Zeinab Hamza - Academia.edu (original) (raw)
Papers by Zeinab Hamza
Fibers and Polymers, Aug 1, 2022
Scientific Reports
Enaminonitrile pyridine derivative was used as a precursor for preparation of fourteen heterocycl... more Enaminonitrile pyridine derivative was used as a precursor for preparation of fourteen heterocyclic compounds using both conventional thermal and microwave techniques. Diverse organic reagents, such as chloroacetyl chloride, acetic anhydride, chloroacetic acid, carbon disulfide, p-toluene sulfonyl chloride, maleic anhydride, phthalic anhydride, were used. The chemical formulae and structures of isolated derivatives were obtained using different analytical and spectroscopic techniques such as IR, 1H-, 13C-NMR as well as mass spectrometry. The spectroscopic analyses revealed diverse structure arrangements for the products. Molecular structure optimization of certain compounds were performed by the density functional theory (DFT/B3LYP) method and the basis set 6–31 G with double zeta plus polarization (d,p). The antimicrobial inhibition and the antioxidant activity of the reported compounds were screened. Compounds 5, 6, 11 and 13 exhibited the highest antibacterial inhibition, while c...
Egyptian Journal of Chemistry, Nov 30, 2022
Current Organic Synthesis
Background: The studies on the potential usage of benzene sulfonamide derivatives as anticancer a... more Background: The studies on the potential usage of benzene sulfonamide derivatives as anticancer agents are limited. benzene sulfonamide derivatives are currently used as anticancer agents against different breast cancer cell lines, such as MCF-7, lung cancer cells (A549), prostate cancer cells (Du-145), and cervical cells (HeLa) Objective: A series of new sulfonamide drugs are synthesized by reacting aldehydes thio-semi-carbazones derivatives with benzene sulphonyl chloride to form benzylidene-N-(phenylsulfonyl) hydrazine-1-carbothioamide derivatives. Studying the anticancer effects against MCF-7 breast carcinoma cell lines and the antioxidant activities of these newly synthesized compounds. Methods: Studying the anticancer effects against MCF-7 breast carcinoma cell lines and the antioxidant activities of these newly synthesized compounds. To study the anti-breast cancer activity of the newly synthesized compounds, a molecular docking study is used to analyze the binding energy for...
BioNanoScience
Materials and Methods Collection of plants and extraction procedure Fresh leaves and stem bark of... more Materials and Methods Collection of plants and extraction procedure Fresh leaves and stem bark of Lovoa trichiliodes Harm. were
Environmental Science and Pollution Research
The word "Matlodextrin" in the title need to be changed to "Maltodextrin". The affiliation of the... more The word "Matlodextrin" in the title need to be changed to "Maltodextrin". The affiliation of the author "Turki M. Al-Shaikh" need to be changed to (1) instead of (2). Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
The article analyzes the main features of crime, which are important in the study of adverse even... more The article analyzes the main features of crime, which are important in the study of adverse events in order to identify specific patterns of development. We consider properties such crime, as secrecy and reprisals that have a direct impact on latency.
![Research paper thumbnail of Design, Synthesis and Biological Evaluation of Novel Pyrano[2,3-c]pyrazoles And Their Sugar Derivatives as Antimicrobial, Antioxidant and Anticancer Agents](https://attachments.academia-assets.com/88880626/thumbnails/1.jpg)
](Egyptian Journal of Chemistry
Natural product research, Jan 17, 2015
The marine soft corals Sarcophyton trocheliophorum crude extracts possessed antimicrobial activit... more The marine soft corals Sarcophyton trocheliophorum crude extracts possessed antimicrobial activity towards pathogenic bacterial strains, i.e. Bacillus cereus, Salmonella typhi, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Bioassay-guided fractionation indicated that the antimicrobial effect was due to the presence of terpenoid bioactive derivatives. Further biological assays of the n-hexane fractions were carried out using turbidity assay, inhibition zone assay and minimum inhibitory concentration for investigating the growth-inhibition effect towards the Gram-positive and Gram-negative bacteria. The fractions were screened and the structure of the isolated compound was justified by interpretation of the spectroscopic data, mainly mass spectrometry (GC-MS). The structure was assigned as (5S)-3-[(3E,5S)-5-hydroxy-3-hepten-6-yn-1-yl]-5-methyl-2(5H)-furanone and was effective at concentrations as low as 0.20 mg/mL. The above findings, in the course of our ongoing...
1 1.1Statement of the problem 2 1.2 Objective of the study 3 1.3 Organization of the study 3 Chap... more 1 1.1Statement of the problem 2 1.2 Objective of the study 3 1.3 Organization of the study 3 Chapter two: 2. Literature review 4 2.1 Linked between research-extension-farmers & farmers organization 4 2.2 Guatemala & Nepal 6 2.3 Zambia 8 2.4 improving linkage Mechanisms 2.5 Suggested planning cycle and its steps. 2.6 Studies and plans to strengthen research-extension linkages. 2.7 Agricultural Extension Histories. 2.8 Methods of improving linkages.
Journal of Biochemical and Molecular Toxicology
Environmental Science and Pollution Research
Environmental Science and Pollution Research
Nucleosides, Nucleotides & Nucleic Acids
Egyptian Journal of Chemistry
A FLATOXINS (AFs) are difuranocoumarin derivatives produced as secondary metabolites by fungi bel... more A FLATOXINS (AFs) are difuranocoumarin derivatives produced as secondary metabolites by fungi belonging to several Aspergillus species. Aflatoxin B 1 (AFB 1) is one of the most potent naturally occurring hepatic carcinogens to both human and animals and is classified as a group (1) human carcinogen. Therefore, the aim of this study is to assess the effect of encapsulating polyvinylpyrrolidone (PVP 10, 360 and 1300 kDa)-Tannic acid complexed nanoparticles (PVP-TA NPs) inside yeast cell walls (YCW) to remediate AFB 1 in the gastrointestinal models. Glucan Mannan Lipid Particles (GMLPs) from Saccharomycesces cerevisie cell walls showed the highest AFB 1 adsorption in simulated gastric fluid (SGF) after 10 min, and in simulated intestinal fluid (SIF) after1 h. Glucan Mannan Lipid Particles are hollow 3-4-micron porous microspheres that provide an efficient system for the synthesis and encapsulation of AFB 1-absorbing nanoparticles (NPs). Although tannic acid (28%) was released from GMLP particles after three water washes, only 10, 5.6 and 7.6% of the total loaded TA was released when complexed with optimal ratios of PVP 10, 360 and 1300 kDa; respectively. Fluorescence microscopic images supported the conclusion that PVP TA complexed NP cores were successfully synthesized inside the GMLPs. Encapsulation of PVP TA NPs inside GMLPs significantly increased the stability of the GMLP encapsulated PVP TA NPs formulation. Data also showed that AFB 1 adsorption by the multi-functional GMLP PVP-TA NPs was enhanced synergistically in SGF and in SIF binding compared to individual GMLP.
Acta poloniae pharmaceutica, 2016
The present study describes the in vitro cytotoxic effects of soft coral (Sarcophyton tiochelioph... more The present study describes the in vitro cytotoxic effects of soft coral (Sarcophyton tiocheliophorum). Soft corals of genus Sarcophyton were reported to contain compounds that are active against brine shrimp and promote paclitaxel cytotoxicity in the human colon cancer Caco-2 cell line. The n-hexane extract of the soft coral Sarcophyton tiocheliophorum induced significant dose-dependent toxicity (LC₅₀ 96.7 ppm) compared with ethyl acetate (LC₅₀. 120 ppm). We reported the most active cytotoxic level to be correspondence to LC₅₀ values of 20.2, 59.2 ppm and 18.9 and 26 ppm. Accordingly, bio-assay guided fractionation was conducted to identi- fy the bioactive compounds. Arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid were characterized based on GC-MS analyses. Our results demonstrate the value of marine products as a natural source of medicinally interesting cytotoxic compounds.
Fibers and Polymers, Aug 1, 2022
Scientific Reports
Enaminonitrile pyridine derivative was used as a precursor for preparation of fourteen heterocycl... more Enaminonitrile pyridine derivative was used as a precursor for preparation of fourteen heterocyclic compounds using both conventional thermal and microwave techniques. Diverse organic reagents, such as chloroacetyl chloride, acetic anhydride, chloroacetic acid, carbon disulfide, p-toluene sulfonyl chloride, maleic anhydride, phthalic anhydride, were used. The chemical formulae and structures of isolated derivatives were obtained using different analytical and spectroscopic techniques such as IR, 1H-, 13C-NMR as well as mass spectrometry. The spectroscopic analyses revealed diverse structure arrangements for the products. Molecular structure optimization of certain compounds were performed by the density functional theory (DFT/B3LYP) method and the basis set 6–31 G with double zeta plus polarization (d,p). The antimicrobial inhibition and the antioxidant activity of the reported compounds were screened. Compounds 5, 6, 11 and 13 exhibited the highest antibacterial inhibition, while c...
Egyptian Journal of Chemistry, Nov 30, 2022
Current Organic Synthesis
Background: The studies on the potential usage of benzene sulfonamide derivatives as anticancer a... more Background: The studies on the potential usage of benzene sulfonamide derivatives as anticancer agents are limited. benzene sulfonamide derivatives are currently used as anticancer agents against different breast cancer cell lines, such as MCF-7, lung cancer cells (A549), prostate cancer cells (Du-145), and cervical cells (HeLa) Objective: A series of new sulfonamide drugs are synthesized by reacting aldehydes thio-semi-carbazones derivatives with benzene sulphonyl chloride to form benzylidene-N-(phenylsulfonyl) hydrazine-1-carbothioamide derivatives. Studying the anticancer effects against MCF-7 breast carcinoma cell lines and the antioxidant activities of these newly synthesized compounds. Methods: Studying the anticancer effects against MCF-7 breast carcinoma cell lines and the antioxidant activities of these newly synthesized compounds. To study the anti-breast cancer activity of the newly synthesized compounds, a molecular docking study is used to analyze the binding energy for...
BioNanoScience
Materials and Methods Collection of plants and extraction procedure Fresh leaves and stem bark of... more Materials and Methods Collection of plants and extraction procedure Fresh leaves and stem bark of Lovoa trichiliodes Harm. were
Environmental Science and Pollution Research
The word "Matlodextrin" in the title need to be changed to "Maltodextrin". The affiliation of the... more The word "Matlodextrin" in the title need to be changed to "Maltodextrin". The affiliation of the author "Turki M. Al-Shaikh" need to be changed to (1) instead of (2). Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
The article analyzes the main features of crime, which are important in the study of adverse even... more The article analyzes the main features of crime, which are important in the study of adverse events in order to identify specific patterns of development. We consider properties such crime, as secrecy and reprisals that have a direct impact on latency.
Egyptian Journal of Chemistry
Natural product research, Jan 17, 2015
The marine soft corals Sarcophyton trocheliophorum crude extracts possessed antimicrobial activit... more The marine soft corals Sarcophyton trocheliophorum crude extracts possessed antimicrobial activity towards pathogenic bacterial strains, i.e. Bacillus cereus, Salmonella typhi, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Bioassay-guided fractionation indicated that the antimicrobial effect was due to the presence of terpenoid bioactive derivatives. Further biological assays of the n-hexane fractions were carried out using turbidity assay, inhibition zone assay and minimum inhibitory concentration for investigating the growth-inhibition effect towards the Gram-positive and Gram-negative bacteria. The fractions were screened and the structure of the isolated compound was justified by interpretation of the spectroscopic data, mainly mass spectrometry (GC-MS). The structure was assigned as (5S)-3-[(3E,5S)-5-hydroxy-3-hepten-6-yn-1-yl]-5-methyl-2(5H)-furanone and was effective at concentrations as low as 0.20 mg/mL. The above findings, in the course of our ongoing...
1 1.1Statement of the problem 2 1.2 Objective of the study 3 1.3 Organization of the study 3 Chap... more 1 1.1Statement of the problem 2 1.2 Objective of the study 3 1.3 Organization of the study 3 Chapter two: 2. Literature review 4 2.1 Linked between research-extension-farmers & farmers organization 4 2.2 Guatemala & Nepal 6 2.3 Zambia 8 2.4 improving linkage Mechanisms 2.5 Suggested planning cycle and its steps. 2.6 Studies and plans to strengthen research-extension linkages. 2.7 Agricultural Extension Histories. 2.8 Methods of improving linkages.
Journal of Biochemical and Molecular Toxicology
Environmental Science and Pollution Research
Environmental Science and Pollution Research
Nucleosides, Nucleotides & Nucleic Acids
Egyptian Journal of Chemistry
A FLATOXINS (AFs) are difuranocoumarin derivatives produced as secondary metabolites by fungi bel... more A FLATOXINS (AFs) are difuranocoumarin derivatives produced as secondary metabolites by fungi belonging to several Aspergillus species. Aflatoxin B 1 (AFB 1) is one of the most potent naturally occurring hepatic carcinogens to both human and animals and is classified as a group (1) human carcinogen. Therefore, the aim of this study is to assess the effect of encapsulating polyvinylpyrrolidone (PVP 10, 360 and 1300 kDa)-Tannic acid complexed nanoparticles (PVP-TA NPs) inside yeast cell walls (YCW) to remediate AFB 1 in the gastrointestinal models. Glucan Mannan Lipid Particles (GMLPs) from Saccharomycesces cerevisie cell walls showed the highest AFB 1 adsorption in simulated gastric fluid (SGF) after 10 min, and in simulated intestinal fluid (SIF) after1 h. Glucan Mannan Lipid Particles are hollow 3-4-micron porous microspheres that provide an efficient system for the synthesis and encapsulation of AFB 1-absorbing nanoparticles (NPs). Although tannic acid (28%) was released from GMLP particles after three water washes, only 10, 5.6 and 7.6% of the total loaded TA was released when complexed with optimal ratios of PVP 10, 360 and 1300 kDa; respectively. Fluorescence microscopic images supported the conclusion that PVP TA complexed NP cores were successfully synthesized inside the GMLPs. Encapsulation of PVP TA NPs inside GMLPs significantly increased the stability of the GMLP encapsulated PVP TA NPs formulation. Data also showed that AFB 1 adsorption by the multi-functional GMLP PVP-TA NPs was enhanced synergistically in SGF and in SIF binding compared to individual GMLP.
Acta poloniae pharmaceutica, 2016
The present study describes the in vitro cytotoxic effects of soft coral (Sarcophyton tiochelioph... more The present study describes the in vitro cytotoxic effects of soft coral (Sarcophyton tiocheliophorum). Soft corals of genus Sarcophyton were reported to contain compounds that are active against brine shrimp and promote paclitaxel cytotoxicity in the human colon cancer Caco-2 cell line. The n-hexane extract of the soft coral Sarcophyton tiocheliophorum induced significant dose-dependent toxicity (LC₅₀ 96.7 ppm) compared with ethyl acetate (LC₅₀. 120 ppm). We reported the most active cytotoxic level to be correspondence to LC₅₀ values of 20.2, 59.2 ppm and 18.9 and 26 ppm. Accordingly, bio-assay guided fractionation was conducted to identi- fy the bioactive compounds. Arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid were characterized based on GC-MS analyses. Our results demonstrate the value of marine products as a natural source of medicinally interesting cytotoxic compounds.