Fast dissolving tablets: a novel approach (original) (raw)

A Comprehensive Review on Fast (Mouth) Dissolving Tablets

2021

This review unfolds the comprehensive knowledge on the formulations of fast (mouth) dissolving tablets. Across the globe, 1/3 population has difficulty swallowing tablets. Fast Dissolving Tablets (FDTs) have gotten always expanding requests during the last decade, and the field has become a quickly developing region in the drug business. US Food and Drug Administration (USFDA) characterized quick-dissolving tablet (FDT) as "the structure of a strong measurement containing a therapeutic substance or dynamic fixing which deteriorate quickly ordinarily inside merely seconds when put upon the tongue. Mouth dissolving tablets are strong dose structures that, when put in the mouth, break down, disintegrate and discharge dynamic specialist inside a couple of moments without the requirement for water. Geriatric and pediatric patients experience trouble in swallowing tablets, which prompts poor patient compliance. Fast Dissolving tablets have numerous impacts on better drug delivery wit...

New Approach on Rapid Mouth Dissolving Tablets: A Review

2013

Mouth Dissolving Tablet (MDT) technology has been gaining significance now-a-days with wide variety of drugs serving many purposes. Mouth Dissolving Tablets (MDT) has ever increased their demand in the last decade since they disintegrate in saliva in less than 60 seconds. Mouth Dissolving Drug Delivery Systems serves as a major benefit over the conventional dosage forms since the drug gets rapidly disintegrated & dissolves in the saliva without the use of water. In spite of the downside i.e., lack of immediate onset of action; these oral dosage forms have beneficial such as self-medication, increased the patient compliance, ease of manufacturing and lack of pain as comparison to conventional technologies. The objective of this article is to review the development of MDTs, challenges in formulation, he objective of this article is to review the development of MDTs, challenges in formulation, benefit, limitation ,new MDT technologies and evaluation methodologies.benefit, limitation ...

Fast Dissolving Tablets: As a Preferred Alternative to conventional tablets

AEGAEUM JOURNAL, 2020

Improvement of patient's compliance has always a challenge towards the development of oral drug delivery system. Recent advances in Novel Drug Delivery Systems (NDDS) aim was to manufacture and administrate patients convenient dosage form. It was said to be a best alternative to conventional dosage to the patients having swallowing problems, psychic, paediatrics, geriatric and bedridden , unconscious patients. FDTs are solid with liquid unit dosage forms, which disintegrate or dissolve rapidly(within or less than 60 min) in the mouth without chewing and water. In particular, this review describes in detail on FDT mechanisms, Properties of FDT, advantages and disadvantages, ingredients used in dosage, evaluation, FDT technologies (based on lyophilization, molding, sublimation, and compaction, spray drying), rescent trends on FDT and case study on FDT.

A review on fast dissolving tablets (FDTs)

The oral route is the most acceptable routes among the various routes for different age group of the patients because it is regarded as safest, most convenient and economical route. Therefore, recently researcher and pharmaceutical companies developed the fast dissolving tablet (FDT) by modifying the physiochemical parameter of drugs to their need with improved patient compliance and convenience. FDTs are solid dosages forms which dissolve rapidly in saliva without chewing and additional water. USFDA define FDTs to be the solid oral preparation that disintegrate rapidly in the oral cavity with an in-vitro disintegration time of 30 seconds or less. FDTs improved patient compliance and also overcome the disadvantages of conventional dosage form especially dysphagia (difficulty in swallowing) in pediatric and geriatric patients. Over the last decade FDTs have grown steadily in demand and importance as a convenient, potentially safer alternative to conventional tablets and capsules. The growing importance for this is due to the potential advantages offered by this technology for various kinds of patients suffering from different diseases and disabilities. This review includes ideal properties, characteristics, challenges in formulation, suitability of drug candidates, various technologies developed for FDT, patented technologies, evaluation methods and various marketed products.

An Overview on Mouth Dissolving Tablets

Oral route having the high patient compliance in regarded as the most convenient, safest and also the most economical method of drug delivery. Fast dissolving tablets are one such most advantageous example of the oral drug delivery. These tablets readily dissolve or disintegrate in the saliva i.e. within <60sec without the need for water. They have been formulated for pediatric, geriatric and bedridden patients. This type of dosage forms are also ideal for active patients who are busy and traveling and may not have access to water. FDTs have gained considerable attention for those patients who have difficulties in swallowing because of dysphagia, hand tremors problems and have additional advantage for unconscious, young patients with underdeveloped muscular and nervous system. This review describes the various advantages, limitations, desired characteristics, formulation aspects, super-disintegrants employed; technologies developed for FDTs, evaluation tests, and marketed formulations.

Fast Dissolving Tablets: Review

Research Journal of Pharmaceutical Dosage Forms and Technology, 2015

Fast Dissolving Tablet accommodation the organization and enhanced patient consistence are vital in the outline of oral drug delivery framework. which remains the perfect course of drug delivery inspite of different burden of Oral course having the most noteworthy patient consistence is viewed as the most suitable, most secure furthermore the most efficient system for drug delivery. Quick dissolving tablets is one such most beneficial sample of the oral drug delivery. These tablets promptly break up or crumble in the salivation i.e.within 60 sec without the requirement for water. They have been defined for pediatric, geriatric and out of commission patients. These kind of dose structures are likewise perfect for dynamic patients who are occupied and voyaging and might not have entry to water. FDTs have increased generous consideration for those patients who experience issues in gulping on account of dysphagia, hand tremors issues have supplementary playing point for oblivious, youthful patients with immature solid and sensory system. This article endeavors to present a complete survey with respect to innovative advances made so far in the zone of assessment of quick dissolving tablets as for unique qualities of these special measurements structures.

FAST DISSOLVING TABLETS: A NOVEL APPROCH TO DRUG DELIVERY – A REVIEW

Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. Yet, Dysphagia is a common problem encountered in all age groups in concern to solid dosage forms. To overcome such problems, certain innovative drug delivery systems, like Fast dissolving tablets (FDT) have been developed. Fast dissolving tablets have received ever – increasing demand during the last decade and the field has become a rapidly growing area in the Pharmaceutical industry. These are novel dosage forms which will rapidly disintegrate or dissolve in the saliva without the need of water. FDT’s have been formulated for pediatric, geriatric, bedridden patients and for active patients who are busy and traveling and may not have access to water.This review depicts the various aspects of FDT formulation,superdisintegrants and technologies developed for FDT, along with various drugs explored, evaluation tests and marketed formulations of FDT’s. Key words:Fast dissolving tablets, Superdisintegrants, Evaluation of fast dissolving tablets, Fast dissolving

Review On: Fast Dissolving Tablet

Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however hand tremors, dysphasia in case of geriatric patients, the underdeveloped muscular and nervous systems in young individuals and h case of uncooperative patients, the problem of swallowing is common phenomenon which leads to poor patient compliance1.To overcome these drawbacks, mouth dissolving tablets (MDT) or orally disintegrating tablets; (ODT) has emerged as alternative oral dosage forms. These are novel types; of tablets that disintegrate/dissolve/ disperse in saliva within few seconds'. According to European Pharmacopoeia, the ODT should disperse/disintegrate in less than three minutes. The basic approach used in development of MDT is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab). Polyvinylpyrrolidone (Polyplasdone) etc. which provide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva. The bioavailability of some drugs may be increased due to absorption of drugs in oral cavity and also due to pregastric absorption of saliva containing dispersed drugs that pass down into the stomach. Moreover, the amount of drug that is subject to first pass metabolism is reduced as compared to standard tablets. 1-3

Fast Dissolving Tablets: Needs to Enhance Bioavailability

International Research Journal of Pharmacy, 2013

Oral route is the most important and preferred route for drug administration due to the convenience, ease of administration and patient compliance. Tablet is the most preferred conventional oral unit dosage form. During tablet administration dysphasia is the main problem. Fast dissolving tablets can reduce this problem by dissolving and disintegrating rapidly within few seconds in mouth without water. Fast dissolving tablets become advantageous for those patients which have swallowing problem for example pediatric, geriatric and mentally ill patients. This review describes the introduction, advantages, disadvantages, excipients used, various techniques used in formulation and evaluation parameters.

FAST DISSOLVING TABLETS: A CONCISE REVIEW

Rapid dissolving drug-conveyance frameworks was started and created in the late 1970s as a distinct option for tablets, containers, and syrups for pediatric and geriatric patients who encounters challenges in gulping conventional oral dosage form.To enhance the bioavailability andminimize the side effects of patients, for example, geriatric patients which encountering Parkinson's issue or hand tremors like tablets.From present scenariopatients confronting the issues like dysphagia that bringing about the high incidence of rebelliousness from both pharmaceutical and commercial enterprises as well as patients since they are advantageous to be fabricated and controlled. Oral course is the most favored course for organization of different medications since it is viewed as most secure, most helpful and temperate course. As of late, analyst built up the quick deteriorating tablets with enhanced patient consistence and comfort. Fast dispersible tablets deteriorate either quickly in water, to shape a balanced out suspension, or scatter promptly in the mouth to be gulped without the guide of waters.