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Papers by resha khan

Research paper thumbnail of Crustacean dopamine receptors: localization and G protein coupling in the stomatogastric ganglion

Journal of Neurochemistry, 2008

Neuromodulators, such as dopamine (DA), control motor activity in many systems. To begin to under... more Neuromodulators, such as dopamine (DA), control motor activity in many systems. To begin to understand how DA modulates motor behaviors, we study a well-defined model: the crustacean stomatogastric nervous system (STNS). The spiny lobster STNS receives both neuromodulatory and neurohormonal dopaminergic input, and extensive background information exists on the cellular and network effects of DA. However, there is a void of information concerning the mechanisms of DA signal transduction in this system. In this study, we show that Gs, Gi, and Gq are activated in response to DA in STNS membrane preparations from five crustacean species representing distant clades in the order Decapoda. Three evolutionarily conserved DA receptors mediate this response in spiny lobsters: D 1αPan , D 1βPan and D 1αPan. G protein coupling for these receptors can vary with the cell type. In the native membrane, the D 1αPan receptor couples with Gs and Gq, the D 1βPan receptor couples with Gs, and the D 2αPan receptor couples with Gi. All three receptors are localized exclusively to the synaptic neuropil and most likely generate global biochemical signals that alter ion channels in distant compartments, as well as local signals.

Research paper thumbnail of Crustacean dopamine receptors: localization and G protein coupling in the stomatogastric ganglion

Journal of Neurochemistry, 2008

Neuromodulators, such as dopamine (DA), control motor activity in many systems. To begin to under... more Neuromodulators, such as dopamine (DA), control motor activity in many systems. To begin to understand how DA modulates motor behaviors, we study a well-defined model: the crustacean stomatogastric nervous system (STNS). The spiny lobster STNS receives both neuromodulatory and neurohormonal dopaminergic input, and extensive background information exists on the cellular and network effects of DA. However, there is a void of information concerning the mechanisms of DA signal transduction in this system. In this study, we show that Gs, Gi, and Gq are activated in response to DA in STNS membrane preparations from five crustacean species representing distant clades in the order Decapoda. Three evolutionarily conserved DA receptors mediate this response in spiny lobsters: D 1αPan , D 1βPan and D 1αPan. G protein coupling for these receptors can vary with the cell type. In the native membrane, the D 1αPan receptor couples with Gs and Gq, the D 1βPan receptor couples with Gs, and the D 2αPan receptor couples with Gi. All three receptors are localized exclusively to the synaptic neuropil and most likely generate global biochemical signals that alter ion channels in distant compartments, as well as local signals.

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