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Papers by paulo V R carvalho
Annales De Dermatologie Et De Venereologie, 2003
Journal of Medicinal Chemistry, Feb 11, 2010
In addition to lowering blood pressure, telmisartan, an angiotensin (AT(1)) receptor blocker, has... more In addition to lowering blood pressure, telmisartan, an angiotensin (AT(1)) receptor blocker, has recently been shown to exert pleiotropic effects as a partial agonist of nuclear peroxisome proliferator-activated receptor gamma (PPAR gamma). On the basis of these findings and docking pose similarity between telmisartan and rosiglitazone in PPAR gamma active site, two classes of benzimidazole derivatives were designed and synthesized as dual PPAR gamma agonist/angiotensin II antagonists for the possible treatment of metabolic syndrome. Compound 4, a bisbenzimidazole derivative showed the best affinity for the AT(1) receptor with a K(i) = 13.4 nM, but it was devoid of PPAR gamma activity. On the other hand 9, a monobenzimidazole derivative, showed the highest activity in PPAR gamma transactivation assay (69% activation) with no affinity for the AT(1) receptor. Docking studies lead to the designing of a molecule with dual activity, 10, with moderate PPARgamma activity (29%) and affinity for the AT(1) receptor (K(i) = 2.5 microM).
Revista De Economia Publica Urbana Urban Public Economics Review, 2014
Cadernos De Geografia, 2005
Revista Brasileira De Terapia Intensiva, 2008
Revista Dental Press De Ortodontia E Ortopedia Facial, 2008
Journal of Chromatography a, Apr 1, 1995
INCIDÊNCIA DE LESÃO DE LARINGE POR INTUBAÇÃO EM UNIDADE DE TERAPIA INTENSIVA PEDIÁTRICA E ESTUDO ... more INCIDÊNCIA DE LESÃO DE LARINGE POR INTUBAÇÃO EM UNIDADE DE TERAPIA INTENSIVA PEDIÁTRICA E ESTUDO DOS FATORES DE RISCO FERNANDO BARCELLOS DO AMARAL; MARIANA MAGNUS SMITH; GABRIEL KUHL; PAULO JOSÉ CAUDURO ...
Rev Dent Press Ortodon Ortoped Facial, Aug 1, 2000
... 1 / 1, BBO, seleciona. para imprimir. Fotocópia. Almeida, Renato Rodrigues de. Id: 12728. Aut... more ... 1 / 1, BBO, seleciona. para imprimir. Fotocópia. Almeida, Renato Rodrigues de. Id: 12728. Autor: Henriques, José Fernando Castanha; Carvalho, Paulo Eduardo Guedes; Janson, Guilherme dos Reis Pereira; Freitas, Marcos Roberto de; Almeida, Renato Rodrigues de. ...
Annales De Dermatologie Et De Venereologie, 2003
Journal of Medicinal Chemistry, Feb 11, 2010
In addition to lowering blood pressure, telmisartan, an angiotensin (AT(1)) receptor blocker, has... more In addition to lowering blood pressure, telmisartan, an angiotensin (AT(1)) receptor blocker, has recently been shown to exert pleiotropic effects as a partial agonist of nuclear peroxisome proliferator-activated receptor gamma (PPAR gamma). On the basis of these findings and docking pose similarity between telmisartan and rosiglitazone in PPAR gamma active site, two classes of benzimidazole derivatives were designed and synthesized as dual PPAR gamma agonist/angiotensin II antagonists for the possible treatment of metabolic syndrome. Compound 4, a bisbenzimidazole derivative showed the best affinity for the AT(1) receptor with a K(i) = 13.4 nM, but it was devoid of PPAR gamma activity. On the other hand 9, a monobenzimidazole derivative, showed the highest activity in PPAR gamma transactivation assay (69% activation) with no affinity for the AT(1) receptor. Docking studies lead to the designing of a molecule with dual activity, 10, with moderate PPARgamma activity (29%) and affinity for the AT(1) receptor (K(i) = 2.5 microM).
Revista De Economia Publica Urbana Urban Public Economics Review, 2014
Cadernos De Geografia, 2005
Revista Brasileira De Terapia Intensiva, 2008
Revista Dental Press De Ortodontia E Ortopedia Facial, 2008
Journal of Chromatography a, Apr 1, 1995
INCIDÊNCIA DE LESÃO DE LARINGE POR INTUBAÇÃO EM UNIDADE DE TERAPIA INTENSIVA PEDIÁTRICA E ESTUDO ... more INCIDÊNCIA DE LESÃO DE LARINGE POR INTUBAÇÃO EM UNIDADE DE TERAPIA INTENSIVA PEDIÁTRICA E ESTUDO DOS FATORES DE RISCO FERNANDO BARCELLOS DO AMARAL; MARIANA MAGNUS SMITH; GABRIEL KUHL; PAULO JOSÉ CAUDURO ...
Rev Dent Press Ortodon Ortoped Facial, Aug 1, 2000
... 1 / 1, BBO, seleciona. para imprimir. Fotocópia. Almeida, Renato Rodrigues de. Id: 12728. Aut... more ... 1 / 1, BBO, seleciona. para imprimir. Fotocópia. Almeida, Renato Rodrigues de. Id: 12728. Autor: Henriques, José Fernando Castanha; Carvalho, Paulo Eduardo Guedes; Janson, Guilherme dos Reis Pereira; Freitas, Marcos Roberto de; Almeida, Renato Rodrigues de. ...