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Papers by reza tahvilian

Journal of Reports in Pharmaceutical Sciences

Abstract The genus Hymenocrater, belong to the Lamiaceae family, consist of 21 species throughout... more Abstract The genus Hymenocrater, belong to the Lamiaceae family, consist of 21 species throughout the world. In Iran, about 9 species are present, of which some are endemic. Plants belonging to these genuses are pharmacologically active and have been used in folk medicine all around the world. The aim of the present study was to detect the essential oils composition of Hymenocrater longiflorus Benth. collected from Paveh, Kermanshah province. Plant sample was dried in shade condition and the essential oil of the plant obtained by hydrodistillation by Clevenger type apparatus was analyzed by GC/MS. Yield of essential oil was (1.5 % v/w). The major components of the oil of H. longiflorus Benth were Hedycarvol (22.2), α-Cadinol (20.43), β-Bourbonene (5.76%), α-Terpineol (4.95%), Eudesmol (4.84%), β-Bourbonene (4.69%), Caryophylene oxide (4.32%) and Geijerene (4.08%), Caryophelen (2.99), Sabinene (2.6%), 1,8-cineole (2.58%), δ-Amorphene (2.58%), δ-Caddinene (2.24%) and α-Pinene (2.07%) were the main compounds with the greatest content. Keywords: Hymenocrater longiflorus Benth , Essential oils, GC/MS, Paveh.

Research in Pharmaceutical Sciences, Sep 1, 2012

Jordan Journal of Agricultural Sciences, Sep 9, 2015

The genus Salvia, belong to the Lamiaceae family, consist of about 700 to 900 species throughout ... more The genus Salvia, belong to the Lamiaceae family, consist of about 700 to 900 species throughout the world. Plants belonging to genus Salvia are pharmacologically active and have been used in folk medicine all around the world. The aim of the present study was to detect the essential oils composition of Salvia multicaulis Vahl. collected from Paveh, Kermanshah province. Aerial parts of plant samples were dried in shade condition and the essential oil of the plant obtained by hydrodistillation by Clevenger type apparatus was analyzed by GC/MS. Yield of essential oil was (1.5 % v/w). The results of essential oil analysis showed that among all determined compounds: bornyl acetate (19.46%), borneol (18.53%), camphor (15.21%), β-caryophyllene (5.89%), camphene (5.52%), α-pinene (5.29%), 1,8 Cineol (2.44%) were the main compounds with the greatest content.

PubMed, 2010

Clomipramine is a tricyclic antidepressant. Different methods for determination of clomipramine h... more Clomipramine is a tricyclic antidepressant. Different methods for determination of clomipramine hydrochloride in plasma have been described. Most of these procedures favor the use of acidic back-extraction in extraction procedure and HPLC as the analytical technique. In this study, the clomipramine extraction procedure was modified and a direct injection to the column was performed to shorten the time of sample preparation considerably. Furthermore, the method was applied in bioequivalence study of new formulations of clomipramine in comparison with reference tablets. THE DRUG AND INTERNAL STANDARD WERE EXTRACTED FROM PLASMA WITH HEPTAN : isoamyl alcohol (95:5) and re-extracted with 200 μL of orthophosphoric acid (0.3% v/v). The organic layer was discharged and analysis was performed on C8 reverse phase ODS2 HPLC column with a mobile phase, acetonitrile : water (75:25) and UV detection set at 215 nm. Additionally, a single dose study was carried out with a two-sequence, crossover block-randomized design for bioequivalence study. Clomipramine tablets (3 × 25 mg) of either formulations (reference or test products) were administered separately in two occasions to 12 fasting healthy male volunteers. Blood samples were taken prior to and at 9 points within 48 h after dose administration. The retention time of internal standard (cisapride), clomipramine, and desmethyl clomipramine were 5.6 ± 0.2, 10.3 ± 0.3, and 9.5 ± 0.3 min, respectively. The standard curve covering the concentration ranges of 2.5-120 ng/mL was linear (r(2) = 0.9950 and 0.9979) for clomipramine and desmethyl clomipramine. The co-efficient of variation for intra-day and inter-day accuracy and precision was less than 18.3%. The pharmacokinetic parameters Cmax and Tmax were obtained directly from plasma clomipramine concentrations. Kel was estimated by log-linear regression and AUC was calculated by the linear trapezoidal rule. The pharmacokinetic parameters AUC and Cmax were tested for equivalence after log-transformation of data. The 90% standard confidence intervals of the mean values for the test/reference ratios, AUC, and Cmax were within the acceptable bioequivalence limits of 0.80-1.20. These results indicated that the analytical method was linear and accurate. Test and reference formulations were found to be bioequivalent and therefore interchangeable.

PubMed, 2018

The objective of this research was in-vitro germination and callus induction of Onosma bulbotrich... more The objective of this research was in-vitro germination and callus induction of Onosma bulbotrichum (O.bulbotrichum) as a medicinal herb which belongs to Boraginaceae family. For germination, the seeds were cultured on growth regulator-free MS medium and for callus induction, seeds were sown on modified MS medium containing different concentrations of kinetin (kn)- Indole-3-acetic acid (IAA) and kn- 2,4-D (2,4-dichlorophenoxyacetic acid), respectively. The plates were maintained in the dark at growth chamber. After 7 days seed germination on hormone-free medium and after 10 days callus initiation on modified medium in the presence of hormones was occurred. The maximum pigmented callus (100%) was observed on modified MS medium with a combination of 0.2 mg.L-1 IAA + 2.10 mg.L-1 kn. Shikonin determination was performed by HPLC method. In addition, total hydroxynaphtoquinons as polyphenols in sum of callus and culture medium were measured by spectrophotometric method and revealed that total naphtoquinones content at IAA was more than 2, 4-D.

Comparative clinical pathology, May 30, 2018

Comparative clinical pathology, Jul 4, 2018

European Journal of Hospital Pharmacy, Mar 1, 2013

stable in patients switched from all pre-study ESAs. The observed adverse events profile was in l... more stable in patients switched from all pre-study ESAs. The observed adverse events profile was in line with expectations for the study population. No conflict of interest. Evaluating thE StandardS of hoSpital pharmaciES in thErapEutic cEntrES affiliatEd with of KErmanShah univErSity of mEdical SciEncES, iran

Applied Nanoscience, Nov 23, 2021

Jelly candy is a novel and promising method for advanced drug delivery, especially among children... more Jelly candy is a novel and promising method for advanced drug delivery, especially among children due to the enjoyable taste of candy products. The anti-fever and analgistic properties of acetaminophen in the effective treatment of mild to moderate pain has been well-studied over the past few decades. This study aims to prepare a novel dosage form of acetaminophen nanoparticles jelly candies that are suitable for children to consume. Polyethylene glycol 6000 was dissolved in distilled water and then acetaminophen powder dissolved in ethanol, added rapidly to the stirring solution of polyethylene glycol 6000. Gelling agents consisting of gelatin and starch were added to the nanoparticle solution. The final solution was stirred well and allowed to dry at refrigerator temperature for 24 h. Characterization tests such as DSC, FT-IR spectroscopy, surface electron microscopy (SEM) and transmission electron microscopy (TEM) imaging, and release profiles of both nanoparticles and jelly candies were done. FT-IR results confirmed the formation of nanoparticles. The size of the synthesized nanoparticles was about 38–50 nm. Cumulative drug release of the nanoparticles in the jelly candies was about 74% after 24 h, the the nanoparticles’ release profile obeys the Hixon–Crowell model, and the jelly candies show first-order release profiles. The oral jelly candies loaded with nanoparticles can be the next generation of novel dosage forms of acetaminophen because of their ease of consumption and higher compliance among children than the conventional oral tablets. Further studies are needed to confirm these findings.

Applied Organometallic Chemistry, Sep 5, 2019

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering, Oct 28, 2012

In any hospital, a drug distribution system is required to supply the medication prescribed for e... more In any hospital, a drug distribution system is required to supply the medication prescribed for each inpatient. The drug distribution system includes all the processes that occur between the prescription of a drug and the administration of that drug to the patient. There are many varieties of drug distribution system in use throughout the world, but all have the same goal: to ensure that each dose of medication administered to each patient is exactly that which was intended by the prescriber. Wonderfully, there are still some physicians in Iran who think about a big store of drugs, when they hear the words "hospital pharmacy". Their day to day hospital care experiences had shown them before, that the only thing which is expected from a hospital pharmacy is supplying medicines. Many of the hospital managers in Iran who are basically supposed to be physicians do think the same [1, 2]. In many developing countries today, modern and advanced healthcare system is benefited from hospital drugstores and clinical pharmacists as great invaluable elements in curing process [3, 4]. Branches of a standard hospital pharmacy are recommended to be wide spread in different departments of the hospital for ensuring the high quality pharmaceutical care services [5]. There are particular standards for hospital pharmacy administration in Iran in addition to some efficient and interesting worldwide ones. These standards can be used after being modified according to our cultural and even religious desires [6]. A survey done by Malik et al showed that the most important problems in hospital pharmacies management are dearth of personal, equipments and spaces deficiency and warranty of persuading continuous drug services [7]. There are few published studies done in Iran on this case. In a study done by Vaziri on selected hospitals affiliated with Iranian Social Security Organization (ISSO), lots of deficiencies and inelegances was subjectively observed in equipments, desired spaces and dispensing processes that definitely cause a waste in human resources and the organization funds, and may consequently impose a reduction in ISSO services proficiency and safety too [8]. In another study Mortazavi et al emphasized on a huge gap between hospital pharmacy services represented in 12 surveyed hospitals affiliated with Shahid Beheshti University of Medical Sciences and the standard guidelines. 1 Inadequacy of needed space for professional services, non standard equipments and instruments and low rate of (clinical) pharmacist effective attendance in clinical wards were reported to be remarkable problems for establishing a standard scientific pharmaceutical care service [1]. On the way of moving from traditional hospital pharmacies to the more scientific and modern ones, it seems crucial to have an analysis before making any decision on this important issue. The importance of Kermanshah as an international border caused to change it to the therapeutic city center beside Iraq in west of Iran. Despite the essential role of administrative authorities of this province on the health care system of the country, to our best of knowledge, there is no previously published research on the basic needs of the above mentioned movement. The aim of this study was to evaluate pharmacy store and storage conditions, equipments, process of ordering, receiving, storing and delivering of the in-patient pharmacies located in hospitals affiliated with Kermanshah University of medical sciences (KUMS). The words "hospital pharmacy" and "drugstore" are used interchangeably within this article and "pharmacy management" is the ideal scientific gold standard terminology for them.

Comparative clinical pathology, Feb 17, 2018

Applied Biochemistry and Biotechnology, Oct 6, 2021

In biological systems, carbon nanotubes can enhance the biological effects of drugs and reduce th... more In biological systems, carbon nanotubes can enhance the biological effects of drugs and reduce their side effects. Methamphetamine (METH) is a stimulant drug that induces cell death in various cell types, primarily neural cells. On the other hand, specific doses of atorvastatin (ATO) can stimulate cell growth and inhibit cell death in different cell lines. This study aimed to investigate the improvement effect of ATO@single-walled carbon nanotube (SWCNT) on METH-induced cell cytotoxicity in the U87 glioblastoma cell line. In this study, cells were cultured in 10 mM of METH during the cell treatment with 0–10 nM of ATO and ATO@SWCNT. The conjugated drugs to SWCNT as Van der Waals were detected using field emission scanning electron microscopy, Fourier transform-infrared spectroscopy, and other analyses. Then, the in vitro proliferating of ATO@SWCNT was explored against glioblastoma cells compared to pure ATO. This examine was performed using methyl thiazole tetrazolium approach, terminal deoxynucleotidyl transferase deoxy uridine-triphosphate nick end labeling assay, caspase-3 method, lactate dehydrogenase assay, and RH-123 assay with 10 mM METH. The results obtained from transmission electron microscopy analysis showed the average size of 50 nm for ATO@SWCNT. This study indicated that U87 cells, which were exposed to METH and suffered cell death, were severely reduced in the presence of ATO, especially ATO@SWCNT (for its anti-apoptotic effect), but they survived. This study suggests that ATO, which was primarily used to reduce blood lipids, can significantly reduce brain cell death. The findings of this study indicate that by using SWCNT, more drugs can reach the target cells. This method reduces the total amount of required medication and shows a more beneficial therapeutic effect. Graphical abstract

Online Journal of Veterinary Research, 2017

DOAJ (DOAJ: Directory of Open Access Journals), 2018

Journal of Pharmaceutical and Biomedical Analysis, Oct 1, 2003

A sensitive and specific reversed phase HPLC method was developed to quantitate plasma levels of ... more A sensitive and specific reversed phase HPLC method was developed to quantitate plasma levels of cisapride in order to conduct comparative bioavailability studies. The drug and internal standard was extracted from plasma with heptane–isoamyl alcohol (95:5 v/v) and back extracted with sulfuric acid. The acidic layer was then re-extracted with the same extracting solvent. The separated organic layer was evaporated

Comparative clinical pathology, Jun 14, 2018

Ethnomedicinal plants are recommended for the prevention, control, and treatment of several disea... more Ethnomedicinal plants are recommended for the prevention, control, and treatment of several diseases. Due to the rapid growth of global interest in use of medicinal plants, their effects and safety evaluation have become substantial. In this study, Bellis perennis L aqueous extract (BP) was extracted to investigate its hematoprotective and nephroprotective activities on renal structural, hematological, and biochemical changes in CCl 4-induced nephrotoxicity in male mice. Fifty male mice were divided into five groups (n = 10): Group I served as control and received 1 mL/kg olive oil intraperitoneally and 0.5 mL distilled water through gavage; group II served as untreated group and received 1 mg/kg CCl 4 mixed with olive oil in the ratio of 1:1, intraperitoneally and 0.5 mL distilled water orally; and groups III, IV, V, and VI received CCl 4 mixed with olive oil in the ratio of 1:1 intraperitoneally and 50, 100, and 200 mg/kg of BP through gavage for 45 consecutive days. At 45th day, the mice were dissected, blood and kidney samples collected for hematological, biochemical, and histological parameters analysis. The data were analyzed using one-way ANOVA and post hoc Duncan's tests. Histologically, different doses of BP (especially BP200) could significantly (p ≤ 0.05) decrease the volume and length of the renal structures as compared to the untreated group. Hematologically, BP could reduce significantly (p ≤ 0.05) the raised levels of WBC, platelet, and increased RBC parameters as compared to the untreated group. Biochemically, BP at all dose (especially BP200) could significantly (p ≤ 0.05) reduce the raised levels of urea and creatinine and increased SOD and CAT levels as compared to the untreated group. BP has protective properties on the kidney and blood, thereby reducing the causation of hematotoxicity and nephrotoxicity in experimental mice.

Comparative clinical pathology, Mar 29, 2018

Using ethno-medicinal plants is the oldest way of mankind to treat the several diseases. Due to t... more Using ethno-medicinal plants is the oldest way of mankind to treat the several diseases. Due to the rapid growth of global interest in use of medicinal plants, their effects and safety evaluation have become substantial. In this study, Alyssum meniocoides (AM) Boiss aqueous extract was extracted to investigate its nephroprotective activity on renal structural and biochemical changes in streptozotocin-induced diabetic nephrotoxicity in male mice. In this study, 80 mice were used. Diabetes was experimentally induced by intraperitoneal injection of streptozotocin (STZ) in 70 mice. Fasting blood glucose (FBG) levels were assessed everyday by glucometer strips. Mice with plasma glucose level > 250 mg/dL were considered diabetic. After 3 days, they were divided randomly into 8 groups. Groups 1 and 2 served as non-diabetic and untreated diabetic controls, respectively. Group 3 received 40 mg/kg glibenclamide orally. Groups 4, 5, 6, 7, and 8 were given 10, 20, 40, 80, and 160 mg/kg, respectively of AM for 20 days orally. At the 20th day, the mice were dissected, blood and kidney samples collected for biochemical and histological analysis. Histologically, several doses of AM could significantly (p ≤ 0.05) decrease the volume and length of the renal structures as compared to the untreated group. Biochemically, AM at all doses could significantly (p ≤ 0.05) reduce the raised levels of urea and creatinine and increased SOD and catalase (CAT) levels as compared to the untreated group. In conclusion, AM has nephroprotective property, thereby reducing the causation of diabetes in experimental mice.

Pharmacoepidemiology and Drug Safety

PurposeHypertension (HTN) is one of the most common risk factors for non‐communicable chronic dis... more PurposeHypertension (HTN) is one of the most common risk factors for non‐communicable chronic diseases. The aim of the current study is to evaluate the prescribing patterns of antihypertensive medications in Kermanshah Province, west of Iran.MethodsThe Ravansar Non‐Communicable Diseases (RaNCD) cohort study is the first Kurdish community‐based study; subjects' age ranged from 35 to 65 years. In order to examine the use of medications to control blood pressure, participants were asked to bring all prescribed medications to the study center. Treatments were compared with 2013 European Society of Hypertension (ESH)/European Society of Cardiology (ESC) Guidelines for the management of arterial HTN.ResultsFrom a total of 10 040 participants in RaNCD cohort, 1575 (15.7%) individuals were hypertensive, of whom, 1271 (80.7%) people were aware of their condition. From 1153 (73.20%) people under treatment, 840 (72.8%) had their HTN properly controlled. The most common medications used to ...