priyanka maurya - Academia.edu (original) (raw)
Papers by priyanka maurya
International Journal of Health Sciences (IJHS), Aug 10, 2022
Background and objective: Applying liposomal gels in transdermal drug delivery system has evoked ... more Background and objective: Applying liposomal gels in transdermal drug delivery system has evoked considerable interest because of their good activity for osteoarthritis. The aim of present study was to prepare and characterize liposomes of NSAIDS drug meloxicam, which may deliver these drugs to the target site more efficiently and also overcome the problem related with oral drug delivery of the drug. Methodology: In the present investigation efficiency of liposomes as a novel lipid for topical delivery of meloxicam has been evaluated. Liposomes were optimize by varying concentration of phospholipids cholesterol and ethanol. Liposomes formulation with soya lecithin, cholesterol and ethanol was optimized. Result: On characterization spherical, unilamellar vesicle with smooth surface were observed under Scanning electron microscopy and F4 formulation shows the best result. Conclusion: Suggested as liposomes as an efficient carriers for meloxicam topical drug delivery.
International Journal of Pharmaceutical Sciences Review and Research
Intellectual Property Right is exclusive right is granted by government of India for protection o... more Intellectual Property Right is exclusive right is granted by government of India for protection originality of work of inventor. Simple intellectual property right is intangible creation of human mind. In this intellectual Property right includes in Patent, Trademark, Trades crates, Industrial design, Layout design and Copyright oriented rights. Intellectual right is important for maintaining the quality, safety, efficacy of any Pharmaceutical product and services. It is certification authority and standard authority for certification and identification of product in would wide market. This intellectual property right is the rights given to people over the creation of their minds. They usually give the creator an exclusive right over the use of his/her creations for a certain period of time. Intellectual property refers to creations of the mind, inventions in artistic, literary, scientific and industrial field. It is important application for Protection of invention of inventor and ...
World journal of pharmacology
The major challenge faced by today's pharmacologist and formulation scientist is ocular drug ... more The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal, dynamic and static ocular barriers. Also, therapeutic drug levels are not maintained for longer duration in target tissues. In the past two decades, ocular drug delivery research acceleratedly advanced towards developing a novel, safe and patient compliant formulation and drug delivery devices/techniques, which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also, it includes development of conventional topical formulations such as suspensions, emulsions and ointments. Various nanoformulat...
The Open Nanomedicine Journal, 2018
Background and Objective: Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has ... more Background and Objective: Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good water-solubility and biocompatibility. The aim of present study was to prepare and characterize ethosomes of antileprotic drug Dapsone (DAP) together with an antibiotic Cloxacillin Sodium (CLXS) which may deliver these drugs to targeted site more efficiently than marketed gel preparation of DAP and also overcome the problems related with oral administration of CLXS. Methodology: Ethosomes were prepared by cold method then characterized for particle size, Entrapment Efficiency (EE), zeta potential and permeation studies. Vesicular size was determined by Scanning Electron Microscopy (SEM) and found to be varied from 127±9.01 to 215±7.23 nm depending on the concentrations of soya lecithin and ethanol. Results: The average percent drug entrapment efficiency of formulations ranged between 52.31% to 73.51% and 49.07% to 71.91% for DAP and CLXS...
IJRDO-Journal of Applied Science
Over the past ten years, people working in the field of drug delivery systems have become increas... more Over the past ten years, people working in the field of drug delivery systems have become increasingly interested in designing vesicles as a tool to improve drug delivery. A hydrating mixture of cholesterol and nonionic surfactants forms niosomes, which are vesicles. Liposomes, microspheres, engineering science,small emulsions, antibody loaded drug delivery , magnetic microcapsules,implantable pumps, and niosomes are just a few of the unique methods employed to administer these medications. There are two requirements before designing and developing a novel drug delivery system (NDDS). It must first spread the medication at a preset rate and then release an amount of medication at the site of action that is therapeutically efficacious. These requirements cannot be satisfied by conventional dose forms. In essence, niosomes are non-ionic surfactant-based vesicles in which a group of surfactant macromolecules forms a bilayer to form a membrane that entirely seals off an aqueous solut...
IJRDO-Journal of Applied Science
Nutraceuticals have gotten impressive interest due to their assumed wellbeing. The Present articl... more Nutraceuticals have gotten impressive interest due to their assumed wellbeing. The Present article centers around the requirement for devouring proper weight control plans, medical problems encompassing inability to stick to the realized smart dieting models, improvement of new nutraceuticals/useful food varieties/food supplements with novel medical advantages, clarification components of activity of these items, to characterize and comprehend the logical, detailing and administrative parts of nutraceutical. This article might go about as an apparatus to side by side with the new improvements in nutraceutical research.
IJRDO-Journal of Applied Science
Numerous issues arise in the field of solubility augmentation. Pharmacosomes, a revolutionary met... more Numerous issues arise in the field of solubility augmentation. Pharmacosomes, a revolutionary method based on lipid medication delivery, have emerged. Pharmacosomes are covalently bound, colloidal, nanometric-size micelles, vesicles, or hexagonal assemblies of colloidal drug dispersions to the phospholipid. Due to their special qualities such tiny size, amphiphilicity, active drug loading, high entrapment efficiency, and stability, they serve as suitable carriers for drug administration fairly accurately. In addition to lowering therapy costs, drug leakage and toxicity, increasing the bioavailability of poorly soluble medications, and having restorative benefits, they aid in the regulated release of pharmaceuticals at the site of action. This medication delivery system's capabilities have expanded to accommodate more medicines.
Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body d... more Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and target the active entity to the site of action. A number of novel drug delivery systems have emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery, dendrimer carriers being one of them. Dendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions. It is a novel three dimensional structure and these three components are: a central core, an interior dendritic structure (the branches), and an exterior surface with functional surface groups. It is also improve the physical, chemical properties due to their structure. Its other properties like very small size, polyvalenc, monodispersit, stability make it an appropriate carrier for delivering drugs with precision and selectivity. The terminal groups are modified to attach biologically active substances for targeting purpose. Dendr...
This review is mainly about transungual drug delivery which means transfer of drug across the ker... more This review is mainly about transungual drug delivery which means transfer of drug across the keratinized nails to treat nail diseases and increasing bioavailability of various drugs used for nail diseases. Nail diseases are mainly caused by fungal infections, fungi are responsible for more than half of the nail diseases. So treatment of such infections is not possible by oral administration of drugs , hence transungual drug delivery system has been introduced.The reason behind the limited therapeutic effectiveness of a current topical treatment is because they cannot sufficiently penetrate in the nail plate to transport a therapeutically sufficient quantity of antifungal drug to the target sites to eradicate the protection. Also it is difficult to analysis the drug's penetration. d. Lack of proper in vitro methods to measure the extent of drug permeation across the nail plate is the major difficulty in the development of transungual delivery. Penetration of topical antifungal t...
Gold has been used as a therapeutic agent to treat a wide variety of rheumatic diseases including... more Gold has been used as a therapeutic agent to treat a wide variety of rheumatic diseases including psoriatic arthritis, juvenile arthritis and discoid lupus erythematosus. Although the use of gold has been largely superseded by newer drugs, gold nanoparticles are being used effectively in laboratory based clinical diagnostic methods while concurrently showing great promise in vivo either as a diagnostic imaging agent or a therapeutic agent. For these reasons, gold nanoparticles are therefore well placed to enter mainstream clinical practice in the near future. Hence, in the present review we are discussing the synthesis and applications of gold nanoparticles in the field of medicine and targeted drug delivery. Nanotechnology has become one of the most interesting and advanced areas of research in this field. Among nanoparticles, gold nanoparticles demonstrate special advantages in this field due to their unique properties, small size and high surface area-to-volume ratio. These parti...
International Journal of Drug Delivery Technology, 2017
In present study, matrix tablets of Omeprazole (OPZ) were formulated by wet granulation technique... more In present study, matrix tablets of Omeprazole (OPZ) were formulated by wet granulation technique using a combination of hydroxyl propyl methyl cellulose (HPMC K15M) and ethyl cellulose (EC) in varying ratios and the effect of polymer ratio as well as their concentration on drug release profile was investigated. Response surface methodology (RSM) was conducted to optimize matrix tablets. Compressed tablets were evaluated for hardness, friability, weight variation, drug content and in vitro dissolution studies. The dissolution study was performed in pH1.2 for the first 2 h and in phosphate buffer (pH 7.4) for another 5 h. The optimized formulation was compared with other formulations using similarity (ƒ2) and dissimilarity factor (ƒ1) test. The results of RSM indicated that both X1 (the blending ratio of HPMC K15M K15M and Carbopol 934P 934P) and X2 (polymer blend concentration)have significant effect on in-vitro drug release profile. Hardness, friability, weight variation and drug c...
International Journal of Science, Technology & Society, 2018
This study intended to develop and evaluate isotretinoin (ITR) loaded nanoparticles taking chitos... more This study intended to develop and evaluate isotretinoin (ITR) loaded nanoparticles taking chitosan as a polymer of interest. Ionic crosslinking method was utilized to prepare nanoparticles. Nanoparticles were formulated using varying ratios (chitosan: tripolyphosphate) and evaluated for its size, distribution of size, zeta potential, percentage of ITR entrapped within nanoparticles, in vitro drug release and its stability under accelerated conditions. The prepared nanoparticles (NPs) were spherical, white in color and free flowing, 321± 4.5 nm was the average size of optimized chitosan nanoparticles and it was able to entrap 88.76 ± 3.5%. The outcomes assured vast promise of the CNs of ITR (optimized) in management of acne and also increasing the therapeutic efficacy, thus establish to be a promising, effective and patient compliant formulation. INTRODUCTION Acne, a cutaneous pleomorphic condition of the pilosebaceous unit involving sebum production rate anomaly and described by in...
International Journal of Health Sciences (IJHS), Aug 10, 2022
Background and objective: Applying liposomal gels in transdermal drug delivery system has evoked ... more Background and objective: Applying liposomal gels in transdermal drug delivery system has evoked considerable interest because of their good activity for osteoarthritis. The aim of present study was to prepare and characterize liposomes of NSAIDS drug meloxicam, which may deliver these drugs to the target site more efficiently and also overcome the problem related with oral drug delivery of the drug. Methodology: In the present investigation efficiency of liposomes as a novel lipid for topical delivery of meloxicam has been evaluated. Liposomes were optimize by varying concentration of phospholipids cholesterol and ethanol. Liposomes formulation with soya lecithin, cholesterol and ethanol was optimized. Result: On characterization spherical, unilamellar vesicle with smooth surface were observed under Scanning electron microscopy and F4 formulation shows the best result. Conclusion: Suggested as liposomes as an efficient carriers for meloxicam topical drug delivery.
International Journal of Pharmaceutical Sciences Review and Research
Intellectual Property Right is exclusive right is granted by government of India for protection o... more Intellectual Property Right is exclusive right is granted by government of India for protection originality of work of inventor. Simple intellectual property right is intangible creation of human mind. In this intellectual Property right includes in Patent, Trademark, Trades crates, Industrial design, Layout design and Copyright oriented rights. Intellectual right is important for maintaining the quality, safety, efficacy of any Pharmaceutical product and services. It is certification authority and standard authority for certification and identification of product in would wide market. This intellectual property right is the rights given to people over the creation of their minds. They usually give the creator an exclusive right over the use of his/her creations for a certain period of time. Intellectual property refers to creations of the mind, inventions in artistic, literary, scientific and industrial field. It is important application for Protection of invention of inventor and ...
World journal of pharmacology
The major challenge faced by today's pharmacologist and formulation scientist is ocular drug ... more The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal, dynamic and static ocular barriers. Also, therapeutic drug levels are not maintained for longer duration in target tissues. In the past two decades, ocular drug delivery research acceleratedly advanced towards developing a novel, safe and patient compliant formulation and drug delivery devices/techniques, which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also, it includes development of conventional topical formulations such as suspensions, emulsions and ointments. Various nanoformulat...
The Open Nanomedicine Journal, 2018
Background and Objective: Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has ... more Background and Objective: Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good water-solubility and biocompatibility. The aim of present study was to prepare and characterize ethosomes of antileprotic drug Dapsone (DAP) together with an antibiotic Cloxacillin Sodium (CLXS) which may deliver these drugs to targeted site more efficiently than marketed gel preparation of DAP and also overcome the problems related with oral administration of CLXS. Methodology: Ethosomes were prepared by cold method then characterized for particle size, Entrapment Efficiency (EE), zeta potential and permeation studies. Vesicular size was determined by Scanning Electron Microscopy (SEM) and found to be varied from 127±9.01 to 215±7.23 nm depending on the concentrations of soya lecithin and ethanol. Results: The average percent drug entrapment efficiency of formulations ranged between 52.31% to 73.51% and 49.07% to 71.91% for DAP and CLXS...
IJRDO-Journal of Applied Science
Over the past ten years, people working in the field of drug delivery systems have become increas... more Over the past ten years, people working in the field of drug delivery systems have become increasingly interested in designing vesicles as a tool to improve drug delivery. A hydrating mixture of cholesterol and nonionic surfactants forms niosomes, which are vesicles. Liposomes, microspheres, engineering science,small emulsions, antibody loaded drug delivery , magnetic microcapsules,implantable pumps, and niosomes are just a few of the unique methods employed to administer these medications. There are two requirements before designing and developing a novel drug delivery system (NDDS). It must first spread the medication at a preset rate and then release an amount of medication at the site of action that is therapeutically efficacious. These requirements cannot be satisfied by conventional dose forms. In essence, niosomes are non-ionic surfactant-based vesicles in which a group of surfactant macromolecules forms a bilayer to form a membrane that entirely seals off an aqueous solut...
IJRDO-Journal of Applied Science
Nutraceuticals have gotten impressive interest due to their assumed wellbeing. The Present articl... more Nutraceuticals have gotten impressive interest due to their assumed wellbeing. The Present article centers around the requirement for devouring proper weight control plans, medical problems encompassing inability to stick to the realized smart dieting models, improvement of new nutraceuticals/useful food varieties/food supplements with novel medical advantages, clarification components of activity of these items, to characterize and comprehend the logical, detailing and administrative parts of nutraceutical. This article might go about as an apparatus to side by side with the new improvements in nutraceutical research.
IJRDO-Journal of Applied Science
Numerous issues arise in the field of solubility augmentation. Pharmacosomes, a revolutionary met... more Numerous issues arise in the field of solubility augmentation. Pharmacosomes, a revolutionary method based on lipid medication delivery, have emerged. Pharmacosomes are covalently bound, colloidal, nanometric-size micelles, vesicles, or hexagonal assemblies of colloidal drug dispersions to the phospholipid. Due to their special qualities such tiny size, amphiphilicity, active drug loading, high entrapment efficiency, and stability, they serve as suitable carriers for drug administration fairly accurately. In addition to lowering therapy costs, drug leakage and toxicity, increasing the bioavailability of poorly soluble medications, and having restorative benefits, they aid in the regulated release of pharmaceuticals at the site of action. This medication delivery system's capabilities have expanded to accommodate more medicines.
Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body d... more Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and target the active entity to the site of action. A number of novel drug delivery systems have emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery, dendrimer carriers being one of them. Dendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions. It is a novel three dimensional structure and these three components are: a central core, an interior dendritic structure (the branches), and an exterior surface with functional surface groups. It is also improve the physical, chemical properties due to their structure. Its other properties like very small size, polyvalenc, monodispersit, stability make it an appropriate carrier for delivering drugs with precision and selectivity. The terminal groups are modified to attach biologically active substances for targeting purpose. Dendr...
This review is mainly about transungual drug delivery which means transfer of drug across the ker... more This review is mainly about transungual drug delivery which means transfer of drug across the keratinized nails to treat nail diseases and increasing bioavailability of various drugs used for nail diseases. Nail diseases are mainly caused by fungal infections, fungi are responsible for more than half of the nail diseases. So treatment of such infections is not possible by oral administration of drugs , hence transungual drug delivery system has been introduced.The reason behind the limited therapeutic effectiveness of a current topical treatment is because they cannot sufficiently penetrate in the nail plate to transport a therapeutically sufficient quantity of antifungal drug to the target sites to eradicate the protection. Also it is difficult to analysis the drug's penetration. d. Lack of proper in vitro methods to measure the extent of drug permeation across the nail plate is the major difficulty in the development of transungual delivery. Penetration of topical antifungal t...
Gold has been used as a therapeutic agent to treat a wide variety of rheumatic diseases including... more Gold has been used as a therapeutic agent to treat a wide variety of rheumatic diseases including psoriatic arthritis, juvenile arthritis and discoid lupus erythematosus. Although the use of gold has been largely superseded by newer drugs, gold nanoparticles are being used effectively in laboratory based clinical diagnostic methods while concurrently showing great promise in vivo either as a diagnostic imaging agent or a therapeutic agent. For these reasons, gold nanoparticles are therefore well placed to enter mainstream clinical practice in the near future. Hence, in the present review we are discussing the synthesis and applications of gold nanoparticles in the field of medicine and targeted drug delivery. Nanotechnology has become one of the most interesting and advanced areas of research in this field. Among nanoparticles, gold nanoparticles demonstrate special advantages in this field due to their unique properties, small size and high surface area-to-volume ratio. These parti...
International Journal of Drug Delivery Technology, 2017
In present study, matrix tablets of Omeprazole (OPZ) were formulated by wet granulation technique... more In present study, matrix tablets of Omeprazole (OPZ) were formulated by wet granulation technique using a combination of hydroxyl propyl methyl cellulose (HPMC K15M) and ethyl cellulose (EC) in varying ratios and the effect of polymer ratio as well as their concentration on drug release profile was investigated. Response surface methodology (RSM) was conducted to optimize matrix tablets. Compressed tablets were evaluated for hardness, friability, weight variation, drug content and in vitro dissolution studies. The dissolution study was performed in pH1.2 for the first 2 h and in phosphate buffer (pH 7.4) for another 5 h. The optimized formulation was compared with other formulations using similarity (ƒ2) and dissimilarity factor (ƒ1) test. The results of RSM indicated that both X1 (the blending ratio of HPMC K15M K15M and Carbopol 934P 934P) and X2 (polymer blend concentration)have significant effect on in-vitro drug release profile. Hardness, friability, weight variation and drug c...
International Journal of Science, Technology & Society, 2018
This study intended to develop and evaluate isotretinoin (ITR) loaded nanoparticles taking chitos... more This study intended to develop and evaluate isotretinoin (ITR) loaded nanoparticles taking chitosan as a polymer of interest. Ionic crosslinking method was utilized to prepare nanoparticles. Nanoparticles were formulated using varying ratios (chitosan: tripolyphosphate) and evaluated for its size, distribution of size, zeta potential, percentage of ITR entrapped within nanoparticles, in vitro drug release and its stability under accelerated conditions. The prepared nanoparticles (NPs) were spherical, white in color and free flowing, 321± 4.5 nm was the average size of optimized chitosan nanoparticles and it was able to entrap 88.76 ± 3.5%. The outcomes assured vast promise of the CNs of ITR (optimized) in management of acne and also increasing the therapeutic efficacy, thus establish to be a promising, effective and patient compliant formulation. INTRODUCTION Acne, a cutaneous pleomorphic condition of the pilosebaceous unit involving sebum production rate anomaly and described by in...