ayşe Erbakan - Academia.edu (original) (raw)

Papers by ayşe Erbakan

Journal of the College of Physicians and Surgeons Pakistan

Objective: To investigate the effect of SGLT2-i and GLP-1RA as an add-on therapy to metformin on ... more Objective: To investigate the effect of SGLT2-i and GLP-1RA as an add-on therapy to metformin on weight loss and body composition, and to compare their effects on glucose and lipid parameters. Study Design: A descriptive study.

The Lancet. Global health, Mar 1, 2018

There is little evidence on the use of secondary prevention medicines for cardiovascular disease ... more There is little evidence on the use of secondary prevention medicines for cardiovascular disease by socioeconomic groups in countries at different levels of economic development. We assessed use of antiplatelet, cholesterol, and blood-pressure-lowering drugs in 8492 individuals with self-reported cardiovascular disease from 21 countries enrolled in the Prospective Urban Rural Epidemiology (PURE) study. Defining one or more drugs as a minimal level of secondary prevention, wealth-related inequality was measured using the Wagstaff concentration index, scaled from -1 (pro-poor) to 1 (pro-rich), standardised by age and sex. Correlations between inequalities and national health-related indicators were estimated. The proportion of patients with cardiovascular disease on three medications ranged from 0% in South Africa (95% CI 0-1·7), Tanzania (0-3·6), and Zimbabwe (0-5·1), to 49·3% in Canada (44·4-54·3). Proportions receiving at least one drug varied from 2·0% (95% CI 0·5-6·9) in Tanzania...

Frontiers in endocrinology, Jul 10, 2024

Curēus, Mar 29, 2024

Lifestyle adjustments are essential in the management of type 2 diabetes mellitus (T2DM). Mindful... more Lifestyle adjustments are essential in the management of type 2 diabetes mellitus (T2DM). Mindful eating involves being more attentive to and aware of meals. This study aimed to investigate the relationship between mindful eating and glycemic control, as well as body mass index (BMI), in people with T2DM. Materials and methods This cross-sectional study included 448 participants who had been diagnosed with T2DM for at least six months. The participants were categorized into three groups based on their HbA1c levels. The Turkish adaptation of the Mindful Eating Questionnaire (MEQ-30) was employed to assess levels of mindful eating behavior. Obesity was defined as a BMI ≥ 30. Anthropometric measurements, laboratory tests, and questionnaire responses were also collected. Results Participants with well-controlled diabetes (HbA1c ≤7%) demonstrated significantly higher scores on the MEQ-30 and its various subgroups in comparison to those with poorly controlled diabetes (HbA1c >9%). The suboptimal glycemic control groups exhibited noticeable variations in mindful eating behaviors. Moreover, participants with lower BMIs displayed stronger inclinations toward mindful eating. Weak negative correlations were observed between BMI and specific MEQ-30 subgroups. Notably, subgroups such as emotional eating, eating control, eating discipline, and interference demonstrated weak negative correlations with the HbA1c levels. Conclusion Higher levels of mindful eating were associated with lower levels of HbA1c and BMI, indicating that incorporating mindful eating practices may present promising advantages for individuals diagnosed with type 2 diabetes, specifically in terms of glycemic control and weight management.

Ankara Medical Journal, Dec 31, 2022

Objectives: This study aims to investigate the association between caregiver anxiety and the risk... more Objectives: This study aims to investigate the association between caregiver anxiety and the risk of malnutrition among caretakers. Materials and Methods: A total of 200 caregivers whose patients were hospitalized in internal medicine clinics were included in a cross-sectional study. Patients were screened with the Nutritional Risk Screening (NRS) 2002 and divided into two groups: Patients with scores <3 (patients without nutritional support) and with scores ≥3 (patients with nutritional support). Caregiver distress was assessed using the State-Trait Anxiety Inventory (STAI). Results: Anxiety scores were high for all caregivers (mean state anxiety score 42.4 (min=20, max=70, median=42) and median trait anxiety score 41 (min=25, max=64, mean=41.4). However, the anxiety scores of caregivers of patients with malnutrition did not differ from those of caregivers of patients without malnutrition(for NRS score < 3 versus ≥3, state anxiety score 41.4±10.1 versus 42.7±10.1, p=0.428, and trait anxiety score 40±12 versus 41±13, p=0.494, respectively). Caring for patients for more than one year without support or with minimal support was significantly associated with higher anxiety scores compared to caring for more than one year with support or caring for less than six months without support (for state and trait anxiety, 50.4±9.1 vs 41.0± 9.7, p < 0.001 and 49±10 vs 40±12, p < 0.001, respectively). Conclusion: The absence of a support system and the duration of caregiving were found to be associated with an increased risk of caregiver anxiety, especially when both factors were present. However, no effect was observed on malnutrition status based on levels of anxiety among caregivers.

Maltepe tıp dergisi, Dec 31, 2021

The frequency of coexistent cardio-metabolic diseases in COVID-19 patients and their effects on c... more The frequency of coexistent cardio-metabolic diseases in COVID-19 patients and their effects on clinical outcomes COVID-19 hastalarında eşlik eden kardiyo-metabolik hastalık sıklıkları ve klinik sonlanımlar üzerine etkileri SUMMARY Aim: We aimed to determine the frequency and characteristics of cardio-metabolic comorbidities (CMC) in patients hospitalized with the diagnosis of COVID-19 disease. Material and Methods: In this retrospective study, 159 patients with a confirmed diagnosis of COVID-19 with polymerase chain reaction (PCR) were included out of 313 patients hospitalized with suspected COVID-19. CMC frequencies, patients characteristics, duration of hospitalizations, and clinical outcomes (discharge, death, ICU need) were determined. Results: In COVID-19 patients, the frequencies of hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, chronic kidney disease, congestive heart failure, and cerebrovascular disease were 39%, 24.5%, 24.5%, 20.1%, 11.9%, 9.4%, and 8.2%, respectively. There were 79 cases (49.1%) with at least 1 CMC and 42 (26.1%) cases with ≥3 CMC. The median duration of hospitalization was four days, the mortality rate was 1.3%, and the frequency of ICU need was 2.5%. All CMC frequencies increased significantly with advancing age (p<0.05 for all). Compared to PCR negative cases, the mean duration of hospitalization (p=0.001) was longer, and the frequency of hypertension (p=0.008) was lower in PCR-positive COVID-19 patients. Conclusion: Cardio-metabolic comorbidity frequencies in hospitalized COVID-19 patients were not higher than COVID-19 PCR negative cases and similar age groups without COVID-19 infection in national epidemiological studies. The presence of multiple CMCs were approximately one of every 4 cases, in all of those who died and in half of those who developed ICU needs, suggests that the coexistence of CMCs rather than their presence alone causes a cumulative risk increase on clinical outcomes associated with COVID-19.

Clinical Nutrition, Sep 1, 2017

Results: Participants mean age was 27.55 ± 11.70 years. More than half of the consumers were norm... more Results: Participants mean age was 27.55 ± 11.70 years. More than half of the consumers were normal weight (60%) and nearly 29% of them were overweight and obese. Consumers declared that safety, nutrition and naturalness were the most important values when purchasing yoghurt and probiotic yoghurt. While purchasing these products male consumers pay more attention to origin than environment value when compared with females (p < 0.05). Both healthy and unhealthy participants pay more attention naturalness than other food values except for safety (p < 0.05). Environment value was important in healthy eaters compared to convenience however convenience was more important value in unhealthy eaters. Both groups pay attention to nutrition compare to other food values (p < 0.05). Conclusion: This study showed that safety, nutrition and naturalness of foods were the most important food values for participants. Consumers food value preferences were same while purchasing yoghurt and probiotic yoghurt as a functional food.

Journal of Health Sciences and Medicine

Aim: This study aimed to examine the blood-borne viral infections such as hepatitis B, hepatitis ... more Aim: This study aimed to examine the blood-borne viral infections such as hepatitis B, hepatitis C and human immunodeficiency virus (HIV) and to determine the risk factors in hemodialysis patients. Material and Method: The datas of patients who underwent hemodialysis in the hemodialysis unit of our hospital between March 1, 2020 and March 1, 2021 were reviewed retrospectively. Their sociodemographic characteristics, habits, underlying diseases and virological indicators related to hepatitis B, hepatitis C and HIV were obtained from patient files and hospital data processing system. Results:A total of 96 patients were included in the study. Of them, 43.8% (n=42) were female and 56.2% (n=54) were male. Their mean age was 62.61±18.11 years, ranging from 17 to 92. The duration of dialysis was less than 3 months for 46.9% (n=45) of the patients, between 3 months and 3 years for 19.8% (n=19), and 3 years and above for 33.3% (n=32). Thirty patients (31.3%) had diabetes mellitus. In additio...

Annals of medical research, 2022

Aim: The effects of different doses of metformin on the contractility of female Sprague-Dawley ra... more Aim: The effects of different doses of metformin on the contractility of female Sprague-Dawley rat bladder strips were evaluated. Materials and Methods: Rats were decapitated and the bladder strips measuring 2-4 × 6-12 mm prepared from the whole urinary bladder were suspended in isolated tissue organ baths. Tissues in the chambers were rinsed every 30 minutes for 60 minutes and allowed to equilibrate. Afterwards, 10-4 M acetylcholine was added to all isolated tissue baths. After one hour of rinsing, metformin (2 mM) was added and incubated 30 minutes. After 30 minutes, the same dose of acetylcholine was added without rinsing, and immediately after this protocol was performed with 10 mM and 20 mM metformin doses. Results: All of these doses led to increased contractions in a dose-dependent manner. The 2 mM dose did not induce any contraction in area (213.67±33.10 %) compared to control, but there was a significant increase in peak-to-peak amplitude (127.65±4.24 %, p=0.009). In addition, the peak-to-peak amplitude was significantly increased at the 10 mM and 20 mM doses (163.86±8.57 % and 162.58±6.76 %, p=0.0001, respectively) compared to the control and there was a statistically significant difference. In addition, the area value increased significantly compared to control at the 20 mM dose alone (3767.64±733.70 %, p=0.0001). Conclusion: Our present data show that the treatment of varied high doses of metformin may lead to the increase of contractions at ex vivo isolated tissue bath. Therefore, this effect can escalate some symptoms of diabetic bladder dysfunction.

DergiPark (Istanbul University), Dec 31, 2021

Maltepe Tıp Dergisi, 2021

Amaç: Bu çalışmanın amacı dahiliye dışındaki servislerde yatan hastalarda tanı konulmamış diyabet... more Amaç: Bu çalışmanın amacı dahiliye dışındaki servislerde yatan hastalarda tanı konulmamış diyabet prevalansının belirlenmesi ve diyabet farkındalığının olmaması ile ilişkili faktörlerin değerlendirilmesidir. Hastalar ve Yöntem: Bu çok merkezli, tanımlayıcı, kesitsel çalışma dahili ve cerrahi kliniklerde yatmakta olan 630 katılımcı ile yapılmıştır. Katılımcıların antropometrik ölçümleri, glukoz ve HbA1c ölçümleri yapılmıştır. Bilinen diyabet tanısı olmayıp yatışı sırasında HbA1c değeri ≥ 6,5% olanlar diyabet farkındalığı olmayanlar olarak tanımlanmıştır. Bulgular: Bilinen diyabeti olanların sayısı 190 iken (%30,2), 396 (%62,9) kişinin diyabeti yoktu, 44 (%7) hastada ise bilinmeyen diyabet saptandı. Diyabet farkındalığı olmayanlarda bilinen diyabet grubundakilere göre fazla oranda genç (<45 yaş) ve erkek hasta vardı (p<0.01, p<0.05). Diyabet farkındalığı olmayanlarda fazla kilolu olanların ve komorbiditesi olmayanların oranı bilinen diyabetlilerden daha yüksekti (p<0,01, p...

Medeniyet Medical Journal, 2020

Objective: Maturity-onset diabetes of the young (MODY) is a non-rare group of monogenic inherited... more Objective: Maturity-onset diabetes of the young (MODY) is a non-rare group of monogenic inherited diabetes which is commonly confused with type 1 and type 2 diabetes. Due to high costs of genetic tests that provide a definitive diagnosis, some screening scales are used to identify the high-risk patients. In this study, we aimed to evaluate whether (MODY Probability Calculator [MPC]) which is one of the screening tests will be helpful in identifying our high-risk patients among young patients with type 2 diabetes Method: The patients received the diagnosis of type 2 diabetes aged <35 years were included in the study. The anthropometric characteristics of the patients, the treatments they received at the time of diagnosis, and the current treatments were recorded by retrospectively scanning patient files.The patients with the diagnosis of type 1 diabetes having autoantibodies to the pancreas were excluded from the study. The probability of MODY was calculated using MPC.. Results: The mean age of 72 patients (40% female) was 41.5±7.2 years. Eighteen of the patients (25%) were using insulin at the time of diagnosis. The mean HbA1c was 8.6±2.2% and C-peptide was 2.35±1.52 ng/ml. The mean MODY positive predictive score calculated by MPC for risk of MODY was 11.23 percent. There were 61 patients (84.7%) with a risk of ≤20%, 9 patients (12.5%) with a risk of 20-50%, and 2 patients (2.8%) with ≥50%. In the group with MODY PPV score >20%, the age of onset of diabetes and the body mass index was significantly lower than the others (p<0.05, for both). There was no significant difference between current treatments of both groups. Conclusion: It has been reported that MODY risk calculated by MPC may yield different results in different populations. The results of this study showed that 15% of our young-onset diabetes patients had an MPC score above 20 percent. Requesting MODY genetic tests in this 15% of the patient group can be presented as a practical suggestion.

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi, 2020

Amaç: Diyabetik nöropati sıklıkla hastanın şikayeti olursa veya önlenebilecek komplikasyonlar gel... more Amaç: Diyabetik nöropati sıklıkla hastanın şikayeti olursa veya önlenebilecek komplikasyonlar gelişmişse tanı almaktadır. Tip 2 diyabetli (T2DM) hastalarda diyabetik periferik nöropati (DPN) varlığının bildirildiğinden daha sık olduğu hipotezinden yola çıkarak bu hasta grubunda DPN sıklığını ve ilişkili olduğu durumları araştırmayı planladık. Yöntem: Diyabet polikliniklerimize başvuran 336 tip 2 diyabetli hasta çalışmaya alındı. Anamnezleri, demografik ve antropometrik bilgileri, kullandıkları ilaçlar ve laboratuvar verileri kaydedildi. Diyabetik nöropatiyi saptamak amacıyla MNSI (Michigan Neuropathy Screening Instrument) skorlaması ve Semmes-Weinstein monofilaman testi uygulandı. Bulgular: Bu 336 hastanın (yaş ortalaması 57,9±10 yıl, %63,7’si kadın) ortalama diyabet süresi 9,5±7,8 yıldı. HbA1c, açlık kan şekeri ve vücut kütle indeksi ortalaması sırasıyla %8,7±2, 182±89 mg/dl ve 32±5,8 kg/m2 bulundu. DPN sıklığı %38,7 (n=130) saptandı. Daha önce nöropati tedavisi başlanmış olan 32 h...

Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2019

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Clinical Nutrition, 2018

Results: Milk and milk products, tough food, dried beans, pastry/ dessert weren't easily tolerate... more Results: Milk and milk products, tough food, dried beans, pastry/ dessert weren't easily tolerated at 6months. 12 of the participants (50%), 14 of the participants (56.4%), 9 of the participants (37.5%), 11 of the participants (45.8%) were stated they can't consume milk and milk products, tough food, dried beans, pastry/ dessert respectively. Conclusions: The bariatric procedure leads to nutrient restriction which affects not only nutrient uptake but also nutrient diversity. Definition of food tolerance should be important for the overall evaluation of patient's condition after bariatric surgery (

Diabetes, Metabolic Syndrome and Obesity

Background: Visceral adiposity is an important risk factor for cardiometabolic diseases. Objectiv... more Background: Visceral adiposity is an important risk factor for cardiometabolic diseases. Objective: To determine whether the Metabolic Score for Visceral Fat (METS-VF) is more effective than other adiposity indices in predicting visceral fat area (VFA). Methods: In this single-center and cross-sectional study, we included patients aged 20-50 years, without diabetes and coronary artery disease, who underwent computed tomography (CT) including the third lumbar vertebra. Age, blood pressure, waist circumference (WC), hip circumference, fasting lipids, and glucose were assessed. VFA was measured by cross-sectional examination of CT. The correlation of WC, body mass index (BMI), waist-hip ratio (WHR), lipid accumulation product (LAP), visceral adiposity index (VAI), a body shape index (ABSI), body roundness index (BRI), and METS-VF with VFA was analyzed by correlation analysis. The cutoff values and area under the curve (AUC) for identifying increased VFA (>130 cm 2) were determined. Results: We included 185 individuals with mean age 38.2 ± 8 and female predominance (58.4%). There was a significant positive correlation between all indices and VFA (p<0.001). ROC analysis revealed that METS-VF and WC demonstrated the highest predictive value for identifying increased VFA. In both men (p=0.001) and women (p<0.001), METS-VF (AUC 0.922 and 0.939, respectively) showed a significant superiority over ABSI (AUC 0.702 and 0.658, respectively), and VAI (AUC 0.731 and 0.725, respectively). Additionally, in women, its superiority over WHR (AUC 0.807) was also statistically significant (p=0.003). We identified a METS-VF cutoff point >6.4 in males >6.5 in females and WC cutoff point >88 cm in males (AUC 0.922), >90.5 cm in females (AUC 0.938). Conclusion: METS-VF is strongly associated with visceral adiposity and better to predict increased VFA. However, its superiority over WC, BMI, BRI, and LAP was not significant. The results emphasize that WC is more appealing as screening indicator for visceral adiposity considering its easy use. Clinical Trial Registry Name: Clinicaltrials.gov (http://www.clinicaltrials.gov). Clinical Trial Registry Url: https://clinicaltrials.gov/ct2/show/NCT05648409. Clinical Trial Registry Number: NCT05648409.

Cerrahpasa Medical Journal