imen rezgani - Academia.edu (original) (raw)
Papers by imen rezgani
Archives of Endocrinology and Metabolism, Mar 23, 2022
Objective: There is little data about the remission phase in adolescents and young adults with ne... more Objective: There is little data about the remission phase in adolescents and young adults with newly diagnosed type 1 diabetes mellitus (T1D). The aims of this study were to determine the prevalence of remission and its predicting factors among adolescents and young adults with newly diagnosed T1D and to assess the association between remission and long-term glycemic control in this population. Subjects and methods: This is a longitudinal and retrospective study including 128 type 1 diabetic patients aged between 12 and 30 years at diabetes onset. Clinical, biological and therapeutic features were collected at diagnosis and for 5 years after diagnosis. Remission was defined by an HbA1c < 6.5% with a daily insulin dose < 0.5 IU/kg/day. Results: Twenty-three patients (18%) experienced a remission. The peak of remission prevalence was at 6 months after diabetes diagnosis. An insulin dose at discharge <0.8 IU/kg/day was independently associated with remission (p=0.03, adjusted OR [CI 95%] = 0.2 [0.1-0.9]). A low socioeconomic level was independently associated with non remission (p=0.02, adjusted OR [CI 95%] = 4.3 [1.3-14.3]). HbA1c was significantly lower during the first five years of follow-up in remitters. The daily insulin dose was significantly lower during the first four years of follow-up in remitters. Conclusions: Occurrence of remission in adolescents and young adults with newly diagnosed T1D is associated with better glycemic control and lower insulin requirements during the first 5 years of follow-up. A lower initial dose of insulin was associated with a higher percentage of remission.
Clinical Case Reports, Nov 1, 2022
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-... more This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
The Journal of Clinical Endocrinology & Metabolism
Context Some women living with type 1 diabetes complain of changes in glucose values according to... more Context Some women living with type 1 diabetes complain of changes in glucose values according to the different phases of menstruation. Objective To evaluate this variability through continuous glucose monitoring (CGM) data in type 1 diabetes patients. Design Observational study. Setting Ambulatory data, recruitment in 2 centers in the Paris region. Patients Twenty-four women with type 1 diabetes having spontaneous menstrual cycles. Intervention Collection of CGM data for 62 spontaneous menstrual cycles, with evaluation of five 3-day phases during each cycle: (1) early follicular (menstruations), (2) mid-follicular, (3) peri-ovulatory, (4) mid-luteal, and (5) late luteal. Main outcome measure Time in range (TIR, prespecified). Results TIR decreased for each consecutive phase (61 ± 18%; 59 ± 18%; 59 ± 20%; 57 ± 18%; and 55 ± 20%, P = 0.02). The linear mixed model highlighted a decrease in TIR in the mid-luteal (P = 0.03) and late luteal (P < 0.001) phases compared with the early f...
Medicine, 2016
Thyroid hormone resistance syndrome (THRS) is a rare disorder with increased concentrations of fr... more Thyroid hormone resistance syndrome (THRS) is a rare disorder with increased concentrations of free thyroxine (FT4) and triiodothyronine (FT3), but normal or slightly increased thyroid-stimulating hormone (TSH). The mutations in the thyroid hormone receptor β (THRβ) gene are thought to be the main pathogenesis. The aims of this study were to present 1 pedigree of Chinese THRS, summarize their clinical characteristics, and analyze the gene mutation. The clinical characteristics and thyroid function of the proband and his family members were collected. Gene mutations were analyzed by DNA sequencing. The proband and his mother exhibited symptoms of hyperthyroidism, such as palpitations, heat intolerance, and perspiration. The mother also had atrial fibrillation. The rest of the kindred did not display clinical manifestations of hyper- or hypothyroidism. DNA sequencing revealed a heterozygous G>A missense mutation at position 949 in Exon 9 of THRβ both in the patient and his mother, ...
La Tunisie médicale, Jul 20, 2022
Additional file 1: Table S1. Epicardial adipose tissue volume according to cardio-vascular risk f... more Additional file 1: Table S1. Epicardial adipose tissue volume according to cardio-vascular risk factors. Table S2. Epicardial adipose tissue volume according to diabetes-related complications. Table S3. Epicardial adipose tissue volume according to treatment.
Annales d'Endocrinologie, 2018
Déclaration de liens d'intérêts Les auteurs déclarent ne pas avoir de liens d'intérêts.
Cardiovascular Diabetology, 2021
Background Epicardial adipose tissue (EAT) has anatomic and functional proximity to the heart and... more Background Epicardial adipose tissue (EAT) has anatomic and functional proximity to the heart and is considered a novel diagnostic marker and therapeutic target in cardiometabolic diseases. The aim of this study was to evaluate whether EAT volume was associated with coronary artery calcification (CAC) in people living with diabetes, independently of confounding factors. Methods We included all consecutive patients with diabetes whose EAT volume and CAC score were measured using computed tomography between January 1, 2019 and September 30, 2020 in the Department of Diabetology-Endocrinology-Nutrition at Avicenne Hospital, France. Determinants of EAT volume and a CAC score ≥ 100 Agatston units (AU) were evaluated. Results The study population comprised 409 patients (218 men). Mean (± standard deviation) age was 57 ± 12 years, and 318, 56 and 35 had type 2 (T2D), type 1 (T1D), or another type of diabetes, respectively. Mean body mass index (BMI) was 29 ± 6 kg/m2, mean AET volume 93 ± 3...
Nutrition, Metabolism and Cardiovascular Diseases, 2021
Background and aims To evaluate the prevalence and prognostic value of metabolic syndrome (MetS) ... more Background and aims To evaluate the prevalence and prognostic value of metabolic syndrome (MetS) in patients admitted for Coronavirus Disease 2019 (COVID-19). Methods and results In this monocentric cohort retrospective study, we consecutively included all adult patients admitted to COVID 19 units between April 9 and May 29, 2020, and between February 1 and March 26, 2021. MetS was defined when at least three of the following components were met: android obesity, high HbA1c, hypertension, hypertriglyceridemia and low HDL-cholesterol. COVID-19 deterioration was defined as the need for nasal oxygen flow ≥ 6 l/min within 28 days after admission. We included 155 patients (55.5% men, mean age 61.7 years old, mean body mass index 29.8 kg/m2). Fifty-six patients (36.1%) had COVID-19 deterioration. MetS was present in 126 patients (81.3%) and was associated with COVID-19 deterioration (no MetS vs MetS: 13.7% and 41.2%, respectively, p<0.01). Logistic regression taking into account MetS, age, gender, ethnicity, period of inclusion and Charlson Index showed that COVID-19 deterioration was 5.3 times more likely in MetS patients (95% confidence interval 1.3-20.2) than non-MetS patients. Conclusions Over 81.3% of patients hospitalized in COVID-19 units had MetS. This syndrome appears to be an independent risk factor of COVID-19 deterioration.
Annales d'Endocrinologie, 2018
Annales d'Endocrinologie, 2018
Archives of Cardiovascular Diseases Supplements, 2019
Archives of Cardiovascular Diseases Supplements, 2019
We in this paper propose a realizable framework TECU, which embeds task-specific strategies into ... more We in this paper propose a realizable framework TECU, which embeds task-specific strategies into update schemes of coordinate descent, for optimizing multivariate non-convex problems with coupled objective functions. On one hand, TECU is capable of improving algorithm efficiencies through embedding productive numerical algorithms, for optimizing univariate sub-problems with nice properties. From the other side, it also augments probabilities to receive desired results, by embedding advanced techniques in optimizations of realistic tasks. Integrating both numerical algorithms and advanced techniques together, TECU is proposed in a unified framework for solving a class of non-convex problems. Although the task embedded strategies bring inaccuracies in sub-problem optimizations, we provide a realizable criterion to control the errors, meanwhile, to ensure robust performances with rigid theoretical analyses. By respectively embedding ADMM and a residual-type CNN in our algorithm framework, the experimental results verify both efficiency and effectiveness of embedding task-oriented strategies in coordinate descent for solving practical problems.
Endocrine Abstracts, 2019
Endocrine Abstracts, 2019
Endocrine Abstracts, 2019
Endocrine Abstracts, 2019
Archives of Endocrinology and Metabolism, Mar 23, 2022
Objective: There is little data about the remission phase in adolescents and young adults with ne... more Objective: There is little data about the remission phase in adolescents and young adults with newly diagnosed type 1 diabetes mellitus (T1D). The aims of this study were to determine the prevalence of remission and its predicting factors among adolescents and young adults with newly diagnosed T1D and to assess the association between remission and long-term glycemic control in this population. Subjects and methods: This is a longitudinal and retrospective study including 128 type 1 diabetic patients aged between 12 and 30 years at diabetes onset. Clinical, biological and therapeutic features were collected at diagnosis and for 5 years after diagnosis. Remission was defined by an HbA1c < 6.5% with a daily insulin dose < 0.5 IU/kg/day. Results: Twenty-three patients (18%) experienced a remission. The peak of remission prevalence was at 6 months after diabetes diagnosis. An insulin dose at discharge <0.8 IU/kg/day was independently associated with remission (p=0.03, adjusted OR [CI 95%] = 0.2 [0.1-0.9]). A low socioeconomic level was independently associated with non remission (p=0.02, adjusted OR [CI 95%] = 4.3 [1.3-14.3]). HbA1c was significantly lower during the first five years of follow-up in remitters. The daily insulin dose was significantly lower during the first four years of follow-up in remitters. Conclusions: Occurrence of remission in adolescents and young adults with newly diagnosed T1D is associated with better glycemic control and lower insulin requirements during the first 5 years of follow-up. A lower initial dose of insulin was associated with a higher percentage of remission.
Clinical Case Reports, Nov 1, 2022
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-... more This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
The Journal of Clinical Endocrinology & Metabolism
Context Some women living with type 1 diabetes complain of changes in glucose values according to... more Context Some women living with type 1 diabetes complain of changes in glucose values according to the different phases of menstruation. Objective To evaluate this variability through continuous glucose monitoring (CGM) data in type 1 diabetes patients. Design Observational study. Setting Ambulatory data, recruitment in 2 centers in the Paris region. Patients Twenty-four women with type 1 diabetes having spontaneous menstrual cycles. Intervention Collection of CGM data for 62 spontaneous menstrual cycles, with evaluation of five 3-day phases during each cycle: (1) early follicular (menstruations), (2) mid-follicular, (3) peri-ovulatory, (4) mid-luteal, and (5) late luteal. Main outcome measure Time in range (TIR, prespecified). Results TIR decreased for each consecutive phase (61 ± 18%; 59 ± 18%; 59 ± 20%; 57 ± 18%; and 55 ± 20%, P = 0.02). The linear mixed model highlighted a decrease in TIR in the mid-luteal (P = 0.03) and late luteal (P < 0.001) phases compared with the early f...
Medicine, 2016
Thyroid hormone resistance syndrome (THRS) is a rare disorder with increased concentrations of fr... more Thyroid hormone resistance syndrome (THRS) is a rare disorder with increased concentrations of free thyroxine (FT4) and triiodothyronine (FT3), but normal or slightly increased thyroid-stimulating hormone (TSH). The mutations in the thyroid hormone receptor β (THRβ) gene are thought to be the main pathogenesis. The aims of this study were to present 1 pedigree of Chinese THRS, summarize their clinical characteristics, and analyze the gene mutation. The clinical characteristics and thyroid function of the proband and his family members were collected. Gene mutations were analyzed by DNA sequencing. The proband and his mother exhibited symptoms of hyperthyroidism, such as palpitations, heat intolerance, and perspiration. The mother also had atrial fibrillation. The rest of the kindred did not display clinical manifestations of hyper- or hypothyroidism. DNA sequencing revealed a heterozygous G>A missense mutation at position 949 in Exon 9 of THRβ both in the patient and his mother, ...
La Tunisie médicale, Jul 20, 2022
Additional file 1: Table S1. Epicardial adipose tissue volume according to cardio-vascular risk f... more Additional file 1: Table S1. Epicardial adipose tissue volume according to cardio-vascular risk factors. Table S2. Epicardial adipose tissue volume according to diabetes-related complications. Table S3. Epicardial adipose tissue volume according to treatment.
Annales d'Endocrinologie, 2018
Déclaration de liens d'intérêts Les auteurs déclarent ne pas avoir de liens d'intérêts.
Cardiovascular Diabetology, 2021
Background Epicardial adipose tissue (EAT) has anatomic and functional proximity to the heart and... more Background Epicardial adipose tissue (EAT) has anatomic and functional proximity to the heart and is considered a novel diagnostic marker and therapeutic target in cardiometabolic diseases. The aim of this study was to evaluate whether EAT volume was associated with coronary artery calcification (CAC) in people living with diabetes, independently of confounding factors. Methods We included all consecutive patients with diabetes whose EAT volume and CAC score were measured using computed tomography between January 1, 2019 and September 30, 2020 in the Department of Diabetology-Endocrinology-Nutrition at Avicenne Hospital, France. Determinants of EAT volume and a CAC score ≥ 100 Agatston units (AU) were evaluated. Results The study population comprised 409 patients (218 men). Mean (± standard deviation) age was 57 ± 12 years, and 318, 56 and 35 had type 2 (T2D), type 1 (T1D), or another type of diabetes, respectively. Mean body mass index (BMI) was 29 ± 6 kg/m2, mean AET volume 93 ± 3...
Nutrition, Metabolism and Cardiovascular Diseases, 2021
Background and aims To evaluate the prevalence and prognostic value of metabolic syndrome (MetS) ... more Background and aims To evaluate the prevalence and prognostic value of metabolic syndrome (MetS) in patients admitted for Coronavirus Disease 2019 (COVID-19). Methods and results In this monocentric cohort retrospective study, we consecutively included all adult patients admitted to COVID 19 units between April 9 and May 29, 2020, and between February 1 and March 26, 2021. MetS was defined when at least three of the following components were met: android obesity, high HbA1c, hypertension, hypertriglyceridemia and low HDL-cholesterol. COVID-19 deterioration was defined as the need for nasal oxygen flow ≥ 6 l/min within 28 days after admission. We included 155 patients (55.5% men, mean age 61.7 years old, mean body mass index 29.8 kg/m2). Fifty-six patients (36.1%) had COVID-19 deterioration. MetS was present in 126 patients (81.3%) and was associated with COVID-19 deterioration (no MetS vs MetS: 13.7% and 41.2%, respectively, p<0.01). Logistic regression taking into account MetS, age, gender, ethnicity, period of inclusion and Charlson Index showed that COVID-19 deterioration was 5.3 times more likely in MetS patients (95% confidence interval 1.3-20.2) than non-MetS patients. Conclusions Over 81.3% of patients hospitalized in COVID-19 units had MetS. This syndrome appears to be an independent risk factor of COVID-19 deterioration.
Annales d'Endocrinologie, 2018
Annales d'Endocrinologie, 2018
Archives of Cardiovascular Diseases Supplements, 2019
Archives of Cardiovascular Diseases Supplements, 2019
We in this paper propose a realizable framework TECU, which embeds task-specific strategies into ... more We in this paper propose a realizable framework TECU, which embeds task-specific strategies into update schemes of coordinate descent, for optimizing multivariate non-convex problems with coupled objective functions. On one hand, TECU is capable of improving algorithm efficiencies through embedding productive numerical algorithms, for optimizing univariate sub-problems with nice properties. From the other side, it also augments probabilities to receive desired results, by embedding advanced techniques in optimizations of realistic tasks. Integrating both numerical algorithms and advanced techniques together, TECU is proposed in a unified framework for solving a class of non-convex problems. Although the task embedded strategies bring inaccuracies in sub-problem optimizations, we provide a realizable criterion to control the errors, meanwhile, to ensure robust performances with rigid theoretical analyses. By respectively embedding ADMM and a residual-type CNN in our algorithm framework, the experimental results verify both efficiency and effectiveness of embedding task-oriented strategies in coordinate descent for solving practical problems.
Endocrine Abstracts, 2019
Endocrine Abstracts, 2019
Endocrine Abstracts, 2019
Endocrine Abstracts, 2019