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Papers by mohammad fazilati

The Lancet Gastroenterology & Hepatology, 2021

Industrial & Engineering Chemistry Research, 2009

The photocatalytic degradation of a model textile dye, methyl orange (MO), using anodized titaniu... more The photocatalytic degradation of a model textile dye, methyl orange (MO), using anodized titanium dioxide (TiO 2) nanotubes has been investigated. The effects of light intensity, dye concentration, external bias, pH, and nanotube dimensions (length, diameter, and wall thickness) on MO photodegradation have been examined. The application of a minimal bias of +0.0 versus saturated calomel electrode (SCE) can enhance the dye degradation at least 10 times compared to unbiased conditions for dye concentrations between 20 and 100 µM. The overall initial dye degradation rate demonstrates three types of dependence on dye concentration over a range from 2.5-100 µM. For lower dye concentrations (2.5-40 µM) and natural pH (∼6.0) conditions, Langmuir-Hinshelwood (LH) kinetics was observed. The nanotubes diameter, calcination condition, and the anatase-to-rutile ratio in the crystalline TiO 2 nanotubes together influence the photocatalytic and photoelectrochemical properties of the TiO 2 nanotubes.

MOJ Biology and Medicine, 2021

Tissue engineering has developed strategy for the repair and regeneration of a variety of tissues... more Tissue engineering has developed strategy for the repair and regeneration of a variety of tissues. The demand for effective treatment strategies of cartilage cause to autologous human Mesenchymal stem cells (hMSC) used for the repair of cartilage defects. In this study effect of some factors on human MSCs for differentiation to chondrocyte were surveyed such as Present of Poly Ɛ-caprolactone (PCL) nanofibrous scaffold and cold atmospheric plasma (CAP), also effect and amount of synovial fluid were evaluated. In this experimental study cell culture for differentiation assay performed in 6 well pellets by DMEM high glucose medium with a supplement of 10% FBS and synovial fluid 5% and 10% of medium add to pellets for 21 days. Total cellular RNA extracted was used for analysis by RT-PCR. Alcian blue staining confirmed the chondrogenic differentiation. MTT assay results in this study showed that the cells proliferation gradually increased from 1st day to 21st days on the electrospun nano...

Annals of Military and Health Sciences Research, 2022

International Journal of Preventive Medicine, 2013

Background: Acute kidney injury (AKI) has been recognized as one of the most complex clinical com... more Background: Acute kidney injury (AKI) has been recognized as one of the most complex clinical complications in modern medicine, and ischemia/reperfusion (I/R) injury is well-known as a main reason of AKI. In addition, AKI leads to important systemic consequences such as acute lung injury. This study was designed to investigate the role of erythropoietin (EPO) on kidney function makers and tissue damage; and lung endothelial permeability and lung water content (LWC) in bilateral renal I/R injury model in rats. Methods: Male Wistar rats were randomly divided into three groups of sham, I/R, and I/R treated with EPO (I/R + EPO) groups. The I/R and I/R + EPO groups were subjected to bilateral renal I/R injury; however, only the I/R + EPO group received EPO (500 IU/kg, i.p.) 2 h before ischemia surgery, and the same dose was continued once a day for 3 days after ischemia. The sham group underwent a surgical procedure without ischemia process. Results: The blood urea nitrogen (BUN) and ser...

Jentashapir Journal of Cellular and Molecular Biology, 2020

Background: Over the past decades, little attention is paid to using herbal remedies to improve v... more Background: Over the past decades, little attention is paid to using herbal remedies to improve various diseases, especially cancer. Moringa oleifera (MO) is one of the herbs with numerous medicinal properties. Objectives: The current study aimed to evaluate the cytotoxicity effects of methanolic leaf extract on human liver cancer HepG2 cell lines. Methods: First methanolic extract of Moringa oleifera flavonoid compounds were measured, and then quercetin was identified as one of the flavonoid compounds in methanolic leaf extract by high-performance liquid chromatography (HPLC). HepG-2 cell line were treated with (0, 30, 40, 50, 60, and 70 µg/mL) methanolic extract of MO, quercetin (50 µg/mL), and doxorubicin (1 µg/mL). After 48 hours, the cytotoxic activity of various concentrations of MO methanolic extract against the liver cancer cell line was assessed using an MTT assay. Results: In this study, the total flavonoids and quercetin in the leaves of MO was, respectively, 3.69 (mg/g) ...

Article history: Received 15 June 2014 Received in revised form 8 July 2014 Accepted 4 September ... more Article history: Received 15 June 2014 Received in revised form 8 July 2014 Accepted 4 September 2014 Available online 20 September 2014

Introduction Cancer is now a major cause of mortality throughout the World [1]. In the developed ... more Introduction Cancer is now a major cause of mortality throughout the World [1]. In the developed world, it is generally exceeded only by cardiovascular disease but developing countries are responsible for the globally increasing trend. Over 10 million new cases and over 7 million deaths from cancer occurred worldwide in 2000. The contribution of developing countries was 53% for incidence and 56% for deaths. From 1990 to 2000, the incidence and deaths increased by 2.4% per annum by 2020, it is predicted that these diseases will be causing seven out of every 10 deaths in developing countries (Fig. 1) [2-5]. Figure 1. Static of cancer incidence and deaths in 2012. Based on high costs cancer treatment strategies (Fig. 2) [6], in recent years antioxidants therapy has been developed to prevent cancer. Studies showed that free radicals can lead to degenerative disease like cancer, aging, age related macular degeneration etc [7]. Figure 2. Cost of cancer care by phase of care, in 2010. Anti...

Journal of Applied Biotechnology Reports, 2016

The human body needs essential nutrients in order to function, grow, and stay healthy. Our bodies... more The human body needs essential nutrients in order to function, grow, and stay healthy. Our bodies cannot make these nutrients, so get them from our diet. On the other hand, some diet-related diseases can be caused by certain improper food ingredients and body inability of absorbing them. Then the idea of purifying beneficial ingredients formed. Poly-unsaturated fatty acid such as gamma-linoleic acid (GLA) is a group of essential fatty acids particularly favorable for its application in nutraceutical and pharmaceutical industries. GLA plays significant roles in improving human body functions. It has gained its importance in the last four decades for having a positive effect on the most of the chronic diseases of modern society, including cancer, diabetes, heart disease, arthritis, Alzheimer's disease, etc. Then, it has been used as a dietary supplement for the treatment of various health problems and have inflammatory component. One of the richest sources of GLA is a kind of mic...

Iranian Journal of Allergy, Asthma and Immunology, 2020

Purification and preparation of three diagnostic antigens used for the detection of human T-lymph... more Purification and preparation of three diagnostic antigens used for the detection of human T-lymphotropic virus (HTLV)-I/-II infection in E.coli are different parts of a multi-step method. In this study, our aim was to design a chimeric protein for the simultaneous detection of HTLV-I and HTLV-II antibodies. Immunodominant B cell linear epitopes of envelope and capsid proteins of HTLV-I/-II were selected and linked together; using a suitable amino acid linker and a chimeric antigen (CA). The codon-optimized synthetic DNA encoding the CA was subcloned into the pGS21aexpression vector and CA expressed as His-GST fused protein in E. coli BL21 (DE3) cells. Then the recombinant CA was purified, using the Ni-NTA (Nickle Nitrilotriacetic acid) affinity chromatography under native conditions. The Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and densitometric scanning results showed that CA accounted for 15% of the total cellular proteins and approximately 50% of the e...

Journal of Biology and Today's World, 2018

IET Nanobiotechnology, 2019

Biology and Medicine, 2018

Food Packaging and Shelf Life, 2019

Abstract The overall aim of this research is to introduce a novel approach for maintaining a grea... more Abstract The overall aim of this research is to introduce a novel approach for maintaining a greater amount of cinnamon essential oil (CEO) in the material. We used the Pickering stabilization method, in order to increase the antioxidant and antifungal properties of carboxymethyl cellulose (CMC)-polyvinyl alcohol (PVA) based films. The light transmission, antioxidant and antifungal properties of the films were studied. In addition, the effect of the packaging was studied on the shelf life of bread. The results showed great improvement of the antifungal and antioxidant properties of the prepared films. The films containing 1.5 and 3% CEO were highly effective against P. digitatum and showed complete inhibition in in vitro and in vivo tests. Moreover, the films exhibited a good UV inhibitory effect. Consequently, the CEO Pickering emulsion was an ideal alternative for incorporation with CMC-PVA based films for increasing the shelf life of bread.

$Research paper thumbnail of Paratricepital approach for fixation of distal humerus fracture in adults - A good alternative$

International Journal of Orthopaedics Sciences, 2017

Distal humerus fractures most commonly managed by surgical approaches that disrupt the extensor m... more Distal humerus fractures most commonly managed by surgical approaches that disrupt the extensor mechanism of elbow. Paratricepital posterior approach for distal humerus fracture fixation done by orthogonal or parallel plate construct. Methods: 30 cases of distal humerus fractures are taken. Bicolumnar fixation done by elevating and retracting the triceps of the distal humerus keeping triceps insertion undisturbed by orthogonal or parallel plate construct. Early active-assisted range of motion initiated within limits of pain. Age group was 15 to 60 years. Among all patients 10% of fractures were Type C1, 6.66% of fractures were Type C2, Type A 50% and Type B fractures is 33.33%.Radiograph (x-ray) and functional evaluation was done by MEPS (Mayo Elbow Performance Score), DASH (Disability of Arm Shoulder and Hand) questionnaire. Results: All thirty fractures healed primarily. The median arc of elbow motion was 115 0 (range 70 0 to 140 0) with standard deviation of 1.33. Average score is 91(range 80-105) with standard deviation of 1.66, indicating excellent result. Conclusions: Paratricepital posterior approach results in excellent healing, a mean flexion extensor arc of more than 100 degree, maintenance of almost normal elbow extensor strength. Implication: Paratricepital posterior approach should be considered whenever distal humerus fracture are to be fixed especially in Type A and Type B fractures.

Gene, 2017

BACKGROUND The metabolic syndrome (MetS) is a clustering of metabolic disorders that is associate... more BACKGROUND The metabolic syndrome (MetS) is a clustering of metabolic disorders that is associated with an increased risk of developing cardiovascular-disease, diabetes, and related diseases. Against this background, Vascular Endothelial Growth Factor (VEGF) plays an essential role in angiogenesis, vascular permeability, and hematopoiesis and its increased level is reported to be associated with increasing the risk of developing cardiovascular-disease, stroke and diabetes. Therefore the aim of present study was to explore the association of serum VEGF level and its associated genetic-polymorphism, rs10738760 (A>G) at 9p24.2, in 850 subjects with/without MetS. METHODS MetS was defined according to the International-Diabetes-Federation criteria. Genotyping was carried out using Polymerase chain reaction-amplification refractory mutation system. Anthropometric/biochemical parameters, including FBG, Triglyceride, HDL, TC, etc., were determined followed by univariate and multivariate analyses. RESULTS MetS patients had significantly higher levels of BMI, waist-circumference, cholesterol, triglyceride, Hs-CRP and SBP/DBP, while the HDL-C levels was lower in patients group, compared to control group (P<0.05). Moreover, our analysis showed that MetS patients with GA or AA genotypes had a significantly (P=0.03) higher serum level of VEGF. CONCLUSIONS we demonstrate an association between a VEGF genetic variant with MetS, suggesting its role as a risk stratification factor for MetS.

Regarding this fact that the measurement of acetylcholine esterase (AChE) is done by medical meth... more Regarding this fact that the measurement of acetylcholine esterase (AChE) is done by medical method and this method is time-consuming and costly, so creating a sensor for fast and easy measurement with low cost is essential in our society due to excessive use of pesticides. It can be say that biosensors could be replaced tby the present analytical methods. Enzyme-based electrochemical biosensors because of their high sensitivity, fast response, and miniature size are appropriate as a promising alternative to pesticides. Through modifying glassy carbon electrode surface with cadmium oxide nanoparticles and acetylcholinesterase and discussed the electrochemical behavior of this protein structure the possibility of paraxon toxin concentration detection and measurement has been provided from electrochemistry. Cadmium oxide nanoparticles were synthesized by chemical methods in the laboratory and this claim that this synthesized Nano particles are cadmium oxide, was confirmed by using X-r...