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Research paper thumbnail of A study of the clinico-etiological profile of UTI in patients of Type 2 diabetes mellitus in a tertiary care hospital of Upper Assam

Assam Journal of Internal Medicine

Research paper thumbnail of Improved Treatment Outcomes With Modified Induction Therapy in Acute Myeloid Leukemia (AML): A Retrospective Observational Study From a Regional Cancer Center

Curēus, Jan 31, 2024

Background: The aggressive, genetically diverse group of malignant illnesses known as acute myelo... more Background: The aggressive, genetically diverse group of malignant illnesses known as acute myeloid leukemia (AML) is characterized by clonally related myeloblast invasion of the bone marrow, blood, and other organs. The treatment regimen plays a crucial role in the management of AML, and it is associated with poor overall survival and enhanced risk of relapse. Induction therapy with a 7+3 DA regimen (daunorubicin + ara-C) has been the treatment of choice for young and fit patients. Objective: To evaluate the effect of dose modification in young and fit patients for a modified treatment regimen. Methods: This was a retrospective, observational study of AML patients to analyze the outcomes of modified induction therapy in AML patients enrolled at Dr. B. Borooah Cancer Institute, Guwahati, Assam, India, from October 2021 to March 2022. The outcomes of modified induction therapy with intensive chemotherapy (modified 7+3 DA) and low-intensity chemotherapy decitabine (10 days) and venetoclax + azacytidine (seven days) were considered after the first two cycles or 60 days, whichever was earlier. Results: Data from 31 patients with de-novo AML was analyzed; the median age of the patients was 41 years (range: 2-71 years), and the male-to-female ratio was 1.8. There were seven patients in the pediatric age group (2-13 years), and 19%, 65%, and 13% of patients belonged to favorable, intermediate, and high-risk groups, respectively. With regards to modified induction therapy (n=31), 20 (65%) patients received modified "7+3 DA", nine (29%) received hypomethylating agents (HMA, decitabine only), and two patients received HMA (azacitidnie) + venetoclax. Additionally, 23/31 patients completed at least two cycles of induction therapy. Overall, 60 day-induction mortality was 13%, and the complete remission (CR) and partial remission (PR) rates were 48% and 26%, respectively. In patients who received modified "7+3 DA", the CR rate was 55%. Conclusions: The notable reduction in deaths due to infections observed in our study suggests that centers with limited resources for preventing neutropenic complications during induction therapies in AML patients could consider adopting this modified regimen.

Research paper thumbnail of A Study of Haematological Manifestations of Sle with Special Reference to Disease Activity

Background: Our understanding of Systemic Lupus Erythematosus (SLE) has been evolved very signifi... more Background: Our understanding of Systemic Lupus Erythematosus (SLE) has been evolved very significantly over the period of last few decades. The hematological abnormalities though more commonly seen are not properly evaluated or estimated and are not given enough representation . In some of these cases presenting with Anaemia, Thrombocytopenia, Pancytopenia or Thrombotic episodes, especially so in young females, the diagnosis may be delayed or initially missed if the index of suspicion is low or if there is improper and inadequate follow up. Thus keeping this in mind this study as be carried out. Aim and Objectives :(1) To study Haematological manifestations of SLE and (2) To study its correlation with the disease severity. Materials and Methods: This study is an Observational Cross Sectional Study done in Assam Medical College for a period of one year. All cases who fulfilled the ACR criteria 1997 who came to Rheumatology opd and those who admitted in Medicine ward taken up for the...

Research paper thumbnail of A Study of the Clinico-Etiological Profile of Acute Encephalitis Syndrome Cases in a Tertiary Care Hospital of Upper Assam with Special Reference to Japanese Encephalitis

International Journal of Contemporary Medical Research [IJCMR], Jun 1, 2019

Introduction: Acute Encephalitis Syndrome is a major health problem in Assam, claiming thousands ... more Introduction: Acute Encephalitis Syndrome is a major health problem in Assam, claiming thousands of lives every year and crippling the survivors. Japanese Encephalitis is the leading agent of this group. Much emphasis has been given to the vaccination drive but the effort has not been fruitful. This study aims to explore the common presentations of these diseases, the causative agents and the vaccination status of those affected. Material and methods: This is a single centre observational study carried out in Unit-V of the

Research paper thumbnail of A study of correlation of serum vitamin D3 level with disease activity of systemic lupus erythematosus

The Journal of the Association of Physicians of India, 2016

Research paper thumbnail of A STUDY OF THE COMPLICATIONS OF TYPE 2 DIABETES MELLITUS IN A TERTIARY CARE HOSPITAL AND THEIR CORRELATION WITH HbA1c LEVELS

Paripex Indian Journal Of Research, 2019

A STUDY OF THE COMPLICATIONS OF TYPE 2 DIABETES MELLITUS IN A TERTIARY CARE HOSPITAL AND THEIR CO... more A STUDY OF THE COMPLICATIONS OF TYPE 2 DIABETES MELLITUS IN A TERTIARY CARE HOSPITAL AND THEIR CORRELATION WITH HbA1c LEVELS

Research paper thumbnail of An Undiagnosed Case of Epilepsy for 13 Years Presenting in Status Epilepticus

Journal of Evolution of Medical and Dental Sciences, 2020

Research paper thumbnail of Vitamin D status and its relationship with systemic lupus erythematosus as a determinant and outcome of disease activity

Hormone Molecular Biology and Clinical Investigation, 2019

Background The importance of vitamin D (VD) in systemic lupus erythematosus (SLE) is being increa... more Background The importance of vitamin D (VD) in systemic lupus erythematosus (SLE) is being increasingly appreciated, with studies suggesting a relationship between VD deficiency and SLE onset/disease activity. We investigated VD status in SLE patients and its associations with disease activity in a geographical region of India receiving low solar ultraviolet-B (UV-B) index. Materials and methods We enrolled 109 SLE patients along with 109 healthy controls belonging to same ethnicity and localities. Demographic and clinico-laboratory information were recorded. VD status was assessed by estimating serum 25-hydroxyvitamin D (25-OH-D) concentrations (deficient: <20 ng/mL, insufficient: 21–29 ng/mL, and sufficient/normal: ≥30 ng/mL) using an enzyme-linked fluorescent assay (ELFA). The SLE Disease Activity Index (SLEDAI) scoring system was used to evaluate disease activity. The association between VD status and disease activity was assessed by univariate and multivariate approaches. Re...

Research paper thumbnail of A study of the clinico-etiological profile of UTI in patients of Type 2 diabetes mellitus in a tertiary care hospital of Upper Assam

Assam Journal of Internal Medicine

Research paper thumbnail of Improved Treatment Outcomes With Modified Induction Therapy in Acute Myeloid Leukemia (AML): A Retrospective Observational Study From a Regional Cancer Center

Curēus, Jan 31, 2024

Background: The aggressive, genetically diverse group of malignant illnesses known as acute myelo... more Background: The aggressive, genetically diverse group of malignant illnesses known as acute myeloid leukemia (AML) is characterized by clonally related myeloblast invasion of the bone marrow, blood, and other organs. The treatment regimen plays a crucial role in the management of AML, and it is associated with poor overall survival and enhanced risk of relapse. Induction therapy with a 7+3 DA regimen (daunorubicin + ara-C) has been the treatment of choice for young and fit patients. Objective: To evaluate the effect of dose modification in young and fit patients for a modified treatment regimen. Methods: This was a retrospective, observational study of AML patients to analyze the outcomes of modified induction therapy in AML patients enrolled at Dr. B. Borooah Cancer Institute, Guwahati, Assam, India, from October 2021 to March 2022. The outcomes of modified induction therapy with intensive chemotherapy (modified 7+3 DA) and low-intensity chemotherapy decitabine (10 days) and venetoclax + azacytidine (seven days) were considered after the first two cycles or 60 days, whichever was earlier. Results: Data from 31 patients with de-novo AML was analyzed; the median age of the patients was 41 years (range: 2-71 years), and the male-to-female ratio was 1.8. There were seven patients in the pediatric age group (2-13 years), and 19%, 65%, and 13% of patients belonged to favorable, intermediate, and high-risk groups, respectively. With regards to modified induction therapy (n=31), 20 (65%) patients received modified "7+3 DA", nine (29%) received hypomethylating agents (HMA, decitabine only), and two patients received HMA (azacitidnie) + venetoclax. Additionally, 23/31 patients completed at least two cycles of induction therapy. Overall, 60 day-induction mortality was 13%, and the complete remission (CR) and partial remission (PR) rates were 48% and 26%, respectively. In patients who received modified "7+3 DA", the CR rate was 55%. Conclusions: The notable reduction in deaths due to infections observed in our study suggests that centers with limited resources for preventing neutropenic complications during induction therapies in AML patients could consider adopting this modified regimen.

Research paper thumbnail of A Study of Haematological Manifestations of Sle with Special Reference to Disease Activity

Background: Our understanding of Systemic Lupus Erythematosus (SLE) has been evolved very signifi... more Background: Our understanding of Systemic Lupus Erythematosus (SLE) has been evolved very significantly over the period of last few decades. The hematological abnormalities though more commonly seen are not properly evaluated or estimated and are not given enough representation . In some of these cases presenting with Anaemia, Thrombocytopenia, Pancytopenia or Thrombotic episodes, especially so in young females, the diagnosis may be delayed or initially missed if the index of suspicion is low or if there is improper and inadequate follow up. Thus keeping this in mind this study as be carried out. Aim and Objectives :(1) To study Haematological manifestations of SLE and (2) To study its correlation with the disease severity. Materials and Methods: This study is an Observational Cross Sectional Study done in Assam Medical College for a period of one year. All cases who fulfilled the ACR criteria 1997 who came to Rheumatology opd and those who admitted in Medicine ward taken up for the...

Research paper thumbnail of A Study of the Clinico-Etiological Profile of Acute Encephalitis Syndrome Cases in a Tertiary Care Hospital of Upper Assam with Special Reference to Japanese Encephalitis

International Journal of Contemporary Medical Research [IJCMR], Jun 1, 2019

Introduction: Acute Encephalitis Syndrome is a major health problem in Assam, claiming thousands ... more Introduction: Acute Encephalitis Syndrome is a major health problem in Assam, claiming thousands of lives every year and crippling the survivors. Japanese Encephalitis is the leading agent of this group. Much emphasis has been given to the vaccination drive but the effort has not been fruitful. This study aims to explore the common presentations of these diseases, the causative agents and the vaccination status of those affected. Material and methods: This is a single centre observational study carried out in Unit-V of the

Research paper thumbnail of A study of correlation of serum vitamin D3 level with disease activity of systemic lupus erythematosus

The Journal of the Association of Physicians of India, 2016

Research paper thumbnail of A STUDY OF THE COMPLICATIONS OF TYPE 2 DIABETES MELLITUS IN A TERTIARY CARE HOSPITAL AND THEIR CORRELATION WITH HbA1c LEVELS

Paripex Indian Journal Of Research, 2019

A STUDY OF THE COMPLICATIONS OF TYPE 2 DIABETES MELLITUS IN A TERTIARY CARE HOSPITAL AND THEIR CO... more A STUDY OF THE COMPLICATIONS OF TYPE 2 DIABETES MELLITUS IN A TERTIARY CARE HOSPITAL AND THEIR CORRELATION WITH HbA1c LEVELS

Research paper thumbnail of An Undiagnosed Case of Epilepsy for 13 Years Presenting in Status Epilepticus

Journal of Evolution of Medical and Dental Sciences, 2020

Research paper thumbnail of Vitamin D status and its relationship with systemic lupus erythematosus as a determinant and outcome of disease activity

Hormone Molecular Biology and Clinical Investigation, 2019

Background The importance of vitamin D (VD) in systemic lupus erythematosus (SLE) is being increa... more Background The importance of vitamin D (VD) in systemic lupus erythematosus (SLE) is being increasingly appreciated, with studies suggesting a relationship between VD deficiency and SLE onset/disease activity. We investigated VD status in SLE patients and its associations with disease activity in a geographical region of India receiving low solar ultraviolet-B (UV-B) index. Materials and methods We enrolled 109 SLE patients along with 109 healthy controls belonging to same ethnicity and localities. Demographic and clinico-laboratory information were recorded. VD status was assessed by estimating serum 25-hydroxyvitamin D (25-OH-D) concentrations (deficient: <20 ng/mL, insufficient: 21–29 ng/mL, and sufficient/normal: ≥30 ng/mL) using an enzyme-linked fluorescent assay (ELFA). The SLE Disease Activity Index (SLEDAI) scoring system was used to evaluate disease activity. The association between VD status and disease activity was assessed by univariate and multivariate approaches. Re...