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Papers by martin lee

Research paper thumbnail of Evaluation of various adaptive voltage positioning (AVP) schemes for computer power sources

Journal of the Chinese Institute of Engineers, 2007

The latest computer CPUs require the use of DC power converters with AVP. Three commonly-used AVP... more The latest computer CPUs require the use of DC power converters with AVP. Three commonly-used AVP control schemes were compared using small-signal loop gain analysis. From the comparison results emerges the fourth scheme proposed recently: the Native current-mode AVP scheme (NAVP). NAVP provides inherent phase current balancing, cycle-to-cycle protection, large stability margin, good line regulation, and constant output impedance. It compares favorably against the other three schemes.

Research paper thumbnail of Multicenter Trial to Evaluate the Safety and Potential Efficacy of Pooled Human Fibrin Sealant for the Treatment of Burn Wounds

The Journal of Trauma: Injury, Infection, and Critical Care, 1999

The primary purpose of this multicenter study was to evaluate the safety and potential efficacy o... more The primary purpose of this multicenter study was to evaluate the safety and potential efficacy of a solvent/detergent-treated commercial fibrin sealant (human) for topical hemostasis in skin grafting. The study involved a prospective evaluation of changes in viral titers in patients with burns less than 15% after treatment with fibrin sealant (human). Each patient served as his/her own control for an unblinded, randomized comparison of donor site hemostasis and healing. Preoperative serum was obtained to screen for viral titers. At autografting, the recipient site and one of two randomly chosen donor sites were treated with fibrin sealant (human). The use of other hemostatic agents, including epinephrine was prohibited. Each donor site was covered with gauze to collect blood for estimation of the relative amount of bleeding. The healing of the graft and donor sites was observed. Viral titers and wounds were checked monthly for 6 months, and at 9 and 12 months postoperatively. Viral titers for human immunodeficiency virus; hepatitis A, B, and C; Epstein-Barr virus; and cytomegalovirus were obtained before and after treatment. Of 47 patients, 34 completed the full year of observation. After treatment, there were no seroconversions to any of the aforementioned viruses. Bleeding at the recipient site appeared well controlled with fibrin sealant (human). Although investigators felt that fibrin sealant (human) improved donor site hemostasis, differences in hemoglobin measurements of blood-soaked dressings failed to reach significance. No differences were noted with regard to acceleration of donor site healing, graft take, or scar maturation at the two groups of donor sites. Anecdotally, the maturation of the recipient site appeared to be accelerated. Fibrin sealant (human) is safe for use during excision and grafting, and its topical hemostatic potential needs to be examined in patients with larger burns. Its role in scar maturation also needs to be investigated.

Research paper thumbnail of Compensator design for adaptive voltage positioning (AVP) for multiphase VRMs

2006 37th IEEE Power Electronics Specialists Conference

Abstract—In an AVP scheme, feedback compensation design is crucial to achieve a desirable constan... more Abstract—In an AVP scheme, feedback compensation design is crucial to achieve a desirable constant converter output impedance while maintaining converter stability. The model proposed and the analysis given provides insightful view of the interaction of the two performances. ...

Research paper thumbnail of Fresh frozen plasma prepared with amotosalen HCl (S‐59) photochemical pathogen inactivation: transfusion of patients with congenital coagulation factor deficiencies

Transfusion, 2005

BACKGROUND: Photochemical treatment (PCT) with amotosalen HCl (S‐59) was developed to inactivate ... more BACKGROUND: Photochemical treatment (PCT) with amotosalen HCl (S‐59) was developed to inactivate pathogens and white blood cells in plasma (PCT‐FFP) used for transfusion support.STUDY DESIGN AND METHODS: An open‐label, multicenter trial was conducted in patients with congenital coagulation factor deficiencies (factors [F]I, FII, FV, FVII, FX, FXI, and FXIII and protein C) to measure the kinetics of specific coagulation factors, hemostatic efficacy, and safety of PCT‐FFP. Posttransfusion prothrombin time (PT), partial thromboplastin time (PTT), and clinical hemostasis were evaluated before and after PCT‐FFP transfusions.RESULTS: Thirty‐four patients received 107 transfusions of PCT‐FFP for kinetic studies or therapeutic indications (mean dose, 12.8 ± 8.5 mL/kg). Incremental factor recoveries ranged from 0.9 to 2.4 IU per dL per IU per kg (FII, FV, FVII, FX, FXI, and protein C). Mean pretransfusion PT (20.7 ± 22.2 sec) corrected after PCT‐FFP (13.8 ± 2.4 sec, p < 0.001). Mean pretr...

Research paper thumbnail of Pharmacokinetic study of FFP photochemically treated with amotosalen (S-59) and UV light compared to FFP in healthy volunteers anticoagulated with warfarin

Research paper thumbnail of Association of specialist involvement and quality of care for Parkinson's disease

Research paper thumbnail of Effect of a Dementia Care Management Intervention on Primary Care Provider Knowledge, Attitudes, and Perceptions of Quality of Care

Journal of the American Geriatrics Society, 2006

OBJECTIVES: To evaluate the effect of a multicomponent dementia care management program on primar... more OBJECTIVES: To evaluate the effect of a multicomponent dementia care management program on primary care provider knowledge, attitudes, and perceptions of quality of dementia care.DESIGN: A clinic‐level randomized, controlled trial of a comprehensive care management program for patients with dementia and their nonprofessional caregivers. The program included provider education and protocols for care managers to communicate with patients' medical providers.SETTING: Sixteen clinics (eight intervention, eight usual care) in three healthcare systems in San Diego, California.PARTICIPANTS: Two hundred thirty‐two medical providers; 129 from eight intervention clinics; 103 from eight usual‐care clinics.MEASUREMENTS: Providers were surveyed 9 months after intervention onset on knowledge (five items on four topics), attitudes about dementia (three items), and perception of quality of dementia care in their practice setting (three items). Multivariable linear and logistic regression models ...

Research paper thumbnail of Use of Fibrin Sealant in Thermal Injury

Journal of Burn Care & Rehabilitation, 1997

Research paper thumbnail of Understanding Asthma Medical Nonadherence In Adult and Pediatric Populations

Journal of Allergy and Clinical Immunology, 2014

Research paper thumbnail of Implementing collaborative care for depression treatment in primary care: A cluster randomized evaluation of a quality improvement practice redesign

Implementation Science, 2011

Research paper thumbnail of Understanding the relationship among pharmacoadherence measures, asthma control test scores, and office-based spirometry

Annals of Allergy, Asthma & Immunology, 2012

Background: This study used accepted asthma metrics and pharmaceutical claim data to develop a ne... more Background: This study used accepted asthma metrics and pharmaceutical claim data to develop a new asthma metric as a possible surrogate for spirometry and to better assess asthma control. Objective: To develop and validate a new asthma metric called the Rescue Index (RI) based on ␤ 2-agonist dispensings and to test the feasibility of a multivariate model to construct a global asthma metric called the Asthma Control Index (ACI). Methods: This prospective, observational, multicenter cohort study was conducted at the Naval Medical Center San Diego (NMCSD) and at the Phoenix VA Health Care System (PVAHCS). Pharmacy claim data were correlated with the ACT, Medication Adherence Report Scale for Asthma (MARS-A), and spirometry using univariate and multivariate analyses. Results: A total of 263 individuals enrolled in the study, and 95 (PVAHCS) and 156 (NMCSD) individuals completed the study. In the PVAHCS, the ACT correlated with the asthma medication ratio (AMR) (ϭ 0.37, P Ͻ .001) and inversely correlated with the RI (ϭ Ϫ0.33, P ϭ .001), the RI inversely correlated with forced expiratory volume in 1 second (FEV 1) (ϭ Ϫ0.22, P ϭ .03) and the FEV 1 to forced vital capacity ratio (ϭ 0.22, P ϭ .03). In the NMCSD population, the ACT correlated with the MARS-A (ϭ 0.23, P ϭ .006), FEV 1 did not correlate with ACT (ϭ 0.09, P ϭ .25) or MARS-A (ϭ 0.16, P ϭ .047) but directly correlated with the RI (ϭ 0.19, P ϭ .03). The AMR was strongly inversely correlated with RI in both populations (Ϫ0.74, P Ͻ .001 in the PVAHCS group and Ϫ0.78, P Ͻ .001 in the NMCSD group). When multivariate models were applied to the NMCSD and PVAHCS groups, the combination of RI and MARS-A was the best predictor of spirometry. Conclusion: The RI shows promise as a new asthma metric because it correlated with AMR in both cohorts. However, because RI correlated with adult spirometry and ACT only, further validation studies are needed before RI may be included in an ACI metric.

Research paper thumbnail of No Shortcuts to the ‘End of History’ - Summer 2004

New Perspectives Quarterly, 2008

Research paper thumbnail of Evaluation of various adaptive voltage positioning (AVP) schemes for computer power sources

Journal of the Chinese Institute of Engineers, 2007

The latest computer CPUs require the use of DC power converters with AVP. Three commonly-used AVP... more The latest computer CPUs require the use of DC power converters with AVP. Three commonly-used AVP control schemes were compared using small-signal loop gain analysis. From the comparison results emerges the fourth scheme proposed recently: the Native current-mode AVP scheme (NAVP). NAVP provides inherent phase current balancing, cycle-to-cycle protection, large stability margin, good line regulation, and constant output impedance. It compares favorably against the other three schemes.

Research paper thumbnail of Multicenter Trial to Evaluate the Safety and Potential Efficacy of Pooled Human Fibrin Sealant for the Treatment of Burn Wounds

The Journal of Trauma: Injury, Infection, and Critical Care, 1999

The primary purpose of this multicenter study was to evaluate the safety and potential efficacy o... more The primary purpose of this multicenter study was to evaluate the safety and potential efficacy of a solvent/detergent-treated commercial fibrin sealant (human) for topical hemostasis in skin grafting. The study involved a prospective evaluation of changes in viral titers in patients with burns less than 15% after treatment with fibrin sealant (human). Each patient served as his/her own control for an unblinded, randomized comparison of donor site hemostasis and healing. Preoperative serum was obtained to screen for viral titers. At autografting, the recipient site and one of two randomly chosen donor sites were treated with fibrin sealant (human). The use of other hemostatic agents, including epinephrine was prohibited. Each donor site was covered with gauze to collect blood for estimation of the relative amount of bleeding. The healing of the graft and donor sites was observed. Viral titers and wounds were checked monthly for 6 months, and at 9 and 12 months postoperatively. Viral titers for human immunodeficiency virus; hepatitis A, B, and C; Epstein-Barr virus; and cytomegalovirus were obtained before and after treatment. Of 47 patients, 34 completed the full year of observation. After treatment, there were no seroconversions to any of the aforementioned viruses. Bleeding at the recipient site appeared well controlled with fibrin sealant (human). Although investigators felt that fibrin sealant (human) improved donor site hemostasis, differences in hemoglobin measurements of blood-soaked dressings failed to reach significance. No differences were noted with regard to acceleration of donor site healing, graft take, or scar maturation at the two groups of donor sites. Anecdotally, the maturation of the recipient site appeared to be accelerated. Fibrin sealant (human) is safe for use during excision and grafting, and its topical hemostatic potential needs to be examined in patients with larger burns. Its role in scar maturation also needs to be investigated.

Research paper thumbnail of Compensator design for adaptive voltage positioning (AVP) for multiphase VRMs

2006 37th IEEE Power Electronics Specialists Conference

Abstract—In an AVP scheme, feedback compensation design is crucial to achieve a desirable constan... more Abstract—In an AVP scheme, feedback compensation design is crucial to achieve a desirable constant converter output impedance while maintaining converter stability. The model proposed and the analysis given provides insightful view of the interaction of the two performances. ...

Research paper thumbnail of Fresh frozen plasma prepared with amotosalen HCl (S‐59) photochemical pathogen inactivation: transfusion of patients with congenital coagulation factor deficiencies

Transfusion, 2005

BACKGROUND: Photochemical treatment (PCT) with amotosalen HCl (S‐59) was developed to inactivate ... more BACKGROUND: Photochemical treatment (PCT) with amotosalen HCl (S‐59) was developed to inactivate pathogens and white blood cells in plasma (PCT‐FFP) used for transfusion support.STUDY DESIGN AND METHODS: An open‐label, multicenter trial was conducted in patients with congenital coagulation factor deficiencies (factors [F]I, FII, FV, FVII, FX, FXI, and FXIII and protein C) to measure the kinetics of specific coagulation factors, hemostatic efficacy, and safety of PCT‐FFP. Posttransfusion prothrombin time (PT), partial thromboplastin time (PTT), and clinical hemostasis were evaluated before and after PCT‐FFP transfusions.RESULTS: Thirty‐four patients received 107 transfusions of PCT‐FFP for kinetic studies or therapeutic indications (mean dose, 12.8 ± 8.5 mL/kg). Incremental factor recoveries ranged from 0.9 to 2.4 IU per dL per IU per kg (FII, FV, FVII, FX, FXI, and protein C). Mean pretransfusion PT (20.7 ± 22.2 sec) corrected after PCT‐FFP (13.8 ± 2.4 sec, p < 0.001). Mean pretr...

Research paper thumbnail of Pharmacokinetic study of FFP photochemically treated with amotosalen (S-59) and UV light compared to FFP in healthy volunteers anticoagulated with warfarin

Research paper thumbnail of Association of specialist involvement and quality of care for Parkinson's disease

Research paper thumbnail of Effect of a Dementia Care Management Intervention on Primary Care Provider Knowledge, Attitudes, and Perceptions of Quality of Care

Journal of the American Geriatrics Society, 2006

OBJECTIVES: To evaluate the effect of a multicomponent dementia care management program on primar... more OBJECTIVES: To evaluate the effect of a multicomponent dementia care management program on primary care provider knowledge, attitudes, and perceptions of quality of dementia care.DESIGN: A clinic‐level randomized, controlled trial of a comprehensive care management program for patients with dementia and their nonprofessional caregivers. The program included provider education and protocols for care managers to communicate with patients' medical providers.SETTING: Sixteen clinics (eight intervention, eight usual care) in three healthcare systems in San Diego, California.PARTICIPANTS: Two hundred thirty‐two medical providers; 129 from eight intervention clinics; 103 from eight usual‐care clinics.MEASUREMENTS: Providers were surveyed 9 months after intervention onset on knowledge (five items on four topics), attitudes about dementia (three items), and perception of quality of dementia care in their practice setting (three items). Multivariable linear and logistic regression models ...

Research paper thumbnail of Use of Fibrin Sealant in Thermal Injury

Journal of Burn Care & Rehabilitation, 1997

Research paper thumbnail of Understanding Asthma Medical Nonadherence In Adult and Pediatric Populations

Journal of Allergy and Clinical Immunology, 2014

Research paper thumbnail of Implementing collaborative care for depression treatment in primary care: A cluster randomized evaluation of a quality improvement practice redesign

Implementation Science, 2011

Research paper thumbnail of Understanding the relationship among pharmacoadherence measures, asthma control test scores, and office-based spirometry

Annals of Allergy, Asthma & Immunology, 2012

Background: This study used accepted asthma metrics and pharmaceutical claim data to develop a ne... more Background: This study used accepted asthma metrics and pharmaceutical claim data to develop a new asthma metric as a possible surrogate for spirometry and to better assess asthma control. Objective: To develop and validate a new asthma metric called the Rescue Index (RI) based on ␤ 2-agonist dispensings and to test the feasibility of a multivariate model to construct a global asthma metric called the Asthma Control Index (ACI). Methods: This prospective, observational, multicenter cohort study was conducted at the Naval Medical Center San Diego (NMCSD) and at the Phoenix VA Health Care System (PVAHCS). Pharmacy claim data were correlated with the ACT, Medication Adherence Report Scale for Asthma (MARS-A), and spirometry using univariate and multivariate analyses. Results: A total of 263 individuals enrolled in the study, and 95 (PVAHCS) and 156 (NMCSD) individuals completed the study. In the PVAHCS, the ACT correlated with the asthma medication ratio (AMR) (ϭ 0.37, P Ͻ .001) and inversely correlated with the RI (ϭ Ϫ0.33, P ϭ .001), the RI inversely correlated with forced expiratory volume in 1 second (FEV 1) (ϭ Ϫ0.22, P ϭ .03) and the FEV 1 to forced vital capacity ratio (ϭ 0.22, P ϭ .03). In the NMCSD population, the ACT correlated with the MARS-A (ϭ 0.23, P ϭ .006), FEV 1 did not correlate with ACT (ϭ 0.09, P ϭ .25) or MARS-A (ϭ 0.16, P ϭ .047) but directly correlated with the RI (ϭ 0.19, P ϭ .03). The AMR was strongly inversely correlated with RI in both populations (Ϫ0.74, P Ͻ .001 in the PVAHCS group and Ϫ0.78, P Ͻ .001 in the NMCSD group). When multivariate models were applied to the NMCSD and PVAHCS groups, the combination of RI and MARS-A was the best predictor of spirometry. Conclusion: The RI shows promise as a new asthma metric because it correlated with AMR in both cohorts. However, because RI correlated with adult spirometry and ACT only, further validation studies are needed before RI may be included in an ACI metric.

Research paper thumbnail of No Shortcuts to the ‘End of History’ - Summer 2004

New Perspectives Quarterly, 2008