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Papers by andreas manios
Diagnostics, Jan 21, 2024
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Plastic surgery, 2001
A ctinic lesions of the skin may become apparent during the third decade of life or later. In dis... more A ctinic lesions of the skin may become apparent during the third decade of life or later. In disorders such as xeroderma pigmentosum, lesions appear early, even in childhood (1). Heredity, prolonged sun exposure and the action of several chemical factors, promote the development of lesions (2). One manifestation of sun-damaged skin is actinic elastosis. When lesions are located on the neck, the disorder is known as Farmer's neck or cutis rhomboidalis nuchae. When the upper extremities are affected, the disorder is known as actinic comedonal plaques or solar elastotic bands (3). When the ear is affected, it is known as nodular chondrodermatitis,
Journal of Craniofacial Surgery, 2016
Journal of Plastic Reconstructive and Aesthetic Surgery, Aug 1, 2010
Nowadays, as in the past, much attention is paid to aesthetic operations in women, while only inf... more Nowadays, as in the past, much attention is paid to aesthetic operations in women, while only infrequently have such operations been referred to in males. Generally, male aesthetic surgery was introduced to surgical practise during the 19th century. In this study, we analysed the practise of such operations in Byzantine times and in other ancient cultures with surgical knowledge, i.e. ancient India and China The sixth book of Paul of Aegina's "Epitome of Medicine" was studied for description of aesthetic operations in males in the Byzantine period, since this book is completely devoted to surgery and is generally considered to be the most important reference for surgery in Byzantine times. The original text and its excellent translation by Francis Adams were used. References concerning aesthetic operations for males were identified. Accordingly, historical work and reviews on plastic surgery in ancient India and China were studied. Mainly, two aesthetic surgical procedures for males in the Byzantine period were identified. These two procedures comprise gynaecomastia and rhacosis (scrotal relaxation). Two different techniques were reported for the surgical management of gynaecomastia, through sub-mammary or supra-mammary access. Two procedures were noted for rhacosis, for which Paul of Aegina reproduced the respective chapters from Leonides' and Antyllus' works. Evidence supporting male aesthetic surgery in ancient India and China or elsewhere was not found. Despite the dubious aesthetic result, the existence of different aesthetic surgical techniques in males substantiate the advanced level of surgery achieved by physicians in the Byzantine period.
Acta Chirurgica Belgica, Nov 2, 2018
Introduction: Polydactyly, or polydactylism, is a common congenital disorder of the limbs, consis... more Introduction: Polydactyly, or polydactylism, is a common congenital disorder of the limbs, consisting of any digit duplication beyond the normal five. The term syndactyly refers to fused digits. We herein present a thorough description of these diseases together with their surgical treatment, provided by Oribasius, a Byzantine physician of the 4th century. To our knowledge, this is the earliest description of supernumerary and fused fingers and their surgical management. Material and Methods: We conducted a thorough study of Oribasius' work. Results: The 15th chapter of the 47th book of Oribasius' work is devoted to finger abnormalities (i.e. polydactyly and syndactyly) and their surgical treatment. Discussion: With regard to the extensive medical knowledge of the 4th century as survived in Oribasius' work, these descriptions comprise, to the best of our knowledge, the earliest written references to the surgical treatment of polydactyly and syndactyly.
Advances in Experimental Medicine and Biology, 2021
Facial reconstruction is employed in medical science and archaeology. Though quite popular as ant... more Facial reconstruction is employed in medical science and archaeology. Though quite popular as anthropological method, it has not so far been used in the orthodox ecclesiastical tradition. This work presents the facial reconstruction of St Eftychios of Crete, who lived between the ninth and tenth centuries. Computed tomography and reverse engineering methods were employed to complete the task. Reconstruction of the mandible and the missing left zygomatic arch was implemented following the Sassouni method. The American method was followed for the soft tissues, with clay deposition of appropriate thickness, on the surface of the skull model. The eyes, nose, and lips were added based on the dimensions of the underlying bone structures. Long hair and beard were added, according to the classic Byzantine tradition pattern of the time period. The final bust developed was then digitized, using a 3D non-contact laser scanner. The 3D geometry produced was employed to produce a mold with vacuum casting techniques. This mold provides the ability to produce copies of the bust, if needed. At the same time, a realistic 3D representation of the Saint's bust was developed, with the aid of special software, in order to compare the traditional forensic reconstruction to the pure digital one. This work is the first case of a Saint's facial reconstruction in the Orthodox Church. The facial reconstruction process, with all the limitations considered, offers the ability to present a realistic aspect of a Greek Orthodox Church Saint, in a form that is easily accessible. Both physical and digital facial reconstruction processes were based on scientific data, so they were as accurate as possible, considering that the mandible was missing in the skull. The facial reconstruction was entirely implemented in Greece creating the basis for similar work in the future. The final bust developed was donated to the Odigitria Monastery, to be exhibited to its visitors.
World journal of clinical oncology, Aug 24, 2022
Psychosomatics, Jul 1, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Canadian Journal of Plastic Surgery, Jun 1, 2001
A ctinic lesions of the skin may become apparent during the third decade of life or later. In dis... more A ctinic lesions of the skin may become apparent during the third decade of life or later. In disorders such as xeroderma pigmentosum, lesions appear early, even in childhood (1). Heredity, prolonged sun exposure and the action of several chemical factors, promote the development of lesions (2). One manifestation of sun-damaged skin is actinic elastosis. When lesions are located on the neck, the disorder is known as Farmer's neck or cutis rhomboidalis nuchae. When the upper extremities are affected, the disorder is known as actinic comedonal plaques or solar elastotic bands (3). When the ear is affected, it is known as nodular chondrodermatitis,
International Journal of Dermatology, 2006
American Journal of Tropical Medicine and Hygiene, May 1, 2004
This study estimated the clinical effectiveness of five different antibiotic regimens (doxycyclin... more This study estimated the clinical effectiveness of five different antibiotic regimens (doxycycline, chloramphenicol, ciprofloxacin, doxycycline plus chloramphenicol, and doxycycline plus ciprofloxacin) administered for infection with Rickettsia typhi in terms of the duration of the fever. Eighty-seven patients with endemic typhus were hospitalized between 1993 and 1998 at the General Hospital of Chania in Chania, Crete, Greece. The mean time to defervescence was 2.9 days for doxycycline, 4.0 days for chloramphenicol, and 4.2 days for ciprofloxacin. In patients receiving combinations of doxycycline plus chloramphenicol and doxycycline plus ciprofloxacin, fever subsided in 3.4 and 4.0 days, respectively. The outcome was favorable in all patients, and no deaths or relapses were observed within two months.
International Journal of Dermatology, Jun 21, 2010
Basal cell carcinoma (BCC) is very common and usually encountered when it is small in size. Giant... more Basal cell carcinoma (BCC) is very common and usually encountered when it is small in size. Giant BCC (i.e. greater than 5 cm in diameter) is quite rare and comprises 0.5 percent of all BCC. Extremely rarely, tumors larger than 20 cm have been reported. Herein, a case with an enormous, vegetating BCC of the abdominal wall, 30 x 20 cm in size, is described. This report demonstrates that such a case can still be observed in the civilized world of the 21st century, which remains profoundly astonishing. A literature survey was performed and revealed only 7 cases with such super giant BCC (i.e. larger than 20 cm in diameter). Generally, this tumor attains these enormous proportions due to neglect on the patient's part, and is usually located at sites covered by clothes. Treatment is mainly surgical and generally curative, resulting also in an improved quality of life. Tumor size of more than 10 cm in diameter is associated with increased risk for metastatic disease, severe morbidity and consequently impaired prognosis.
Dermatologic Surgery, Dec 1, 1996
The finite element analysis (FEA) is a recently introduced method in biomechanics that permits mo... more The finite element analysis (FEA) is a recently introduced method in biomechanics that permits modeling of complex structures considering them as an aggregate of small elements. Skin flaps are highly suggested to be amenable to the continuum mechanic laws that underly the development of FEA. A combination of "large deformation analysis," based on FEA with the criteria for skin flap selection, was attempted. Serial defects were experimentally created on piglet skin stripes, which were consequently covered through designing appropriate flaps. Skin samples were modeled after the development of a computer FEA program and they were scanned by incorporating their photographs. On the graphic interfaces the flap movement, the closure of the defect, and the whole deformation were found to match with the skin stripe postincisional alterations. This work permits the prediction and offers planning guides for different skin reconstructions.
BMC Research Notes, Jun 14, 2021
Objective: Computerized clinical image analysis is shown to improve diagnostic accuracy for cutan... more Objective: Computerized clinical image analysis is shown to improve diagnostic accuracy for cutaneous melanoma but its effectiveness in preoperative assessment of melanoma thickness has not been studied. The aim of this study, is to explore how melanoma thickness correlates with computer-assisted objectively obtained color and geometric variables. All patients diagnosed with cutaneous melanoma with available clinical images prior to tumor excision were included in the study. All images underwent digital processing with an automated non-commercial software. The software provided measurements for geometrical variables, i.e., overall lesion surface, maximum diameter, perimeter, circularity, eccentricity, mean radius, as well as for color variables, i.e., range, standard deviation, coefficient of variation and skewness in the red, green, and blue color space. Results: One hundred fifty-six lesions were included in the final analysis. The mean tumor thickness was 1.84 mm (range 0.2-25). Melanoma thickness was strongly correlated with overall surface area, maximum diameter, perimeter and mean lesion radius. Thickness was moderately correlated with eccentricity, green color and blue color. We conclude that geometrical and color parameters, as objectively extracted by computer-aided clinical image processing, may correlate with tumor thickness in patients with cutaneous melanoma. However, these correlations are not strong enough to reliably predict tumor thickness.
World Journal of Surgery, Oct 21, 2014
Background The aim of this study was to evaluate the effects of surgically induced weight loss on... more Background The aim of this study was to evaluate the effects of surgically induced weight loss on the abdominal adipose tissue depots and the metabolic profile in morbidly obese (MO) patients. Methods The study was performed with a semi-automated quantification of adipose tissue compartments on singleslice abdominal CT series before surgery, 6 and 12 months after bariatric surgery. Thirty-eight MO patients with mean age of 35.7 ± 10.1 years and mean body mass index (BMI) of 43.6 ± 6.5 kg/m 2 were studied (20 patients underwent gastric banding and 18 patients underwent sleeve gastrectomy). Anthropometric measurements, metabolic and inflammatory parameters were analyzed in each patient. Results Markedly decreased levels of total abdominal adipose tissue, abdominal subcutaneous adipose tissue (AbSAT) and visceral adipose tissue (VAT) at 6 and 12 months were noted in comparison to the preoperative values. The total % reduction of VAT was significant higher in comparison to the total % reduction of AbSAT at 12 months after bariatric surgery (P \ 0.01) with the mean ratio of AbSAT/VAT to increase from 4.1 ± 1.7 preoperatively to 6.2 ± 3.1 at 12 months postoperatively (P \ 0.001). In addition, high-sensitivity C-reactive protein (hsCRP) decreased significantly with weight loss after bariatric surgery and the total abdominal lipid loss was related to the decrease in hsCRP. Conclusions Significant changes in abdominal lipid deposition occurred in MO patients 6 and 12 months after bariatric surgery. The changes were significantly, correlated with the magnitude of BMI loss. The fat redistribution may contribute to the improvements in metabolic abnormalities. C. Galanakis and M. Daskalakis have contributed equally to this study.
Journal of Medical Engineering & Technology, 2008
This paper presents rapid prototyping and reverse engineering techniques applied to create an imp... more This paper presents rapid prototyping and reverse engineering techniques applied to create an implant for the surgical reconstruction of a large cranial defect. A series of computed tomography (CT) images was obtained and purpose built software was used to extract the cranial geometry in a point cloud. The point cloud produced was used for: (a) the creation of a stereolithographic (STL) physical model for direct assessment of the cranial defect; and (b) the creation of a 3D mould model for the fabrication of the patient-specific implant.
Dermatology, 2003
We report a case of Netherton syndrome manifested as congenital ichthyosiform erythroderma, trich... more We report a case of Netherton syndrome manifested as congenital ichthyosiform erythroderma, trichorrhexis invaginata and atopy, who in early adulthood developed multiple, aggressive epithelial neoplasms in sun-exposed areas of the skin, in areas with papillomatous skin hyperplasia and at the left parotid region. The occurrence of cutaneous neoplasia has been reported in syndromes with congenital ichthyosis and suggests that the underlying genetic defects may cause the development of cancer in prone patients.
Antimicrobial Agents and Chemotherapy, Dec 1, 2001
The effectiveness of newer macrolides in acute Q fever for 113 patients was recorded. The mean ti... more The effectiveness of newer macrolides in acute Q fever for 113 patients was recorded. The mean times to defervescence were 2.9 days for doxycycline and 3.3, 3.9, 3.9, and 6.4 days for clarithromycin, roxithromycin, erythromycin, and -lactams, respectively (P < 0.01 for macrolides versus -lactams). We conclude that macrolides may be an adequate empirical antibiotic therapy for acute Q fever.
Surgical Innovation, Jun 4, 2022
Headache is a prevalent clinical symptom and condition, whose management has been challenging fro... more Headache is a prevalent clinical symptom and condition, whose management has been challenging from the antiquity to the 21st century. Physicians in the Greek, Roman and Byzantine antiquity employed surgical techniques to treat headache in patients presenting with persistent symptoms that were not alleviated with conservative means. A survey in the medical literature of the period reveals that two surgical procedures, periscyphismus and section of the temporal vessels, were developed for this purpose. The present study describes the techniques presented in the sources of the period and elaborates on their evolution and influence across different historical periods and contexts.
Diagnostics, Jan 21, 2024
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Plastic surgery, 2001
A ctinic lesions of the skin may become apparent during the third decade of life or later. In dis... more A ctinic lesions of the skin may become apparent during the third decade of life or later. In disorders such as xeroderma pigmentosum, lesions appear early, even in childhood (1). Heredity, prolonged sun exposure and the action of several chemical factors, promote the development of lesions (2). One manifestation of sun-damaged skin is actinic elastosis. When lesions are located on the neck, the disorder is known as Farmer's neck or cutis rhomboidalis nuchae. When the upper extremities are affected, the disorder is known as actinic comedonal plaques or solar elastotic bands (3). When the ear is affected, it is known as nodular chondrodermatitis,
Journal of Craniofacial Surgery, 2016
Journal of Plastic Reconstructive and Aesthetic Surgery, Aug 1, 2010
Nowadays, as in the past, much attention is paid to aesthetic operations in women, while only inf... more Nowadays, as in the past, much attention is paid to aesthetic operations in women, while only infrequently have such operations been referred to in males. Generally, male aesthetic surgery was introduced to surgical practise during the 19th century. In this study, we analysed the practise of such operations in Byzantine times and in other ancient cultures with surgical knowledge, i.e. ancient India and China The sixth book of Paul of Aegina&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;Epitome of Medicine&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; was studied for description of aesthetic operations in males in the Byzantine period, since this book is completely devoted to surgery and is generally considered to be the most important reference for surgery in Byzantine times. The original text and its excellent translation by Francis Adams were used. References concerning aesthetic operations for males were identified. Accordingly, historical work and reviews on plastic surgery in ancient India and China were studied. Mainly, two aesthetic surgical procedures for males in the Byzantine period were identified. These two procedures comprise gynaecomastia and rhacosis (scrotal relaxation). Two different techniques were reported for the surgical management of gynaecomastia, through sub-mammary or supra-mammary access. Two procedures were noted for rhacosis, for which Paul of Aegina reproduced the respective chapters from Leonides&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; and Antyllus&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; works. Evidence supporting male aesthetic surgery in ancient India and China or elsewhere was not found. Despite the dubious aesthetic result, the existence of different aesthetic surgical techniques in males substantiate the advanced level of surgery achieved by physicians in the Byzantine period.
Acta Chirurgica Belgica, Nov 2, 2018
Introduction: Polydactyly, or polydactylism, is a common congenital disorder of the limbs, consis... more Introduction: Polydactyly, or polydactylism, is a common congenital disorder of the limbs, consisting of any digit duplication beyond the normal five. The term syndactyly refers to fused digits. We herein present a thorough description of these diseases together with their surgical treatment, provided by Oribasius, a Byzantine physician of the 4th century. To our knowledge, this is the earliest description of supernumerary and fused fingers and their surgical management. Material and Methods: We conducted a thorough study of Oribasius' work. Results: The 15th chapter of the 47th book of Oribasius' work is devoted to finger abnormalities (i.e. polydactyly and syndactyly) and their surgical treatment. Discussion: With regard to the extensive medical knowledge of the 4th century as survived in Oribasius' work, these descriptions comprise, to the best of our knowledge, the earliest written references to the surgical treatment of polydactyly and syndactyly.
Advances in Experimental Medicine and Biology, 2021
Facial reconstruction is employed in medical science and archaeology. Though quite popular as ant... more Facial reconstruction is employed in medical science and archaeology. Though quite popular as anthropological method, it has not so far been used in the orthodox ecclesiastical tradition. This work presents the facial reconstruction of St Eftychios of Crete, who lived between the ninth and tenth centuries. Computed tomography and reverse engineering methods were employed to complete the task. Reconstruction of the mandible and the missing left zygomatic arch was implemented following the Sassouni method. The American method was followed for the soft tissues, with clay deposition of appropriate thickness, on the surface of the skull model. The eyes, nose, and lips were added based on the dimensions of the underlying bone structures. Long hair and beard were added, according to the classic Byzantine tradition pattern of the time period. The final bust developed was then digitized, using a 3D non-contact laser scanner. The 3D geometry produced was employed to produce a mold with vacuum casting techniques. This mold provides the ability to produce copies of the bust, if needed. At the same time, a realistic 3D representation of the Saint's bust was developed, with the aid of special software, in order to compare the traditional forensic reconstruction to the pure digital one. This work is the first case of a Saint's facial reconstruction in the Orthodox Church. The facial reconstruction process, with all the limitations considered, offers the ability to present a realistic aspect of a Greek Orthodox Church Saint, in a form that is easily accessible. Both physical and digital facial reconstruction processes were based on scientific data, so they were as accurate as possible, considering that the mandible was missing in the skull. The facial reconstruction was entirely implemented in Greece creating the basis for similar work in the future. The final bust developed was donated to the Odigitria Monastery, to be exhibited to its visitors.
World journal of clinical oncology, Aug 24, 2022
Psychosomatics, Jul 1, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Canadian Journal of Plastic Surgery, Jun 1, 2001
A ctinic lesions of the skin may become apparent during the third decade of life or later. In dis... more A ctinic lesions of the skin may become apparent during the third decade of life or later. In disorders such as xeroderma pigmentosum, lesions appear early, even in childhood (1). Heredity, prolonged sun exposure and the action of several chemical factors, promote the development of lesions (2). One manifestation of sun-damaged skin is actinic elastosis. When lesions are located on the neck, the disorder is known as Farmer's neck or cutis rhomboidalis nuchae. When the upper extremities are affected, the disorder is known as actinic comedonal plaques or solar elastotic bands (3). When the ear is affected, it is known as nodular chondrodermatitis,
International Journal of Dermatology, 2006
American Journal of Tropical Medicine and Hygiene, May 1, 2004
This study estimated the clinical effectiveness of five different antibiotic regimens (doxycyclin... more This study estimated the clinical effectiveness of five different antibiotic regimens (doxycycline, chloramphenicol, ciprofloxacin, doxycycline plus chloramphenicol, and doxycycline plus ciprofloxacin) administered for infection with Rickettsia typhi in terms of the duration of the fever. Eighty-seven patients with endemic typhus were hospitalized between 1993 and 1998 at the General Hospital of Chania in Chania, Crete, Greece. The mean time to defervescence was 2.9 days for doxycycline, 4.0 days for chloramphenicol, and 4.2 days for ciprofloxacin. In patients receiving combinations of doxycycline plus chloramphenicol and doxycycline plus ciprofloxacin, fever subsided in 3.4 and 4.0 days, respectively. The outcome was favorable in all patients, and no deaths or relapses were observed within two months.
International Journal of Dermatology, Jun 21, 2010
Basal cell carcinoma (BCC) is very common and usually encountered when it is small in size. Giant... more Basal cell carcinoma (BCC) is very common and usually encountered when it is small in size. Giant BCC (i.e. greater than 5 cm in diameter) is quite rare and comprises 0.5 percent of all BCC. Extremely rarely, tumors larger than 20 cm have been reported. Herein, a case with an enormous, vegetating BCC of the abdominal wall, 30 x 20 cm in size, is described. This report demonstrates that such a case can still be observed in the civilized world of the 21st century, which remains profoundly astonishing. A literature survey was performed and revealed only 7 cases with such super giant BCC (i.e. larger than 20 cm in diameter). Generally, this tumor attains these enormous proportions due to neglect on the patient's part, and is usually located at sites covered by clothes. Treatment is mainly surgical and generally curative, resulting also in an improved quality of life. Tumor size of more than 10 cm in diameter is associated with increased risk for metastatic disease, severe morbidity and consequently impaired prognosis.
Dermatologic Surgery, Dec 1, 1996
The finite element analysis (FEA) is a recently introduced method in biomechanics that permits mo... more The finite element analysis (FEA) is a recently introduced method in biomechanics that permits modeling of complex structures considering them as an aggregate of small elements. Skin flaps are highly suggested to be amenable to the continuum mechanic laws that underly the development of FEA. A combination of "large deformation analysis," based on FEA with the criteria for skin flap selection, was attempted. Serial defects were experimentally created on piglet skin stripes, which were consequently covered through designing appropriate flaps. Skin samples were modeled after the development of a computer FEA program and they were scanned by incorporating their photographs. On the graphic interfaces the flap movement, the closure of the defect, and the whole deformation were found to match with the skin stripe postincisional alterations. This work permits the prediction and offers planning guides for different skin reconstructions.
BMC Research Notes, Jun 14, 2021
Objective: Computerized clinical image analysis is shown to improve diagnostic accuracy for cutan... more Objective: Computerized clinical image analysis is shown to improve diagnostic accuracy for cutaneous melanoma but its effectiveness in preoperative assessment of melanoma thickness has not been studied. The aim of this study, is to explore how melanoma thickness correlates with computer-assisted objectively obtained color and geometric variables. All patients diagnosed with cutaneous melanoma with available clinical images prior to tumor excision were included in the study. All images underwent digital processing with an automated non-commercial software. The software provided measurements for geometrical variables, i.e., overall lesion surface, maximum diameter, perimeter, circularity, eccentricity, mean radius, as well as for color variables, i.e., range, standard deviation, coefficient of variation and skewness in the red, green, and blue color space. Results: One hundred fifty-six lesions were included in the final analysis. The mean tumor thickness was 1.84 mm (range 0.2-25). Melanoma thickness was strongly correlated with overall surface area, maximum diameter, perimeter and mean lesion radius. Thickness was moderately correlated with eccentricity, green color and blue color. We conclude that geometrical and color parameters, as objectively extracted by computer-aided clinical image processing, may correlate with tumor thickness in patients with cutaneous melanoma. However, these correlations are not strong enough to reliably predict tumor thickness.
World Journal of Surgery, Oct 21, 2014
Background The aim of this study was to evaluate the effects of surgically induced weight loss on... more Background The aim of this study was to evaluate the effects of surgically induced weight loss on the abdominal adipose tissue depots and the metabolic profile in morbidly obese (MO) patients. Methods The study was performed with a semi-automated quantification of adipose tissue compartments on singleslice abdominal CT series before surgery, 6 and 12 months after bariatric surgery. Thirty-eight MO patients with mean age of 35.7 ± 10.1 years and mean body mass index (BMI) of 43.6 ± 6.5 kg/m 2 were studied (20 patients underwent gastric banding and 18 patients underwent sleeve gastrectomy). Anthropometric measurements, metabolic and inflammatory parameters were analyzed in each patient. Results Markedly decreased levels of total abdominal adipose tissue, abdominal subcutaneous adipose tissue (AbSAT) and visceral adipose tissue (VAT) at 6 and 12 months were noted in comparison to the preoperative values. The total % reduction of VAT was significant higher in comparison to the total % reduction of AbSAT at 12 months after bariatric surgery (P \ 0.01) with the mean ratio of AbSAT/VAT to increase from 4.1 ± 1.7 preoperatively to 6.2 ± 3.1 at 12 months postoperatively (P \ 0.001). In addition, high-sensitivity C-reactive protein (hsCRP) decreased significantly with weight loss after bariatric surgery and the total abdominal lipid loss was related to the decrease in hsCRP. Conclusions Significant changes in abdominal lipid deposition occurred in MO patients 6 and 12 months after bariatric surgery. The changes were significantly, correlated with the magnitude of BMI loss. The fat redistribution may contribute to the improvements in metabolic abnormalities. C. Galanakis and M. Daskalakis have contributed equally to this study.
Journal of Medical Engineering & Technology, 2008
This paper presents rapid prototyping and reverse engineering techniques applied to create an imp... more This paper presents rapid prototyping and reverse engineering techniques applied to create an implant for the surgical reconstruction of a large cranial defect. A series of computed tomography (CT) images was obtained and purpose built software was used to extract the cranial geometry in a point cloud. The point cloud produced was used for: (a) the creation of a stereolithographic (STL) physical model for direct assessment of the cranial defect; and (b) the creation of a 3D mould model for the fabrication of the patient-specific implant.
Dermatology, 2003
We report a case of Netherton syndrome manifested as congenital ichthyosiform erythroderma, trich... more We report a case of Netherton syndrome manifested as congenital ichthyosiform erythroderma, trichorrhexis invaginata and atopy, who in early adulthood developed multiple, aggressive epithelial neoplasms in sun-exposed areas of the skin, in areas with papillomatous skin hyperplasia and at the left parotid region. The occurrence of cutaneous neoplasia has been reported in syndromes with congenital ichthyosis and suggests that the underlying genetic defects may cause the development of cancer in prone patients.
Antimicrobial Agents and Chemotherapy, Dec 1, 2001
The effectiveness of newer macrolides in acute Q fever for 113 patients was recorded. The mean ti... more The effectiveness of newer macrolides in acute Q fever for 113 patients was recorded. The mean times to defervescence were 2.9 days for doxycycline and 3.3, 3.9, 3.9, and 6.4 days for clarithromycin, roxithromycin, erythromycin, and -lactams, respectively (P < 0.01 for macrolides versus -lactams). We conclude that macrolides may be an adequate empirical antibiotic therapy for acute Q fever.
Surgical Innovation, Jun 4, 2022
Headache is a prevalent clinical symptom and condition, whose management has been challenging fro... more Headache is a prevalent clinical symptom and condition, whose management has been challenging from the antiquity to the 21st century. Physicians in the Greek, Roman and Byzantine antiquity employed surgical techniques to treat headache in patients presenting with persistent symptoms that were not alleviated with conservative means. A survey in the medical literature of the period reveals that two surgical procedures, periscyphismus and section of the temporal vessels, were developed for this purpose. The present study describes the techniques presented in the sources of the period and elaborates on their evolution and influence across different historical periods and contexts.