Mohammad Zarandi - Academia.edu (original) (raw)

Papers by Mohammad Zarandi

Research paper thumbnail of A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming

Research paper thumbnail of Synthesis and Applications of Porphyrin-Biomacromolecule Conjugates

Frontiers in Chemistry, 2021

With potential applications in materials and especially in light-responsive biomedicine that targ... more With potential applications in materials and especially in light-responsive biomedicine that targets cancer tissue selectively, much research has focused on developing covalent conjugation techniques to tether porphyrinoid units to various biomacromolecules. This review details the key synthetic approaches that have been employed in the recent decades to conjugate porphyrinoids with oligonucleotides and peptides/proteins. In addition, we provide succinct discussions on the subsequent applications of such hybrid systems and also give a brief overview of the rapidly progressing field of porphyrin-antibody conjugates. Since nucleic acid and peptide systems vary in structure, connectivity, functional group availability and placement, as well as stability and solubility, tailored synthetic approaches are needed for conjugating to each of these biomacromolecule types. In terms of tethering to ONs, porphyrins are typically attached by employing bioorthogonal chemistry (e.g., using phosphor...

Research paper thumbnail of Comparison Between Topological Properties Of Hyperx And Generalized Hypercube For Interconnection Networks

Journal of Mathematics and Computer Science, 2014

In order to design an interconnection network, it is essential to have a comprehensive understand... more In order to design an interconnection network, it is essential to have a comprehensive understanding about properties and limitations of the network. These properties and limitations are characterized by the topology of the network. Since a topology sets constraints and costs, it plays a critical role in all interconnection networks. Different topologies have been proposed for interconnection networks in literature. The Generalized Hypercube is one of the oldest topologies that can be mentioned. Recently a group of researchers at HP Lab have introduced a new topology for these networks, called HyperX. Despite of many similarities between these two topologies, there are significant differences between their performances and costs. It seems that this important issue has been neglected in contexts of interconnection networks. In this paper, we compare HyperX and Generalized Hypercube topologies under some key topological measures. We show that HyperX is somehow better than Generalized Hypercube in the sense of topological properties.

Research paper thumbnail of Electrospun poly (N-isopropylacrylamide-co-acrylic acid)/cellulose laurate blend nanofibers containing adapalene: Morphology, drug release, and cell culture studies

International Journal of Polymeric Materials and Polymeric Biomaterials, 2016

In this work, a thermo-and pH-sensitive polymer based on poly (N-isopropylacrylamide-co-acrylic a... more In this work, a thermo-and pH-sensitive polymer based on poly (N-isopropylacrylamide-co-acrylic acid)/ cellulose laurate blend [P(NIPAAm-co-AAc)/CL] was electrospun to produce nanofibers containing adapalene. The synthesized P(NIPAAm-co-AAc), and CL were characterized by ATR-FTIR and 1 H NMR spectroscopies. The thermal behavior of the electrospun nanofibrous samples were determined by a DSC. Afterward, the drug release in different temperatures and pHs from the nanofibers was investigated by UV-vis spectrophotometry and then the LCST behavior of the samples containing adapalene was observed by an ESEM. Moreover, the fibroblast cells culture was carried out with and without adapalene and the cell cytotoxicity of the samples was evaluated via MTT assay. The results from (H&E) and DAPI staining of the viable cells onto the samples surfaces revealed the adapalene has a remarkable short-term potential for the fibroblast cells mortality. It was found that the adapalene loaded electrospun nanofibrous samples enabled to minimize the adverse side effects of the drug by controlling release during three days of cell culture.

Research paper thumbnail of Solving recursive equations in analytical modeling of distributed systems

2015 7th Conference on Information and Knowledge Technology (IKT), 2015

With rapid development of distributed systems and cloud systems and also increasing tendency to N... more With rapid development of distributed systems and cloud systems and also increasing tendency to Network on Chip Architectures, need to description and analysis of these systems has been more felt. To evaluate performance of distributed systems, analytical modeling is a very notable for designers and developers. A class of issues that makes obstacles in the way of modeling these systems is finding solution for series that are recursive and the current term value related to values which are themselves related to the current term value. In this study, several solutions proposed that not only can solve the problem in specific and complicated situation, but also can obtain answers with high precision.

Research paper thumbnail of MGP-INTACTSKY: Multitree Genetic Programming-based learning of INTerpretable and ACcurate TSK sYstems for dynamic portfolio trading

Applied Soft Computing, 2015

In this paper, a Multitree Genetic Programming-based method is developed to learn an INTerpretabl... more In this paper, a Multitree Genetic Programming-based method is developed to learn an INTerpretable and ACcurate Takagi-Sugeno-Kang (TSK) fuzzy rule based sYstem (MGP-INTACTSKY) for dynamic portfolio trading. The MGP-INTACTSKY utilizes a TSK model with a new structure to develop a more interpretable and accurate system for dynamic portfolio trading. In the new structure of TSK, disjunctive normal form rules with variable structured consequent parts are developed in which the absence of some input variables is allowed. Input variables are the most influential technical indices which are selected by stepwise regression analysis. The technical indices are computed using wavelet transformed stock price series to eliminate the noise. The proposed system directly induces the preferred portfolio weights from the stock's technical indices through time. Here, genetic programming with the multitree structure is applied to learn the TSK fuzzy rule bases with the Pittsburgh approach. With this approach, the correlation of different stocks is properly considered during the evolutionary process. To evaluate the performance of the MGP-INTACTSKY for portfolio trading, the proposed model is implemented on the Tehran Stock Exchange as an emerging market as well as Toronto and Frankfurt Stock Exchanges as two mature markets. The experimental results show that the proposed model outperforms other methods such as the momentum strategy, the multitree genetic programming-based crisp system, the genetic algorithm-based first order TSK system, the buy and hold approach and the market's main index in terms of accuracy and interpretability.

Research paper thumbnail of A systematic fuzzy modeling for scheduling of textile manufacturing system

22nd International Conference of the North American Fuzzy Information Processing Society, NAFIPS 2003

This paper presents a fuzzy expert system for Textile manufacturing system using fuzzy cluster an... more This paper presents a fuzzy expert system for Textile manufacturing system using fuzzy cluster analysis. The proposed approach consists of two phases. The first phase is developed with an unsupervised learning and involves a baseline design to effectively identify a prototype fuzzy system. At this phase, a cluster analysis approach is implemented. For the aim of determination of the optimal values of clustering parameters, i.e., weighting exponent (m), and the number of clusters (c), Genetic Algorithms (GAs) are used. At the second phase, fine tuning process is done to adjust the parameters identified in the baseline design, subject to supervised learning. This phase is realized by using approximate reasoning module. Approximate reasoning parameters are also optimized, using GAs. Finally, the proposed approach is tested and validated by applying it to scheduling system of a Textile industry and comparing the results with a Sugeno-type fuzzy system modeling that uses subtractive clustering in its structure identification stage. The results show that the proposed fuzzy system has a better representation of the behavior of the complex systems, such as Textile industries.

Research paper thumbnail of Drug release, cell adhesion and wound healing evaluations of electrospun carboxymethyl chitosan/polyethylene oxide nanofibres containing phenytoin sodium and vitamin C

IET Nanobiotechnology, 2015

In this work, N, O-carboxymethyl chitosan (CMCS) samples from virgin chitosan (CS) were synthesis... more In this work, N, O-carboxymethyl chitosan (CMCS) samples from virgin chitosan (CS) were synthesised and CMCS/polyethylene oxide (PEO) (50/50) blend nanofibrous samples were successfully electrospun from their aqueous solution. The electrospinning conditions to achieve smooth and fine diameter nanofibrous mats were optimised via D-optimal design approach. Afterwards, vitamin C and phenytoin sodium (PHT-Na) were added to these samples for producing wound dressing materials. H-nuclear magnetic resonance, scanning electron microscopy and Fourier transform infrared tests for the evaluation of functionalised CS, morphology and biodegradability studies of CMCS/PEO blend nanofibrous samples were applied. The kinetic and drug release mechanism for vitamin C and PHT-Na drug-loaded electrospun samples were also investigated by UV-vis spectrophotometer and high performance liquid chromatography, respectively. The results showed an approximately similar drug release rate of the two drugs and followed Higuchi's kinetic model. The stem cells viability and their adhesion on the surface of the samples containing PHT-Na and vitamin C were carried out using MTT assay and the best cells' biocompatibility was obtained using both drugs into the CMCS/PEO nanofibrous samples. Moreover, the in vivo animal wound model results revealed that the electrospun samples containing vitamin C and PHT-Na (1%) had a remarkable efficiency in the wounds' closure and their healing process compared with vitamin C/PHT-Na (50/50) ointment. Finally, the histology observations showed that the wound treated with optimised electrospun samples containing two drugs enabled regeneration of epidermis layers due to collagen fibres accumulation followed by granulating tissues formation without necrosis.

Research paper thumbnail of Parameterized interval valued fuzzy expert systems for feasibility study of projects

22nd International Conference of the North American Fuzzy Information Processing Society, NAFIPS 2003

Fuzzy system models are enriched by interval valued sets. They can better represent the expert&am... more Fuzzy system models are enriched by interval valued sets. They can better represent the expert's knowledge and are more flexible and robust in decision-making. This paper addresses several parameterized models for combination of FDCF and FCCF, fuzzy conjunctive canonical form and fuzzy disjunctive canonical form. Then the optimal parameters are gained through an optimization method to assign the best membership

Research paper thumbnail of Performance analysis of fault tolerant multistage interconnection networked parallel instrumentation with concurrent testing and diagnosis

Perfomnce and reliabiliry are two of the most crucial issues in today's high-performance instrume... more Perfomnce and reliabiliry are two of the most crucial issues in today's high-performance instrumentation and measurement systems, Instrumentation and measurement systems have found and enjoyed their performance enhancement through parallel and distributed processing. High speed and density Mufitage Interconnection Networks (MINs) is a widelyused subsystem of parallel processing and communication systems. New performance models are proposed to evaluate the fault tolerant MIN in this paper, thereby establishing a sound foundation for assuring the performance and rehbili@ of fault tolerant M I " with high confidence level during parallel instrumenfatian. A concurrent fault detection and recovery scheme for MlNs is introduced to enable a generic approach to fault tolerance by rerouting over the redundant interconnection links. A switch architecture to realize the concurrent testing and diagnosis is shown. Theproposedperformance modeh are devehped and used to evaluake the compound effect of the fault tolerant operations such as testing, diagnosis and recovery on the throughput anddelay. Results are shown on single transient andpermanent stuck-at faults on links and storage units in switching elemenh. It is shown that the performance degradaiion for the overhead due to the fault tolerance is quite graceful while the performance degradation without faulr recovery is unacceptable.

Research paper thumbnail of A novel approach to dynamic portfolio trading system using multitree genetic programming

Knowledge-Based Systems, 2014

Dynamic portfolio trading system is used to allocate one's capital to a number of securities thro... more Dynamic portfolio trading system is used to allocate one's capital to a number of securities through time in a way to maximize the portfolio return and to minimize the portfolio risk. Genetic programming (GP) as an artificial intelligence technique has been used successfully in the financial field, especially for the forecasting tasks in the financial markets. In this paper, GP is used to develop a dynamic portfolio trading system to capture dynamics of stock market prices through time. The proposed approach takes an integrated view on multiple stocks when the GP evolves and generates a rule base for dynamic portfolio trading based on the technical indices. In the present research, a multitree GP forest has been developed to extend the GP structure to extract multiple trading rules from historical data. Furthermore, the consequent part of each trading rule includes a function rather than a constant value. Besides, the transaction cost of trading which plays an important role in the profitability of a dynamic portfolio trading system is taken into account. This model was used to develop dynamic portfolio trading systems. The profitability of the model was examined for both the emerging and the mature markets. The numerical results show that the proposed model significantly outperforms other traditional models of dynamic and static portfolio selection in terms of the portfolio return and risk adjusted return.

Research paper thumbnail of Morphology, drug release, antibacterial, cell proliferation, and histology studies of chamomile-loaded wound dressing mats based on electrospun nanofibrous poly(ɛ-caprolactone)/polystyrene blends

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2013

For the first time, it has been tried to achieve optimum conditions for electrospun poly(e-caprol... more For the first time, it has been tried to achieve optimum conditions for electrospun poly(e-caprolactone)/polystyrene (PCL/PS) nanofibrous samples as active wound dressings containing chamomile via D-optimal design approach. In this work, systematic in vitro and in vivo studies were carried out by drug release rate, antibacterial and antifungal evaluations, cell culture, and rat wound model along with histology observation. The optimized samples were prepared under the following electrospinning conditions: PCL/PS ratio (65/35), PCL concentration 9%(w/v), PS concentration 14%(w/v), distance between the syringe needle tip and the collector 15.5 cm, applied voltage 18 kV, and solution flow rate 0.46 mL h 21. The FE-SEM micrographs showed electrospun PCL/PS (65/35) nanofibrous sample containing 15% chamomile had a minimum average diameter (175 nm) compared to the neat samples (268 nm). The drug released resulted in a gradual and high amount of chamomile from the optimized PCL/PS nanofibrous sample (70%) in respect to PCL and PS nanofibers after 48 h. This claim was also confirmed by antibacterial and antifungal evaluations in which an inhibitory zone with a diameter of about 7.6 mm was formed. The rat wound model results also indicated that the samples loaded with 15% chamomile extract were remarkably capable to heal the wounds up to 99 6 0.5% after 14 days post-treatment periods. The adhesion of mesenchymal stem cells and their viability on the optimized samples were confirmed by MTT analysis. Also, the electrospun nanofibrous mats based on PCL/PS (65/35) showed a high efficiency in the wound closure and healing process compared to the reference sample, PCL/PS nanofibers without chamomile. Finally, the histology analysis revealed that the formation of epithelial tissues, the lack of necrosis and collagen fibers accumulation in the dermis tissues for the above optimized samples. V

Research paper thumbnail of Fuzzy Models for Link Prediction in Social Networks

International Journal of Intelligent Systems, 2013

Research paper thumbnail of TCvisor: A hypervisor level secure storage

Internet Technology and …

In this paper, we present design and implementation of TCvisor, a new trusted hypervisor. To this... more In this paper, we present design and implementation of TCvisor, a new trusted hypervisor. To this end, TCvisor provides a secure storage with different isolated view per user by using para-passthrough and combined key. In this regard, virtualization technology of ...

Research paper thumbnail of A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming

Research paper thumbnail of Synthesis and Applications of Porphyrin-Biomacromolecule Conjugates

Frontiers in Chemistry, 2021

With potential applications in materials and especially in light-responsive biomedicine that targ... more With potential applications in materials and especially in light-responsive biomedicine that targets cancer tissue selectively, much research has focused on developing covalent conjugation techniques to tether porphyrinoid units to various biomacromolecules. This review details the key synthetic approaches that have been employed in the recent decades to conjugate porphyrinoids with oligonucleotides and peptides/proteins. In addition, we provide succinct discussions on the subsequent applications of such hybrid systems and also give a brief overview of the rapidly progressing field of porphyrin-antibody conjugates. Since nucleic acid and peptide systems vary in structure, connectivity, functional group availability and placement, as well as stability and solubility, tailored synthetic approaches are needed for conjugating to each of these biomacromolecule types. In terms of tethering to ONs, porphyrins are typically attached by employing bioorthogonal chemistry (e.g., using phosphor...

Research paper thumbnail of Comparison Between Topological Properties Of Hyperx And Generalized Hypercube For Interconnection Networks

Journal of Mathematics and Computer Science, 2014

In order to design an interconnection network, it is essential to have a comprehensive understand... more In order to design an interconnection network, it is essential to have a comprehensive understanding about properties and limitations of the network. These properties and limitations are characterized by the topology of the network. Since a topology sets constraints and costs, it plays a critical role in all interconnection networks. Different topologies have been proposed for interconnection networks in literature. The Generalized Hypercube is one of the oldest topologies that can be mentioned. Recently a group of researchers at HP Lab have introduced a new topology for these networks, called HyperX. Despite of many similarities between these two topologies, there are significant differences between their performances and costs. It seems that this important issue has been neglected in contexts of interconnection networks. In this paper, we compare HyperX and Generalized Hypercube topologies under some key topological measures. We show that HyperX is somehow better than Generalized Hypercube in the sense of topological properties.

Research paper thumbnail of Electrospun poly (N-isopropylacrylamide-co-acrylic acid)/cellulose laurate blend nanofibers containing adapalene: Morphology, drug release, and cell culture studies

International Journal of Polymeric Materials and Polymeric Biomaterials, 2016

In this work, a thermo-and pH-sensitive polymer based on poly (N-isopropylacrylamide-co-acrylic a... more In this work, a thermo-and pH-sensitive polymer based on poly (N-isopropylacrylamide-co-acrylic acid)/ cellulose laurate blend [P(NIPAAm-co-AAc)/CL] was electrospun to produce nanofibers containing adapalene. The synthesized P(NIPAAm-co-AAc), and CL were characterized by ATR-FTIR and 1 H NMR spectroscopies. The thermal behavior of the electrospun nanofibrous samples were determined by a DSC. Afterward, the drug release in different temperatures and pHs from the nanofibers was investigated by UV-vis spectrophotometry and then the LCST behavior of the samples containing adapalene was observed by an ESEM. Moreover, the fibroblast cells culture was carried out with and without adapalene and the cell cytotoxicity of the samples was evaluated via MTT assay. The results from (H&E) and DAPI staining of the viable cells onto the samples surfaces revealed the adapalene has a remarkable short-term potential for the fibroblast cells mortality. It was found that the adapalene loaded electrospun nanofibrous samples enabled to minimize the adverse side effects of the drug by controlling release during three days of cell culture.

Research paper thumbnail of Solving recursive equations in analytical modeling of distributed systems

2015 7th Conference on Information and Knowledge Technology (IKT), 2015

With rapid development of distributed systems and cloud systems and also increasing tendency to N... more With rapid development of distributed systems and cloud systems and also increasing tendency to Network on Chip Architectures, need to description and analysis of these systems has been more felt. To evaluate performance of distributed systems, analytical modeling is a very notable for designers and developers. A class of issues that makes obstacles in the way of modeling these systems is finding solution for series that are recursive and the current term value related to values which are themselves related to the current term value. In this study, several solutions proposed that not only can solve the problem in specific and complicated situation, but also can obtain answers with high precision.

Research paper thumbnail of MGP-INTACTSKY: Multitree Genetic Programming-based learning of INTerpretable and ACcurate TSK sYstems for dynamic portfolio trading

Applied Soft Computing, 2015

In this paper, a Multitree Genetic Programming-based method is developed to learn an INTerpretabl... more In this paper, a Multitree Genetic Programming-based method is developed to learn an INTerpretable and ACcurate Takagi-Sugeno-Kang (TSK) fuzzy rule based sYstem (MGP-INTACTSKY) for dynamic portfolio trading. The MGP-INTACTSKY utilizes a TSK model with a new structure to develop a more interpretable and accurate system for dynamic portfolio trading. In the new structure of TSK, disjunctive normal form rules with variable structured consequent parts are developed in which the absence of some input variables is allowed. Input variables are the most influential technical indices which are selected by stepwise regression analysis. The technical indices are computed using wavelet transformed stock price series to eliminate the noise. The proposed system directly induces the preferred portfolio weights from the stock's technical indices through time. Here, genetic programming with the multitree structure is applied to learn the TSK fuzzy rule bases with the Pittsburgh approach. With this approach, the correlation of different stocks is properly considered during the evolutionary process. To evaluate the performance of the MGP-INTACTSKY for portfolio trading, the proposed model is implemented on the Tehran Stock Exchange as an emerging market as well as Toronto and Frankfurt Stock Exchanges as two mature markets. The experimental results show that the proposed model outperforms other methods such as the momentum strategy, the multitree genetic programming-based crisp system, the genetic algorithm-based first order TSK system, the buy and hold approach and the market's main index in terms of accuracy and interpretability.

Research paper thumbnail of A systematic fuzzy modeling for scheduling of textile manufacturing system

22nd International Conference of the North American Fuzzy Information Processing Society, NAFIPS 2003

This paper presents a fuzzy expert system for Textile manufacturing system using fuzzy cluster an... more This paper presents a fuzzy expert system for Textile manufacturing system using fuzzy cluster analysis. The proposed approach consists of two phases. The first phase is developed with an unsupervised learning and involves a baseline design to effectively identify a prototype fuzzy system. At this phase, a cluster analysis approach is implemented. For the aim of determination of the optimal values of clustering parameters, i.e., weighting exponent (m), and the number of clusters (c), Genetic Algorithms (GAs) are used. At the second phase, fine tuning process is done to adjust the parameters identified in the baseline design, subject to supervised learning. This phase is realized by using approximate reasoning module. Approximate reasoning parameters are also optimized, using GAs. Finally, the proposed approach is tested and validated by applying it to scheduling system of a Textile industry and comparing the results with a Sugeno-type fuzzy system modeling that uses subtractive clustering in its structure identification stage. The results show that the proposed fuzzy system has a better representation of the behavior of the complex systems, such as Textile industries.

Research paper thumbnail of Drug release, cell adhesion and wound healing evaluations of electrospun carboxymethyl chitosan/polyethylene oxide nanofibres containing phenytoin sodium and vitamin C

IET Nanobiotechnology, 2015

In this work, N, O-carboxymethyl chitosan (CMCS) samples from virgin chitosan (CS) were synthesis... more In this work, N, O-carboxymethyl chitosan (CMCS) samples from virgin chitosan (CS) were synthesised and CMCS/polyethylene oxide (PEO) (50/50) blend nanofibrous samples were successfully electrospun from their aqueous solution. The electrospinning conditions to achieve smooth and fine diameter nanofibrous mats were optimised via D-optimal design approach. Afterwards, vitamin C and phenytoin sodium (PHT-Na) were added to these samples for producing wound dressing materials. H-nuclear magnetic resonance, scanning electron microscopy and Fourier transform infrared tests for the evaluation of functionalised CS, morphology and biodegradability studies of CMCS/PEO blend nanofibrous samples were applied. The kinetic and drug release mechanism for vitamin C and PHT-Na drug-loaded electrospun samples were also investigated by UV-vis spectrophotometer and high performance liquid chromatography, respectively. The results showed an approximately similar drug release rate of the two drugs and followed Higuchi's kinetic model. The stem cells viability and their adhesion on the surface of the samples containing PHT-Na and vitamin C were carried out using MTT assay and the best cells' biocompatibility was obtained using both drugs into the CMCS/PEO nanofibrous samples. Moreover, the in vivo animal wound model results revealed that the electrospun samples containing vitamin C and PHT-Na (1%) had a remarkable efficiency in the wounds' closure and their healing process compared with vitamin C/PHT-Na (50/50) ointment. Finally, the histology observations showed that the wound treated with optimised electrospun samples containing two drugs enabled regeneration of epidermis layers due to collagen fibres accumulation followed by granulating tissues formation without necrosis.

Research paper thumbnail of Parameterized interval valued fuzzy expert systems for feasibility study of projects

22nd International Conference of the North American Fuzzy Information Processing Society, NAFIPS 2003

Fuzzy system models are enriched by interval valued sets. They can better represent the expert&am... more Fuzzy system models are enriched by interval valued sets. They can better represent the expert's knowledge and are more flexible and robust in decision-making. This paper addresses several parameterized models for combination of FDCF and FCCF, fuzzy conjunctive canonical form and fuzzy disjunctive canonical form. Then the optimal parameters are gained through an optimization method to assign the best membership

Research paper thumbnail of Performance analysis of fault tolerant multistage interconnection networked parallel instrumentation with concurrent testing and diagnosis

Perfomnce and reliabiliry are two of the most crucial issues in today's high-performance instrume... more Perfomnce and reliabiliry are two of the most crucial issues in today's high-performance instrumentation and measurement systems, Instrumentation and measurement systems have found and enjoyed their performance enhancement through parallel and distributed processing. High speed and density Mufitage Interconnection Networks (MINs) is a widelyused subsystem of parallel processing and communication systems. New performance models are proposed to evaluate the fault tolerant MIN in this paper, thereby establishing a sound foundation for assuring the performance and rehbili@ of fault tolerant M I " with high confidence level during parallel instrumenfatian. A concurrent fault detection and recovery scheme for MlNs is introduced to enable a generic approach to fault tolerance by rerouting over the redundant interconnection links. A switch architecture to realize the concurrent testing and diagnosis is shown. Theproposedperformance modeh are devehped and used to evaluake the compound effect of the fault tolerant operations such as testing, diagnosis and recovery on the throughput anddelay. Results are shown on single transient andpermanent stuck-at faults on links and storage units in switching elemenh. It is shown that the performance degradaiion for the overhead due to the fault tolerance is quite graceful while the performance degradation without faulr recovery is unacceptable.

Research paper thumbnail of A novel approach to dynamic portfolio trading system using multitree genetic programming

Knowledge-Based Systems, 2014

Dynamic portfolio trading system is used to allocate one's capital to a number of securities thro... more Dynamic portfolio trading system is used to allocate one's capital to a number of securities through time in a way to maximize the portfolio return and to minimize the portfolio risk. Genetic programming (GP) as an artificial intelligence technique has been used successfully in the financial field, especially for the forecasting tasks in the financial markets. In this paper, GP is used to develop a dynamic portfolio trading system to capture dynamics of stock market prices through time. The proposed approach takes an integrated view on multiple stocks when the GP evolves and generates a rule base for dynamic portfolio trading based on the technical indices. In the present research, a multitree GP forest has been developed to extend the GP structure to extract multiple trading rules from historical data. Furthermore, the consequent part of each trading rule includes a function rather than a constant value. Besides, the transaction cost of trading which plays an important role in the profitability of a dynamic portfolio trading system is taken into account. This model was used to develop dynamic portfolio trading systems. The profitability of the model was examined for both the emerging and the mature markets. The numerical results show that the proposed model significantly outperforms other traditional models of dynamic and static portfolio selection in terms of the portfolio return and risk adjusted return.

Research paper thumbnail of Morphology, drug release, antibacterial, cell proliferation, and histology studies of chamomile-loaded wound dressing mats based on electrospun nanofibrous poly(ɛ-caprolactone)/polystyrene blends

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2013

For the first time, it has been tried to achieve optimum conditions for electrospun poly(e-caprol... more For the first time, it has been tried to achieve optimum conditions for electrospun poly(e-caprolactone)/polystyrene (PCL/PS) nanofibrous samples as active wound dressings containing chamomile via D-optimal design approach. In this work, systematic in vitro and in vivo studies were carried out by drug release rate, antibacterial and antifungal evaluations, cell culture, and rat wound model along with histology observation. The optimized samples were prepared under the following electrospinning conditions: PCL/PS ratio (65/35), PCL concentration 9%(w/v), PS concentration 14%(w/v), distance between the syringe needle tip and the collector 15.5 cm, applied voltage 18 kV, and solution flow rate 0.46 mL h 21. The FE-SEM micrographs showed electrospun PCL/PS (65/35) nanofibrous sample containing 15% chamomile had a minimum average diameter (175 nm) compared to the neat samples (268 nm). The drug released resulted in a gradual and high amount of chamomile from the optimized PCL/PS nanofibrous sample (70%) in respect to PCL and PS nanofibers after 48 h. This claim was also confirmed by antibacterial and antifungal evaluations in which an inhibitory zone with a diameter of about 7.6 mm was formed. The rat wound model results also indicated that the samples loaded with 15% chamomile extract were remarkably capable to heal the wounds up to 99 6 0.5% after 14 days post-treatment periods. The adhesion of mesenchymal stem cells and their viability on the optimized samples were confirmed by MTT analysis. Also, the electrospun nanofibrous mats based on PCL/PS (65/35) showed a high efficiency in the wound closure and healing process compared to the reference sample, PCL/PS nanofibers without chamomile. Finally, the histology analysis revealed that the formation of epithelial tissues, the lack of necrosis and collagen fibers accumulation in the dermis tissues for the above optimized samples. V

Research paper thumbnail of Fuzzy Models for Link Prediction in Social Networks

International Journal of Intelligent Systems, 2013

Research paper thumbnail of TCvisor: A hypervisor level secure storage

Internet Technology and …

In this paper, we present design and implementation of TCvisor, a new trusted hypervisor. To this... more In this paper, we present design and implementation of TCvisor, a new trusted hypervisor. To this end, TCvisor provides a secure storage with different isolated view per user by using para-passthrough and combined key. In this regard, virtualization technology of ...