saleh othman - Academia.edu (original) (raw)

Papers by saleh othman

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 1998

The aim of this work is to see whether distinction between biliary atresia and biliary hypoplasia... more The aim of this work is to see whether distinction between biliary atresia and biliary hypoplasia is possible or not and to present the value and usefulness of hepatobiliary scintigraphy in the investigation of infants with persistent hyperbilirubinemia. Seventy-seven patients of the age between five days and six months (average 62 days), 43 females and 34 males of which 65 Saudi, and 12 non-Saudis were investigated. Laboratory tests, abdominal ultrasound, hepatobiliary scintigraphy, liver biopsy, explorative laparatomy and intraoperative cholangiography were performed whenever indicated. The findings on hepatobiliary scintigraphy of nonvisualization of the gallbladder and no activity in the bowel upto 24 hours post injection were considered consistent with the diagnosis of biliary atresia. Minimal bowel activity, or visualization of the gallbladder where consistent with biliary hypoplasia. In addition, the liver in the two entities appeared in a different shape and can be used as a...

Pak J Med Sci July-September, 2009

Objective: To select a subgroup of type-2 diabetics with two additional prespecified risk factors... more Objective: To select a subgroup of type-2 diabetics with two additional prespecified risk factors to see that whether there is any benefit of screening such patients. Methodology: Five hundred twenty six patients were sent for treadmill stress test or thallium scan. Those who had abnormal results were advised coronary angiography. The angiographically proven CAD was correlated with various risk factors to find the relationship between the disease and variables. Results: Two hundred thirty five (48%) patients had abnormal results and among them 158 (67%) underwent coronary angiography. Among these 21% had evidence of CAD. Coronary artery bypass grafting (CABG) was performed in 35(33%) patients, catheter based intervention (PCI) in 44(40%) patients and 30(27%) patients were not suitable for intervention. Duration of diabetes, smoking, diabetic retinopathy, albuminuria, and peripheral vascular disease were significant predictor of asymptomatic CAD. Conclusion: This study has demonstrated strong relationship between risk factors and asymptomatic CAD in type2 diabetics.

Saudi medical …, 2006

Objective: To report on moyamoya syndrome (MMS) as a risk factor for stroke in a prospective and ... more Objective: To report on moyamoya syndrome (MMS) as a risk factor for stroke in a prospective and retrospective cohort of Saudi children. The usual and novel associations of MMS in this cohort will also be described. Methods: Children with stroke were evaluated at the Division of ...

Childs Nervous System, 1997

Six patients (4 boys and 2 girls) with hemiconvulsion-hemiplegia-epilepsy (HHE) syndrome are desc... more Six patients (4 boys and 2 girls) with hemiconvulsion-hemiplegia-epilepsy (HHE) syndrome are described. They had prolonged seizures, lasting from 30 min to 12 h, at ages 1–4 years. These took the form of hemiconvulsion in three of the children and generalized tonic–clonic seizures in the others, being preceded by hemifacial twitching or head and eye deviation in two. They were followed by hemiplegia, which cleared with time in five patients, apart from subtle pyramidal tract signs. One child had spastic quadriparesis, choreiform movements, contracture deformities and severe mental retardation following repeated status epilepticus. Subsequent epilepsy developed in five patients and was satisfactorily controlled with carbamazepine and/or phenobarbitone. Cerebral hemiatrophy was documented in all patients by cranial computed tomography and/or magnetic resonance imaging. Single photon emission computed tomography (done in 4 patients) showed ipsilateral hypoperfusion (of the damaged hemi...

Saudi Medical Journal, 1997

Objectives: To present the value and usefulness of hepatobiliary scintigraphy in the investigatio... more Objectives: To present the value and usefulness of hepatobiliary scintigraphy in the investigation of infants with persistent hyperbilirubinemia through our experience in King Khaled University Hospital at King Saud University, Riyadh. Setting: King Khalid University Hospital, Departments of Nuclear Medicine, Pediatrics and Pediatric Surgery. Patients and methods: Seventy-seven patients aged between 5 days and 6 months (average 62 days ), 43 females and 34 males, 65 Saudi and 12 non-Saudi were investigated. Laboratory tests, abdominal ultrasound, hepatobiliary scintigraphy, liver biopsy, explorative laparatomy and intraoperative cholangiography were performed whenever indicated. The findings on hepatobiliary scintigraphy of non-visualization of the gallbladder and no activity in the bowel up to 24 hours post injection (p.i.) were considered consistent with the diagnosis of biliary atresia. Results: Thirty four infants were diagnosed by hepatobiliary scintigraphy as having biliary at...

Pakistan Journal of Medical Sciences, 2009

Objective: To select a subgroup of type-2 diabetics with two additional prespecified risk factors... more Objective: To select a subgroup of type-2 diabetics with two additional prespecified risk factors to see that whether there is any benefit of screening such patients. Methodology: Five hundred twenty six patients were sent for treadmill stress test or thallium scan. Those who had abnormal results were advised coronary angiography. The angiographically proven CAD was correlated with various risk factors to find the relationship between the disease and variables. Results: Two hundred thirty five (48%) patients had abnormal results and among them 158 (67%) underwent coronary angiography. Among these 21% had evidence of CAD. Coronary artery bypass grafting (CABG) was performed in 35(33%) patients, catheter based intervention (PCI) in 44(40%) patients and 30(27%) patients were not suitable for intervention. Duration of diabetes, smoking, diabetic retinopathy, albuminuria, and peripheral vascular disease were significant predictor of asymptomatic CAD. Conclusion: This study has demonstrat...

Asia Pacific Journal of Multidisciplinary Research, 2015

The objective of this study was to assess the diagnostic value of quantitative ultrasound (QUS) a... more The objective of this study was to assess the diagnostic value of quantitative ultrasound (QUS) and Osteoporosis self-assessment tool (OST) compared with Dual Energy x-ray absorptiometry (DXA), and to identify the best cut-off value for determining low bone mineral density (BMD) among postmenopausal women in Riyadh, Saudi Arabia. We conducted a community based cross-sectional study on 224 randomly selected post-menopausal women. Women visited primary heath care centers for answering self-administered questionnaireand screening for low BMD using QUS technique. OST was calculated based on age and weight. DXA scanwas performedforlumbar spine and femur neck at King Khalid University Hospital, Riyadh. Mean age of participants was 58.05(±8.97) years. The prevalence of low BMD at lumbar spine and femur neck was 56% and 28% respectively. The best cut-off value for QUS and OST was ≤-1 and ≤2 respectively. QUS yielded sensitivity and specificity of 73% vs 47% for lumbar spine (area under curv...

... 1988) Abstract. 24 children with urolithiasis of the upper urinary tract were treated by extr... more ... 1988) Abstract. 24 children with urolithiasis of the upper urinary tract were treated by extracorporeal shock wave lithotripsy (ESWL). ... In conclusion we believe that ESWL is a success-ful, low-risk procedure for treatment of upper uri-nary tract urolithiasis in children. ...

Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India

A 33 years old female patient with chronic renal transplant rejection proved by MAG3, ultrasound ... more A 33 years old female patient with chronic renal transplant rejection proved by MAG3, ultrasound and graft biopsy presented with abdominal pain and fever. Part of her work up included gallium-67 scan which revealed diffuse abnormal graft uptake with multifocal areas of marked uptake. Findings were interpreted as acute lobar nephronia. Repeat gallium scan two weeks after intravenous antibiotic therapy showed significant response reflected by resolution of most of focal areas of increased uptake which was parallel to clinical improvement.

Acta Endocrinologica (Bucharest), 2014

Objective: To select a subgroup of type-2 diabetics with two additional prespecified risk factors... more Objective: To select a subgroup of type-2 diabetics with two additional prespecified risk factors to see that whether there is any benefit of screening such patients. Methodology: Five hundred twenty six patients were sent for treadmill stress test or thallium scan. Those who had abnormal results were advised coronary angiography. The angiographically proven CAD was correlated with various risk factors to find the relationship between the disease and variables. Results: Two hundred thirty five (48%) patients had abnormal results and among them 158 (67%) underwent coronary angiography. Among these 21% had evidence of CAD. Coronary artery bypass grafting (CABG) was performed in 35(33%) patients, catheter based intervention (PCI) in 44(40%) patients and 30(27%) patients were not suitable for intervention. Duration of diabetes, smoking, diabetic retinopathy, albuminuria, and peripheral vascular disease were significant predictor of asymptomatic CAD. Conclusion: This study has demonstrated strong relationship between risk factors and asymptomatic CAD in type2 diabetics.

Singapore medical journal, 2011

We report a case of mycosis fungoides in a 27-year-old woman who presented with a lump in the for... more We report a case of mycosis fungoides in a 27-year-old woman who presented with a lump in the forehead. The condition was confirmed with tissue diagnosis. Gallium scintigraphy accurately delineated the complete extent of the disease, and served as a reference for objective assessment of response of the disease to treatment.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 1997

The objective is to present the usefulness of hepatobiliary scintigraphy in the investigation of ... more The objective is to present the usefulness of hepatobiliary scintigraphy in the investigation of children with suspected choledochal cysts through our experience in King Khalid University Hospital at King Saud University, Riyadh. Seven patients aged between I and 10 years (average 4.8 yrs) comprising six females and one male were investigated. Laboratory tests, abdominal Ultrasound and/or CT, and cholangiography were performed whenever indicated. Persistent activity in a dilated common bile duct, with or without dilatation of intrahepatic bile ducts, was considered a positive indicator for choledochal cyst disease. Four children with cystic dilatation (type I) were diagnosed by hepatobiliary scintigraphy, one saccular (type II), and two cases of Caroli's disease (type V). The diagnosis of choledochal cyst was proven by surgery with histological confirmation. Visualization of the gallbladder occurred in one case only. The common bile duct was seen in four cases. Late activity in ...

Saudi medical journal, 2005

We conducted this prospective study to establish the correlation between dual energy x-ray absorp... more We conducted this prospective study to establish the correlation between dual energy x-ray absorptiometry (DXA), quantitative ultrasound (QUS) and single energy x-ray absorptiometry (SXA) and to establish the role of QUS and SXA as a screening tool for osteoporosis. We carried out measurements of bone mineral density (BMD) of lumbar spine and femoral neck using DXA, QUS of heel using ultrasound densitometer, and BMD of forearm using SXA. We performed all the measurements at the Nuclear Medicine Division of King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between 2002 and 2004. We obtained the measurements of 437 female adult patients, aged 20-87 years. We expressed all the values as mean +/- SD. The BMD (g/cm2) of lumbar spine was 1 +/- 0.18, and femoral neck was 0.88 +/- 0.17. The broad band ultrasound attenuation (BUA) of the heel was 74.9 +/- 39.1 dB/MHz, the speed of sound (SOS) was 1542.5 +/- 81.4 m/s, and the estimated BMD was 0.52 +/- 0.15 (g/cm2). The BMD of ...

Saudi medical journal, 2004

To assess the prevalence of osteopenia and osteoporosis among Saudi postmenopausal women with non... more To assess the prevalence of osteopenia and osteoporosis among Saudi postmenopausal women with non-insulin dependent type 2 diabetes mellitus (T2DM). The study was carried out at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia from February 2000 to September 2002. Bone mineral density (BMD) of the lumbar spine and femoral neck using dual x-ray absorptiometry (DXA; Lunar Wisconsin), were performed in 104 postmenopausal Saudi women with T2DM, and 101 postmenopausal non-diabetic women (control). Bone mineral density was measured in gm/cm2 and both T-score and Z-score were measured but only T-score was used for analysis based on World Health Organization criteria. Bone profile, 25(OH) Vitamin D, 1,25(OH)2 Vitamin D, parathyroid hormone and urine deoxypyridinoline (DPD) were measured in most patients and controls. Body fat measurement around the biceps muscles using Futrex (body composition analyzer) were performed in patients and controls. Years postmenopausal, duration ...

Saudi medical journal, 2004

This prospective study was conducted to demonstrate the role of bone mineral density (BMD) and bo... more This prospective study was conducted to demonstrate the role of bone mineral density (BMD) and bone scan in the management of adult Saudi female patients with established diagnosis of osteomalacia. Bone scan using Tc99m methylene diphosphonate (MDP) and BMD of the lumbar spine and femoral neck using dual x-ray absorptiometry (DXA) were performed at the time of diagnosis 6 months and one year after therapy in 96 Saudi female patients attending the metabolic bone disease clinic at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia, between January 1997 through to June 1999, aged between 20 and 73-years (mean 42 years). Alkaline phosphatase, calcium and inorganic phosphorus were measured for all patients before and after treatment. 25 Hydroxy Vitamin D was only measured with the first BMD measurements. The bone profile showed typical biochemical abnormalities of osteomalacia. The bone scan showed feature of "superscan" in all patients and "pseudofractures&q...

Journal of Ayub Medical College, Abbottabad : JAMC

Image Registration is a process of aligning two or more images so that corresponding feature can ... more Image Registration is a process of aligning two or more images so that corresponding feature can be related objectively. Integration of corresponding and complementary information from various images has become an important area of computation in medical imaging. Merging different images of the same patient taken by different modalities or acquired at different times is quite useful in interpreting lower resolution functional images, such as those provided by nuclear medicine, in determining spatial relationships of structures seen in different modalities. This will help in planning surgery and longitudinal follow up. The aim of this article was to introduce image registration to all those who are working in field of medical sciences in general and medical doctors in particular; and indicate how and where this specialty is moving to provide better health care services.

Saudi medical journal, 2006

To report on moyamoya syndrome (MMS) as a risk factor for stroke in a prospective and retrospecti... more To report on moyamoya syndrome (MMS) as a risk factor for stroke in a prospective and retrospective cohort of Saudi children. The usual and novel associations of MMS in this cohort will also be described. Children with stroke were evaluated at the Division of Pediatric Neurology at King Khalid University Hospital, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia during the periods July 1992 to February 2001 (retrospective study) and February 2001 to March 2003 (prospective study). Investigations for suspected cases included hemostatic assays, biochemical, and serological tests. Neuroimaging included CT, MRI, magnetic resonance angiography (MRA), single photon computerized tomography (SPECT) brain scan and conventional cerebral angiography. Moyamoya syndrome was the underlying risk factor for stroke in 6 (5.8%) of the 104 children (aged one month to 12 years). They were 4 females and 2 males. Their first cerebral ischemic event occurred at a mean age of 45 m...

The Open Pediatric Medicine Journal, 2009

Background: Herpes Simplex Virus (HSV) is the most common cause of acute sporadic focal encephali... more Background: Herpes Simplex Virus (HSV) is the most common cause of acute sporadic focal encephalitis. Early Diagnosis is, therefore, crucial for predicting outcome. Improved laboratory technology and improved neuroimaging accessibility have enhanced our ability to diagnose this condition. Aims: To assess the reliability of different investigative tools in diagnosing and subsequent management of herpes simplex encephalitis (HSE); as well as the impact of infection and its relapse on the outcome of a cohort of 18 children evaluated during a period of 13 years. Methods: This combined prospective and retrospective study describes the clinical, laboratory, electroencephalographic and diagnostic imaging studies; and outcome in a cohort of 18 children with HSE over a period of 13 years. It also details the clinical and diagnostic features of 3 patients who relapsed. Results: The commonest initial presenting symptoms and signs were fever (100%), seizures (72%) irritability (50%) and weakness/hemiparesis (39%). Cerebrospinal fluid (CSF) pleocytosis was found in 62%, red blood cells (RBCs) >10x10 6 /L in 81% and raised proteins (>0.59g/L) in 52%. Examination for herpes simplex virus (HSV) by polymerase chain reaction (PCR) was positive in 50% (6/12). Electroencephalographic changes were universally abnormal (17/17; 100%) and periodic lateralization discharges (PLEDS) were seen in 35% (6/17). During the acute stage (days 1-8 from symptom onset), magnetic resonance imaging (MRI) revealed abnormalities in 91% (10/11), cranial computed tomography (CT) in 50% (5/10) and single photon emission computed tomography (SPECT), within < 7 days, in 75% (6/8). All patients were treated with intravenous acyclovir. There were no deaths but 3 patients relapsed after periods ranging between 18 days and 66 months. Eleven (61%) patients had no or minor sequelae (good outcome) and 7 (39%) had moderate or severe sequelae (poor outcome). Delayed initiation of therapy (> 3days from onset of symptoms) had significant association with poor outcome (P = 0.002). Initial negative PCR results may become positive on subsequent CSF specimen. Conclusion: Diagnosis of HSE requires combined clinical, laboratory, electroencephalographic and neuroimaging studies. Negative results of PCR do not exclude the infection and should not interrupt the treatment. Early diagnosis and initiation of treatment minimize the devastating effect of HSE. Full course treatment with acyclovir for 21 days is also crucial for prognosis and prevention of subsequent relapse.

Saudi Journal of Gastroenterology, 2012

Background/Aim: The objective of this study was to assess the value of hepatobiliary scintigraphy... more Background/Aim: The objective of this study was to assess the value of hepatobiliary scintigraphy (HS) for the diagnosis of right upper quadrant (RUQ) abdominal pain in patients with normal hepatobiliary ultrasound (HU). This is an observational study with a retrospective analysis of data from March 2008 to August 2010. Materials and Methods: We reviewed the HS results of 30 patients, aged 29-69 years (average 45.8 years); 12 male and 18 female patients. Patient selection to perform the HS was RUQ abdominal pain, suspected hepatobiliary disorder, and negative HU. All patients had gone through the standard procedure of HS. Results: Based on predefined interpretation criteria, HS results were divided into 2 patterns: Normal (n=8, 25.8%) and abnormal (n=22, 73%): 18 patients (81.8%) having early gallbladder (GB) and common bile duct visualization, and delayed transit to small bowel (SB), which can be seen only after a fatty meal with normal or abnormal GB ejection fraction (GBEF) pattern characteristic of Oddi's sphincter dyskinesia. The remaining 4 patients (8.18%) had acalculous cholycystitis pattern: Delayed GB visualization with activity appearing in SB before GB. Conclusion: HS with fatty meal stimulation and GBEF estimation seems to be a reliable test, which may reveal a biliary cause in more than 70% of patients with RUQ abdominal pain and normal HU. Normal results exclude functional biliary cause. The decision for invasive or noninvasive therapeutic approach may depend on the results of HS.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 1998

The aim of this work is to see whether distinction between biliary atresia and biliary hypoplasia... more The aim of this work is to see whether distinction between biliary atresia and biliary hypoplasia is possible or not and to present the value and usefulness of hepatobiliary scintigraphy in the investigation of infants with persistent hyperbilirubinemia. Seventy-seven patients of the age between five days and six months (average 62 days), 43 females and 34 males of which 65 Saudi, and 12 non-Saudis were investigated. Laboratory tests, abdominal ultrasound, hepatobiliary scintigraphy, liver biopsy, explorative laparatomy and intraoperative cholangiography were performed whenever indicated. The findings on hepatobiliary scintigraphy of nonvisualization of the gallbladder and no activity in the bowel upto 24 hours post injection were considered consistent with the diagnosis of biliary atresia. Minimal bowel activity, or visualization of the gallbladder where consistent with biliary hypoplasia. In addition, the liver in the two entities appeared in a different shape and can be used as a...

Pak J Med Sci July-September, 2009

Objective: To select a subgroup of type-2 diabetics with two additional prespecified risk factors... more Objective: To select a subgroup of type-2 diabetics with two additional prespecified risk factors to see that whether there is any benefit of screening such patients. Methodology: Five hundred twenty six patients were sent for treadmill stress test or thallium scan. Those who had abnormal results were advised coronary angiography. The angiographically proven CAD was correlated with various risk factors to find the relationship between the disease and variables. Results: Two hundred thirty five (48%) patients had abnormal results and among them 158 (67%) underwent coronary angiography. Among these 21% had evidence of CAD. Coronary artery bypass grafting (CABG) was performed in 35(33%) patients, catheter based intervention (PCI) in 44(40%) patients and 30(27%) patients were not suitable for intervention. Duration of diabetes, smoking, diabetic retinopathy, albuminuria, and peripheral vascular disease were significant predictor of asymptomatic CAD. Conclusion: This study has demonstrated strong relationship between risk factors and asymptomatic CAD in type2 diabetics.

Saudi medical …, 2006

Objective: To report on moyamoya syndrome (MMS) as a risk factor for stroke in a prospective and ... more Objective: To report on moyamoya syndrome (MMS) as a risk factor for stroke in a prospective and retrospective cohort of Saudi children. The usual and novel associations of MMS in this cohort will also be described. Methods: Children with stroke were evaluated at the Division of ...

Childs Nervous System, 1997

Six patients (4 boys and 2 girls) with hemiconvulsion-hemiplegia-epilepsy (HHE) syndrome are desc... more Six patients (4 boys and 2 girls) with hemiconvulsion-hemiplegia-epilepsy (HHE) syndrome are described. They had prolonged seizures, lasting from 30 min to 12 h, at ages 1–4 years. These took the form of hemiconvulsion in three of the children and generalized tonic–clonic seizures in the others, being preceded by hemifacial twitching or head and eye deviation in two. They were followed by hemiplegia, which cleared with time in five patients, apart from subtle pyramidal tract signs. One child had spastic quadriparesis, choreiform movements, contracture deformities and severe mental retardation following repeated status epilepticus. Subsequent epilepsy developed in five patients and was satisfactorily controlled with carbamazepine and/or phenobarbitone. Cerebral hemiatrophy was documented in all patients by cranial computed tomography and/or magnetic resonance imaging. Single photon emission computed tomography (done in 4 patients) showed ipsilateral hypoperfusion (of the damaged hemi...

Saudi Medical Journal, 1997

Objectives: To present the value and usefulness of hepatobiliary scintigraphy in the investigatio... more Objectives: To present the value and usefulness of hepatobiliary scintigraphy in the investigation of infants with persistent hyperbilirubinemia through our experience in King Khaled University Hospital at King Saud University, Riyadh. Setting: King Khalid University Hospital, Departments of Nuclear Medicine, Pediatrics and Pediatric Surgery. Patients and methods: Seventy-seven patients aged between 5 days and 6 months (average 62 days ), 43 females and 34 males, 65 Saudi and 12 non-Saudi were investigated. Laboratory tests, abdominal ultrasound, hepatobiliary scintigraphy, liver biopsy, explorative laparatomy and intraoperative cholangiography were performed whenever indicated. The findings on hepatobiliary scintigraphy of non-visualization of the gallbladder and no activity in the bowel up to 24 hours post injection (p.i.) were considered consistent with the diagnosis of biliary atresia. Results: Thirty four infants were diagnosed by hepatobiliary scintigraphy as having biliary at...

Pakistan Journal of Medical Sciences, 2009

Objective: To select a subgroup of type-2 diabetics with two additional prespecified risk factors... more Objective: To select a subgroup of type-2 diabetics with two additional prespecified risk factors to see that whether there is any benefit of screening such patients. Methodology: Five hundred twenty six patients were sent for treadmill stress test or thallium scan. Those who had abnormal results were advised coronary angiography. The angiographically proven CAD was correlated with various risk factors to find the relationship between the disease and variables. Results: Two hundred thirty five (48%) patients had abnormal results and among them 158 (67%) underwent coronary angiography. Among these 21% had evidence of CAD. Coronary artery bypass grafting (CABG) was performed in 35(33%) patients, catheter based intervention (PCI) in 44(40%) patients and 30(27%) patients were not suitable for intervention. Duration of diabetes, smoking, diabetic retinopathy, albuminuria, and peripheral vascular disease were significant predictor of asymptomatic CAD. Conclusion: This study has demonstrat...

Asia Pacific Journal of Multidisciplinary Research, 2015

The objective of this study was to assess the diagnostic value of quantitative ultrasound (QUS) a... more The objective of this study was to assess the diagnostic value of quantitative ultrasound (QUS) and Osteoporosis self-assessment tool (OST) compared with Dual Energy x-ray absorptiometry (DXA), and to identify the best cut-off value for determining low bone mineral density (BMD) among postmenopausal women in Riyadh, Saudi Arabia. We conducted a community based cross-sectional study on 224 randomly selected post-menopausal women. Women visited primary heath care centers for answering self-administered questionnaireand screening for low BMD using QUS technique. OST was calculated based on age and weight. DXA scanwas performedforlumbar spine and femur neck at King Khalid University Hospital, Riyadh. Mean age of participants was 58.05(±8.97) years. The prevalence of low BMD at lumbar spine and femur neck was 56% and 28% respectively. The best cut-off value for QUS and OST was ≤-1 and ≤2 respectively. QUS yielded sensitivity and specificity of 73% vs 47% for lumbar spine (area under curv...

... 1988) Abstract. 24 children with urolithiasis of the upper urinary tract were treated by extr... more ... 1988) Abstract. 24 children with urolithiasis of the upper urinary tract were treated by extracorporeal shock wave lithotripsy (ESWL). ... In conclusion we believe that ESWL is a success-ful, low-risk procedure for treatment of upper uri-nary tract urolithiasis in children. ...

Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India

A 33 years old female patient with chronic renal transplant rejection proved by MAG3, ultrasound ... more A 33 years old female patient with chronic renal transplant rejection proved by MAG3, ultrasound and graft biopsy presented with abdominal pain and fever. Part of her work up included gallium-67 scan which revealed diffuse abnormal graft uptake with multifocal areas of marked uptake. Findings were interpreted as acute lobar nephronia. Repeat gallium scan two weeks after intravenous antibiotic therapy showed significant response reflected by resolution of most of focal areas of increased uptake which was parallel to clinical improvement.

Acta Endocrinologica (Bucharest), 2014

Objective: To select a subgroup of type-2 diabetics with two additional prespecified risk factors... more Objective: To select a subgroup of type-2 diabetics with two additional prespecified risk factors to see that whether there is any benefit of screening such patients. Methodology: Five hundred twenty six patients were sent for treadmill stress test or thallium scan. Those who had abnormal results were advised coronary angiography. The angiographically proven CAD was correlated with various risk factors to find the relationship between the disease and variables. Results: Two hundred thirty five (48%) patients had abnormal results and among them 158 (67%) underwent coronary angiography. Among these 21% had evidence of CAD. Coronary artery bypass grafting (CABG) was performed in 35(33%) patients, catheter based intervention (PCI) in 44(40%) patients and 30(27%) patients were not suitable for intervention. Duration of diabetes, smoking, diabetic retinopathy, albuminuria, and peripheral vascular disease were significant predictor of asymptomatic CAD. Conclusion: This study has demonstrated strong relationship between risk factors and asymptomatic CAD in type2 diabetics.

Singapore medical journal, 2011

We report a case of mycosis fungoides in a 27-year-old woman who presented with a lump in the for... more We report a case of mycosis fungoides in a 27-year-old woman who presented with a lump in the forehead. The condition was confirmed with tissue diagnosis. Gallium scintigraphy accurately delineated the complete extent of the disease, and served as a reference for objective assessment of response of the disease to treatment.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 1997

The objective is to present the usefulness of hepatobiliary scintigraphy in the investigation of ... more The objective is to present the usefulness of hepatobiliary scintigraphy in the investigation of children with suspected choledochal cysts through our experience in King Khalid University Hospital at King Saud University, Riyadh. Seven patients aged between I and 10 years (average 4.8 yrs) comprising six females and one male were investigated. Laboratory tests, abdominal Ultrasound and/or CT, and cholangiography were performed whenever indicated. Persistent activity in a dilated common bile duct, with or without dilatation of intrahepatic bile ducts, was considered a positive indicator for choledochal cyst disease. Four children with cystic dilatation (type I) were diagnosed by hepatobiliary scintigraphy, one saccular (type II), and two cases of Caroli's disease (type V). The diagnosis of choledochal cyst was proven by surgery with histological confirmation. Visualization of the gallbladder occurred in one case only. The common bile duct was seen in four cases. Late activity in ...

Saudi medical journal, 2005

We conducted this prospective study to establish the correlation between dual energy x-ray absorp... more We conducted this prospective study to establish the correlation between dual energy x-ray absorptiometry (DXA), quantitative ultrasound (QUS) and single energy x-ray absorptiometry (SXA) and to establish the role of QUS and SXA as a screening tool for osteoporosis. We carried out measurements of bone mineral density (BMD) of lumbar spine and femoral neck using DXA, QUS of heel using ultrasound densitometer, and BMD of forearm using SXA. We performed all the measurements at the Nuclear Medicine Division of King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between 2002 and 2004. We obtained the measurements of 437 female adult patients, aged 20-87 years. We expressed all the values as mean +/- SD. The BMD (g/cm2) of lumbar spine was 1 +/- 0.18, and femoral neck was 0.88 +/- 0.17. The broad band ultrasound attenuation (BUA) of the heel was 74.9 +/- 39.1 dB/MHz, the speed of sound (SOS) was 1542.5 +/- 81.4 m/s, and the estimated BMD was 0.52 +/- 0.15 (g/cm2). The BMD of ...

Saudi medical journal, 2004

To assess the prevalence of osteopenia and osteoporosis among Saudi postmenopausal women with non... more To assess the prevalence of osteopenia and osteoporosis among Saudi postmenopausal women with non-insulin dependent type 2 diabetes mellitus (T2DM). The study was carried out at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia from February 2000 to September 2002. Bone mineral density (BMD) of the lumbar spine and femoral neck using dual x-ray absorptiometry (DXA; Lunar Wisconsin), were performed in 104 postmenopausal Saudi women with T2DM, and 101 postmenopausal non-diabetic women (control). Bone mineral density was measured in gm/cm2 and both T-score and Z-score were measured but only T-score was used for analysis based on World Health Organization criteria. Bone profile, 25(OH) Vitamin D, 1,25(OH)2 Vitamin D, parathyroid hormone and urine deoxypyridinoline (DPD) were measured in most patients and controls. Body fat measurement around the biceps muscles using Futrex (body composition analyzer) were performed in patients and controls. Years postmenopausal, duration ...

Saudi medical journal, 2004

This prospective study was conducted to demonstrate the role of bone mineral density (BMD) and bo... more This prospective study was conducted to demonstrate the role of bone mineral density (BMD) and bone scan in the management of adult Saudi female patients with established diagnosis of osteomalacia. Bone scan using Tc99m methylene diphosphonate (MDP) and BMD of the lumbar spine and femoral neck using dual x-ray absorptiometry (DXA) were performed at the time of diagnosis 6 months and one year after therapy in 96 Saudi female patients attending the metabolic bone disease clinic at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia, between January 1997 through to June 1999, aged between 20 and 73-years (mean 42 years). Alkaline phosphatase, calcium and inorganic phosphorus were measured for all patients before and after treatment. 25 Hydroxy Vitamin D was only measured with the first BMD measurements. The bone profile showed typical biochemical abnormalities of osteomalacia. The bone scan showed feature of "superscan" in all patients and "pseudofractures&q...

Journal of Ayub Medical College, Abbottabad : JAMC

Image Registration is a process of aligning two or more images so that corresponding feature can ... more Image Registration is a process of aligning two or more images so that corresponding feature can be related objectively. Integration of corresponding and complementary information from various images has become an important area of computation in medical imaging. Merging different images of the same patient taken by different modalities or acquired at different times is quite useful in interpreting lower resolution functional images, such as those provided by nuclear medicine, in determining spatial relationships of structures seen in different modalities. This will help in planning surgery and longitudinal follow up. The aim of this article was to introduce image registration to all those who are working in field of medical sciences in general and medical doctors in particular; and indicate how and where this specialty is moving to provide better health care services.

Saudi medical journal, 2006

To report on moyamoya syndrome (MMS) as a risk factor for stroke in a prospective and retrospecti... more To report on moyamoya syndrome (MMS) as a risk factor for stroke in a prospective and retrospective cohort of Saudi children. The usual and novel associations of MMS in this cohort will also be described. Children with stroke were evaluated at the Division of Pediatric Neurology at King Khalid University Hospital, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia during the periods July 1992 to February 2001 (retrospective study) and February 2001 to March 2003 (prospective study). Investigations for suspected cases included hemostatic assays, biochemical, and serological tests. Neuroimaging included CT, MRI, magnetic resonance angiography (MRA), single photon computerized tomography (SPECT) brain scan and conventional cerebral angiography. Moyamoya syndrome was the underlying risk factor for stroke in 6 (5.8%) of the 104 children (aged one month to 12 years). They were 4 females and 2 males. Their first cerebral ischemic event occurred at a mean age of 45 m...

The Open Pediatric Medicine Journal, 2009

Background: Herpes Simplex Virus (HSV) is the most common cause of acute sporadic focal encephali... more Background: Herpes Simplex Virus (HSV) is the most common cause of acute sporadic focal encephalitis. Early Diagnosis is, therefore, crucial for predicting outcome. Improved laboratory technology and improved neuroimaging accessibility have enhanced our ability to diagnose this condition. Aims: To assess the reliability of different investigative tools in diagnosing and subsequent management of herpes simplex encephalitis (HSE); as well as the impact of infection and its relapse on the outcome of a cohort of 18 children evaluated during a period of 13 years. Methods: This combined prospective and retrospective study describes the clinical, laboratory, electroencephalographic and diagnostic imaging studies; and outcome in a cohort of 18 children with HSE over a period of 13 years. It also details the clinical and diagnostic features of 3 patients who relapsed. Results: The commonest initial presenting symptoms and signs were fever (100%), seizures (72%) irritability (50%) and weakness/hemiparesis (39%). Cerebrospinal fluid (CSF) pleocytosis was found in 62%, red blood cells (RBCs) >10x10 6 /L in 81% and raised proteins (>0.59g/L) in 52%. Examination for herpes simplex virus (HSV) by polymerase chain reaction (PCR) was positive in 50% (6/12). Electroencephalographic changes were universally abnormal (17/17; 100%) and periodic lateralization discharges (PLEDS) were seen in 35% (6/17). During the acute stage (days 1-8 from symptom onset), magnetic resonance imaging (MRI) revealed abnormalities in 91% (10/11), cranial computed tomography (CT) in 50% (5/10) and single photon emission computed tomography (SPECT), within < 7 days, in 75% (6/8). All patients were treated with intravenous acyclovir. There were no deaths but 3 patients relapsed after periods ranging between 18 days and 66 months. Eleven (61%) patients had no or minor sequelae (good outcome) and 7 (39%) had moderate or severe sequelae (poor outcome). Delayed initiation of therapy (> 3days from onset of symptoms) had significant association with poor outcome (P = 0.002). Initial negative PCR results may become positive on subsequent CSF specimen. Conclusion: Diagnosis of HSE requires combined clinical, laboratory, electroencephalographic and neuroimaging studies. Negative results of PCR do not exclude the infection and should not interrupt the treatment. Early diagnosis and initiation of treatment minimize the devastating effect of HSE. Full course treatment with acyclovir for 21 days is also crucial for prognosis and prevention of subsequent relapse.

Saudi Journal of Gastroenterology, 2012

Background/Aim: The objective of this study was to assess the value of hepatobiliary scintigraphy... more Background/Aim: The objective of this study was to assess the value of hepatobiliary scintigraphy (HS) for the diagnosis of right upper quadrant (RUQ) abdominal pain in patients with normal hepatobiliary ultrasound (HU). This is an observational study with a retrospective analysis of data from March 2008 to August 2010. Materials and Methods: We reviewed the HS results of 30 patients, aged 29-69 years (average 45.8 years); 12 male and 18 female patients. Patient selection to perform the HS was RUQ abdominal pain, suspected hepatobiliary disorder, and negative HU. All patients had gone through the standard procedure of HS. Results: Based on predefined interpretation criteria, HS results were divided into 2 patterns: Normal (n=8, 25.8%) and abnormal (n=22, 73%): 18 patients (81.8%) having early gallbladder (GB) and common bile duct visualization, and delayed transit to small bowel (SB), which can be seen only after a fatty meal with normal or abnormal GB ejection fraction (GBEF) pattern characteristic of Oddi's sphincter dyskinesia. The remaining 4 patients (8.18%) had acalculous cholycystitis pattern: Delayed GB visualization with activity appearing in SB before GB. Conclusion: HS with fatty meal stimulation and GBEF estimation seems to be a reliable test, which may reveal a biliary cause in more than 70% of patients with RUQ abdominal pain and normal HU. Normal results exclude functional biliary cause. The decision for invasive or noninvasive therapeutic approach may depend on the results of HS.