to evaluate if it can be used as a sensitive biomarker in this capacity.
-Methods:
This study consists of around 23 healthy controls and 46 individuals with LN. These participants were separated into two equal groups according to disease activity as determined by the SLEDAI (SLE Disease Activity Index): 23 cases with LN who had disease activity and 23 cases who did not. The concentration of human serum Renalase (RNLS) was evaluated using a very sensitive commercial enzyme immunoassay that captures renalase from serum using (RNLS) antibody.
- Results:
Renalase concentrations were significantly greater in LN cases than in healthy controls (P-value <0.001). Additionally, cases with active LN exhibited significantly greater serum renalase concentrations than those with inactive LN (P-value <0.005). Serum renalase concentrations were positively connected with 24-h urine protein excretion, SLEDAI, ESR, CRP, and ds-DNA but were negatively related to serum C3 and the class (particularly in the proliferative type) (Class III, IV, more than class V).
-Conclusion:
Serum renalase levels were associated with disease symptoms in LN and may serve as a biomarker for disease activity in LN.

Research paper thumbnail of Detection of Serum Level Changes of Matrix METALLOPROTIENASE-13 and Inter LEUKIN-1 Beta During Remission and Flare-Ups of Primary Osteoarthritis of the Knees