mba director - Academia.edu (original) (raw)
Papers by mba director
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Anti Corros Method Mater, 1993
ABSTRACT The corrosion inhibitive efficiencies of substituted dithiomalonamides have been determi... more ABSTRACT The corrosion inhibitive efficiencies of substituted dithiomalonamides have been determined at different concentrations for 304 SS in H"SUB 3" PO"SUB 4" -HCl mixture at 25 degrees C using potentiostatic technique. The percentage inhibition efficiencies have been found to increase with increasing concentrations of inhibitors. 1,5-Di-p-methylphenyl-2,4-Dithiomalonamide was found to be the most effective inhibitor followed by: 1,5-Di-p-methoxyphenyl-2,4-Dithiomalonamide, 1,5-Di-phenyl-2,4-Dithiomalonamide, 1,5-Di-p-chlorophenyl-2,4-Dithoimalonamide. Marked influence of the inhibitors is observed in decreasing the critical current density and enlarging the passive range. (Authors)
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Data Revues 22105220 V3i1 S2210522013000063, 2013
ABSTRACT Demethoxycurcumin (DMC) is one of the main bioactive and stable constituent from the mix... more ABSTRACT Demethoxycurcumin (DMC) is one of the main bioactive and stable constituent from the mixture of polyphenols, collectively referred as curcuminoids. The study aimed to investigate the anti-arthritic potential and possible mechanism of DMC in Freund's complete adjuvant (FCA) arthritis rat model. Rat paw edema, body weight changes, alterations in hematological (Hb, RBC, WBC and ESR) and biochemical parameters were observed. ELISA analysis was performed to detect serum TNF-α, IL-1β, IL-6 and IL-10 followed by real-time RT-PCR for determining pro/anti-inflammatory markers in synovium tissue. DMC (60 mg/kg b.w.) significantly ameliorated paw swelling and regained the body weight loss. Also DMC treatment brought back the altered hematological and biochemical parameters comparable to non-immunized rats. DMC administration remarkably suppressed the overproduction and mRNA expression of TNF-α, IL-1β and IL-6 in contrast to IL-10, which was markedly increased by DMC treatment. Dramatic inhibition of histopathological and radiological changes caused by FCA injection was observed in DMC treated group. Taken together, the study demonstrates that DMC is an effective anti-arthritic fraction from the group of curcuminoids responsible for the anti-inflammatory and reparative effects, which could be mediated via decrease in mRNA expression of TNF-α, IL-1β and IL-6 and increase of IL-10.
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Angewandte Chemie International Edition, Aug 1, 2001
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Chemical Engineering Education, 1989
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Phytother Res, 1995
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The Faseb Journal, Mar 1, 2006
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The Journal of Neuroscience the Official Journal of the Society For Neuroscience, Jun 1, 2001
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Enzyme and Microbial Technology, Jul 1, 2003
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The Journal of Biological Chemistry, May 23, 2003
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Immunological Investigations, 1996
In vivo growth of Dalton's lymphoma (DL), a spontaneous T cell lymphoma, has been found t... more In vivo growth of Dalton's lymphoma (DL), a spontaneous T cell lymphoma, has been found to increase the count of peripheral blood leukocytes (PBL). However, bone marrow cell proliferation and differentiation remained unaffected (A. Kumar and S.M. Singh, Immunol. Cell Biol., 73, 220-225). The present investigations were undertaken to study the effect of DL growth on the blastogenic response of splenocytes. A decrease in the wet weight of the spleen and in the count of splenocytes was observed at the early DL-bearing stage which, however, increased through the mid and late stages of the tumor growth. In vitro, the blastogenic response of the splenocytes of DL-bearing mice to phytohemagglutinin (PHA) was low at the early stage of the tumor, and subsequently increased at the mid and late stages. Macrophage-derived nitric oxide (NO) was found to be involved in regulating the blastogenic response of the splenocytes. DL cells are thus shown to influence splenocyte blastogenesis by altering the NO production of splenic macrophages.
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Proceedings of the National Academy of Sciences, Dec 1, 1983
We have constructed a frameshift mutation in the simian virus 40 early region using a novel metho... more We have constructed a frameshift mutation in the simian virus 40 early region using a novel method of oligonucleotide-directed mutagenesis. The mutated DNA specifies an 84,000-dalton large tumor antigen that consists of approximately equal to 75,000 daltons encoded by the wild-type reading frame and 9,000 daltons, by the alternative reading frame (wild-type large tumor antigen is approximately equal to 82,000 daltons). The frameshifted carboxyl terminus of the protein bears a strong similarity to the same region of polyoma virus middle-sized tumor antigen. We have found that the mutant DNA is unable to replicate when introduced into permissive monkey cells and incapable of transforming nonpermissive mouse cells.
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The Faseb Journal, Apr 1, 2014
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Biochemical and Biophysical Research Communications, Mar 23, 2007
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Indian Veterinary Journal, 1996
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Bmc Bioinformatics, 2010
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Biochimica Et Biophysica Acta Protein Structure and Molecular Enzymology, Mar 1, 1988
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American Journal of Hypertension, Dec 31, 2006
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Anti Corros Method Mater, 1993
ABSTRACT The corrosion inhibitive efficiencies of substituted dithiomalonamides have been determi... more ABSTRACT The corrosion inhibitive efficiencies of substituted dithiomalonamides have been determined at different concentrations for 304 SS in H"SUB 3" PO"SUB 4" -HCl mixture at 25 degrees C using potentiostatic technique. The percentage inhibition efficiencies have been found to increase with increasing concentrations of inhibitors. 1,5-Di-p-methylphenyl-2,4-Dithiomalonamide was found to be the most effective inhibitor followed by: 1,5-Di-p-methoxyphenyl-2,4-Dithiomalonamide, 1,5-Di-phenyl-2,4-Dithiomalonamide, 1,5-Di-p-chlorophenyl-2,4-Dithoimalonamide. Marked influence of the inhibitors is observed in decreasing the critical current density and enlarging the passive range. (Authors)
Bookmarks Related papers MentionsView impact
Data Revues 22105220 V3i1 S2210522013000063, 2013
ABSTRACT Demethoxycurcumin (DMC) is one of the main bioactive and stable constituent from the mix... more ABSTRACT Demethoxycurcumin (DMC) is one of the main bioactive and stable constituent from the mixture of polyphenols, collectively referred as curcuminoids. The study aimed to investigate the anti-arthritic potential and possible mechanism of DMC in Freund's complete adjuvant (FCA) arthritis rat model. Rat paw edema, body weight changes, alterations in hematological (Hb, RBC, WBC and ESR) and biochemical parameters were observed. ELISA analysis was performed to detect serum TNF-α, IL-1β, IL-6 and IL-10 followed by real-time RT-PCR for determining pro/anti-inflammatory markers in synovium tissue. DMC (60 mg/kg b.w.) significantly ameliorated paw swelling and regained the body weight loss. Also DMC treatment brought back the altered hematological and biochemical parameters comparable to non-immunized rats. DMC administration remarkably suppressed the overproduction and mRNA expression of TNF-α, IL-1β and IL-6 in contrast to IL-10, which was markedly increased by DMC treatment. Dramatic inhibition of histopathological and radiological changes caused by FCA injection was observed in DMC treated group. Taken together, the study demonstrates that DMC is an effective anti-arthritic fraction from the group of curcuminoids responsible for the anti-inflammatory and reparative effects, which could be mediated via decrease in mRNA expression of TNF-α, IL-1β and IL-6 and increase of IL-10.
Bookmarks Related papers MentionsView impact
Angewandte Chemie International Edition, Aug 1, 2001
Bookmarks Related papers MentionsView impact
Chemical Engineering Education, 1989
Bookmarks Related papers MentionsView impact
Phytother Res, 1995
Bookmarks Related papers MentionsView impact
The Faseb Journal, Mar 1, 2006
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
The Journal of Neuroscience the Official Journal of the Society For Neuroscience, Jun 1, 2001
Bookmarks Related papers MentionsView impact
Enzyme and Microbial Technology, Jul 1, 2003
Bookmarks Related papers MentionsView impact
The Journal of Biological Chemistry, May 23, 2003
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Immunological Investigations, 1996
In vivo growth of Dalton's lymphoma (DL), a spontaneous T cell lymphoma, has been found t... more In vivo growth of Dalton's lymphoma (DL), a spontaneous T cell lymphoma, has been found to increase the count of peripheral blood leukocytes (PBL). However, bone marrow cell proliferation and differentiation remained unaffected (A. Kumar and S.M. Singh, Immunol. Cell Biol., 73, 220-225). The present investigations were undertaken to study the effect of DL growth on the blastogenic response of splenocytes. A decrease in the wet weight of the spleen and in the count of splenocytes was observed at the early DL-bearing stage which, however, increased through the mid and late stages of the tumor growth. In vitro, the blastogenic response of the splenocytes of DL-bearing mice to phytohemagglutinin (PHA) was low at the early stage of the tumor, and subsequently increased at the mid and late stages. Macrophage-derived nitric oxide (NO) was found to be involved in regulating the blastogenic response of the splenocytes. DL cells are thus shown to influence splenocyte blastogenesis by altering the NO production of splenic macrophages.
Bookmarks Related papers MentionsView impact
Proceedings of the National Academy of Sciences, Dec 1, 1983
We have constructed a frameshift mutation in the simian virus 40 early region using a novel metho... more We have constructed a frameshift mutation in the simian virus 40 early region using a novel method of oligonucleotide-directed mutagenesis. The mutated DNA specifies an 84,000-dalton large tumor antigen that consists of approximately equal to 75,000 daltons encoded by the wild-type reading frame and 9,000 daltons, by the alternative reading frame (wild-type large tumor antigen is approximately equal to 82,000 daltons). The frameshifted carboxyl terminus of the protein bears a strong similarity to the same region of polyoma virus middle-sized tumor antigen. We have found that the mutant DNA is unable to replicate when introduced into permissive monkey cells and incapable of transforming nonpermissive mouse cells.
Bookmarks Related papers MentionsView impact
The Faseb Journal, Apr 1, 2014
Bookmarks Related papers MentionsView impact
Biochemical and Biophysical Research Communications, Mar 23, 2007
Bookmarks Related papers MentionsView impact
Indian Veterinary Journal, 1996
Bookmarks Related papers MentionsView impact
Bmc Bioinformatics, 2010
Bookmarks Related papers MentionsView impact
Biochimica Et Biophysica Acta Protein Structure and Molecular Enzymology, Mar 1, 1988
Bookmarks Related papers MentionsView impact
American Journal of Hypertension, Dec 31, 2006
Bookmarks Related papers MentionsView impact