rosalba de nola - Academia.edu (original) (raw)
Papers by rosalba de nola
BMC Infectious Diseases
Background Clinical evidence suggests that pregnant women are more vulnerable to COVID-19, since ... more Background Clinical evidence suggests that pregnant women are more vulnerable to COVID-19, since they are at increased risk for disease progression and for obstetric complications, such as premature labor, miscarriage, preeclampsia, cesarean delivery, fetal growth restriction and perinatal death. Despite this evidence, pregnant women are often excluded from clinical trials, resulting in limited knowledge on COVID-19 management. The aim of this systematic review and meta-analysis is to provide better evidence on the efficacy and safety of available COVID-19 treatment in pregnant women. Methods Four authors searched major electronic databases from inception until 1 st November-2022 for controlled trials/observational studies, investigating outcomes after the administration of anti-SARS-CoV-2 treatments in pregnant women affected by COVID-19. The analyses investigated the cumulative incidence of delivery and maternal outcomes in pregnant women, comparing those taking active medication ...
Abstract Ovarian cancer is a heterogeneous tumor with highly variable clinical features. However,... more Abstract Ovarian cancer is a heterogeneous tumor with highly variable clinical features. However, it is diagnosed based on rigid, traditional criteria, and the prognosis is defined according to the major histomorphological pattern and degree of differentiation of the tumor. Recently, the gene expression profile, mutational status, epigenetic features, and gene drivers of ovarian cancer have been explored in molecular analyses, which has led to the identification of novel disease subtypes based on molecular signatures. In the clinical setting, these signatures not only allow an accurate prognostic prediction but also contribute to targeted therapy that includes angiogenesis inhibitors and small molecules in combination, or not, with conventional chemotherapy. Molecular signatures of ovarian cancer have also been detected in several studies investigating the genomics of high-grade serous tumors. The pro-angiogenic and mesenchymal nature of these signals suggests that major antitumor activity can be achieved with bevacizumab, as the prototypic antiangiogenic drug, and other angiogenesis inhibitors. This chapter summarizes current knowledge of ovarian cancer from a genomic perspective, focusing on the molecular subtypes of these tumors, as revealed using extended high-throughput analyses, as well as the latest personalized treatment options.
Annals of Oncology, Sep 1, 2018
Medicine, 2018
Rationale: PNETs (primitive neuroectodermal tumors) are a family of highly malignant neoplasms ch... more Rationale: PNETs (primitive neuroectodermal tumors) are a family of highly malignant neoplasms characterized by small round cells of neuroepithelial origin. They usually involve bone and soft tissues, and have a higher incidence in childhood. Patient concerns: In this case report, we describe the obstetric and oncological outcome of a huge mass diagnosed as a leiomyoma in a 39-year-old pregnant woman who complained of low back pain, dysuria, and urinary frequency at 22 weeks of gestation. Diagnoses: During the 25th week of pregnancy, the patient was referred to our hospital at night with severe anemia and suspected hemoperitoneum. She underwent an emergency caesarean section, delivering a female fetus weighing 400 g, with an Apgar score of 7 at 1 minute and 9 at 5 minutes. Intervention: During surgery, we found a huge uterine sarcoma-like metastatic tumor, invading the pelvic peritoneum and parametria bilaterally; the adnexae seemed disease-free. We performed a type B radical hysterectomy, bilateral salpingooophorectomy, pelvic peritonectomy, omentectomy, appendectomy, and excision of a bulky lymph node. Seven days after delivery, staging computed tomography (CT) scan demonstrated a large lombo-aortic lymph node compressing the left renal vein and we completed debulking with a second surgery, including diaphragmatic peritonectomy and excision of a huge lymph node by lombo-aortic lymphadenectomy, requiring partial reconstruction of an infiltrated renal vein. Outcome: Ten days after the second surgery, echo-color Doppler showed a regular microcirculation in the left kidney. The patient was discharged after 10 days, and the baby after 1 month, both in good health. Histological examination revealed a uterine body cPNET (central primitive neuroectodermal tumor) orienting the clinical management toward chemotherapy with cisplatin and etoposide. Lessons: PNETs are aggressive neoplasms, usually diagnosed at an advanced stage. Due to their low incidence, universally accepted guidelines are still unavailable. Radical surgery leaving no macroscopic residual disease is mandatory in advanced stages. A good fertility-sparing procedure can be performed only in young women at early stages of disease, when the wish for childbearing is not yet fulfilled. Abbreviations: DSRCT = Desmoplastic Small Round Cell Tumours, EFT = Ewing's family of tumours, FISH = Fluorescence in situ hybridisation, PNETs = primitive neuroectodermal tumours, SCCOHT = small-cell carcinoma of the ovary, hypercalcaemic type.
E-Posters, Nov 1, 2021
evaluating the effect of liberal NACT administration on casemix-standardized median overall survi... more evaluating the effect of liberal NACT administration on casemix-standardized median overall survival and 1-year mortality rates. Results We identified 19,562 patients treated in 332 cancer programs that increased use of NACT from 21.7% in 2004-2009 to 42.2% in 2010-2015 and 19,737 patients treated in 332 programs that marginally increased use of NACT (20.1% to 22.5%) over the same period. Standardized median overall survival improved by similar magnitudes in programs with liberal (from 31.6 to 37.9 months; 6.3-month difference; 95% CI, 4.2-8.3) and restrictive (from 31.4 to 36.8 months; 5.4month difference, 95% CI, 3.5-7.3) use of NACT after 2010 (difference-indifferences , 0.9 months; 95% CI, À1.9 to 3.7). One-year mortality declined more in programs with liberal (from 25.6% to 19.3%; risk difference, À5.2%; 95% CI, À6.4 to À4.1) than with restrictive (from 24.9% to 21.8%; risk difference, À3.2%, 95% CI, À4.3 to À2.0) use of NACT (difference-indifferences , À2.1%; 95% CI, À3.7 to À0.5). Conclusions Compared with cancer programs that administered NACT restrictively, those that administered it liberally achieved similar improvements in median overall survival and larger declines in short-term mortality.
E-Posters, Nov 1, 2021
Objectives Clear cell ovarian cancer (OC) is a rare type of epithelial cancer commonly associated... more Objectives Clear cell ovarian cancer (OC) is a rare type of epithelial cancer commonly associated with endometriosis.
Medicine, Nov 1, 2018
Rationale: Placental site trophoblastic tumor (PSTT) is a very rare malignant tumor, belonging to... more Rationale: Placental site trophoblastic tumor (PSTT) is a very rare malignant tumor, belonging to a family of pregnancy-related illnesses, called gestational trophoblastic diseases (GTD). Less than 300 cases of PSTT have been reported in literature, with an incidence of ≈ 1/50,000-100,000 pregnancies representing only 0.23% to 3.00% of all GTDs. Patient concerns: Our report describes 2 additional cases of PSTT outlining their main diagnostic features and the subsequent management. The first case presented contemporary to a persistent hydatidiform mole in a 37-year-old woman, para 2042; whereas the second one originated 5 years after a miscarriage in 43-year-old woman, para 1031 with a previous diagnosis of breast cancer, and shared some features with placental site nodule (PSN), a benign condition. Diagnosis: The first case had a difficult diagnosis because there was an amenorrhea of 11th week with high serum beta-human chorionic gonadotropin (beta-HCG) and an initial ultrasound image of vesicular mole. After the Dilatation and Curettage, histology confirmed the previous hypothesis. However, the final histology of PSTT was obtained after major surgery. On the contrary, the diagnosis of the second case was less challenging but surprising, thanks to a routine trans-vaginal ultrasound showing a suspicious endometrial thickness positive for PSTT at a subsequent hysteroscopic guided biopsy. Interventions: The treatment consisted of hysterectomy and subsequent follow up. Lymphadenectomy or lymph node sampling were not performed due to the initial stage of the disease. Outcomes: In the first case, there were high values of serum beta-HCG that plummeted after the surgery, whereas in the second one they had been always negative. Hereafter, both went through a follow up with periodic serum oncological markers, imaging studies and clinical evaluation, which have showed negative result for 3 years and 15 months, respectively. Lessons: A detailed gynecological ultrasound examination could be extremely helpful to understand the next diagnostic step of echo-guided D&C or hysteroscopic biopsy and for a pre-operative staging assessment. On the contrary, determining the serum beta-HCG's curve is crucial just in case of an initial positive value to pursue clinical evaluation and follow-up. In case of good prognostic factors, the main therapy remains hysterectomy. Abbreviations: beta-HCG = beta-human chorionic gonadotropin, CC = choriocarcinoma, CK pool = cytokeratin pool, CT-scan = computed tomography scan, D&C = dilatation and curettage, EMA/CO = Etoposide, methotrexate with leucovorin rescue and actinomycin D, given on day 1 and 2 and cyclophosphamide and vincristine given on day 8, EP/EMA = Etoposide and platinum alternating with etoposide, methotrexate/folinic acid rescue, actinomycin-D, ETT = Epithelioid trophoblastic tumor, FIGO = International Federation of Gynecology and Obstetrics, GTD = gestational trophoblastic Disease, GTNs = gestational trophoblastic neoplasms, GTT = gestational trophoblastic tumor, HM = hydatidiform mole, HPL = human placental lactogen, PSN = placental site nodule, PSTT = placental site trophoblastic tumor, TE/TP = Paclitaxel, cisplatin/ paclitaxel, etoposide, WHO = World Health Organization.
Rivista Urologia, Dec 5, 2012
Abbreviations and Acronyms eCrCl ϭ estimated creatinine clearance EGF ϭ epidermal growth factor G... more Abbreviations and Acronyms eCrCl ϭ estimated creatinine clearance EGF ϭ epidermal growth factor GFR ϭ glomerular filtration rate MAG3 ϭ mercaptoacetyltriglycine MCP-1 ϭ monocyte chemotactic peptide-1 UTI ϭ urinary tract infection
Critical Reviews in Oncology Hematology, Jun 1, 2021
Uterine cervical cancer is the fourth most frequent gynecological tumor worldwide. The tumor micr... more Uterine cervical cancer is the fourth most frequent gynecological tumor worldwide. The tumor microenvironment of cervical cancer is the result of persistent high-risk human papillomavirus infection together with stromal activation of estrogen receptor alpha and the pro-angiogenic and pro-inflammatory activity of immune cells, mainly T-helper 17 cells and tumor-associated macrophages. Therapeutic management (e.g., immunotherapy, especially in advanced cases) may be influenced by the translational implications of tumoral stroma crosstalk and an abundance of tumor-infiltrating lymphocytes within the tumor microenvironment. The prognosis of cervical cancer is inversely correlated with microvessel density, making anti-angiogenic strategies with agents such as bevacizumab crucial for improving both progression-free survival and overall survival in patients with advanced and recurrent tumors.
Rivista Urologia, Dec 5, 2012
Vaccines
This is a monocentric and cross-sectional study conducted at the COVID-19 Division of the Obstetr... more This is a monocentric and cross-sectional study conducted at the COVID-19 Division of the Obstetrical and Gynecological Unit and Intensive Care Units (ICUs) of Policlinico di Bari, in Bari, Italy, between September 2020 and April 2022. This study aimed to identify the prevalence of severe-critical COVID-19 illness requiring access to the Intensive Care Unit (ICU) among 287 pregnant patients, and possible correlations between the SARS-CoV-2 variants, the specific pandemic wave (dominated by wild, Alpha, Delta, and Omicron strains), and severe-critical adverse maternal outcomes. The prevalence of severe-critical COVID-19 illness was 2.8% (8/287), reaching 4.9% (8/163) excluding the 4th wave (Omicron dominant). The Delta variant determined the highest risk ratio and odds for access to the ICU due to severe-critical COVID-19-related symptoms compared to the other variants (wild, Alpha, Omicron). During the third wave (Delta), the ICU cases underwent a higher rate of hyperimmune plasma i...
Oncogenomics, 2019
Ovarian cancer is a heterogeneous tumor with highly variable clinical features. However, it is di... more Ovarian cancer is a heterogeneous tumor with highly variable clinical features. However, it is diagnosed based on rigid, traditional criteria, and the prognosis is defined according to the major histomorphological pattern and degree of differentiation of the tumor. Recently, the gene expression profile, mutational status, epigenetic features, and gene drivers of ovarian cancer have been explored in molecular analyses, which has led to the identification of novel disease subtypes based on molecular signatures. In the clinical setting, these signatures not only allow an accurate prognostic prediction but also contribute to targeted therapy that includes angiogenesis inhibitors and small molecules in combination, or not, with conventional chemotherapy. Molecular signatures of ovarian cancer have also been detected in several studies investigating the genomics of high-grade serous tumors. The pro-angiogenic and mesenchymal nature of these signals suggests that major antitumor activity c...
Journal of Urology, 2013
Abbreviations and Acronyms eCrCl ϭ estimated creatinine clearance EGF ϭ epidermal growth factor G... more Abbreviations and Acronyms eCrCl ϭ estimated creatinine clearance EGF ϭ epidermal growth factor GFR ϭ glomerular filtration rate MAG3 ϭ mercaptoacetyltriglycine MCP-1 ϭ monocyte chemotactic peptide-1 UTI ϭ urinary tract infection
Cancers, 2022
Background: Pathogenic variants in homologous recombination repair (HRR) genes other than BRCA1/2... more Background: Pathogenic variants in homologous recombination repair (HRR) genes other than BRCA1/2 have been associated with a high risk of ovarian cancer (OC). In current clinical practice, genetic testing is generally limited to BRCA1/2. Herein, we investigated the mutational status of both BRCA1/2 and 5 HRR genes in 69 unselected OC, evaluating the advantage of multigene panel testing in everyday clinical practice. Methods: We analyzed 69 epithelial OC samples using an NGS custom multigene panel of the 5 HRR pathways genes, beyond the genetic screening routine of BRCA1/2 testing. Results: Overall, 19 pathogenic variants (27.5%) were detected. The majority (21.7%) of patients displayed a deleterious mutation in BRCA1/2, whereas 5.8% harbored a pathogenic variant in one of the HRR genes. Additionally, there were 14 (20.3%) uncertain significant variants (VUS). The assessment of germline mutational status showed that a small number of variants (five) were not detected in the correspo...
Journal of Clinical Medicine, 2021
Background: During the lockdown period caused by the SARS-CoV-2 pandemic, we monitored via online... more Background: During the lockdown period caused by the SARS-CoV-2 pandemic, we monitored via online survey the trend of allergic symptoms and the therapeutic compliance in patients followed at our center. Material and methods: In June 2020, we selected children followed at the Allergy and Immunology Service of Umberto I Hospital, aged between 6 and 16 years old, diagnosed with asthma and/or rhinitis and sensitized to grass pollen or dust mite. We sent an email with 12 multiple-choice questions investigating several areas: type of disease and sensitization, recurrence of symptoms, medication use during lockdown compared to the same period of the previous year. Results: The results of 82 questionnaires showed that 17.8% of patients suffered from asthma, 24.4% from rhinitis, and 57.8% from both. Within the group of asthmatic children, most of them presented an improvement of their symptoms. Likewise, with regard to allergic rhinitis, most of them reported better clinical conditions. Rega...
Critical Reviews in Oncology/Hematology
Uterine cervical cancer is the fourth most frequent gynecological tumor worldwide. The tumor micr... more Uterine cervical cancer is the fourth most frequent gynecological tumor worldwide. The tumor microenvironment of cervical cancer is the result of persistent high-risk human papillomavirus infection together with stromal activation of estrogen receptor alpha and the pro-angiogenic and pro-inflammatory activity of immune cells, mainly T-helper 17 cells and tumor-associated macrophages. Therapeutic management (e.g., immunotherapy, especially in advanced cases) may be influenced by the translational implications of tumoral stroma crosstalk and an abundance of tumor-infiltrating lymphocytes within the tumor microenvironment. The prognosis of cervical cancer is inversely correlated with microvessel density, making anti-angiogenic strategies with agents such as bevacizumab crucial for improving both progression-free survival and overall survival in patients with advanced and recurrent tumors.
BMC Infectious Diseases
Background Clinical evidence suggests that pregnant women are more vulnerable to COVID-19, since ... more Background Clinical evidence suggests that pregnant women are more vulnerable to COVID-19, since they are at increased risk for disease progression and for obstetric complications, such as premature labor, miscarriage, preeclampsia, cesarean delivery, fetal growth restriction and perinatal death. Despite this evidence, pregnant women are often excluded from clinical trials, resulting in limited knowledge on COVID-19 management. The aim of this systematic review and meta-analysis is to provide better evidence on the efficacy and safety of available COVID-19 treatment in pregnant women. Methods Four authors searched major electronic databases from inception until 1 st November-2022 for controlled trials/observational studies, investigating outcomes after the administration of anti-SARS-CoV-2 treatments in pregnant women affected by COVID-19. The analyses investigated the cumulative incidence of delivery and maternal outcomes in pregnant women, comparing those taking active medication ...
Abstract Ovarian cancer is a heterogeneous tumor with highly variable clinical features. However,... more Abstract Ovarian cancer is a heterogeneous tumor with highly variable clinical features. However, it is diagnosed based on rigid, traditional criteria, and the prognosis is defined according to the major histomorphological pattern and degree of differentiation of the tumor. Recently, the gene expression profile, mutational status, epigenetic features, and gene drivers of ovarian cancer have been explored in molecular analyses, which has led to the identification of novel disease subtypes based on molecular signatures. In the clinical setting, these signatures not only allow an accurate prognostic prediction but also contribute to targeted therapy that includes angiogenesis inhibitors and small molecules in combination, or not, with conventional chemotherapy. Molecular signatures of ovarian cancer have also been detected in several studies investigating the genomics of high-grade serous tumors. The pro-angiogenic and mesenchymal nature of these signals suggests that major antitumor activity can be achieved with bevacizumab, as the prototypic antiangiogenic drug, and other angiogenesis inhibitors. This chapter summarizes current knowledge of ovarian cancer from a genomic perspective, focusing on the molecular subtypes of these tumors, as revealed using extended high-throughput analyses, as well as the latest personalized treatment options.
Annals of Oncology, Sep 1, 2018
Medicine, 2018
Rationale: PNETs (primitive neuroectodermal tumors) are a family of highly malignant neoplasms ch... more Rationale: PNETs (primitive neuroectodermal tumors) are a family of highly malignant neoplasms characterized by small round cells of neuroepithelial origin. They usually involve bone and soft tissues, and have a higher incidence in childhood. Patient concerns: In this case report, we describe the obstetric and oncological outcome of a huge mass diagnosed as a leiomyoma in a 39-year-old pregnant woman who complained of low back pain, dysuria, and urinary frequency at 22 weeks of gestation. Diagnoses: During the 25th week of pregnancy, the patient was referred to our hospital at night with severe anemia and suspected hemoperitoneum. She underwent an emergency caesarean section, delivering a female fetus weighing 400 g, with an Apgar score of 7 at 1 minute and 9 at 5 minutes. Intervention: During surgery, we found a huge uterine sarcoma-like metastatic tumor, invading the pelvic peritoneum and parametria bilaterally; the adnexae seemed disease-free. We performed a type B radical hysterectomy, bilateral salpingooophorectomy, pelvic peritonectomy, omentectomy, appendectomy, and excision of a bulky lymph node. Seven days after delivery, staging computed tomography (CT) scan demonstrated a large lombo-aortic lymph node compressing the left renal vein and we completed debulking with a second surgery, including diaphragmatic peritonectomy and excision of a huge lymph node by lombo-aortic lymphadenectomy, requiring partial reconstruction of an infiltrated renal vein. Outcome: Ten days after the second surgery, echo-color Doppler showed a regular microcirculation in the left kidney. The patient was discharged after 10 days, and the baby after 1 month, both in good health. Histological examination revealed a uterine body cPNET (central primitive neuroectodermal tumor) orienting the clinical management toward chemotherapy with cisplatin and etoposide. Lessons: PNETs are aggressive neoplasms, usually diagnosed at an advanced stage. Due to their low incidence, universally accepted guidelines are still unavailable. Radical surgery leaving no macroscopic residual disease is mandatory in advanced stages. A good fertility-sparing procedure can be performed only in young women at early stages of disease, when the wish for childbearing is not yet fulfilled. Abbreviations: DSRCT = Desmoplastic Small Round Cell Tumours, EFT = Ewing's family of tumours, FISH = Fluorescence in situ hybridisation, PNETs = primitive neuroectodermal tumours, SCCOHT = small-cell carcinoma of the ovary, hypercalcaemic type.
E-Posters, Nov 1, 2021
evaluating the effect of liberal NACT administration on casemix-standardized median overall survi... more evaluating the effect of liberal NACT administration on casemix-standardized median overall survival and 1-year mortality rates. Results We identified 19,562 patients treated in 332 cancer programs that increased use of NACT from 21.7% in 2004-2009 to 42.2% in 2010-2015 and 19,737 patients treated in 332 programs that marginally increased use of NACT (20.1% to 22.5%) over the same period. Standardized median overall survival improved by similar magnitudes in programs with liberal (from 31.6 to 37.9 months; 6.3-month difference; 95% CI, 4.2-8.3) and restrictive (from 31.4 to 36.8 months; 5.4month difference, 95% CI, 3.5-7.3) use of NACT after 2010 (difference-indifferences , 0.9 months; 95% CI, À1.9 to 3.7). One-year mortality declined more in programs with liberal (from 25.6% to 19.3%; risk difference, À5.2%; 95% CI, À6.4 to À4.1) than with restrictive (from 24.9% to 21.8%; risk difference, À3.2%, 95% CI, À4.3 to À2.0) use of NACT (difference-indifferences , À2.1%; 95% CI, À3.7 to À0.5). Conclusions Compared with cancer programs that administered NACT restrictively, those that administered it liberally achieved similar improvements in median overall survival and larger declines in short-term mortality.
E-Posters, Nov 1, 2021
Objectives Clear cell ovarian cancer (OC) is a rare type of epithelial cancer commonly associated... more Objectives Clear cell ovarian cancer (OC) is a rare type of epithelial cancer commonly associated with endometriosis.
Medicine, Nov 1, 2018
Rationale: Placental site trophoblastic tumor (PSTT) is a very rare malignant tumor, belonging to... more Rationale: Placental site trophoblastic tumor (PSTT) is a very rare malignant tumor, belonging to a family of pregnancy-related illnesses, called gestational trophoblastic diseases (GTD). Less than 300 cases of PSTT have been reported in literature, with an incidence of ≈ 1/50,000-100,000 pregnancies representing only 0.23% to 3.00% of all GTDs. Patient concerns: Our report describes 2 additional cases of PSTT outlining their main diagnostic features and the subsequent management. The first case presented contemporary to a persistent hydatidiform mole in a 37-year-old woman, para 2042; whereas the second one originated 5 years after a miscarriage in 43-year-old woman, para 1031 with a previous diagnosis of breast cancer, and shared some features with placental site nodule (PSN), a benign condition. Diagnosis: The first case had a difficult diagnosis because there was an amenorrhea of 11th week with high serum beta-human chorionic gonadotropin (beta-HCG) and an initial ultrasound image of vesicular mole. After the Dilatation and Curettage, histology confirmed the previous hypothesis. However, the final histology of PSTT was obtained after major surgery. On the contrary, the diagnosis of the second case was less challenging but surprising, thanks to a routine trans-vaginal ultrasound showing a suspicious endometrial thickness positive for PSTT at a subsequent hysteroscopic guided biopsy. Interventions: The treatment consisted of hysterectomy and subsequent follow up. Lymphadenectomy or lymph node sampling were not performed due to the initial stage of the disease. Outcomes: In the first case, there were high values of serum beta-HCG that plummeted after the surgery, whereas in the second one they had been always negative. Hereafter, both went through a follow up with periodic serum oncological markers, imaging studies and clinical evaluation, which have showed negative result for 3 years and 15 months, respectively. Lessons: A detailed gynecological ultrasound examination could be extremely helpful to understand the next diagnostic step of echo-guided D&C or hysteroscopic biopsy and for a pre-operative staging assessment. On the contrary, determining the serum beta-HCG's curve is crucial just in case of an initial positive value to pursue clinical evaluation and follow-up. In case of good prognostic factors, the main therapy remains hysterectomy. Abbreviations: beta-HCG = beta-human chorionic gonadotropin, CC = choriocarcinoma, CK pool = cytokeratin pool, CT-scan = computed tomography scan, D&C = dilatation and curettage, EMA/CO = Etoposide, methotrexate with leucovorin rescue and actinomycin D, given on day 1 and 2 and cyclophosphamide and vincristine given on day 8, EP/EMA = Etoposide and platinum alternating with etoposide, methotrexate/folinic acid rescue, actinomycin-D, ETT = Epithelioid trophoblastic tumor, FIGO = International Federation of Gynecology and Obstetrics, GTD = gestational trophoblastic Disease, GTNs = gestational trophoblastic neoplasms, GTT = gestational trophoblastic tumor, HM = hydatidiform mole, HPL = human placental lactogen, PSN = placental site nodule, PSTT = placental site trophoblastic tumor, TE/TP = Paclitaxel, cisplatin/ paclitaxel, etoposide, WHO = World Health Organization.
Rivista Urologia, Dec 5, 2012
Abbreviations and Acronyms eCrCl ϭ estimated creatinine clearance EGF ϭ epidermal growth factor G... more Abbreviations and Acronyms eCrCl ϭ estimated creatinine clearance EGF ϭ epidermal growth factor GFR ϭ glomerular filtration rate MAG3 ϭ mercaptoacetyltriglycine MCP-1 ϭ monocyte chemotactic peptide-1 UTI ϭ urinary tract infection
Critical Reviews in Oncology Hematology, Jun 1, 2021
Uterine cervical cancer is the fourth most frequent gynecological tumor worldwide. The tumor micr... more Uterine cervical cancer is the fourth most frequent gynecological tumor worldwide. The tumor microenvironment of cervical cancer is the result of persistent high-risk human papillomavirus infection together with stromal activation of estrogen receptor alpha and the pro-angiogenic and pro-inflammatory activity of immune cells, mainly T-helper 17 cells and tumor-associated macrophages. Therapeutic management (e.g., immunotherapy, especially in advanced cases) may be influenced by the translational implications of tumoral stroma crosstalk and an abundance of tumor-infiltrating lymphocytes within the tumor microenvironment. The prognosis of cervical cancer is inversely correlated with microvessel density, making anti-angiogenic strategies with agents such as bevacizumab crucial for improving both progression-free survival and overall survival in patients with advanced and recurrent tumors.
Rivista Urologia, Dec 5, 2012
Vaccines
This is a monocentric and cross-sectional study conducted at the COVID-19 Division of the Obstetr... more This is a monocentric and cross-sectional study conducted at the COVID-19 Division of the Obstetrical and Gynecological Unit and Intensive Care Units (ICUs) of Policlinico di Bari, in Bari, Italy, between September 2020 and April 2022. This study aimed to identify the prevalence of severe-critical COVID-19 illness requiring access to the Intensive Care Unit (ICU) among 287 pregnant patients, and possible correlations between the SARS-CoV-2 variants, the specific pandemic wave (dominated by wild, Alpha, Delta, and Omicron strains), and severe-critical adverse maternal outcomes. The prevalence of severe-critical COVID-19 illness was 2.8% (8/287), reaching 4.9% (8/163) excluding the 4th wave (Omicron dominant). The Delta variant determined the highest risk ratio and odds for access to the ICU due to severe-critical COVID-19-related symptoms compared to the other variants (wild, Alpha, Omicron). During the third wave (Delta), the ICU cases underwent a higher rate of hyperimmune plasma i...
Oncogenomics, 2019
Ovarian cancer is a heterogeneous tumor with highly variable clinical features. However, it is di... more Ovarian cancer is a heterogeneous tumor with highly variable clinical features. However, it is diagnosed based on rigid, traditional criteria, and the prognosis is defined according to the major histomorphological pattern and degree of differentiation of the tumor. Recently, the gene expression profile, mutational status, epigenetic features, and gene drivers of ovarian cancer have been explored in molecular analyses, which has led to the identification of novel disease subtypes based on molecular signatures. In the clinical setting, these signatures not only allow an accurate prognostic prediction but also contribute to targeted therapy that includes angiogenesis inhibitors and small molecules in combination, or not, with conventional chemotherapy. Molecular signatures of ovarian cancer have also been detected in several studies investigating the genomics of high-grade serous tumors. The pro-angiogenic and mesenchymal nature of these signals suggests that major antitumor activity c...
Journal of Urology, 2013
Abbreviations and Acronyms eCrCl ϭ estimated creatinine clearance EGF ϭ epidermal growth factor G... more Abbreviations and Acronyms eCrCl ϭ estimated creatinine clearance EGF ϭ epidermal growth factor GFR ϭ glomerular filtration rate MAG3 ϭ mercaptoacetyltriglycine MCP-1 ϭ monocyte chemotactic peptide-1 UTI ϭ urinary tract infection
Cancers, 2022
Background: Pathogenic variants in homologous recombination repair (HRR) genes other than BRCA1/2... more Background: Pathogenic variants in homologous recombination repair (HRR) genes other than BRCA1/2 have been associated with a high risk of ovarian cancer (OC). In current clinical practice, genetic testing is generally limited to BRCA1/2. Herein, we investigated the mutational status of both BRCA1/2 and 5 HRR genes in 69 unselected OC, evaluating the advantage of multigene panel testing in everyday clinical practice. Methods: We analyzed 69 epithelial OC samples using an NGS custom multigene panel of the 5 HRR pathways genes, beyond the genetic screening routine of BRCA1/2 testing. Results: Overall, 19 pathogenic variants (27.5%) were detected. The majority (21.7%) of patients displayed a deleterious mutation in BRCA1/2, whereas 5.8% harbored a pathogenic variant in one of the HRR genes. Additionally, there were 14 (20.3%) uncertain significant variants (VUS). The assessment of germline mutational status showed that a small number of variants (five) were not detected in the correspo...
Journal of Clinical Medicine, 2021
Background: During the lockdown period caused by the SARS-CoV-2 pandemic, we monitored via online... more Background: During the lockdown period caused by the SARS-CoV-2 pandemic, we monitored via online survey the trend of allergic symptoms and the therapeutic compliance in patients followed at our center. Material and methods: In June 2020, we selected children followed at the Allergy and Immunology Service of Umberto I Hospital, aged between 6 and 16 years old, diagnosed with asthma and/or rhinitis and sensitized to grass pollen or dust mite. We sent an email with 12 multiple-choice questions investigating several areas: type of disease and sensitization, recurrence of symptoms, medication use during lockdown compared to the same period of the previous year. Results: The results of 82 questionnaires showed that 17.8% of patients suffered from asthma, 24.4% from rhinitis, and 57.8% from both. Within the group of asthmatic children, most of them presented an improvement of their symptoms. Likewise, with regard to allergic rhinitis, most of them reported better clinical conditions. Rega...
Critical Reviews in Oncology/Hematology
Uterine cervical cancer is the fourth most frequent gynecological tumor worldwide. The tumor micr... more Uterine cervical cancer is the fourth most frequent gynecological tumor worldwide. The tumor microenvironment of cervical cancer is the result of persistent high-risk human papillomavirus infection together with stromal activation of estrogen receptor alpha and the pro-angiogenic and pro-inflammatory activity of immune cells, mainly T-helper 17 cells and tumor-associated macrophages. Therapeutic management (e.g., immunotherapy, especially in advanced cases) may be influenced by the translational implications of tumoral stroma crosstalk and an abundance of tumor-infiltrating lymphocytes within the tumor microenvironment. The prognosis of cervical cancer is inversely correlated with microvessel density, making anti-angiogenic strategies with agents such as bevacizumab crucial for improving both progression-free survival and overall survival in patients with advanced and recurrent tumors.