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Background: There are no effective studies in west part of India on relationship between higher s... more Background: There are no effective studies in west part of India on relationship between higher serum ferritin levels in impaired glucose individuals, type 2 diabetes mellitus patients are markers for insulin resistance and reinforce to metabolic syndrome. The association between serum ferritin levels, insulin resistance marker (HOMA IR), Glycosylated Hemoglobin A1C with individual components of metabolic syndrome in type 2 diabetes mellitus, impaired fasting glucose, obesity and healthy subjects are unclear. Objectives: This research was delineated to find out the interrelation between serum ferritin levels with fasting glucose levels, waist hip ratio, fasting insulin levels, insulin resistance marker (HOMA-IR) and components of metabolic syndrome in type 2 diabetes mellitus patients, newly identified type 2 diabetes mellitus patients, Impaired fasting glucose subjects and healthy participants. To investigate any menopause transition effects on serum ferritin levels and components ...

Clinical & Medical Biochemistry: Open Access, 2016

Background: Raised serum ferritin levels are associated with insulin resistance, type 2 diabetes ... more Background: Raised serum ferritin levels are associated with insulin resistance, type 2 diabetes mellitus, prediabetic stage, metabolic syndrome (Mets) and cardiovascular risk. The association between Serum ferritin and HbA1c levels with individual components of metabolic syndrome and obesity are unclear. Objectives: The present study was designed to investigate the relationship between serum ferritin levels, fasting Blood glucose levels, waist Hip ratio, fasting insulin levels, homeostasis model assessment (HOMA-IR), and lipid profile in previously diagnosed type 2 diabetes mellitus patients, newly diagnosed patients, impaired fasting glucose subjects and healthy subjects and relationship among iron stores, the metabolic syndrome, and insulin resistance in premenopausal women, postmenopausal women and men. Subjects and methods: 1058 participants included in this study out of them 365 patients with previously diagnosed type 2 diabetes mellitus having poor glycemic control and good glycemic control, 144 patients with newly diagnosed type 2 diabetes mellitus, 189 participants with impaired fasting glucose levels and 360 healthy participants. Fasting blood glucose, Serum ferritin, serum insulin, HbA1c waist hip ratio, and lipid parameters were estimated and Homeostasis Model Assessment-Insulin resistance (HOMA-IR) was calculated. Results: Dichotomizing ferritin concentration in to <300 and >300 ng/ml for men and <150 and >150 ng/ml for women, the odd ratios for newly diagnosed diabetes were 4.94 (95% CI 3.05-8.01) for men 3.61 (2.01-6.48) for women. All multiple linear regression coefficients between ferritin concentration and concentration of insulin, glucose, and glycosylated hemoglobin were positive and significant for men and postmenopausal women. Conclusion: On basis of present studies results, it is concluded that hyperferritinaemia and iron overload may be the primary cause of insulin resistance and metabolic syndrome before overt type 2 diabetes mellitus.

Critical Reviews in Food Science and Nutrition, 2007

The Failure Mode and Effect Analysis (FMEA) model has been applied for the risk assessment of cor... more The Failure Mode and Effect Analysis (FMEA) model has been applied for the risk assessment of corn curl manufacturing. A tentative approach of FMEA application to the snacks industry was attempted in an effort to exclude the presence of GMOs in the final product. This is of crucial importance both from the ethics and the legislation (Regulations EC 1829/2003; EC 1830/2003; Directive EC 18/2001) point of view. The Preliminary Hazard Analysis and the Fault Tree Analysis were used to analyze and predict the occurring failure modes in a food chain system (corn curls processing plant), based on the functions, characteristics, and/or interactions of the ingredients or the processes, upon which the system depends. Critical Control points have been identified and implemented in the cause and effect diagram (also known as Ishikawa, tree diagram, and the fishbone diagram). Finally, Pareto diagrams were employed towards the optimization of GMOs detection potential of FMEA.

Background: There are no effective Teaching-Learning methods for Biochemical basis of disease and... more Background: There are no effective Teaching-Learning methods for Biochemical basis of disease and Metabolic pathways in first MBBS. Objectives: To compare case method with didactic lecture. To evaluate students performance and satisfaction by case based method. Methods: Departmental meeting was conducted to select 3 topics and plan the session. IEC approval was obtained. I MBBS students (117) were first taught on one topic (lipid metabolism) by didactic method and then 2 topics by case based method (CBM). CBM-1 (protein metabolism) was attended by 113 and CBM-2 (Carbohydrate Metabolism) by 126 students. Pre and post test conducted at the end of each session with case based MCQs and short answers. Results: An imperative progress (Z>1.95, Z>2.95, p<0.001)) was observed among the students performance after the CBM sessions compared with didactic method. A 5 point summative scale questionnaire was administered to the students, to know their perception on usefulness of CBM. Near...

International Journal of Bioassays, 2014

To compare three methods for measurement of blood HbA1c as to reliability, ease and time consumpt... more To compare three methods for measurement of blood HbA1c as to reliability, ease and time consumption. Measurements of HbA1c were made in blood from 230 patients with pre-diabetes and diabetes using a turbidimetric inhibition immunoassay (TINIA), which also required measurement of total hemoglobin, a particle-enhanced immune turbidimetric assay (PEITT) without measurement of total hemoglobin, and high performance liquid chromatography (HPLC). There was good concordance between results of PEITT and HPLC methods (r = 0.9401, p<0.0001 and by Deming Regression; y = 0.9978x + 0.24). The average HbA1c (7.52±1.40 %) measured by HPLC was higher than the other methods (TINIA: 7.12±1.66 % and PEITT: 7.26±1.39 %, p<0.0001). The measured total time spent on 240 samples was 81 min. for TINIA, 54min. for PEITT and 540 min. for HPLC. It has been found that, the PEITT method, which is reliable, faster, and easier to perform, can be used as an alternative to TINIA and HPLC measuring system with...

Indian Journal of Obstetrics and Gynecology Research

The objective of present study to find out women for precancerous lesions with the help of pap sm... more The objective of present study to find out women for precancerous lesions with the help of pap smear test as early identification marker. Determine the percentage of cervical cancer in relationship with demographic, education and occupation. To find out pap smear effectiveness in various infections. To find out correlation pap smear findings with symptoms.This is a cross-sectional study involving the screening of women from the rural population of Siddipet district for the assessment of health status using pap smear test who have attended the outpatient department of Obstetrics and Gynecology conducted during the period of August 2019 to May 2021. The present study included 1500 Pap smears, of which the most common abnormality was inflammatory smear, which is followed by atrophic smear. Among all the study respondent’s majority (64.5%) of the women were home makers and not working, remaining participants were either self employed or working women. Percentage of abnormal smear report...

Diabetes mellitus (DM) comprises a group of common metabolic disorders that share common phenotyp... more Diabetes mellitus (DM) comprises a group of common metabolic disorders that share common phenotype of hyperglycemia. Understanding the pathogenesis and preventing long-term complications have been major goals of research in diabetes mellitus. Emerging scientific evidences has disclosed unsuspected influence between iron metabolism and type 2 Diabetes mellitus. Present study was undertaken to assess level of serum ferritin, free iron concentration, in type 2 Diabetes mellitus patients with good and poor glycaemic control and find out correlation between serum ferritin, free iron concentrations with glycaemic control. A cross sectional study consists of 450 patients out of them 150 patients having type 2 DM with good control (Group II), 150 patients with type 2 DM with poor control (Group III) and 150 normal healthy control (Group-I) were selected. Statistically significant increase in serum ferritin and free iron concentration in group III cases compare to Group I and Group II. There...

International Journal of Clinical Biochemistry and Research

Background: There are no effective studies in west part of India on relationship between higher s... more Background: There are no effective studies in west part of India on relationship between higher serum ferritin levels in impaired glucose individuals, type 2 diabetes mellitus patients are markers for insulin resistance and reinforce to metabolic syndrome. The association between serum ferritin levels, insulin resistance marker (HOMA IR), Glycosylated Hemoglobin A1C with individual components of metabolic syndrome in type 2 diabetes mellitus, impaired fasting glucose, obesity and healthy subjects are unclear. Objectives: This research was delineated to find out the interrelation between serum ferritin levels with fasting glucose levels, waist hip ratio, fasting insulin levels, insulin resistance marker (HOMA-IR) and components of metabolic syndrome in type 2 diabetes mellitus patients, newly identified type 2 diabetes mellitus patients, Impaired fasting glucose subjects and healthy participants. To investigate any menopause transition effects on serum ferritin levels and components ...

Clinical & Medical Biochemistry: Open Access, 2016

Background: Raised serum ferritin levels are associated with insulin resistance, type 2 diabetes ... more Background: Raised serum ferritin levels are associated with insulin resistance, type 2 diabetes mellitus, prediabetic stage, metabolic syndrome (Mets) and cardiovascular risk. The association between Serum ferritin and HbA1c levels with individual components of metabolic syndrome and obesity are unclear. Objectives: The present study was designed to investigate the relationship between serum ferritin levels, fasting Blood glucose levels, waist Hip ratio, fasting insulin levels, homeostasis model assessment (HOMA-IR), and lipid profile in previously diagnosed type 2 diabetes mellitus patients, newly diagnosed patients, impaired fasting glucose subjects and healthy subjects and relationship among iron stores, the metabolic syndrome, and insulin resistance in premenopausal women, postmenopausal women and men. Subjects and methods: 1058 participants included in this study out of them 365 patients with previously diagnosed type 2 diabetes mellitus having poor glycemic control and good glycemic control, 144 patients with newly diagnosed type 2 diabetes mellitus, 189 participants with impaired fasting glucose levels and 360 healthy participants. Fasting blood glucose, Serum ferritin, serum insulin, HbA1c waist hip ratio, and lipid parameters were estimated and Homeostasis Model Assessment-Insulin resistance (HOMA-IR) was calculated. Results: Dichotomizing ferritin concentration in to <300 and >300 ng/ml for men and <150 and >150 ng/ml for women, the odd ratios for newly diagnosed diabetes were 4.94 (95% CI 3.05-8.01) for men 3.61 (2.01-6.48) for women. All multiple linear regression coefficients between ferritin concentration and concentration of insulin, glucose, and glycosylated hemoglobin were positive and significant for men and postmenopausal women. Conclusion: On basis of present studies results, it is concluded that hyperferritinaemia and iron overload may be the primary cause of insulin resistance and metabolic syndrome before overt type 2 diabetes mellitus.

Critical Reviews in Food Science and Nutrition, 2007

The Failure Mode and Effect Analysis (FMEA) model has been applied for the risk assessment of cor... more The Failure Mode and Effect Analysis (FMEA) model has been applied for the risk assessment of corn curl manufacturing. A tentative approach of FMEA application to the snacks industry was attempted in an effort to exclude the presence of GMOs in the final product. This is of crucial importance both from the ethics and the legislation (Regulations EC 1829/2003; EC 1830/2003; Directive EC 18/2001) point of view. The Preliminary Hazard Analysis and the Fault Tree Analysis were used to analyze and predict the occurring failure modes in a food chain system (corn curls processing plant), based on the functions, characteristics, and/or interactions of the ingredients or the processes, upon which the system depends. Critical Control points have been identified and implemented in the cause and effect diagram (also known as Ishikawa, tree diagram, and the fishbone diagram). Finally, Pareto diagrams were employed towards the optimization of GMOs detection potential of FMEA.

Background: There are no effective Teaching-Learning methods for Biochemical basis of disease and... more Background: There are no effective Teaching-Learning methods for Biochemical basis of disease and Metabolic pathways in first MBBS. Objectives: To compare case method with didactic lecture. To evaluate students performance and satisfaction by case based method. Methods: Departmental meeting was conducted to select 3 topics and plan the session. IEC approval was obtained. I MBBS students (117) were first taught on one topic (lipid metabolism) by didactic method and then 2 topics by case based method (CBM). CBM-1 (protein metabolism) was attended by 113 and CBM-2 (Carbohydrate Metabolism) by 126 students. Pre and post test conducted at the end of each session with case based MCQs and short answers. Results: An imperative progress (Z>1.95, Z>2.95, p<0.001)) was observed among the students performance after the CBM sessions compared with didactic method. A 5 point summative scale questionnaire was administered to the students, to know their perception on usefulness of CBM. Near...

International Journal of Bioassays, 2014

To compare three methods for measurement of blood HbA1c as to reliability, ease and time consumpt... more To compare three methods for measurement of blood HbA1c as to reliability, ease and time consumption. Measurements of HbA1c were made in blood from 230 patients with pre-diabetes and diabetes using a turbidimetric inhibition immunoassay (TINIA), which also required measurement of total hemoglobin, a particle-enhanced immune turbidimetric assay (PEITT) without measurement of total hemoglobin, and high performance liquid chromatography (HPLC). There was good concordance between results of PEITT and HPLC methods (r = 0.9401, p<0.0001 and by Deming Regression; y = 0.9978x + 0.24). The average HbA1c (7.52±1.40 %) measured by HPLC was higher than the other methods (TINIA: 7.12±1.66 % and PEITT: 7.26±1.39 %, p<0.0001). The measured total time spent on 240 samples was 81 min. for TINIA, 54min. for PEITT and 540 min. for HPLC. It has been found that, the PEITT method, which is reliable, faster, and easier to perform, can be used as an alternative to TINIA and HPLC measuring system with...

Indian Journal of Obstetrics and Gynecology Research

The objective of present study to find out women for precancerous lesions with the help of pap sm... more The objective of present study to find out women for precancerous lesions with the help of pap smear test as early identification marker. Determine the percentage of cervical cancer in relationship with demographic, education and occupation. To find out pap smear effectiveness in various infections. To find out correlation pap smear findings with symptoms.This is a cross-sectional study involving the screening of women from the rural population of Siddipet district for the assessment of health status using pap smear test who have attended the outpatient department of Obstetrics and Gynecology conducted during the period of August 2019 to May 2021. The present study included 1500 Pap smears, of which the most common abnormality was inflammatory smear, which is followed by atrophic smear. Among all the study respondent’s majority (64.5%) of the women were home makers and not working, remaining participants were either self employed or working women. Percentage of abnormal smear report...

Diabetes mellitus (DM) comprises a group of common metabolic disorders that share common phenotyp... more Diabetes mellitus (DM) comprises a group of common metabolic disorders that share common phenotype of hyperglycemia. Understanding the pathogenesis and preventing long-term complications have been major goals of research in diabetes mellitus. Emerging scientific evidences has disclosed unsuspected influence between iron metabolism and type 2 Diabetes mellitus. Present study was undertaken to assess level of serum ferritin, free iron concentration, in type 2 Diabetes mellitus patients with good and poor glycaemic control and find out correlation between serum ferritin, free iron concentrations with glycaemic control. A cross sectional study consists of 450 patients out of them 150 patients having type 2 DM with good control (Group II), 150 patients with type 2 DM with poor control (Group III) and 150 normal healthy control (Group-I) were selected. Statistically significant increase in serum ferritin and free iron concentration in group III cases compare to Group I and Group II. There...

International Journal of Clinical Biochemistry and Research