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Papers by Yazmín Amelia Chirino-Barceló

Revista Médicas UIS, Dec 1, 2013

Introducción: los avances en la medicina perinatal en sociedades con mayor desarrollo industrial,... more Introducción: los avances en la medicina perinatal en sociedades con mayor desarrollo industrial, han generado reducción en las tasas de mortalidad neonatal con una gradual disminución en la edad gestacional con posibilidades de supervivencia. Objetivo: analizar los elementos bioéticos considerados en la toma de decisiones para establecer los límites de viabilidad en el recién nacido. Metodología: se realizó una búsqueda bibliográfica en distintas fuentes y bases de datos electrónicas sobre los aspectos éticos, legal y humanista en relación con el límite de la viabilidad en los recién nacidos. Resultados y conclusiones: se describen dos escenarios clínicos, que son la plataforma para ejemplificar e iniciar el análisis del dilema ético que condiciona el límite de la viabilidad; se discute la zona gris de la neonatología de acuerdo a tasas de sobrevivencia y tasas de mortalidad en distintos países con diferentes características, dividiéndolos en países desarrollados o subdesarrollados. Se realiza el análisis bioético del dilema, en base a las teorías éticas y modelos de discernimiento:

Acta dermato-venereologica, Jan 4, 2023

Anales médicos (México, D.F.), 2013

Surgical site infections (SSI) are identified as a frequent cause of nosocomial infections in chi... more Surgical site infections (SSI) are identified as a frequent cause of nosocomial infections in children's hospitals and it is considered that antimicrobial prophylaxis can prevent SSI. The objective of the study was to examine if the Department of Pediatrics Surgery from a Tertiary Center follow international guidelines for surgical antimicrobial prophylaxis. The design was a crosssectional observational, retrolective study of 81 patients younger than 18 years old, who underwent a surgical intervention between December 2008 and April 2009 by the cardiovascular surgical, general surgical and neurosurgical wards of the Hospital Infantil de Mexico (HIMFG). We registered 99 procedures, six were excluded, two because the patient died within 24 hours of the surgery and four because of lack of information in their files. For the analysis we evaluated 93 procedures in 76 patients since 11 patients underwent two or more surgical interventions. Of the 76 procedures that used antimicrobial prophylaxis, five (6.5%) followed international guidelines for correct antibiotic use. Three cases (3.2%) reported a superficial SSI diagnosed around 14.6 days after surgery. For the population studied we concluded that the antimicrobial prophylaxis is properly applied in 6.5% of the cases. The sample size was too small to calculate the incidence or demonstrate association between the principles of antimicrobial prophylaxis and SSI.

British Journal of Clinical Pharmacology, 2002

Aims To monitor plasma caffeine concentrations and adverse effects and to study the pharmacokinet... more Aims To monitor plasma caffeine concentrations and adverse effects and to study the pharmacokinetics of caffeine in neonatal apnoea in the local Asian population after intravenous administration of caffeine. Methods Eighteen neonates with apnoea were treated with caffeine citrate at a loading dose of 10 mg caffeine base kg x1 and a maintenance dose of 2.5 mg kg x1 day x1. Blood samples, three after loading and two after the maintenance dose on day 2, 3, 7, 14 and 21 were taken and analysed for caffeine and its main metabolites using solid phase extraction and h.p.l.c. Adverse effects were monitored. Sparse data pharmacokinetic analysis was performed using P-Pharm. Results Mean caffeine concentrations varied from 10 to 20 mg l x1 throughout treatment (range 3.6-28.4 mg l x1). These concentrations were efficacious; less so in those with lower concentrations. Adverse effects included gastrointestinal disturbances, diuresis and hyperglycaemia. Pharmacokinetic parameter estimates [mean (coefficient of variation%)] were CL=0.00628 (17.5%) l h x1 and V=0.961 (20.3%) l. CL (l h x1)=0.004248 * wt(kg)+0.00154; r=0.8, P<0.01, explained 64% of the variation. V (l)=0.6299 * wt(kg)+0.259; r=0.67, P<0.01, explained 45% of variation. Model-predicted compared with observed plasma concentrations in a separate group of 10 neonates were unbiased and of good precision. Conclusions The dosing regimen studied was suitable for our local Asian neonates as it resulted in therapeutic caffeine concentrations for adequate treatment of apnoea. Adverse effects were tolerable. Therefore, to avoid a higher incidence of adverse effects, this regimen should be retained and not increased as proposed by other workers. CL and V were within values of those reported for neonatal apnoea. Sparse data analysis showed that weight alone was adequate as the influential variable for the accurate prediction of individual pharmacokinetic parameters, plasma concentrations and for dosage adjustment if required.

Anales Médicos de la Asociación Médica del Centro Médico ABC

Bol Med Hosp Infant …, 2010

In this paper we discuss different aspects of palliative care in pediatrics and how the definitio... more In this paper we discuss different aspects of palliative care in pediatrics and how the definition has changed and evolved. We also define what a terminally ill patient is, list the objectives of care, and how to implement care practices. We describe different ways to diminish physical, social, emotional and spiritual suffering. The dying process is described according to the different stages of child development. The spiritual aspects are now considered an important part of the approach with children. We must keep in mind the different barriers that we may encounter when we initiate palliative care. Education and further research is still needed to improve care and to achieve better results.

PLOS Pathogens, 2013

(A) Time course evaluation of caspase 3, 8, and 9 activation and PARP... more (A) Time course evaluation of caspase 3, 8, and 9 activation and PARP cleavage in EV71-infected HeLa cells (MOI = 10). (B) Effects of caspase and proteasome inhibitors on EV71 induced MAVS cleavage. HeLa cells were mock infected (lane 1) or infected with EV71 (MOI = 10) in the absence (blank, lane 2) or presence of Z-VAD-FMK (ZVAD) (100 µM, lane 3), MG132 (20 µM, lane 4), or both (lane 5). At the 24 h post-infection time point, the cells were harvested and western blot was used to detect MAVS and its cleavage fragments using the anti-MAVS AT107 antibody. (C) Effects of caspase and proteasome inhibitors on IRF3 dimerization. The inhibitor concentrations used in this experiment were the same as in (B).</p