herin mawarti - Academia.edu (original) (raw)

Papers by herin mawarti

International Journal of Social Science, Feb 12, 2023

Background: Covid-19 is a disease caused by acute respiratory syndrome due to corona virus 2. Pat... more Background: Covid-19 is a disease caused by acute respiratory syndrome due to corona virus 2. Patients with Covid-19 experience symptoms of severe shortness of breath resulting in death. The risk of death for Covid-19 sufferers will be greater if the patient has a history of comorbid diseases such as hypertension, diabetes mellitus, cardiovascular disease or kidney disease.Objective: The purpose of this study was to determine the relationship between comorbid diseases and the incidence of mortality in patients with Covid-19.Method: Research design using descriptive analytic. The research population was all Covid-19 sufferers who were treated at Mojowarno Christian Hospital (RSK) during 2021 totaling 450 sufferers. The research sample was 212 respondents with a sampling technique using systematic random sampling. The data was obtained from the medical records of Covid-19 patients who were treated at the Mojowarno Hospital. Statistical test using chi square and odds ratio with a significance level of P <0.05. Results: The results of the study found that comorbid diabetes mellitus showed a result of P: 0.000, meaning that there was a relationship between comorbid diabetes mellitus and the incidence of mortality in patients with Covid-19. Comorbid kidney disease shows a P value: 0.003, meaning that there is a relationship between comorbid kidney disease and the occurrence of mortality in Covid-19 sufferers. Comorbid heart disease results obtained P: 0.089, meaning that there is no relationship between comorbid heart disease and mortality in patients with Covid-19. Hypertensive comorbid disease on mortality with a P value: 0.134 meaning that there is no relationship between hypertension comorbid disease and the risk of mortality in patients with Covid-19. Conclusion:Covid-19 sufferers who have comorbid diabetes mellitus cause greater mortality. This is because diabetes mellitus can cause a cytokine storm which plays a role in increasing the severity of COVID-19 sufferers so that it often causes death.

J-ABDI: Jurnal Pengabdian kepada Masyarakat

SMU Darul Ulum 1 Peterongan Jombang merupakan sekolah menegah umum yang berada di lingkungan pond... more SMU Darul Ulum 1 Peterongan Jombang merupakan sekolah menegah umum yang berada di lingkungan pondok pesantren dimana siswa SMU darul Ulum 1 Peterongan Jombang hampir 95% bertempat tinggal di pondok pesantren. Siswa SMU merupakan remaja antara usia 16 sampai 18 tahun, dimana perkembangan hormonal yang memengaruhi perkembangan fisik, psikologis dan kognitif sedikit banyak menyebabkan remaja mulai menunjukkan ketertarikan pada aktivitas seksual, sehingga masa remaja merupakan masa yang rentan terkena IMS. Mereka jauh dari orang tua yang tidak setiap saat mendapatkan bimbingan dari orang tua tentang kesehatan reproduksi terutama tentang penyakit infeksi menular seksual (IMS). Begitu pula di lingkungan pondok ataupun di sekolah informasi tentang penyakit IMS juga sangat terbatas karena santri/siswa dibatasi dalam penggunaan teknologi informasi. Beberapa Risiko tertular IMS sangat berhubungan dengan perilaku, sehingga edukasi dan counseling merupakan strategi utama dalam upaya pencegahan ...

International Journal of Social Science

Body weight exceeding normal body weight (Overweight) is a cause of increased triglyceride levels... more Body weight exceeding normal body weight (Overweight) is a cause of increased triglyceride levels. High triglyceride levels (hypertriglyceridemia) are a risk for coronary heart disease and diabetes mellitus. Efforts that can be made to reduce hypertriglyceridemia is to reduce the number of meals with the shof diet (sixteen hours of fasting). During fasting triglycerides will be mobilized to produce energy or synthesized into glucose. The aim of this study was to determine the effect of the shof diet on reducing triglyceride levels in overweight adolescents. The research design used the Pre-Experiment One Group Pretest-Postest Design with a population of all female students of the Faculty of Health Sciences who experienced overwight as much as 25. The number of samples was 20 with a sampling technique using purposive sampling. The research instrument uses an observation sheet. Data were analyzed using the Wilcoxon test with a P value ≤ α (α = 0.05). The results showed that the value ...

Jurnal Ilmu Kedokteran dan Kesehatan

Abstrak: Pengaruh Telenursing Terhadap Kepatuhan Minum Obat Pasien Tuberculosis Paru Di Wilayah K... more Abstrak: Pengaruh Telenursing Terhadap Kepatuhan Minum Obat Pasien Tuberculosis Paru Di Wilayah Kerja Puskesmas Dukuhklopo Kabupaten Jombang. Pandemi covid-19 secara umum menurunkan jumlah kunjungan layanan kesehatan serta berdampak negatif pada berbagai sektor publik, terutama pada pelayanan pasien tuberculusis paru. Upaya adaptasi pelayanan kesehatan yang telah dilakukan dengan berbagai cara untuk mengurangi angka kematian yang disebabkan tuberculusis. Namun, cukup besar kemungkinan terjadinya ketidaktuntasan dalam minum obat pasien yang telat dijadwalkan. Untuk mengantisipasi hal tersebut, perlu diberikan informasi kesehatan yang tepat, cepat dan lengkap agar masyarakat yang memang membutuhkan layanan kesehatan, khususnya pada pasien tuberculusis paru menggunakan telenursing. Penelitian ini bertujuan untuk mengetahui pengaruh telenursing terhadap kepatuhan minum obat pasien tuberculosis paru. Metode penelitian Quasy-Experiment dengan desain penelitian postest design group. Pemili...

Introduction: External or internal Stigma on HIV/AIDS patient cannot be denied. It will contribut... more Introduction: External or internal Stigma on HIV/AIDS patient cannot be denied. It will contribute to psychological disorder such as depression and social isolation if it is not overcome. The impact of depression sustained decline in physical and mental condition, thus affecting treatment. The purpose of the research is to find out correlation between depression level and internal stigma at HIV/AIDS patients. Method: This study was a correlation research with cross sectional design. The population of the research was the new HIV patients at VCT Kemuning Clinique in Nopember 2016 at RSUD Dr Soedono Madiun used purposive sampling technique with total sampling 32 patients. The independent variable was internal stigma while dependent variable was depression level. The data analyzed using Spearman Rho test. Results: The result shows that 17 respondents got high internal stigma around, 100% depressions. This high stigma was influenced by some factors, they were feeling of fear when other ...

Jurnal Pengabdian kepada Masyarakat Nusantara

Tujuan pengabdian masyarakat ini adalah melakukan pemeriksaan kesehatan pada anak usia sekolah da... more Tujuan pengabdian masyarakat ini adalah melakukan pemeriksaan kesehatan pada anak usia sekolah dasar di SD Plus Jombang. Pemeriksaan kesehatan meliputi kesehatan dasar atau kesehatan umum dan pemeriksaan kesehatan penglihatan, kesehatan pendengaran dan kesehatan gigi pada anak usia sekolah di SD Plus Jombang. Pelakasanaan kegiatan pengabdian masyarakat ini dilakukan pada tanggal 16 Juni 2022 yang terdiri dari kelas 1 sampai dengan kelas 5. Metode pelaksanaan kegiatan pengabdian masyarakat ini terdiri dari: 1) Tahap persiapan, 2) Tahap pelaksanaan dan 3) Tahap evaluasi. Tahap persiapan meliputi: Rapat koordinasi penentuan jadwal dan penentuan lokasi pemeriksaan, persiapan anggota Tim pelaksana, persiapan alat dan bahan dan setting untuk tempat dan prosedur pelaksanaan. Tahap Pelaksanaan ywaitu pemeriksaan berurutan mulai dari meja pemeriksaan mata, meja pemeriksaan gigi, meja pemeriksaan pendengaran dan meja pemeriksaan umum. Selanjutnya tahap evaluasi berupa tahap4 evaluasi kegia...

FK Universitas Brawijaya, 2012

Konsumsi Epigallocatechin Gallate (EGCG) teh hijau dilaporkan banyak bermanfaat pada upaya pening... more Konsumsi Epigallocatechin Gallate (EGCG) teh hijau dilaporkan banyak bermanfaat pada upaya peningkatan kesehatan, seperti pembakaran lemak, mencegah obesitas dan sensitifitas insulin. Sehingga teh hijau (Camelia sinensis) dari klon GMB4 dapat dikembangkan sebagai agen terapeutik potensial untuk obesitas dan resistensi insulin. Penelitian ini bertujuan untuk membuktikan Epigallocatechin Gallate (EGCG) teh hijau dapat menghambat peningkatan kadar SREBP-1 jaringan adiposa dan resistensi insulin pada tikus galur wistar jantan yang diberi diet tinggi lemak. Penelitian ini dilakukan secara invivo dengan pemeliharaan hewan coba selama 8 minggu yang dibagi dalam lima kelompok perlakuan: (1) kelompok kontrol (-) dengan pemberian diet pakan standart, (2) kelompok kontrol (+) dengan pemberian diet tinggi lemak, (3)Pemberian diet tinggi lemak+EGCG 1mg/kgBB, (4) Pemberian diet tinggi lemak+EGCG 2 mg/kgBB, (5) Pemberian diet tinggi lemak+EGCG 8 mg/kgBB. Pakan tikus diberikan secara oral, sedangkan EGCG per sonde 1 x/hr. Metode yang digunakan dalam penelitian ini adalah ELISA untuk kadar insulin dan SREBP-1 jaringan adiposa dan spektrofotometri untuk glukosa darah puasa. EGCG menurunkan lemak viseral, kadar glukosa, kadar SREBP-1 dan resistensi insulin (HOMA-IR) (p<0,05). Penurunan kadar SREBP-1 secara signifikan sebesar 29,85%(p<0,05) pada dosis 8 mg/kgBB, sedangkan HOMA-IR menurun secara signifikan sebesar 33,89% (p<0,05) pada dosis 8 mg/kgBB. Terdapat hubungan antara kadar SREBP-1 dengan resistensi insulin (HOMA-IR) (p<0,05). Hasil penelitian ini membuktikan bahwa EGCG mampu menghambat resistensi insulin yang mungkin melalui penurunan adipo/lipogenesis SREBP-1 jaringan adiposa, dengan bukti adanya penurunan kadar SREBP-1 jaringan adiposa dan lemak viseral.

Indian Journal of Forensic Medicine & Toxicology, Apr 13, 2021

SLE (Systemic Lupus Erythematosus) is one of autoimmune disease in which the immune system attack... more SLE (Systemic Lupus Erythematosus) is one of autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. Etiology and pathogenesis are not clearly mention until now by the scientist, but environmental factor is contribute to development of Lupus and Flare disease. The objective of this study to explain the relationship between environmental factors and pathogenesis development of SLE, and how the Epigallocatechin-3-Gallate (EGCG) can protect or prevent of organs damage and environmental effects. Method: The research design of this study was used literature review. The data sources collected from Electronic database in Pubmed, Sage, Google Scholar and website of science including reports, journals and mostly published in the last 10 years. Results: The pathomechanism of SLE was influenced by environmental factors and this was caused an increasing of oxidative stress, chronic inflammation, dysregulation of immune system and decreased the clean of immune complex and apoptosis of cells. The production of autoantibodies and immune complex are related with target tissue with is it was caused chronic inflammation and the end it caused irreversible damage in glomerulus of the kidneys, arteries, lungs and other tissues. EGCG plays a protecting role in environmental factors as a trigger because it works as an antioxidant, anti-inflammatory and immunomudulator. So EGCG can as a potential agent to protect SLE. Conclusion: Environmental factors plays an important role as a triger of SLE and flare. Moreover, EGCG as a potential agent to protect the presence of oxidative stress, inflammation and immune dysregulation.

Care Journal, 2022

Pendahuluan:Jerawat atau acne adalah penyakit kulit kronis yang terjadi akibat peradangan kronis ... more Pendahuluan:Jerawat atau acne adalah penyakit kulit kronis yang terjadi akibat peradangan kronis akibat folikel pilosebasea yang dapat terjadi pada wanita maupun pria. Jerawat memiliki dampak serius dalam mempengaruhi penampilan dan kepercayaan diri. Upaya pengobatan nonfarmakologi adalah dengan terapi akupunktur komplementer. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui pengaruh terapi komplementer akupunktur terhadap jerawat. Desain penelitian ini adalah Quasy Experimental dengan metode pendekatan Pre-Post Test Design, sedangkan dalam pengambilan sampel menggunakan teknik Purposive Sampling. Sampel sebanyak 13 responden memenuhi kriteria eksklusi dan eksklusi. Peneliti menggunakan lembar observasi sebagai instrumen penilaian jerawat. Metode: Metode analisis data menggunakan Uji Wilcoxon dengan (p < a) atau (p < 0,05). Pada penelitian ini diperoleh hasil sebagai berikut: tumor (0,011 < 0,05), rubor (0,005 < 0,05), dolor (0,008 < 0,05), dan warna (0,008 ...

Indian Journal of Forensic Medicine & Toxicology, 2021

Objective: This study aims to investigate the effects of green tea administration on TNF-a, Hsp70... more Objective: This study aims to investigate the effects of green tea administration on TNF-a, Hsp70, and TGF-b1 levels in the systemic lupus erythematosus (SLE). Material and methods: A total of 32 mice will be divided into four groups (each 8 mice), namely the control group, the SLE group, the SLE group who were given green tea extract at a dose of 500 mg/kg body weight, and the SLE group who were given green tea extract at a dose of 1000 mg/kg body weight. Analysis of TNF-a, Hsp70, and TGF-b1 levels was carried out using the enzyme-linked immunosorbent assay technique. Results: TNF-a and TGF-b1 levels were significantly increased in the SLE group compared to the control group (p < 0.05). This increase can be significantly reduced through the provision of green tea, even reaching levels comparable to the control group (p > 0.05). Conclusions: It was concluded that green tea containing EGCG can suppress TNF-a and TGF-b1 in the SLE model. Thus, green tea can be an alternative in immunology modulation in SLE.

Propolis to main content flafonoid have antioxidant properties, anti-inflammatory and antibiotic ... more Propolis to main content flafonoid have antioxidant properties, anti-inflammatory and antibiotic believed to be used as an agent in wound healing. The purpose of this study is to prove the effect of propolis on the healing process of burns . The research was carried out in vivo with a sample of 21 rats . Maintenance of experimental animals for 14 days were divided into three treatment groups : (1 ) Giving bioplasenton; ( 2 ) treatment of propolis 1 time a day, (3 ) treatment of propolis 2 times a day. Observation of wound healing observed changes in the diameter of the wound seen in the inflammatory phase – 4 days and the proliferative phase at day -14 . In addition to the observed changes in the diameter of the wound healing and duration until wound is drying . The results showed no significant difference in the diameter of the third group wound treatment, burns and diameter significantly at day -14 ( p = 0.001 ). where the diameter of the wound 3 groups of almost equal groups of 1...

Introduction : Tuberculosis has become a serious health problem in the world. Increased mortalit... more Introduction : Tuberculosis has become a serious health problem in the world. Increased mortality in patients with tuberculosis infection is associated with MDR and hepatotoxic side effects of antituberculosis drugs. Therefore, it is necessary to find an alternative drug that can reduce the hepatotoxic side effects . Objective : This study aims to investigate the benefits of Aloe vera in preventing liver damage as a side effect of antituberculosis drug administration. Method: Twenty-five rats will be divided into five groups, namely the control group (without any treatment), the group of rats treated by anti-tuberculosis drugs, and a group of mice were given antituberculosis drugs and got Aloe vera extract at a dose of 40; 80; and 120 mg/kg body weight. Results: Antituberculosis drugs are isoniazid and rifampicyn a dose of 50 mg/kg body weight. Levels of TNF-a were significantly higher in the antituberculosis group compared with the control group (P 0.05). Conclusion: It was conclu...

1 Department of Clinical Pathology, Faculty of Medicine, Brawijaya University, Malang, Indonesia ... more 1 Department of Clinical Pathology, Faculty of Medicine, Brawijaya University, Malang, Indonesia 2 Department of Physiology, Faculty of Medicine, Brawijaya University, Malang, Indonesia 3 Rheumatology Division, Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Malang, Indonesia 4 Fundamental of Nursing Department, Faculty of Health Science, Pesantren Tinggi Darul Ulum University, Jombang, Indonesia.

This study investigated the effect of EGCG from GMB4 green tea clones inhibit increasing choleste... more This study investigated the effect of EGCG from GMB4 green tea clones inhibit increasing cholesterol levels in male rats with high fat diet. Wistar male rats were fed a diet high in fat for 2 months from 8 weeks of age and determination of the object of research with completely randomized design five treatments and EGCG was given by sonde. Blood cholesterol levels by spektrophometry. EGCG treatment decreased cholesterol levels (p<0.05). Cholesterol levels decreased 55%(p=0.00) at doses of 8 mg / BW. The Results suggested that EGCG one of the most abundant catechins contained in green tea effectively inhibits increased cholesterol levels, that risk factor for cardio vascular disease.

Medico-Legal Update, 2020

This research aimed to reveal the potency of green tea (Camellia sinensis) as immunomodulator, an... more This research aimed to reveal the potency of green tea (Camellia sinensis) as immunomodulator, antiapoptosis agent and anti pyroptosis agent in Systemic Lupus Erythematosus.. The rest samples was downloaded from KNAPSACK Database. Biological activity prediction was conducted by PASS SERVER. Molecular Docking analysis was performed by Autodock Vina in PyRx software v.0.9.3. Complex docking was analyzed and visualized using Discovery Studio Software. The result showed that Camellia sinensis has the main potency as immunomodulatory, antioxidant and anti-inflammation. The highest activity of this herbal is antioxidant. There are few bioactive that have role as immunomodulator. The result of molecular docking can explain the mechanism of active compound as anti-apoptosis and anti-pyroptosis. Docking result showed that Theaflavin has the highest affinity to both activities. It can be concluded that bioactive from Camelia sinensis is promising for curing Systemic Lupus Erythematosus by acting as antioxidant and inhibit apoptosis and pyroptosis mechanism.

International Journal of Women's Health and Reproduction Sciences, 2020

Objectives: Dysmenorrhea is one of several gynecological issues that occur among women of reprodu... more Objectives: Dysmenorrhea is one of several gynecological issues that occur among women of reproductive age. In addition, it appears as pain that forms in the pelvis or lower abdomen and spreads to the back and thighs. The peripheral blood among women with dysmenorrhea increases the synthesis and the concentration of oxytocin, F2α prostaglandin hormone, vasopressin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNFα). In this regard, this study aimed to determine the effect of slow-stroke back massage (SSBM) on the levels of β-endorphins, IL-6, TNF-α, and menstrual pain intensity (MPI). Materials and Methods: Based on the aim of the study, the posttest only quasi-experimental method with the control group design approach, pretest-posttest control group approach, and purposive sampling techniques were applied for sample selection. The samples were divided into SSBM and control groups each containing 20 subjects. The numeric rating scale (NRS), β-endorphin, IL-6, and TNFα levels w...

Jurnal Kedokteran Brawijaya, 2012

Eduhealth, Apr 10, 2012

ABSTRAK Konsumsi epigallocatechin gallate (EGCG) dari teh hijau sudah banyak yang melaporkan berm... more ABSTRAK Konsumsi epigallocatechin gallate (EGCG) dari teh hijau sudah banyak yang melaporkan bermanfaat untuk kesehatan diantaranya membakar lemak, mencegah obesitas sehingga EGCG yang didapat dari teh hijau (Camelia sinensis) yang diperoleh dari klon GMB4 juga berpotensi sebagai agent terapeutik mencegah adanya komplikasi akibat adanya diet tinggi lemak. Tujuan penelitian ini untuk mengetahui efek dari EGCG terhadap kadar sterol regulatory element-binding protein - 1(SREBP-1) pada tikus betina yang diberi diet tinggi lemak. Tikus wistar betina diberi diet tinggi lemak selama 2 bulan dan dikelompokkan dalam lima kelompok perlakuan yaitu ( 1 ) Tikus dengan diet pakan standart ( 2 ) Tikus dengan diet tinggi lemak , ( 3 ) Tikus dengan diet tinggi lemak + EGCG 1 mg/kgBB ( 4 ) Tikus dengan diet tinggi lemak + EGCG 2 mg/kgBB ( 5 ) Tikus dengan diet tinggi lemak + EGCG 2 mg/kgBB. EGCG diberikan per sonde 1x/hari. SREBP-1 jaringan adiposa diperiksa dengan ELISA. Dan hasilnya Kadar SREBP-1 menurun 29.85% (p <0.05) pada dosis 8 mg/kgBB. Dari penelitian ini dapat disimpulkan bahwa EGCG efektif menurunkan kadar SREBP-1 yang merupakan faktor regulator adipo dan lipogenesis suatu patogenesis untuk terjadinya obesitas. Terutama obesitas viseral yang beresiko untuk terjadinya sindroma metabolik. Sehingga disarankan untuk mengkonsumsi teh hijau untuk pencegahan obesitas. Kata Kunci : EGCG GMB4, SREBP-1 adiposa , tikus dengan diet tinggi lem Â ABSTRACT Consumption of epigallocatechin gallate (EGCG) of green tea were reported to have much benefit in improving health, such as increased fat oxidation, prevent obesity so EGCG of green tea (Camelia sinensis) from GMB4 clone may serve as a potential therapeutic agent for prevent komplication from high diet fat. This study investigated the effect isolat EGCG from green tea inhibit increasing adipose tissue sterol regulatory element-binding protein 1( SREBP-1 ) in Male Rats with High Fat Diet. Wistar male rats were fed a diet high in fat for 2 months from 6-8 weeks of age and determination of the object of research with completely randomized design with five treatments, namely (1) Rats with standard feed diet (2) rats with a diet high in fat, (3) rats with high-fat diet + EGCG 1mg/kgBW, (4) rats with high-fat diet + EGCG 2 mg/kgBW, (5) rats with high-fat diet + EGCG 8 mg/kgBW. Feeding rats administered orally, whereas EGCG per sonde 1x/day. Adipose tissue SREBP-1 was measured by ELISA EGCG treatment decreased SREBP-1<0.05) compared with high-fat diet without EGCG treatment. SREBP-1 levels decreased significantly by 29.85% (p <0.05) at doses of 8 mg/kgBW. Results suggested that EGCG effectively inhibits SREBP-1 regulator of adipo/lipogenesis to the pathogenesis of obesity. Especially visceral obesity that risk for the metabolic syndrome. So it is advisable to consume green tea for the prevention of obesity. Key word : EGCG GMB4; SREBP-1 adipose tissue, rat with high diet fat.