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Papers by asish dev

Journal of Clinical/ Pharmaco-Epidemiology Research, 2022

The objective of this review is to bring general awareness amongst the population regarding the g... more The objective of this review is to bring general awareness amongst the population regarding the general healthy practices of social distancing, maintaining hygiene by use of various hand sanitizers, and ensuring prevention of the spread of COVID-19 infection. The general population may be concerned about the effectiveness and safety aspects of alcohol-based hand sanitizers. The harmful effects that might be associated with the excessive use of alcohol-based hand sanitizers. The current article tries to focus on the various ways by which sanitization may be achieved. It also describes the various types of alcohol-based hand sanitizers and extensively talks about their manufacturing methods of them. The queries regarding the hazardous effects of alcohol-based hand sanitizers are also addressed.

Pharmaceutical and Biological Evaluations, 2016

Recently controlled and sustained drug delivery has become the new standard in modern pharmaceuti... more Recently controlled and sustained drug delivery has become the new standard in modern pharmaceutical design and a thorough research has been undertaken in achieving much better drug product effectiveness, reliability and safety. In situ gelling system has become an outstanding among novel drug delivery system (NDDS) in recent years due to its advantages like sustained and prolonged drug action, improved patient compliance and reduced frequency of administration of the drug compared to conventional drug delivery system (DDS). In this system the formulation is in the form of solution and when comes in contact with body fluids it undergoes gelation to form a gel. The formation of gels depends on factors like temperature changes, pH changes, presence of ions and ultraviolet irradiation. Various biodegradable polymers like gellan gum, pectin, alginic acid, chitosan, xyloglucan, etc are used. In situ gels are administered through various routes like oral, ocular, nasal, rectal, vaginal, i...

Pharmaceutical and Biological Evaluations, 2016

The most common route of drug administration is oral route in which drug is swallowed and absorbe... more The most common route of drug administration is oral route in which drug is swallowed and absorbed in systemic circulation through the membrane of gastrointestinal track. But due to common problem of dysphasia number of population finds difficulty in swallowing the conventional dosage form. Sublingual route is very useful when rapid onset of action is desired with good patient compliance than orally ingested tablets. Sublingual tablets can be formulated by various techniques. New sublingual technologies address patient needs & many pharmaceutical, ranging from enhanced life-cycle management to convenient dosing for geriatric, paediatric and psychiatric patients with dysphagia.

Pharmaceutical and Biological Evaluations, 2015

Skin is most liable to have microbial or fungal infections. Emulsions are gellified emulsion in w... more Skin is most liable to have microbial or fungal infections. Emulsions are gellified emulsion in which emulsion is incorporated into gel base. Skin is having different layers like dermis, epidermis and stratum corneum and different sub layers. Emulgels having advantages like Better stability, Hydrophobic drugs can be easily incorporated into gels using d/o/w emulsions, Production feasibility, low preparation cost, Better loading capacity, Controlled release and No intensive sonication with certain disadvantages like poor penetration, skin irritation, bubble formation. Emulgels are of two types micro emulsion gels and nano emulgel. Emulgels are prepared contains aqueous phase made up of water or alcohols, Oil phase made up of mineral oil in combination with soft paraffin or hard paraffin, emulsifiers, gelling agents, anti-oxidants, preservatives, penetration enhancer and humectants. Emulgels are characterised for parameters such as Physical Examination, Rhelogical Studies, Globule s...

Losartan potassium is a potent antihypertensive drug which is a highly specific Angiotensin II Ty... more Losartan potassium is a potent antihypertensive drug which is a highly specific Angiotensin II Type/AT 1 receptor antagonist. It is readily absorbed from the gastro intestinal tract, having oral bioavailability 33% and plasma elimination half life from 1.5 to 2.5 hours. The present study is an attempt to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance of Losartan potassium by developing sustained release tablets. Losartan potassium was formulated as oral sustained release tablets by using HPMC k4M and HPMC k15M. Preformulation studies were carried out to evaluate the parameters like powder flow properties, loss on drying, Drug-excipient compatibility and stress stability. All four formulations showed acceptable IP specifications for weight variation, thickness, hardness and friability. The dissolution studies showed release of drug over a period of 10 hours in zero-order kinetic.

Buccal delivery involves the administration of the desired drug through the buccal mucosal membra... more Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity. The objective of this article is to review buccal drug delivery by discussing the structure and environment of the oral mucosa and highlighting the mechanisms of drug permeation and methodology in evaluating buccal formulations. This review also highlights a brief description of advantages, limitations of buccal drug delivery and theories involved in mucoadhesion along with method of preparation mucoadhesive system, mucoadhesive polymer, and classification of buccal system.

International Journal of Research and Review, 2021

Objective: The objective of the work is to formulate candesartan cilexetil floating bioadhesive t... more Objective: The objective of the work is to formulate candesartan cilexetil floating bioadhesive tablets which can considerably improve the bioavailability of medicine underneath the condition of redoubled continuance of drug in abdomen. Methods: Floating bioadhesive tablet was ready by direct compression of chemical compound like HPMCE15 and Carbopol934p together. Result: After analysis of different evaluation parameter and drug release, F4 batch was selected as promising formulation for delivery of candesartan cilexetil floating bioadhesive tablets with 91.22% drug release at 12th h. Conclusion: Among the further batches, the F4 batch was selected as an optimized batch as a result of the pre-compression and post-compression parameters results area unit satisfactory. Keywords: Candesartan cilexetil, Floating bioadhesive tablets, Polymer, Total floating time.

INDIAN DRUGS, 2013

Mouth Dissolving Tablets (MDTs) have received ever-increasing demand during the last decade and t... more Mouth Dissolving Tablets (MDTs) have received ever-increasing demand during the last decade and the field has become a rapidly growing area of research in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several MDT technologies. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail MDT technologies based on lyophilization, moulding, sublimation and compaction, as well as approaches to enhance the MDT properties, such as spray drying, moisture treatment, sintering, and use of sugar-based disintegrants.

Indian Journal of Pharmaceutical and Biological Research

An oral route of drug administration is the most popular route of administration. It have wide ac... more An oral route of drug administration is the most popular route of administration. It have wide acceptance up to 50-60% of total dosage forms. Tablet is the most popular dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however hand tremors, dysphasia in case of geriatric patients, the underdeveloped muscular and nervous systems in young individuals and case of uncooperative patients, the problem of swallowing is common phenomenon which leads to poor patient compliance. Mouth dissolving tablets (FDT) or fast dissolving tablets; (FDT) has emerged as alternative oral dosage forms. These are novel types of tablets that disintegrate/dissolve/disperse in saliva within few seconds. Fast dissolving tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. This article reviews the Need, advantages, challenges, limitations, mechanis...

Indian Journal of Pharmaceutical and Biological Research

Designing and formulating an ideal pharmaceutical product is a very tedious job for a formulator ... more Designing and formulating an ideal pharmaceutical product is a very tedious job for a formulator as it comprises of multiple objectives. The traditional method followed for years is not only expensive and time consuming but it also needs lot of effort to be put in and in spite of that at times it proves to be unfavourable and unpredictable too.The recent approach to optimise i.e. to achieve the best combination of product and process characteristics under the given conditions is by using Design of Experiment (DoE).Design of Experiment (DoE) is an organised approach to determine the relationship between the factors (Xs) affecting a process and the output of that process (Ys).The recent optimisation methodologies include various approaches that come under the 2 main categories namely, simultaneous optimisation and sequential optimisation. Nowadays there are various software available to carry out the optimisation of pharmaceutical products.

Journal of Drug Delivery and Therapeutics

The objective of the work is to recognize the recent advancements in the modern health care and d... more The objective of the work is to recognize the recent advancements in the modern health care and drug delivery systems. The article describes few recent developments in technology like artificial intelligence, personalized medicines, customized medicines, 3D printing, bioelectronic devices and tele pharmacy, which have the potential to augment health care and drug delivery in coming times. Personalized medication ensures precise health care as per the individual genetic makeup of the patients. The 3D printing technology enables to deliver tailor made solutions to fulfil individual patient requirements. Bioelectronic medicines and devices are new technology where the patient wears a device and its electrical signal cures certain ailments. Tele pharmacy ensures that the technological advances of telecommunications are also passed on to the patient health care sector. Moreover, it can be said that all these modern developments ensure that the quality of life improves and there comes a b...

Asian Journal of Pharmaceutical and Clinical Research

Objective: The objective of this study was to develop an in situ ophthalmic gel of an anti-infect... more Objective: The objective of this study was to develop an in situ ophthalmic gel of an anti-infective drug, moxifloxacin (MOX) hydrochloride (HCL), for sustained ocular delivery for the treatment of bacterial infections of the eye. Method: In the present work the in situ gelling systems were prepared by ion exchange method with the help of various concentrations of gelling agent gelrite (0.08 g, 0.1 g and 0.12 g) and sodium alginate (0.6 g, 0.8 g and 1 g) as viscosity enhancer were added in the formulation; 9 formulations were prepared according to 32 factorial designs and evaluated. The responses were analyzed for the analysis of variance using Design-Expert version 10 software. Statistical models were generated for each response parameter. Results: Optimized formulation batch F7 (0.12% gelrite and 0.6% sodium alginate) was liquid before addition of simulated tear fluid (STF) and underwent rapid gelation on addition of STF and had given 84.05% cumulative drug release; the formulatio...

Indian Journal of Pharmaceutical and Biological Research

The colon is the terminal part of the GIT which has gained as a potential site for delivery of va... more The colon is the terminal part of the GIT which has gained as a potential site for delivery of various novel therapeutic drugs i.e. peptides. Colon targeted drug delivery system (CDDS) is an Promising tool for treatment of inflammatory bowel diseases such as ulcerative colitis, crohn’s disease, colon cancer, amobebiasis by both systemic and topical delivery of dug. This article review a detailed study about disease of colon, diagnosis of diseases of colon, anatomy of colon, factors affecting drug absorption and different approaches of colon including some current approaches like Pulsinicap system, Port system, Probiotic approach, Chronotropic system, Colal-pred system, Enterion capsule Technology Muliparticulate system and some past studies on colon drug delivery with evaluation method for site specific drug delivery to colon.

Journal of Drug Delivery and Therapeutics

Objective: The proposed study is focussed at developing acyclovir microemulsions for topical drug... more Objective: The proposed study is focussed at developing acyclovir microemulsions for topical drug delivery systems. QbD was applied for better understanding of the process and to generate design space, using quality target product profile, critical quality attributes, and risk assessment. The aim of the experiment is to prepare a safe, efficacious, stable and patient compliant microemulsion dosage form of Acyclovir. Materials and methods: Pre-formulation studies were carried out which helped in developing a suitable dosage form. UV, FTIR and DSC studies were done for pre-formulation and post-formulation evaluations. QbD was applied to generate design space, using QTPP, CQA, and risk assessment. Microemulsions of acyclovir were developed by using 32 factorial designs. Pseudo terneary phase diagrams were constructed to screen various surfactants and co-surfactants for the preparation of microemulsions. Two independent variables Oil Concentration (X1) and Smix Concentration (X2) at th...

Journal of Drug Delivery and Therapeutics

Objective: The proposed study is focussed at developing acyclovir microsponges for oral drug deli... more Objective: The proposed study is focussed at developing acyclovir microsponges for oral drug delivery systems. QbD was applied for better understanding of the process and to generate design space, using quality target product profile, critical quality attributes, and risk assessment. The aim of the experiment is to prepare a safe, efficacious, stable and patient compliant microsponge dosage form of Acyclovir. Materials and methods: Pre-formulation studies were carried out which helped in developing a suitable dosage form. UV, FTIR, DSC, and SEM studies were done for pre-formulation and post-formulation evaluations. QbD was applied to generate design space, using QTPP, CQA, and risk assessment. Microsponges of acyclovir were developed by 23 factorial designs. Three variables Drug: Polymer ratio (X1), Concentration of surfactant (X2) and Stirring speed (RPM) (X3) at two levels low and high were selected and response surface plots were generated. The microsponges were prepared by Quas...

Asian Journal of Pharmaceutical and Clinical Research

Objective: The objective of this study was to formulate and optimize a chewable formulation of li... more Objective: The objective of this study was to formulate and optimize a chewable formulation of lidocaine hydrochloride using a 32 factorial design for optimized the superdisintegrant concentration.Methods: Various concentrations of sodium starch glycolate (SSG) (13.33 mg, 26.66 mg, and 40 mg) of superdisintegrant and starch (50 mg, 83 mg, and 116.66 mg) were added in the formulation; nine formulations were prepared according to 32 factorial designs and evaluated. The responses were analyzed for analysis of variance using Design-Expert version 10 software. Statistical models were generated for each response parameter. The models were tested for significance. Procedure to manufacture chewable tablets by direct compression was established.Results: The results show that the presence of a superdisintegrant is desirable for chewable formulation. The best-optimized batch F7 found the batch having starch of amount 116.66 mg and SSG 13.33 mg. All the prepared batches of tablets were within t...

Objective: The objective of the work is to formulate gliclazide bioadhesive tablets that will sig... more Objective: The objective of the work is to formulate gliclazide bioadhesive tablets that will significantly improve the availability of the drug especially under the situations of prolonged use of drug and also reduce the total dosage of administered drug and consequently reduce the side effects. All these factors will ultimately lead to enhanced patient compliance and patient care. Methods: Various natural and semi synthetic polymers were screened and they were selected on the basis of their swelling and gelling properties. The formulated batches were subjected to various evaluation parameters and optimization was done. Results: The F7 batch was concluded to be the best batch in which Xanthan gum (70%) and HPMC K4M (30%) were taken. Stability studies of the optimized batches were conducted as per the ICH guidelines. Conclusions: From this study it was concluded that as the thickness of tablet increases the hardness of tablet decreases which leads to increase in the swelling of the tablet and hence the increase in the drug release.

Journal of Clinical/ Pharmaco-Epidemiology Research, 2022

The objective of this review is to bring general awareness amongst the population regarding the g... more The objective of this review is to bring general awareness amongst the population regarding the general healthy practices of social distancing, maintaining hygiene by use of various hand sanitizers, and ensuring prevention of the spread of COVID-19 infection. The general population may be concerned about the effectiveness and safety aspects of alcohol-based hand sanitizers. The harmful effects that might be associated with the excessive use of alcohol-based hand sanitizers. The current article tries to focus on the various ways by which sanitization may be achieved. It also describes the various types of alcohol-based hand sanitizers and extensively talks about their manufacturing methods of them. The queries regarding the hazardous effects of alcohol-based hand sanitizers are also addressed.

Pharmaceutical and Biological Evaluations, 2016

Recently controlled and sustained drug delivery has become the new standard in modern pharmaceuti... more Recently controlled and sustained drug delivery has become the new standard in modern pharmaceutical design and a thorough research has been undertaken in achieving much better drug product effectiveness, reliability and safety. In situ gelling system has become an outstanding among novel drug delivery system (NDDS) in recent years due to its advantages like sustained and prolonged drug action, improved patient compliance and reduced frequency of administration of the drug compared to conventional drug delivery system (DDS). In this system the formulation is in the form of solution and when comes in contact with body fluids it undergoes gelation to form a gel. The formation of gels depends on factors like temperature changes, pH changes, presence of ions and ultraviolet irradiation. Various biodegradable polymers like gellan gum, pectin, alginic acid, chitosan, xyloglucan, etc are used. In situ gels are administered through various routes like oral, ocular, nasal, rectal, vaginal, i...

Pharmaceutical and Biological Evaluations, 2016

The most common route of drug administration is oral route in which drug is swallowed and absorbe... more The most common route of drug administration is oral route in which drug is swallowed and absorbed in systemic circulation through the membrane of gastrointestinal track. But due to common problem of dysphasia number of population finds difficulty in swallowing the conventional dosage form. Sublingual route is very useful when rapid onset of action is desired with good patient compliance than orally ingested tablets. Sublingual tablets can be formulated by various techniques. New sublingual technologies address patient needs & many pharmaceutical, ranging from enhanced life-cycle management to convenient dosing for geriatric, paediatric and psychiatric patients with dysphagia.

Pharmaceutical and Biological Evaluations, 2015

Skin is most liable to have microbial or fungal infections. Emulsions are gellified emulsion in w... more Skin is most liable to have microbial or fungal infections. Emulsions are gellified emulsion in which emulsion is incorporated into gel base. Skin is having different layers like dermis, epidermis and stratum corneum and different sub layers. Emulgels having advantages like Better stability, Hydrophobic drugs can be easily incorporated into gels using d/o/w emulsions, Production feasibility, low preparation cost, Better loading capacity, Controlled release and No intensive sonication with certain disadvantages like poor penetration, skin irritation, bubble formation. Emulgels are of two types micro emulsion gels and nano emulgel. Emulgels are prepared contains aqueous phase made up of water or alcohols, Oil phase made up of mineral oil in combination with soft paraffin or hard paraffin, emulsifiers, gelling agents, anti-oxidants, preservatives, penetration enhancer and humectants. Emulgels are characterised for parameters such as Physical Examination, Rhelogical Studies, Globule s...

Losartan potassium is a potent antihypertensive drug which is a highly specific Angiotensin II Ty... more Losartan potassium is a potent antihypertensive drug which is a highly specific Angiotensin II Type/AT 1 receptor antagonist. It is readily absorbed from the gastro intestinal tract, having oral bioavailability 33% and plasma elimination half life from 1.5 to 2.5 hours. The present study is an attempt to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance of Losartan potassium by developing sustained release tablets. Losartan potassium was formulated as oral sustained release tablets by using HPMC k4M and HPMC k15M. Preformulation studies were carried out to evaluate the parameters like powder flow properties, loss on drying, Drug-excipient compatibility and stress stability. All four formulations showed acceptable IP specifications for weight variation, thickness, hardness and friability. The dissolution studies showed release of drug over a period of 10 hours in zero-order kinetic.

Buccal delivery involves the administration of the desired drug through the buccal mucosal membra... more Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity. The objective of this article is to review buccal drug delivery by discussing the structure and environment of the oral mucosa and highlighting the mechanisms of drug permeation and methodology in evaluating buccal formulations. This review also highlights a brief description of advantages, limitations of buccal drug delivery and theories involved in mucoadhesion along with method of preparation mucoadhesive system, mucoadhesive polymer, and classification of buccal system.

International Journal of Research and Review, 2021

Objective: The objective of the work is to formulate candesartan cilexetil floating bioadhesive t... more Objective: The objective of the work is to formulate candesartan cilexetil floating bioadhesive tablets which can considerably improve the bioavailability of medicine underneath the condition of redoubled continuance of drug in abdomen. Methods: Floating bioadhesive tablet was ready by direct compression of chemical compound like HPMCE15 and Carbopol934p together. Result: After analysis of different evaluation parameter and drug release, F4 batch was selected as promising formulation for delivery of candesartan cilexetil floating bioadhesive tablets with 91.22% drug release at 12th h. Conclusion: Among the further batches, the F4 batch was selected as an optimized batch as a result of the pre-compression and post-compression parameters results area unit satisfactory. Keywords: Candesartan cilexetil, Floating bioadhesive tablets, Polymer, Total floating time.

INDIAN DRUGS, 2013

Mouth Dissolving Tablets (MDTs) have received ever-increasing demand during the last decade and t... more Mouth Dissolving Tablets (MDTs) have received ever-increasing demand during the last decade and the field has become a rapidly growing area of research in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several MDT technologies. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail MDT technologies based on lyophilization, moulding, sublimation and compaction, as well as approaches to enhance the MDT properties, such as spray drying, moisture treatment, sintering, and use of sugar-based disintegrants.

Indian Journal of Pharmaceutical and Biological Research

An oral route of drug administration is the most popular route of administration. It have wide ac... more An oral route of drug administration is the most popular route of administration. It have wide acceptance up to 50-60% of total dosage forms. Tablet is the most popular dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however hand tremors, dysphasia in case of geriatric patients, the underdeveloped muscular and nervous systems in young individuals and case of uncooperative patients, the problem of swallowing is common phenomenon which leads to poor patient compliance. Mouth dissolving tablets (FDT) or fast dissolving tablets; (FDT) has emerged as alternative oral dosage forms. These are novel types of tablets that disintegrate/dissolve/disperse in saliva within few seconds. Fast dissolving tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. This article reviews the Need, advantages, challenges, limitations, mechanis...

Indian Journal of Pharmaceutical and Biological Research

Designing and formulating an ideal pharmaceutical product is a very tedious job for a formulator ... more Designing and formulating an ideal pharmaceutical product is a very tedious job for a formulator as it comprises of multiple objectives. The traditional method followed for years is not only expensive and time consuming but it also needs lot of effort to be put in and in spite of that at times it proves to be unfavourable and unpredictable too.The recent approach to optimise i.e. to achieve the best combination of product and process characteristics under the given conditions is by using Design of Experiment (DoE).Design of Experiment (DoE) is an organised approach to determine the relationship between the factors (Xs) affecting a process and the output of that process (Ys).The recent optimisation methodologies include various approaches that come under the 2 main categories namely, simultaneous optimisation and sequential optimisation. Nowadays there are various software available to carry out the optimisation of pharmaceutical products.

Journal of Drug Delivery and Therapeutics

The objective of the work is to recognize the recent advancements in the modern health care and d... more The objective of the work is to recognize the recent advancements in the modern health care and drug delivery systems. The article describes few recent developments in technology like artificial intelligence, personalized medicines, customized medicines, 3D printing, bioelectronic devices and tele pharmacy, which have the potential to augment health care and drug delivery in coming times. Personalized medication ensures precise health care as per the individual genetic makeup of the patients. The 3D printing technology enables to deliver tailor made solutions to fulfil individual patient requirements. Bioelectronic medicines and devices are new technology where the patient wears a device and its electrical signal cures certain ailments. Tele pharmacy ensures that the technological advances of telecommunications are also passed on to the patient health care sector. Moreover, it can be said that all these modern developments ensure that the quality of life improves and there comes a b...

Asian Journal of Pharmaceutical and Clinical Research

Objective: The objective of this study was to develop an in situ ophthalmic gel of an anti-infect... more Objective: The objective of this study was to develop an in situ ophthalmic gel of an anti-infective drug, moxifloxacin (MOX) hydrochloride (HCL), for sustained ocular delivery for the treatment of bacterial infections of the eye. Method: In the present work the in situ gelling systems were prepared by ion exchange method with the help of various concentrations of gelling agent gelrite (0.08 g, 0.1 g and 0.12 g) and sodium alginate (0.6 g, 0.8 g and 1 g) as viscosity enhancer were added in the formulation; 9 formulations were prepared according to 32 factorial designs and evaluated. The responses were analyzed for the analysis of variance using Design-Expert version 10 software. Statistical models were generated for each response parameter. Results: Optimized formulation batch F7 (0.12% gelrite and 0.6% sodium alginate) was liquid before addition of simulated tear fluid (STF) and underwent rapid gelation on addition of STF and had given 84.05% cumulative drug release; the formulatio...

Indian Journal of Pharmaceutical and Biological Research

The colon is the terminal part of the GIT which has gained as a potential site for delivery of va... more The colon is the terminal part of the GIT which has gained as a potential site for delivery of various novel therapeutic drugs i.e. peptides. Colon targeted drug delivery system (CDDS) is an Promising tool for treatment of inflammatory bowel diseases such as ulcerative colitis, crohn’s disease, colon cancer, amobebiasis by both systemic and topical delivery of dug. This article review a detailed study about disease of colon, diagnosis of diseases of colon, anatomy of colon, factors affecting drug absorption and different approaches of colon including some current approaches like Pulsinicap system, Port system, Probiotic approach, Chronotropic system, Colal-pred system, Enterion capsule Technology Muliparticulate system and some past studies on colon drug delivery with evaluation method for site specific drug delivery to colon.

Journal of Drug Delivery and Therapeutics

Objective: The proposed study is focussed at developing acyclovir microemulsions for topical drug... more Objective: The proposed study is focussed at developing acyclovir microemulsions for topical drug delivery systems. QbD was applied for better understanding of the process and to generate design space, using quality target product profile, critical quality attributes, and risk assessment. The aim of the experiment is to prepare a safe, efficacious, stable and patient compliant microemulsion dosage form of Acyclovir. Materials and methods: Pre-formulation studies were carried out which helped in developing a suitable dosage form. UV, FTIR and DSC studies were done for pre-formulation and post-formulation evaluations. QbD was applied to generate design space, using QTPP, CQA, and risk assessment. Microemulsions of acyclovir were developed by using 32 factorial designs. Pseudo terneary phase diagrams were constructed to screen various surfactants and co-surfactants for the preparation of microemulsions. Two independent variables Oil Concentration (X1) and Smix Concentration (X2) at th...

Journal of Drug Delivery and Therapeutics

Objective: The proposed study is focussed at developing acyclovir microsponges for oral drug deli... more Objective: The proposed study is focussed at developing acyclovir microsponges for oral drug delivery systems. QbD was applied for better understanding of the process and to generate design space, using quality target product profile, critical quality attributes, and risk assessment. The aim of the experiment is to prepare a safe, efficacious, stable and patient compliant microsponge dosage form of Acyclovir. Materials and methods: Pre-formulation studies were carried out which helped in developing a suitable dosage form. UV, FTIR, DSC, and SEM studies were done for pre-formulation and post-formulation evaluations. QbD was applied to generate design space, using QTPP, CQA, and risk assessment. Microsponges of acyclovir were developed by 23 factorial designs. Three variables Drug: Polymer ratio (X1), Concentration of surfactant (X2) and Stirring speed (RPM) (X3) at two levels low and high were selected and response surface plots were generated. The microsponges were prepared by Quas...

Asian Journal of Pharmaceutical and Clinical Research

Objective: The objective of this study was to formulate and optimize a chewable formulation of li... more Objective: The objective of this study was to formulate and optimize a chewable formulation of lidocaine hydrochloride using a 32 factorial design for optimized the superdisintegrant concentration.Methods: Various concentrations of sodium starch glycolate (SSG) (13.33 mg, 26.66 mg, and 40 mg) of superdisintegrant and starch (50 mg, 83 mg, and 116.66 mg) were added in the formulation; nine formulations were prepared according to 32 factorial designs and evaluated. The responses were analyzed for analysis of variance using Design-Expert version 10 software. Statistical models were generated for each response parameter. The models were tested for significance. Procedure to manufacture chewable tablets by direct compression was established.Results: The results show that the presence of a superdisintegrant is desirable for chewable formulation. The best-optimized batch F7 found the batch having starch of amount 116.66 mg and SSG 13.33 mg. All the prepared batches of tablets were within t...

Objective: The objective of the work is to formulate gliclazide bioadhesive tablets that will sig... more Objective: The objective of the work is to formulate gliclazide bioadhesive tablets that will significantly improve the availability of the drug especially under the situations of prolonged use of drug and also reduce the total dosage of administered drug and consequently reduce the side effects. All these factors will ultimately lead to enhanced patient compliance and patient care. Methods: Various natural and semi synthetic polymers were screened and they were selected on the basis of their swelling and gelling properties. The formulated batches were subjected to various evaluation parameters and optimization was done. Results: The F7 batch was concluded to be the best batch in which Xanthan gum (70%) and HPMC K4M (30%) were taken. Stability studies of the optimized batches were conducted as per the ICH guidelines. Conclusions: From this study it was concluded that as the thickness of tablet increases the hardness of tablet decreases which leads to increase in the swelling of the tablet and hence the increase in the drug release.