Pharmaceutical Niosomes Drug Delivery: A Complete Review of New Delivery System (original) (raw)
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Niosomes: Layered Delivery System For Drug Targeting
International Journal of Scientific Research, 2012
The main purpose of this review is to explore and overview the existing self dispersing formulations resulting from dilution of drug into emulsions, microemulsions and surfactant dispersions. The systematic approach used in preparation of niosome and the presentation of the various physico-chemical and biopharmaceutical aspects should facilitate the comprehension of this interesting field and clarify the main considerations involved in designing and characterizing a specific self dispersing drug delivery system. These Vesicular systems act as new drug delivery systems which enhance bioavailability as well as remedial activity of encapsulated drug in controlled manner. Niosomes formed from non-ionic surfactant vesicular system which can be easily formulated in the laboratory. Method of formulation, nature of surfactant, encapsulated drug temperature at which the lipids are hydrated and the packagings of niosomes play an effective and important role in the formulation of these vesicular systems. This vesicular system has unilamellar and multilamellar structures from the non-ionic surfactants and cholesterol. These are the bilayered structures in which hydrophilic as well as lipophilic drugs can be entrapped. This review article describes all aspects of niosomes including different composition, scalable techniques. Also it focuses on strength of formulation, limitations in respect to industrial applicability and regulatory requirements concerning the drug formulation based on FDA and EMEA documents. The review also provides detailed information of the various types of niosomes formulated for successful delivery by using different encapsulated drugs.
Niosomes: A Controlled and Novel Drug Delivery System
Biological & Pharmaceutical Bulletin, 2011
During the past decade formulation of vesicles as a tool to improve drug delivery, has created a lot of interest amongst the scientist working in the area of drug delivery systems. Vesicular system such as liposomes, niosomes, transferosomes, pharmacosomes and ethosomes provide an alternative to improve the drug delivery. Niosomes play an important role owing to their nonionic properties, in such drug delivery system. Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should deliver the drug in accordance with a predetermined rate and second it should release therapeutically effective amount of drug at the site of action. Conventional dosage forms are unable to meet these requisites. Niosomes are essentially non-ionic surfactant based multilamellar or unilamellar vesicles in which an aqueous solution of solute is entirely enclosed by a membrane resulting from the organization of surfactant macromolecules as bilayer. Niosomes are formed on hydration of non-ionic surfactant film which eventually hydrates imbibing or encapsulating the hydrating aqueous solution. The main aim of development of niosomes is to control the release of drug in a sustained way, modification of distribution profile of drug and for targeting the drug to the specific body site. This paper deals with composition, characterization/evaluation, merits, demerits and applications of niosomes.
Niosomes : as novel vesicular drug delivery system
2018
Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to target sites within the body. The basic component of drug delivery systems is an appropriate carrier that protects the drug from rapid degradation or clearance and thereby enhances drug concentration in target tissues. Niosome are microscopic non-ionic surfactant bilayer vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or their lipids. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Noisome are promising vehicle for drug delivery and being non-ionic, more stable, inexpensive, biodegradable, biocompatible, non immunogenic and exhibit flexibility in their structural characterization. Various additives in niosomes include nonionic surfactant as film forming agent, cholesterol as stabilizing and rigidizing agent for the bilayer and various c...
Novel drug delivery system for the vesicular delivery of drug by the niosomes
Non-ionic surfactant vesicles (or niosomes) are now widely studied as alternates to liposomes. An increasing number of non-ionic surfactant has been found to form vesicles, capable of entrapping hydrophilic and hydrophobic molecules. Drug delivery system using colloidal particulate carrier such as liposomes or niosomes has distinct advantages over conventional dosage forms because the particles can act as drug containing reservoirs. Modification of the particle composition or surface can adjust the affinity for the target site and/or the drug release rate. Niosomes proved to be a promising drug carrier and has potential to reduce the side effects of drugs and increased therapeutic effectiveness in various diseases.
A Novel Drug Delivery System: Niosomes Review
Drug targeting is a kind of mechanism in which the drug is administered in the body in such a way that the drug interacts at a cellular or subcellular level with the target tissue to achieve a desired therapeutic response at a desired location without unwanted interactions at other sites. This can be done by modern methods such as niosomes, which target the drug delivery system. Niosomes are the type of non-ionic surfactant vesicles which are a new approach to liposomes that is biodegradable, non-toxic, more durable and cheaper. Their liposome-like structure and therefore they can represent alternate vesicular structures in relation to liposomes. The niosomes appear to load various types of drugs. This review article describes niosome structure, benefits, drawbacks, niosome preparation methods and pharmaceutical NSV characterisation.
Niosome: An Unique Drug Delivery System
Niosomes are non-ionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. Niosomes are promising vehicle for drug delivery and being non-ionic, it is less toxic and improves the therapeutic index of drug by restricting its action to target cells. This systemic review article deals with preparation methods, characterizations, factors affecting release kinetic, advantages, and applications of niosomes.
Niosomes: A Unique Drug Delivery Tool
World Journal of Pharmacy and Pharmaceutical Sciences, 2014
Synthetic nonionic surfactants such as alkyl or dialkyl poly glycerol ether class when hydrated give niosomes. Niosomes are the drug carriers which provide substitute to liposomes and encapsulate the solutes in a way similar to liposomes. These may be unilamellar or multilamellar vesicles, present more in vitro stability and improved stability of drugs entrapped in comparison with the dosage forms which are conventional. [1] Niosomes can hold amphiphillic as well as lipophilic drugs and have the advantage of being biocompatible, biodegradable and non immunogenic over liposomes. Niosomes are used for targeted as well as controlled release for the treatment of many diseases including cancer, viral and other microbial diseases.
Niosomes are non-ionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. Niosomes are promising vehicle for drug delivery and being non-ionic, it is less toxic and improves the therapeutic index of drug by restricting its action to target cells. This systemic review article deals with preparation methods, characterizations, factors affecting release kinetic, advantages, and applications of niosomes.
NIOSOMES AS AN EMERGING FORMULATION TOOL FOR DRUG DELIVERY-A REVIEW Review Article
International Journal of Applied Pharmaceutics, 2019
Nonionic surfactant based vesicles which are uni/multilamellar in structures are called niosomes. These vesicles contains an aqueous interior surrounded by one or more amphiphilic bilayer membrane forming surfactant which separates them from the bulk solution, and are also called as supramolecular aggregates. Niosomes, being an efficient drug delivery system, investigations are carried out to utilize this system to treat various disorders, to promote improved patient compliance, lesser side effects, reduction in dose, lesser dosage frequency, and higher amount of the drug at the particular site so as to lessen an excessive contact with the whole body. The Pharmacokinetic and Pharmacodynamic profile of Niosomal drug delivery system vary for various entrapped drugs. Drugs that are successful in the mitigation or treatment of CNS disorders should cross the BBB to reach the brain, as BBB seems to be an obstacle for a large number of drugs, including CNS active drugs. This article compiles recent techniques for the preparation and characterization of niosomes, the effect of formulation variables on its physicochemical properties and discussed about its effective applications in drug delivery.
Niosomes as an Emerging Formulation Tool for Drug Delivery-A Review
International Journal of Applied Pharmaceutics, 2019
Nonionic surfactant based vesicles which are uni/multilamellar in structures are called niosomes. These vesicles contains an aqueous interior surrounded by one or more amphiphilic bilayer membrane forming surfactant which separates them from the bulk solution, and are also called as supramolecular aggregates. Niosomes, being an efficient drug delivery system, investigations are carried out to utilize this system to treat various disorders, to promote improved patient compliance, lesser side effects, reduction in dose, lesser dosage frequency, and higher amount of the drug at the particular site so as to lessen an excessive contact with the whole body. The Pharmacokinetic and Pharmacodynamic profile of Niosomal drug delivery system vary for various entrapped drugs. Drugs that are successful in the mitigation or treatment of CNS disorders should cross the BBB to reach the brain, as BBB seems to be an obstacle for a large number of drugs, including CNS active drugs. This article compil...