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Papers by israel Jeremiah

Port Harcourt Medical Journal, 2012

... The pattern of obstructed labour among parturients in a tertiary hospital in southern Nigeria... more ... The pattern of obstructed labour among parturients in a tertiary hospital in southern Nigeria. IJeremiah, V Nwagwu. ... Unemployed housewives, petty traders, hair dressers, seamstresses or farmers comprised 87.6% of the patients. Forty seven (47.4%) babies were stillborn. ...

Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria, Aug 13, 2009

BACKGROUND Induced abortion is the termination of pregnancy through a deliberate intervention int... more BACKGROUND Induced abortion is the termination of pregnancy through a deliberate intervention intended to end the pregnancy. This practice is widespread in Nigeria despite the restrictive abortion laws in Nigeria. Many women still undergo induced abortion every year and endanger their health and lives as induced abortion can only be procured illegally in Nigeria. We hope to determine the proportion of undergraduate students who had induced abortion in the past and the contributing factors. To determine the proportion of the undergraduate students who support the restrictive abortion laws in Nigeria. METHOD A cross sectional questionnaire survey of undergraduate students of the University of Port Harcourt was done through a cluster sampling method along with focus group discussion with some of the respondents. 451 out of 500 administered questionnaires were retrieved and analyzed. RESULT The incidence of induced abortion amongst the respondents was 47.2%. About 40% had never used an effective form of contraception in the past and 13% were unaware of contraception. 77.9% of the induced abortion was by dilation and curettage and 1% by manual vacuum aspiration. Up to two third of the respondents were against legalization of abortion. CONCLUSION Up to 47% of these undergraduates had performed abortion in the past. Protecting educational career was the single most important reason for this. Although most of these undergraduates are against legalizing abortion, they highly patronize unsafe abortion. Improving contraceptive awareness and usage will reduce unwanted pregnancy and induced abortion. This option appears next to total abstinence in reducing the morbidity and mortality from induced abortion in this country.

World Journal Of Advanced Research and Reviews, Dec 30, 2022

Background: Dysfunctional labour is the commonest abnormality of the first stage of labour. It co... more Background: Dysfunctional labour is the commonest abnormality of the first stage of labour. It complicates 50% of nulliparous deliveries and is associated with increased perinatal morbidity and mortality. Dysfunctional labour occurs when the progress in the active phase of labour is abnormally slow (<1 cm/hr). It is largely due to ineffective uterine contractions or slow cervical dilatation. Augmentation of labour with oxytocin is the standard management of dysfunctional labour as it enhances uterine contractions. In many cases, despite good uterine contractions slow progress persists due to cervical smooth muscle spasms. Drotaverine a smooth muscle relaxant can be used to relieve cervical smooth muscle spasms. Aim/objective: This study compared the cervical dilatation rate in term nulliparas following augmentation of dysfunctional labour with oxytocin versus oxytocin and drotaverine. Methods: The study was a single-blinded randomized clinical trial involving 156 term nulliparous women with dysfunctional labour, who were randomized into two groups. Each group had 78 participants and received either oxytocin with a placebo or oxytocin with drotaverine. They were monitored until delivery and the cervical dilatation rates in both groups were compared. Data obtained were analysed using SPSS version 23 software. The level of significance was set at 0.05. Results: The two groups were similar in their baseline characteristics, the mean pre-intervention cervical dilatation rate were also similar (0.53 cm/hr vs. 0.52 cm/hr, p = 0.85). Following augmentation, the cervical dilatation rate in the oxytocin-drotaverine group was significantly faster than in the oxytocin-placebo group (1.60 cm/hr vs. 1.20 cm/hr, p < 0.01). Conclusion: The use of drotaverine with oxytocin in managing dysfunctional labour in term nulliparous women leads to a faster cervical dilatation rate.

World Journal of Advanced Research and Reviews

Background: Dysfunctional labour is the commonest abnormality of the first stage of labour. It co... more Background: Dysfunctional labour is the commonest abnormality of the first stage of labour. It complicates 50% of nulliparous deliveries and is associated with increased perinatal morbidity and mortality. Dysfunctional labour occurs when the progress in the active phase of labour is abnormally slow (<1 cm/hr). It is largely due to ineffective uterine contractions or slow cervical dilatation. Augmentation of labour with oxytocin is the standard management of dysfunctional labour as it enhances uterine contractions. In many cases, despite good uterine contractions slow progress persists due to cervical smooth muscle spasms. Drotaverine a smooth muscle relaxant can be used to relieve cervical smooth muscle spasms. Aim/objective: This study compared the cervical dilatation rate in term nulliparas following augmentation of dysfunctional labour with oxytocin versus oxytocin and drotaverine. Methods: The study was a single-blinded randomized clinical trial involving 156 term nulliparous...

Possible biochemical indices of preeclampsia have been sought for many years. The aim of this stu... more Possible biochemical indices of preeclampsia have been sought for many years. The aim of this study is to evaluate the accuracy of combined measure of maternal serum uric acid level and quantitative serum beta hCG versus serum uric acid level alone as prognostic indicators of pregnancy outcome among preeclamptic patients at the Federal Medical Centre, Yenagoa. This is a hospital based prospective case control study by systematic sampling selection. The two groups comprised of 100 consecutive patients each, one with pre-eclampsia (study group) and the other without pre-eclampsia (control) admitted for management into the antenatal ward and labour ward over the seven-month period of the study. The values of their serum uric acid and beta hCG levels were evaluated on admission and followed up. Data entry and statistical analysis were done using statistical package for social science (windows version 22.0. SPSS Inc; Chicago, USA). Level of significance was set at P < 0.05. The mean serum uric acid level was higher amongst participants with preeclampsia (405.6 ± 99.5 µmol/L) than in those without preeclampsia (232.7 ± 26.3 µmol/L) and this difference was statistically significant (p= 0.001). The prognostic accuracy in predicting pregnancy outcomes were: HELLP syndrome (0.25, 0.44), Eclampsia (0.13, 0.50), Acute Renal Failure (0.27, 0.44), IUGR (0.31, 0.43), IUFD (0.27, 0.38) and Birth Asphyxia (0.35, 0.49) respectively for serum uric acid alone and combined measure of serum uric acid and serum β hCG. Serum uric acid levels were found to be useful prognostic indicators for feto-maternal outcome in women with preeclampsia. However, combined measure of serum uric acid and serum β hCG level in prognosticating pregnancy outcome in preeclamptic women was shown to have a better accuracy than either serum uric acid.

International Journal of Gynecology & Obstetrics, 2009

Objectives: Preoperative use of misoprostol, a synthetic prostaglandin-E1 analogue, has been stud... more Objectives: Preoperative use of misoprostol, a synthetic prostaglandin-E1 analogue, has been studied intensively for various uterine procedures requiring cervical dilatation. In addition, one study has evaluated the efficacy of misoprostol on IUD insertions in nulliparous women. To date, no studies have evaluated the effectiveness or safety of this treatment in repeat IUD or IUS insertions. Materials and Methods: This study was a randomized, doubleblind, placebo controlled study, evaluating the effect of sublingual pretreatment with misoprostol on the insertion easiness of the LNG-IUS. The subjects received a single sublingual dose of 400 mg misoprostol or placebo 3 hours prior to the insertion procedure. The study was a subset of a larger study evaluating the bleeding profile and safety of repeat use of the LNG-IUS, hence subjects were women who had used their 1st LNG-IUS for 4 years 3-9 months and opted for an immediate replacement with a 2nd LNG-IUS. A sample size of 86 subjects was chosen based on biometrical considerations. Easiness of insertion was determined by the physician and painfulness by the subject using Likert-like scales. Results: The proportion of easy insertions was 93% (40/43) and 91% (42/46) in subjects randomized to misoprostol and placebo, respectively (P = 1.0). No or mild pain at insertion was reported by 37% and 35% of subjects in the misoprostol and placebo groups, respectively. Conclusion: Sublingual misoprostol did not have a significant effect on the insertion easiness of the LNG-IUS in subjects having a repeat insertion of the LNG-IUS.

The Nigerian Health Journal, 2009

Background: Infertility is a major global problem and is regarded as a social stigma in the Niger... more Background: Infertility is a major global problem and is regarded as a social stigma in the Nigerian society. At least one in every ten couples of reproductive age has infertility. Galactorrhoea is one of the complaints often associated with infertility. Its relationship with amenorrhoea and infertility is well established. The objective of this study is to determine the incidence and contribution of galactorrhoea to female infertility and to determine any correlation between galactorrhoea and hyperprolactinaemia. Methods: A descriptive prospective study involving 186 consecutive patients presenting with infertility at the University of Port Harcourt teaching Hospital between 1 st January 2009 and 30 th June 2009. All patients presenting with infertility at the gynaecological clinic of the University of Port Harcourt Teaching Hospital between 1 st January 2009 and 30 th June 2009 were included in this study. Data was collected based on a protocol developed for the study. Data collec...

British Journal of Medicine and Medical Research, 2013

Methodology: This study was conducted among 281 pregnant women attending antenatal services at th... more Methodology: This study was conducted among 281 pregnant women attending antenatal services at the hospital. Socio-demographic and obstetric information of the mothers was collected. Samples of cord blood smears of babies were stained with Giemsa and examined for malaria parasites. Results: Plasmodium falciparum was the only malaria parasite species. The prevalence of congenital malaria among newly born was 9.6%. This was more prevalent in women of Para 0 (5.3%) compared to other parities (4.3%) (P = 0.048). Malaria parasite was found in 4(16.7%) of preterm and 23(8.9%) of term deliveries (P>0.05). Conclusion: Congenital malaria is still common in Port Harcourt, Nigeria. It is important that blood smear from neonates are taken and examined for malaria parasite soon after

Background: Infertility is a major global problem and is regarded as a social stigma in the Niger... more Background: Infertility is a major global problem and is regarded as a social stigma in the Nigerian society. At least one in every ten couples of reproductive age has infertility. Galactorrhoea is one of the complaints often associated with infertility. Its relationship with amenorrhoea and infertility is well established. The objective of this study is to determine the incidence and contribution of galactorrhoea to female infertility and to determine any correlation between galactorrhoea and hyperprolactinaemia. Methods: A descriptive prospective study involving 186 consecutive patients presenting with infertility at the stUniversity of Port Harcourt teaching Hospital between 1

Attitudes of antenatal patients at a tertiary hospital

Background: Abortions performed by persons lacking the requisite skills or in environments lackin... more Background: Abortions performed by persons lacking the requisite skills or in environments lacking minimal medical standards or both are considered unsafe. It is estimated that over 20 million unsafe abortions are performed annually and about 70,000 women die globally as a result, with majority occurring in the developing world. This study aims to determine the pattern of complicated unsafe abortions in Niger delta

background: Eclampsia is a leading cause of maternal and perinatal mortality in Nigeria. Preventi... more background: Eclampsia is a leading cause of maternal and perinatal mortality in Nigeria. Preventive and interventional measures have been shown to reduce maternal mortality and morbidity with no significant beneficial effect on neonatal outcomes. The aim of this study is to assess the perinatal outcome of eclampsia at the University of Port-Harcourt teaching Hospital (UPtH). Materials and methods: this prospective, cross-sectional study was conducted on 88 consecutive patients presenting with antepartum eclampsia at the UPtH between 1st January 2007 and 31st December 2008. A protocol was developed and used to collect infor-mation about socio-demographic characteristics, mode of delivery, perinatal complications and outcome. Data collected was entered into a spread sheet using sPss 15.0 for Windows ® statistical software which was also used for analysis. chi square was used to test relationship between variables. P value<0.05 was considered statistically significant. Results: Ther...

Nigerian Hospital Practice, 2018

Background: Cephalopelvic disproportion (CPD) is a disparity between the fetal head and maternal ... more Background: Cephalopelvic disproportion (CPD) is a disparity between the fetal head and maternal pelvis, usually in the absence of fetal or maternal jeopardy. It is a very common complication during labour, and it is associated with a very high caesarean section rate. Delay in intervention could lead to obstructed labour. Short stature, fetal macrosomia and pelvic abnormalities are common risk factors. The aim of this study was to determine the influence of maternal height, age, clinical pelvimetry, and birth weight on cephalopelvic disproportion in the Niger Delta University Teaching Hospital, Bayelsa State.Materials and Methods: This is a retrospective case controlled analysis of 5,205 parturients who received antenatal care, and delivered at the Niger Delta University Teaching Hospital, from January 2010 to December 2015. Of these, 588 patients who had cephalopelvic disproportion were identified. Data concerning their maternal age, parity, height, pelvimetry, gestational age at d...

The Nigerian Health Journal, 2011

Background: Abortions performed by persons lacking the requisite skills or in environments lackin... more Background: Abortions performed by persons lacking the requisite skills or in environments lacking minimal medical standards or both are considered unsafe. It is estimated that over 20 million unsafe abortions are performed annually and about 70,000 women die globally as a result, with majority occurring in the developing world. This study aims to determine the pattern of complicated unsafe abortions in Niger delta University Teaching Hospital (NDUTH) Okolobiri. Methods: The study is a four-year retrospective analysis of cases of complicated unsafe abortion managed at the Niger Delta University Teaching Hospital Okolobiri, Bayelsa state. Results: The prevalence of complicated unsafe abortion during the study period was 4.1% of all deliveries and 14.0% of all gynaecological admissions. Majority (55.6%) of the patients had secondary education, while 31.8% were teenagers. Two thirds had a history of previous termination of pregnancy and 87.3% of the patients had never used any form of ...

International Journal of Health Sciences and Research, 2020

Sertoli-Leydig cell tumor is a very rare ovarian tumor constituting less than 0.5% of all primary... more Sertoli-Leydig cell tumor is a very rare ovarian tumor constituting less than 0.5% of all primary ovarian tumors. It mostly occurs in second and third decades of life. This is a case report of a rare presentation of a huge ovarian Sertoli-Leydig cell tumor presenting like an advanced ovarian cancer in a 62 year old seven years postmenopausal para eight woman. At surgery was a left well encapsulated multilobulated ovarian tumour measuring 28 x28x14cm, weighing 6.2kg and histologically containing clusters of Leydig cells and solid cords of Sertoli cells of intermediate differentiation. The patient presented with a year history of progressive abdominal swelling and irregular vaginal bleeding. She had total abdominal hysterectomy and bilateral salpingo-oophorectomy. About a year on follow-up and stable.

The Nigerian Health Journal, 2011

Background: Pregnant women living with HIV infection are at risk of transmitting HIV to their bab... more Background: Pregnant women living with HIV infection are at risk of transmitting HIV to their babies. Most of this transmission occurs during labour and delivery and during breast feeding. About 45% of all deliveries are conducted in private clinics. This study aims to access the knowledge, attitude and practice of general medical practitioner in Port Harcourt toward the prevention of mother-to-child transmission of HIV. Methods: A questionnaire survey was carried out on two hundred and twenty four private medical practitioners in Port Harcourt. Data management was carried out using ® SPSS 15 for windows statistical software. Results: Only 50% of respondents had read the national guideline on PMTCT while 48.2% had three or more sources of information on PMTCT. Majority of the respondents (95.5%) identified prevention of HIV in the pediatric age group as the primary aim of PMTCT. Labour was identified by 80%of respondents as the time of transmission of MTCT of HIV while 48.2% prefer...

International Journal of Biomedical Science : IJBS, 2011

Objectives: This study was undertaken to assess the prevalence of IgG antibody to Chlamydia trach... more Objectives: This study was undertaken to assess the prevalence of IgG antibody to Chlamydia trachomatis in subfertile patients at the University of Port Harcourt Teaching Hospital and to determine associated factors between this and infertility. Study design: This case controlled study was conducted among 100 women presenting for infertility consultation at the University of Port Harcourt Teaching Hospital. One hundred women with normal intrauterine pregnancies attending the antenatal clinic were used as controls. A questionnaire was used to obtain information on their socio-demographic data, sexual and obstetric history administered to them. 2mls of venous blood was collected, labelled and sent to the laboratory. The presence of IgG antibody to Chlamydia trachomatis was determined. Hysterosalpingography was performed on all infertile women to assess tubal patency. Data management was with SPSS 15.0 for Windows® statistical software. Results: The mean age of the subjects was 30 ± 3....

International Journal of Biomedical Science : IJBS, 2015

OBJECTIVES: To determine the effect of maternal age on pregnancy outcomes in women aged 40 years ... more OBJECTIVES: To determine the effect of maternal age on pregnancy outcomes in women aged 40 years and above at the University of Port Harcourt Teaching Hospital. METHODS: A retrospective comparative study was conducted on women aged ≥40 years (n=249) and a control group aged 20–29 years (n=249) who delivered at ≥28 weeks gestation between January 1, 2008 and December 31, 2012. The medical records of the patients were analyzed using Epi Info 6.04d. Association between maternal age and selected obstetrical variables were assessed using the chi-squared and the two-tailed Fisher exact test. Differences were considered statistically significant when p≤0.05. RESULTS: The mean age of the women in the study group was 41.2 ±1.75 versus 26.10 ± 2.37 in the control group. Advanced maternal age was associated with a significantly higher rate of hypertensive disorders of pregnancy (p=0.01), diabetes mellitus (p<0.01), abnormal lies/presentation (p=0.04), caesarean deliveries (p<0.01) and lo...

There is concern for very obese women and their pregnancy outcomes as obesity confers increased r... more There is concern for very obese women and their pregnancy outcomes as obesity confers increased risk of maternal and perinatal complications. This study aims to determine the prevalence of obesity in pregnancy and the maternal and foetal risk of adverse pregnancy outcome in relation to maternal obesity. This prospective study was carried out at the University of Port Harcourt Teaching Hospital (UPTH) between May 2006 and April 2007. A cohort of 150 pregnant women with BMI ≥ 30kg/m2 who registered for antenatal care were identified and compared with a control group of 150 non-obese pregnant women. The incidence of obesity in the study was 6.0%. More of the obese patients were of low parity. Sixty percent of the obese women had tertiary education. Preeclampsia (14%), malpresentations (5.3%) and prolonged pregnancy (24%) were significantly more common in the obese group. The Caesarean section rate was also higher in the obese group (p<0.001). Foetal macrosomia and birth asphyxia wer...

Port Harcourt Medical Journal, 2012

... The pattern of obstructed labour among parturients in a tertiary hospital in southern Nigeria... more ... The pattern of obstructed labour among parturients in a tertiary hospital in southern Nigeria. IJeremiah, V Nwagwu. ... Unemployed housewives, petty traders, hair dressers, seamstresses or farmers comprised 87.6% of the patients. Forty seven (47.4%) babies were stillborn. ...

Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria, Aug 13, 2009

BACKGROUND Induced abortion is the termination of pregnancy through a deliberate intervention int... more BACKGROUND Induced abortion is the termination of pregnancy through a deliberate intervention intended to end the pregnancy. This practice is widespread in Nigeria despite the restrictive abortion laws in Nigeria. Many women still undergo induced abortion every year and endanger their health and lives as induced abortion can only be procured illegally in Nigeria. We hope to determine the proportion of undergraduate students who had induced abortion in the past and the contributing factors. To determine the proportion of the undergraduate students who support the restrictive abortion laws in Nigeria. METHOD A cross sectional questionnaire survey of undergraduate students of the University of Port Harcourt was done through a cluster sampling method along with focus group discussion with some of the respondents. 451 out of 500 administered questionnaires were retrieved and analyzed. RESULT The incidence of induced abortion amongst the respondents was 47.2%. About 40% had never used an effective form of contraception in the past and 13% were unaware of contraception. 77.9% of the induced abortion was by dilation and curettage and 1% by manual vacuum aspiration. Up to two third of the respondents were against legalization of abortion. CONCLUSION Up to 47% of these undergraduates had performed abortion in the past. Protecting educational career was the single most important reason for this. Although most of these undergraduates are against legalizing abortion, they highly patronize unsafe abortion. Improving contraceptive awareness and usage will reduce unwanted pregnancy and induced abortion. This option appears next to total abstinence in reducing the morbidity and mortality from induced abortion in this country.

World Journal Of Advanced Research and Reviews, Dec 30, 2022

Background: Dysfunctional labour is the commonest abnormality of the first stage of labour. It co... more Background: Dysfunctional labour is the commonest abnormality of the first stage of labour. It complicates 50% of nulliparous deliveries and is associated with increased perinatal morbidity and mortality. Dysfunctional labour occurs when the progress in the active phase of labour is abnormally slow (<1 cm/hr). It is largely due to ineffective uterine contractions or slow cervical dilatation. Augmentation of labour with oxytocin is the standard management of dysfunctional labour as it enhances uterine contractions. In many cases, despite good uterine contractions slow progress persists due to cervical smooth muscle spasms. Drotaverine a smooth muscle relaxant can be used to relieve cervical smooth muscle spasms. Aim/objective: This study compared the cervical dilatation rate in term nulliparas following augmentation of dysfunctional labour with oxytocin versus oxytocin and drotaverine. Methods: The study was a single-blinded randomized clinical trial involving 156 term nulliparous women with dysfunctional labour, who were randomized into two groups. Each group had 78 participants and received either oxytocin with a placebo or oxytocin with drotaverine. They were monitored until delivery and the cervical dilatation rates in both groups were compared. Data obtained were analysed using SPSS version 23 software. The level of significance was set at 0.05. Results: The two groups were similar in their baseline characteristics, the mean pre-intervention cervical dilatation rate were also similar (0.53 cm/hr vs. 0.52 cm/hr, p = 0.85). Following augmentation, the cervical dilatation rate in the oxytocin-drotaverine group was significantly faster than in the oxytocin-placebo group (1.60 cm/hr vs. 1.20 cm/hr, p < 0.01). Conclusion: The use of drotaverine with oxytocin in managing dysfunctional labour in term nulliparous women leads to a faster cervical dilatation rate.

World Journal of Advanced Research and Reviews

Background: Dysfunctional labour is the commonest abnormality of the first stage of labour. It co... more Background: Dysfunctional labour is the commonest abnormality of the first stage of labour. It complicates 50% of nulliparous deliveries and is associated with increased perinatal morbidity and mortality. Dysfunctional labour occurs when the progress in the active phase of labour is abnormally slow (<1 cm/hr). It is largely due to ineffective uterine contractions or slow cervical dilatation. Augmentation of labour with oxytocin is the standard management of dysfunctional labour as it enhances uterine contractions. In many cases, despite good uterine contractions slow progress persists due to cervical smooth muscle spasms. Drotaverine a smooth muscle relaxant can be used to relieve cervical smooth muscle spasms. Aim/objective: This study compared the cervical dilatation rate in term nulliparas following augmentation of dysfunctional labour with oxytocin versus oxytocin and drotaverine. Methods: The study was a single-blinded randomized clinical trial involving 156 term nulliparous...

Possible biochemical indices of preeclampsia have been sought for many years. The aim of this stu... more Possible biochemical indices of preeclampsia have been sought for many years. The aim of this study is to evaluate the accuracy of combined measure of maternal serum uric acid level and quantitative serum beta hCG versus serum uric acid level alone as prognostic indicators of pregnancy outcome among preeclamptic patients at the Federal Medical Centre, Yenagoa. This is a hospital based prospective case control study by systematic sampling selection. The two groups comprised of 100 consecutive patients each, one with pre-eclampsia (study group) and the other without pre-eclampsia (control) admitted for management into the antenatal ward and labour ward over the seven-month period of the study. The values of their serum uric acid and beta hCG levels were evaluated on admission and followed up. Data entry and statistical analysis were done using statistical package for social science (windows version 22.0. SPSS Inc; Chicago, USA). Level of significance was set at P < 0.05. The mean serum uric acid level was higher amongst participants with preeclampsia (405.6 ± 99.5 µmol/L) than in those without preeclampsia (232.7 ± 26.3 µmol/L) and this difference was statistically significant (p= 0.001). The prognostic accuracy in predicting pregnancy outcomes were: HELLP syndrome (0.25, 0.44), Eclampsia (0.13, 0.50), Acute Renal Failure (0.27, 0.44), IUGR (0.31, 0.43), IUFD (0.27, 0.38) and Birth Asphyxia (0.35, 0.49) respectively for serum uric acid alone and combined measure of serum uric acid and serum β hCG. Serum uric acid levels were found to be useful prognostic indicators for feto-maternal outcome in women with preeclampsia. However, combined measure of serum uric acid and serum β hCG level in prognosticating pregnancy outcome in preeclamptic women was shown to have a better accuracy than either serum uric acid.

International Journal of Gynecology & Obstetrics, 2009

Objectives: Preoperative use of misoprostol, a synthetic prostaglandin-E1 analogue, has been stud... more Objectives: Preoperative use of misoprostol, a synthetic prostaglandin-E1 analogue, has been studied intensively for various uterine procedures requiring cervical dilatation. In addition, one study has evaluated the efficacy of misoprostol on IUD insertions in nulliparous women. To date, no studies have evaluated the effectiveness or safety of this treatment in repeat IUD or IUS insertions. Materials and Methods: This study was a randomized, doubleblind, placebo controlled study, evaluating the effect of sublingual pretreatment with misoprostol on the insertion easiness of the LNG-IUS. The subjects received a single sublingual dose of 400 mg misoprostol or placebo 3 hours prior to the insertion procedure. The study was a subset of a larger study evaluating the bleeding profile and safety of repeat use of the LNG-IUS, hence subjects were women who had used their 1st LNG-IUS for 4 years 3-9 months and opted for an immediate replacement with a 2nd LNG-IUS. A sample size of 86 subjects was chosen based on biometrical considerations. Easiness of insertion was determined by the physician and painfulness by the subject using Likert-like scales. Results: The proportion of easy insertions was 93% (40/43) and 91% (42/46) in subjects randomized to misoprostol and placebo, respectively (P = 1.0). No or mild pain at insertion was reported by 37% and 35% of subjects in the misoprostol and placebo groups, respectively. Conclusion: Sublingual misoprostol did not have a significant effect on the insertion easiness of the LNG-IUS in subjects having a repeat insertion of the LNG-IUS.

The Nigerian Health Journal, 2009

Background: Infertility is a major global problem and is regarded as a social stigma in the Niger... more Background: Infertility is a major global problem and is regarded as a social stigma in the Nigerian society. At least one in every ten couples of reproductive age has infertility. Galactorrhoea is one of the complaints often associated with infertility. Its relationship with amenorrhoea and infertility is well established. The objective of this study is to determine the incidence and contribution of galactorrhoea to female infertility and to determine any correlation between galactorrhoea and hyperprolactinaemia. Methods: A descriptive prospective study involving 186 consecutive patients presenting with infertility at the University of Port Harcourt teaching Hospital between 1 st January 2009 and 30 th June 2009. All patients presenting with infertility at the gynaecological clinic of the University of Port Harcourt Teaching Hospital between 1 st January 2009 and 30 th June 2009 were included in this study. Data was collected based on a protocol developed for the study. Data collec...

British Journal of Medicine and Medical Research, 2013

Methodology: This study was conducted among 281 pregnant women attending antenatal services at th... more Methodology: This study was conducted among 281 pregnant women attending antenatal services at the hospital. Socio-demographic and obstetric information of the mothers was collected. Samples of cord blood smears of babies were stained with Giemsa and examined for malaria parasites. Results: Plasmodium falciparum was the only malaria parasite species. The prevalence of congenital malaria among newly born was 9.6%. This was more prevalent in women of Para 0 (5.3%) compared to other parities (4.3%) (P = 0.048). Malaria parasite was found in 4(16.7%) of preterm and 23(8.9%) of term deliveries (P>0.05). Conclusion: Congenital malaria is still common in Port Harcourt, Nigeria. It is important that blood smear from neonates are taken and examined for malaria parasite soon after

Background: Infertility is a major global problem and is regarded as a social stigma in the Niger... more Background: Infertility is a major global problem and is regarded as a social stigma in the Nigerian society. At least one in every ten couples of reproductive age has infertility. Galactorrhoea is one of the complaints often associated with infertility. Its relationship with amenorrhoea and infertility is well established. The objective of this study is to determine the incidence and contribution of galactorrhoea to female infertility and to determine any correlation between galactorrhoea and hyperprolactinaemia. Methods: A descriptive prospective study involving 186 consecutive patients presenting with infertility at the stUniversity of Port Harcourt teaching Hospital between 1

Attitudes of antenatal patients at a tertiary hospital

Background: Abortions performed by persons lacking the requisite skills or in environments lackin... more Background: Abortions performed by persons lacking the requisite skills or in environments lacking minimal medical standards or both are considered unsafe. It is estimated that over 20 million unsafe abortions are performed annually and about 70,000 women die globally as a result, with majority occurring in the developing world. This study aims to determine the pattern of complicated unsafe abortions in Niger delta

background: Eclampsia is a leading cause of maternal and perinatal mortality in Nigeria. Preventi... more background: Eclampsia is a leading cause of maternal and perinatal mortality in Nigeria. Preventive and interventional measures have been shown to reduce maternal mortality and morbidity with no significant beneficial effect on neonatal outcomes. The aim of this study is to assess the perinatal outcome of eclampsia at the University of Port-Harcourt teaching Hospital (UPtH). Materials and methods: this prospective, cross-sectional study was conducted on 88 consecutive patients presenting with antepartum eclampsia at the UPtH between 1st January 2007 and 31st December 2008. A protocol was developed and used to collect infor-mation about socio-demographic characteristics, mode of delivery, perinatal complications and outcome. Data collected was entered into a spread sheet using sPss 15.0 for Windows ® statistical software which was also used for analysis. chi square was used to test relationship between variables. P value<0.05 was considered statistically significant. Results: Ther...

Nigerian Hospital Practice, 2018

Background: Cephalopelvic disproportion (CPD) is a disparity between the fetal head and maternal ... more Background: Cephalopelvic disproportion (CPD) is a disparity between the fetal head and maternal pelvis, usually in the absence of fetal or maternal jeopardy. It is a very common complication during labour, and it is associated with a very high caesarean section rate. Delay in intervention could lead to obstructed labour. Short stature, fetal macrosomia and pelvic abnormalities are common risk factors. The aim of this study was to determine the influence of maternal height, age, clinical pelvimetry, and birth weight on cephalopelvic disproportion in the Niger Delta University Teaching Hospital, Bayelsa State.Materials and Methods: This is a retrospective case controlled analysis of 5,205 parturients who received antenatal care, and delivered at the Niger Delta University Teaching Hospital, from January 2010 to December 2015. Of these, 588 patients who had cephalopelvic disproportion were identified. Data concerning their maternal age, parity, height, pelvimetry, gestational age at d...

The Nigerian Health Journal, 2011

Background: Abortions performed by persons lacking the requisite skills or in environments lackin... more Background: Abortions performed by persons lacking the requisite skills or in environments lacking minimal medical standards or both are considered unsafe. It is estimated that over 20 million unsafe abortions are performed annually and about 70,000 women die globally as a result, with majority occurring in the developing world. This study aims to determine the pattern of complicated unsafe abortions in Niger delta University Teaching Hospital (NDUTH) Okolobiri. Methods: The study is a four-year retrospective analysis of cases of complicated unsafe abortion managed at the Niger Delta University Teaching Hospital Okolobiri, Bayelsa state. Results: The prevalence of complicated unsafe abortion during the study period was 4.1% of all deliveries and 14.0% of all gynaecological admissions. Majority (55.6%) of the patients had secondary education, while 31.8% were teenagers. Two thirds had a history of previous termination of pregnancy and 87.3% of the patients had never used any form of ...

International Journal of Health Sciences and Research, 2020

Sertoli-Leydig cell tumor is a very rare ovarian tumor constituting less than 0.5% of all primary... more Sertoli-Leydig cell tumor is a very rare ovarian tumor constituting less than 0.5% of all primary ovarian tumors. It mostly occurs in second and third decades of life. This is a case report of a rare presentation of a huge ovarian Sertoli-Leydig cell tumor presenting like an advanced ovarian cancer in a 62 year old seven years postmenopausal para eight woman. At surgery was a left well encapsulated multilobulated ovarian tumour measuring 28 x28x14cm, weighing 6.2kg and histologically containing clusters of Leydig cells and solid cords of Sertoli cells of intermediate differentiation. The patient presented with a year history of progressive abdominal swelling and irregular vaginal bleeding. She had total abdominal hysterectomy and bilateral salpingo-oophorectomy. About a year on follow-up and stable.

The Nigerian Health Journal, 2011

Background: Pregnant women living with HIV infection are at risk of transmitting HIV to their bab... more Background: Pregnant women living with HIV infection are at risk of transmitting HIV to their babies. Most of this transmission occurs during labour and delivery and during breast feeding. About 45% of all deliveries are conducted in private clinics. This study aims to access the knowledge, attitude and practice of general medical practitioner in Port Harcourt toward the prevention of mother-to-child transmission of HIV. Methods: A questionnaire survey was carried out on two hundred and twenty four private medical practitioners in Port Harcourt. Data management was carried out using ® SPSS 15 for windows statistical software. Results: Only 50% of respondents had read the national guideline on PMTCT while 48.2% had three or more sources of information on PMTCT. Majority of the respondents (95.5%) identified prevention of HIV in the pediatric age group as the primary aim of PMTCT. Labour was identified by 80%of respondents as the time of transmission of MTCT of HIV while 48.2% prefer...

International Journal of Biomedical Science : IJBS, 2011

Objectives: This study was undertaken to assess the prevalence of IgG antibody to Chlamydia trach... more Objectives: This study was undertaken to assess the prevalence of IgG antibody to Chlamydia trachomatis in subfertile patients at the University of Port Harcourt Teaching Hospital and to determine associated factors between this and infertility. Study design: This case controlled study was conducted among 100 women presenting for infertility consultation at the University of Port Harcourt Teaching Hospital. One hundred women with normal intrauterine pregnancies attending the antenatal clinic were used as controls. A questionnaire was used to obtain information on their socio-demographic data, sexual and obstetric history administered to them. 2mls of venous blood was collected, labelled and sent to the laboratory. The presence of IgG antibody to Chlamydia trachomatis was determined. Hysterosalpingography was performed on all infertile women to assess tubal patency. Data management was with SPSS 15.0 for Windows® statistical software. Results: The mean age of the subjects was 30 ± 3....

International Journal of Biomedical Science : IJBS, 2015

OBJECTIVES: To determine the effect of maternal age on pregnancy outcomes in women aged 40 years ... more OBJECTIVES: To determine the effect of maternal age on pregnancy outcomes in women aged 40 years and above at the University of Port Harcourt Teaching Hospital. METHODS: A retrospective comparative study was conducted on women aged ≥40 years (n=249) and a control group aged 20–29 years (n=249) who delivered at ≥28 weeks gestation between January 1, 2008 and December 31, 2012. The medical records of the patients were analyzed using Epi Info 6.04d. Association between maternal age and selected obstetrical variables were assessed using the chi-squared and the two-tailed Fisher exact test. Differences were considered statistically significant when p≤0.05. RESULTS: The mean age of the women in the study group was 41.2 ±1.75 versus 26.10 ± 2.37 in the control group. Advanced maternal age was associated with a significantly higher rate of hypertensive disorders of pregnancy (p=0.01), diabetes mellitus (p<0.01), abnormal lies/presentation (p=0.04), caesarean deliveries (p<0.01) and lo...

There is concern for very obese women and their pregnancy outcomes as obesity confers increased r... more There is concern for very obese women and their pregnancy outcomes as obesity confers increased risk of maternal and perinatal complications. This study aims to determine the prevalence of obesity in pregnancy and the maternal and foetal risk of adverse pregnancy outcome in relation to maternal obesity. This prospective study was carried out at the University of Port Harcourt Teaching Hospital (UPTH) between May 2006 and April 2007. A cohort of 150 pregnant women with BMI ≥ 30kg/m2 who registered for antenatal care were identified and compared with a control group of 150 non-obese pregnant women. The incidence of obesity in the study was 6.0%. More of the obese patients were of low parity. Sixty percent of the obese women had tertiary education. Preeclampsia (14%), malpresentations (5.3%) and prolonged pregnancy (24%) were significantly more common in the obese group. The Caesarean section rate was also higher in the obese group (p<0.001). Foetal macrosomia and birth asphyxia wer...