muzamil Bashir - Academia.edu (original) (raw)

Papers by muzamil Bashir

International Journal of Recent Surgical and Medical Sciences

Background The COVID-19 pandemic has rapidly affected mortality in India and public health effort... more Background The COVID-19 pandemic has rapidly affected mortality in India and public health efforts must focus on preventing the avoidable fatalities during this pandemic. Understanding various clinical characteristics of the deceased patients of COVID-19 along with the estimation of time interval between the onset of symptoms and admission in hospital and various factors associated with COVID-19 related deaths could inform public health interventions focusing on preventing deaths due to COVID-19. Materials and Methods The present study was a retrospective hospital-based cross-sectional study conducted in Subharti Medical College and Hospital, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India. The duration of the study was 21 months. Data of COVID-19 deaths were collected from the Medical Record Department of Chhatrapati Shivaji Subharti Hospital, Meerut, which is a dedicated Level-3 COVID Hospital. Results Total Deaths due to COVID-19 were 298. Out of 298 deaths, 20...

Healthcare

Background: For centuries, convalescent plasma (CP) has been recommended to treat a diverse set o... more Background: For centuries, convalescent plasma (CP) has been recommended to treat a diverse set of viral diseases. Therefore, the present study was undertaken to evaluate the effectiveness of CP in critically ill COVID-19 patients. Methods and Materials: From 23 March 2021 to 29 December 2021, an open-label, prospective cohort, single-centre study was conducted at Chest Disease Hospital, Jammu and Kashmir, Srinagar. Patients with severe manifestation of coronavirus disease 2019 (COVID-19) under BST (best standard treatment) +CP were prospectively observed in order to evaluate effectiveness of CP therapy and historical control under BST were used as the control group Results: A total of 1667 patients were found positive for COVID-19. Of these, 873 (52.4%), 431 (28.8%), and 363 (21.8%) were moderately, severely, and critically ill, respectively. On 35th day post-infusion of CP, all-cause mortality was higher in the BST (best standard treatment) +CP group 12 (37.5%) compared to 127 (35...

Journal of Infection and Public Health

International Journal of Innovative Research in Medical Science

Mucormycosis is a rapidly progressing fungal infection caused by filamentous fungi in the Mucorac... more Mucormycosis is a rapidly progressing fungal infection caused by filamentous fungi in the Mucoraceae family and is frequently seen in diabetic and immune-compromised patients. Mucormycosis is categorized as rhino-cerebral, pulmonary, cutaneous, and gastrointestinal or disseminated, depending on organ involvement; the most common form is rhino-cerebral (39%). This form may be divided into subtypes based on which tissues are affected: rhino-nasal, rhino-orbital or rhino-orbito-cerebral. Rhino-orbital infection begins when fungal spores are inhaled and invade the nasal mucosa, and sinusitis develops as the fungus spreads to the Para-nasal sinuses. Orbital involvement occurs when the infection invades the orbital wall from the Para-nasal sinuses. Symptoms may include pain, chemosis, vision loss, Ophthalmoplegia and proptosis. Ophthalmoplegia arises from infection of the muscles and orbital space or when the third, fourth and sixth cranial nerves are affected. Peripheral seventh cranial ...

Materials

Chitosan is a biodegradable and biocompatible natural polymer that has been extensively explored ... more Chitosan is a biodegradable and biocompatible natural polymer that has been extensively explored in recent decades. The Food and Drug Administration has approved chitosan for wound treatment and nutritional use. Furthermore, chitosan has paved the way for advancements in different biomedical applications including as a nanocarrier and tissue-engineering scaffold. Its antibacterial, antioxidant, and haemostatic properties make it an excellent option for wound dressings. Because of its hydrophilic nature, chitosan is an ideal starting material for biocompatible and biodegradable hydrogels. To suit specific application demands, chitosan can be combined with fillers, such as hydroxyapatite, to modify the mechanical characteristics of pH-sensitive hydrogels. Furthermore, the cationic characteristics of chitosan have made it a popular choice for gene delivery and cancer therapy. Thus, the use of chitosan nanoparticles in developing novel drug delivery systems has received special attentio...

PLANT ARCHIVES

The most significant biotic constituent in a lake ecosystem is represented by macrophytes in thei... more The most significant biotic constituent in a lake ecosystem is represented by macrophytes in their diverse forms. Macrophytes, because of their capacity to integrate environmental changes over periods of a few years, and reflect the cumulative effects of successive disturbances, are considered excellent indicators of the ecological state of water bodies Macrophytes are by far the most investigated group used for exploring the effects of water level fluctuation on biological organisms in aquatic ecosystems . In lake ecosystems, Overall 31 species of aquatic macrophytes were reported from Anchar Lake with different morphology, which consisted of emergent (14), rooted floating leaf type (08), submerged (06) and free floating (03). The efforts mainly focus on the relationships between water level fluctuation and the presence, species richness, distribution and cover of macrophytes.

Journal of Nanomaterials

The current study was devised to develop alternative, nonantibiotic, and economically viable trea... more The current study was devised to develop alternative, nonantibiotic, and economically viable treatments for bovine mastitis. The concentration of 6.25 μg/mL (25 nm) CuNPs was selected as intramammary (IM) treatment in S. aureus-induced mastitis in rats as this concentration showed a significant zone of inhibition through the in vitro sensitivity test and minimal cell toxicity on fibroblast cell lines. After, this in vivo study was conducted, and rats were divided into four groups of 6 rats each: group I (healthy control/deionized water), group II (disease control), group III (CuNPs), and group IV (gentamicin). Injection of gentamicin IM for 5 days was selected on the basis of an antibiotic sensitivity test. The therapeutic efficacy of CuNPs was assessed on the basis of clinical signs, mammary gland architecture, bacterial load, oxidative stress parameters, and histopathology of mammary glands. The clinical signs of mastitis in group III ameliorated within 3 days of treatment while i...

Diverse Applications of Nanotechnology in the Biological Sciences

Clinical Applications of Immunogenetics, 2022

Advanced Drug Delivery Reviews, 2022

Gene therapy has emerged as a potential platform for treating several dreaded and rare diseases t... more Gene therapy has emerged as a potential platform for treating several dreaded and rare diseases that would not have been possible with traditional therapies. Viral vectors have been widely explored as a key platform for gene therapy due to their ability to efficiently transport nucleic acid-based therapeutics into the cells. However, the lack of precision in their delivery has led to several off-target toxicities. As such, various strategies in the form of non-viral gene delivery vehicles have been explored and are currenlty employed in several therapies including the SARS-CoV-2 vaccine. In this review, we discuss the opportunities lipid nanoparticles (LNPs) present for efficient gene delivery. We also discuss various synthesis strategies via microfluidics for high throughput fabrication of non-viral gene delivery vehicles. We conclude with the recent applications and clinical trials of these vehicles for the delivery of different genetic materials such as CRISPR editors and RNA for different medical conditions ranging from cancer to rare diseases.

A Molecular Approach to Immunogenetics, 2022

Journal of Medical Virology, 2022

Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) induces the production of proinflamm... more Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) induces the production of proinflammatory cytokines, which results in a cytokine storm, and immune‐modulators like Mycobacterium indicus pranii (MIP) might ameliorate coronavirus disease of 2019 (COVID‐19) related cytokine storm. Therefore, the present study evaluates whether MIP offers an advantage in the treatment of severe COVID‐19 patients infected with SARS‐CoV‐2. A prospective MIP cohort study was conducted in chest disease hospitals in Srinagar, Jammu and Kashmir, India. In the present prospective, randomized clinical study, critically severe COVID‐19 patients were divided into two groups, the MIP group (n = 105) and the best standard treatment (BST) group (n = 210). Procalcitonin, ferritin, high‐sensitive C‐reactive protein, D‐dimer levels, and interleukin levels on 5th‐day posttreatment were significantly reduced in the MIP group compared to the BST group. Compared to the BST group, 105 consecutive patients with severe COVID‐19 in the MIP group reported early weaning off ventilation, resolution of chest architecture (computed tomography [CT] scan), a significant increase in SpO2 levels, and decreased mortality with a hazard ratio: 0.234 (95% confidence interval: 0.264–2.31) (p = 0.001). MIP restored SpO2, immune/inflammatory response, normalized lung abnormalities (chest CT scan), and reduced mortality without any serious complications. However, there is a need for placebo‐controlled double‐blind and controlled clinical trials to confirm the efficacy.

Journal of Ethnopharmacology, 2021

ETHNOPHARMACOLOGICAL RELEVANCE In recent years, oxidative stress (OS) and the generation of ROS h... more ETHNOPHARMACOLOGICAL RELEVANCE In recent years, oxidative stress (OS) and the generation of ROS have been recognized as a fundamental pathology contributing, at least partially, to a number of important diseases. However, the therapeutic application has been simplistically limited to using antioxidants with little correction of diseases, and many biomarkers of OS, although confirming and quantifying the magnitude of this pathology, are not suggestive of the underlying causes behind generation of a large amount of free radicals. Unfortunately, research has not noted the multi-implication parallel phenomenon of Ihtiraq (Combustion) in Unani Medicine, which possesses much richer etiopathological sub-typing and much more variegated selective and specific treatments (and prophylactics) corresponding to each sub-type of Ihtiraq; the identification of each sub-type's molecular counterparts can be used to develop not only sub-types of OS pathologies and corresponding selective treatments/prophylactics but also non-biomolecular factors. Eminent Unani physicians described a deteriorative phenomenon, which they termed as 'Ihtiraq' which stands for extreme metabolism or 'combustion' and is recognized as a fundamental pathology, contributing as a major factor to the development of chronic diseases. Further, Unani Medicine also possesses a pathophysiological phenomenon called 'Hararat Ghariba' (Unnatural Heat) whose diverse associations with Ihtiraq may be correlatable as upstream, parallel, or downstream associations of OS and consequent pathologies. AIM OF THE STUDY The aim of the study is to: MATERIAL AND METHODS: This review is presented with a noteworthy insight into Unani concepts and a thorough study of classical Unani literature by Ibn Sina (10th century), Zakaria Razi (9th century), Ibn Rushd (12th century), Ibn al-Nafees (13th century), Majusi (10th century), and Jurjani (11th century), and comparative detailed study of modern concepts of OS from literature databases, as well as Google, recent researches, and review articles. RESULT The study showed very close correspondences between the phenomenon, etiopathology, and treatment and prevention of Ihtiraq in Unani Medicine and OS in contemporary biomolecular medicine. It also revealed sub-types of Ihtiraq and corresponding selective Unani treatments and prophylactics including drugs and non-drug factors. CONCLUSION After a comprehensive study and analysis of the most recent researches and classical theories, it can be stated that OS can be seen as a molecular level expression of Ihtiraq. Further, various components of Ihtiraq may be used to hypothesize molecular sub-types of OS and propose corresponding specific interventions.

Therapeutic Applications of Honey and its Phytochemicals, 2020

Honey is one of the most valued natural products introduced to mankind since antiquity. Tradition... more Honey is one of the most valued natural products introduced to mankind since antiquity. Traditionally, honey is not only used as a food product but also as an alternative remedy for clinical conditions ranging from wound healing to cancer treatment. Honey contains about 200 beneficial bioactive constituents primarily comprising glucose and fructose and it also encompasses some vitamins, amino acids, minerals, and enzymes from fructo-oligosaccharides. Honey is an essential source of phenolic compounds and it is of great interest to see the amount and type of phenolic acids and flavonoids as they are responsible for nutraceutical properties as well as promising pharmacological functions such as antimicrobial, antidiabetic, anticancer, neuroprotective, cardioprotective, and wound healing properties. Additionally, several recent reports have also verified that the phenolic compound profile in honey is closely linked to the botanical and, often, the geographic origin of this food product. In this book chapter, therapeutic effects associated with the bioactive compounds in natural honey have been thoroughly discussed.

International Journal of Fisheries and Aquatic Studies, 2017

The present study deals with the fish diversity undertaken during January 14 to December 2015 in ... more The present study deals with the fish diversity undertaken during January 14 to December 2015 in Anchar Lake. The paper deals with the variety and abundance of fresh water fishes in the lake. The investigation revealed the occurrence of fifteen fish’s species belonging to four orders. Order Cypriniformes were dominated by twelve species, saluriforms, Cyprinidontiformes and Salmoniformes with one species each. Schizothorax esocinus was the dominant fish species which contributed 35.2%. Fish species in the Anchar Lake decreased gradually because of the anthropogenic pressure.

Redox Report, 2021

ABSTRACT Objectives The current study was designed to examine the therapeutic role of hydroalcoho... more ABSTRACT Objectives The current study was designed to examine the therapeutic role of hydroalcoholic extract of Cuscuta reflexa Roxb (CRE) and Peucedanum grande C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats. Methods PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 weeks. Vaginal smears for phase of estrous cycle determination, serum levels of sex androgens, lipid profile, oxidative stress parameters and histopathology of ovarian tissues were investigated. Results Diestrous cycle days treated with CRE (group III) or PGE (group IV) decreased significantly (p < 0.05) compared to PCOS control animals (group II). Moreover, weight of uteri in PCOS animals treated with the plant extracts also increased significantly (p < 0.05) compared to that of group II animals. Histopathological examination showed the protective effect of the CRE and PGE indicated by the disappearance of ovarian cyst. Conclusion The study demonstrated that the CRE and PGE either alone or in combination hold a significant effect in letrozole induced PCOS rat models and could be useful in the management of reproductive and metabolic disorders related to PCOS.

PLANT ARCHIVES, 2021

The most significant biotic constituent in a lake ecosystem is represented by phytoplankton in th... more The most significant biotic constituent in a lake ecosystem is represented by phytoplankton in their diverse forms. phytoplankton because of their capacity to integrate environmental changes over periods of a few years, and reflect the cumulative effects of successive disturbances, are considered excellent biomass ecological state of water bodies Biodiversity to the aquatic ecosystem is quite varied starting from plankton (phytoplankton and zooplankton) to higher vertebrates like fishes. Study of plankton (phytoplankton and zooplankton) diversity and their ecology greatly contribute to an understanding of the basic nature and general economy of an aquatic habitat. In the present study overall, six broad groups of phytoplankton were observed during the present study, which include Bacillariophyceae, Chlorophyceae, Cyanophyceae, Euglenophyceae, Dynophyceae and Cryptoceae