samira jafari - Academia.edu (original) (raw)

Papers by samira jafari

Research paper thumbnail of New generation of nanozyme based-tooth bleaching gel with dual effect: tooth whitening and enamel microhardness improving

Research Square (Research Square), May 19, 2022

Teeth discoloration is one of prevalent aesthetic concerns resulted from intrinsic/ extrinsic rea... more Teeth discoloration is one of prevalent aesthetic concerns resulted from intrinsic/ extrinsic reasons. Bleaching process can be a valuable treatment for patients with severe discolorations, which can cause an immediate change in their teeth color. According to literature review, use of commercial products owing to their high concentration of hydrogen peroxide can lead to lessen the enamel microhardness. Regarding these issues, the purpose of this present scenario is the design of novel three-components dental bleaching systems based on cerium oxide (CeO 2) nanozyme with dual impact, whitening of teeth as well as enhancement of the enamel microhardness. This system composed of three sections: whitening gel (i.e. gel includes H 2 O 2), the activator gel (i.e. gel includes CeO 2 nanozyme) and supplemental gel (i.e. gel includes hydroxyapatite). Base on in vitro and clinical studies, the synthesized whitening system not only is able to bleach the stained teeth but also possesses the microhardness improvement ability. Interestingly, the clinical case reports in current study reveal the remarkable change of tooth color by using the prepared in-o ce whitening dental gel.

Research paper thumbnail of Antioxidant activity and total phenolic content of extracts and fractions of cultivated Leonurus cardiaca L

Planta Medica, Aug 24, 2010

Research paper thumbnail of New generation of nanozyme based-tooth bleaching gel with dual effect: tooth whitening and enamel microhardness improving

Teeth discoloration is one of prevalent aesthetic concerns resulted from intrinsic/ extrinsic rea... more Teeth discoloration is one of prevalent aesthetic concerns resulted from intrinsic/ extrinsic reasons. Bleaching process can be a valuable treatment for patients with severe discolorations, which can cause an immediate change in their teeth color. According to literature review, use of commercial products owing to their high concentration of hydrogen peroxide can lead to lessen the enamel microhardness. Regarding these issues, the purpose of this present scenario is the design of novel three-components dental bleaching systems based on cerium oxide (CeO2) nanozyme with dual impact, whitening of teeth as well as enhancement of the enamel microhardness. This system composed of three sections: whitening gel (i.e. gel includes H2O2), the activator gel (i.e. gel includes CeO2 nanozyme) and supplemental gel (i.e. gel includes hydroxyapatite). Base on in vitro and clinical studies, the synthesized whitening system not only is able to bleach the stained teeth but also possesses the microhar...

Research paper thumbnail of A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles

Advanced Pharmaceutical Bulletin, 2015

In recent decades, the use of nanomaterials has received much attention in industrial and medical... more In recent decades, the use of nanomaterials has received much attention in industrial and medical fields. However, some reports have mentioned adverse effects of these materials on the biological systems and cellular components. There are several major mechanisms for cytotoxicity of nanoparticles (NPs) such as physicochemical properties, contamination with toxic element, fibrous structure, high surface charge and radical species generation. In this review, a brief key mechanisms involved in toxic effect of NPs are given, followed by the in vitro toxicity assays of NPs and prooxidant effects of several NPs such as carbon nanotubes, titanium dioxide NPs, quantum dots, gold NPs and silver NPs.

Research paper thumbnail of Mesoporous Starch Cryoaerogel Material as an Emerging Platform for Oral Drug Delivery: Synthesis and In Vitro Evaluation

Gels

In this study, a starch cryoaerogel formulation was developed as a carrier for poorly water-solub... more In this study, a starch cryoaerogel formulation was developed as a carrier for poorly water-soluble drugs, like atorvastatin. Cryoaerogels were generated through a sol–gel method combined with a freeze-drying technique, and atorvastatin was incorporated into the obtained mesoporous systems during the solvent exchange stage. The formulated drug-loaded polymer structures were characterized in terms of their physicochemical properties, solid-state behavior, and cytotoxicity. They had a pore size of 27.56 nm and a drug loading size of 38.60%. Fourier transform infrared (FTIR) and scanning electron microscopy (SEM) analyses indicated that atorvastatin was successfully incorporated into the cryoaerogel pores. The amorphous nature of the loaded drug was confirmed via X-ray diffraction (XRD). Furthermore, after the atorvastatin incorporation into the cryogel, the volume of nitrogen adsorbed on one gram of cryoaerogel (Vm), as well as the specific surface area (aBET) were reduced. The compar...

Research paper thumbnail of Engineered Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as New Generations of Blood–Brain Barrier Transmitters

ACS Chemical Neuroscience, 2021

The blood-brain barrier (BBB) is considered as the most challenging barrier in brain drug deliver... more The blood-brain barrier (BBB) is considered as the most challenging barrier in brain drug delivery. Indeed, there is a definite link between the BBB integrity defects and central nervous systems (CNS) disorders, such as neurodegenerative diseases and brain cancers, increasing concerns in the contemporary era because of the inability of most therapeutic approaches. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have already been identified as having several advantages in facilitating the transportation of hydrophilic and hydrophobic agents across the BBB. This review first explains BBB functions and its challenges in brain drug delivery, followed by a brief description of nanoparticle-based drug delivery for brain diseases. A detailed presentation of recent progressions in optimizing SLNs and NLCs for controlled release drug delivery, gene therapy, targeted drug delivery, and diagnosis of neurodegenerative diseases and brain cancers is approached. Finally, the problems, challenges, and future perspectives in optimizing these carriers for potential clinical application were described briefly.

Research paper thumbnail of Molecular interaction of fibrinogen with zeolite nanoparticles

Scientific Reports, 2019

Fibrinogen is one of the key proteins that participate in the protein corona composition of many ... more Fibrinogen is one of the key proteins that participate in the protein corona composition of many types of nanoparticles (NPs), and its conformational changes are crucial for activation of immune systems. Recently, we demonstrated that the fibrinogen highly contributed in the protein corona composition at the surface of zeolite nanoparticles. Therefore, understanding the interaction of fibrinogen with zeolite nanoparticles in more details could shed light of their safe applications in medicine. Thus, we probed the molecular interactions between fibrinogen and zeolite nanoparticles using both experimental and simulation approaches. The results indicated that fibrinogen has a strong and thermodynamically favorable interaction with zeolite nanoparticles in a non-cooperative manner. Additionally, fibrinogen experienced a substantial conformational change in the presence of zeolite nanoparticles through a concentration-dependent manner. Simulation results showed that both E- and D-domain ...

Research paper thumbnail of Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions

International Journal of Nanomedicine, 2020

Research paper thumbnail of Antimicrobial activity of carbon-based nanoparticles

Advanced pharmaceutical bulletin, 2015

Due to the vast and inappropriate use of the antibiotics, microorganisms have begun to develop re... more Due to the vast and inappropriate use of the antibiotics, microorganisms have begun to develop resistance to the commonly used antimicrobial agents. So therefore, development of the new and effective antimicrobial agents seems to be necessary. According to some recent reports, carbon-based nanomaterials such as fullerenes, carbon nanotubes (CNTs) (especially single-walled carbon nanotubes (SWCNTs)) and graphene oxide (GO) nanoparticles show potent antimicrobial properties. In present review, we have briefly summarized the antimicrobial activity of carbon-based nanoparticles together with their mechanism of action. Reviewed literature show that the size of carbon nanoparticles plays an important role in the inactivation of the microorganisms. As major mechanism, direct contact of microorganisms with carbon nanostructures seriously affects their cellular membrane integrity, metabolic processes and morphology. The antimicrobial activity of carbon-based nanostructures may interestingly ...

Research paper thumbnail of Biomacromolecule based nanoscaffolds for cell therapy

Journal of Drug Delivery Science and Technology, 2017

Abstract Among stem cells, mesenchymal stromal cells (MSCs) are the most widely used cells in tis... more Abstract Among stem cells, mesenchymal stromal cells (MSCs) are the most widely used cells in tissue engineering because of their easily accessible feature for patients, simple culture and manipulation by viral transduction subsequently the strong expression of transgenes at in vivo / in vitro conditions. In order to support the appropriate proliferation of the MSCs in the implanted site of body tissues, the cells are typically implanted in the target region via biodegradable scaffolds seeded by MSCs. These biomatrixes provide the mechanical support and support the growth factors for the cell attachments and proliferations. This study reviewed comprehensively ideal nanoscaffold properties and their preparation methods based on several attractive biomacromoelecules such as silk, collagen, hyaluronic acid, chitosan, alginate, fibrin in the view of their advantages/disadvantages of using them in the cell therapy/tissue engineering.

Research paper thumbnail of New generation of nanozyme based-tooth bleaching gel with dual effect: tooth whitening and enamel microhardness improving

Research Square (Research Square), May 19, 2022

Teeth discoloration is one of prevalent aesthetic concerns resulted from intrinsic/ extrinsic rea... more Teeth discoloration is one of prevalent aesthetic concerns resulted from intrinsic/ extrinsic reasons. Bleaching process can be a valuable treatment for patients with severe discolorations, which can cause an immediate change in their teeth color. According to literature review, use of commercial products owing to their high concentration of hydrogen peroxide can lead to lessen the enamel microhardness. Regarding these issues, the purpose of this present scenario is the design of novel three-components dental bleaching systems based on cerium oxide (CeO 2) nanozyme with dual impact, whitening of teeth as well as enhancement of the enamel microhardness. This system composed of three sections: whitening gel (i.e. gel includes H 2 O 2), the activator gel (i.e. gel includes CeO 2 nanozyme) and supplemental gel (i.e. gel includes hydroxyapatite). Base on in vitro and clinical studies, the synthesized whitening system not only is able to bleach the stained teeth but also possesses the microhardness improvement ability. Interestingly, the clinical case reports in current study reveal the remarkable change of tooth color by using the prepared in-o ce whitening dental gel.

Research paper thumbnail of Antioxidant activity and total phenolic content of extracts and fractions of cultivated Leonurus cardiaca L

Planta Medica, Aug 24, 2010

Research paper thumbnail of New generation of nanozyme based-tooth bleaching gel with dual effect: tooth whitening and enamel microhardness improving

Teeth discoloration is one of prevalent aesthetic concerns resulted from intrinsic/ extrinsic rea... more Teeth discoloration is one of prevalent aesthetic concerns resulted from intrinsic/ extrinsic reasons. Bleaching process can be a valuable treatment for patients with severe discolorations, which can cause an immediate change in their teeth color. According to literature review, use of commercial products owing to their high concentration of hydrogen peroxide can lead to lessen the enamel microhardness. Regarding these issues, the purpose of this present scenario is the design of novel three-components dental bleaching systems based on cerium oxide (CeO2) nanozyme with dual impact, whitening of teeth as well as enhancement of the enamel microhardness. This system composed of three sections: whitening gel (i.e. gel includes H2O2), the activator gel (i.e. gel includes CeO2 nanozyme) and supplemental gel (i.e. gel includes hydroxyapatite). Base on in vitro and clinical studies, the synthesized whitening system not only is able to bleach the stained teeth but also possesses the microhar...

Research paper thumbnail of A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles

Advanced Pharmaceutical Bulletin, 2015

In recent decades, the use of nanomaterials has received much attention in industrial and medical... more In recent decades, the use of nanomaterials has received much attention in industrial and medical fields. However, some reports have mentioned adverse effects of these materials on the biological systems and cellular components. There are several major mechanisms for cytotoxicity of nanoparticles (NPs) such as physicochemical properties, contamination with toxic element, fibrous structure, high surface charge and radical species generation. In this review, a brief key mechanisms involved in toxic effect of NPs are given, followed by the in vitro toxicity assays of NPs and prooxidant effects of several NPs such as carbon nanotubes, titanium dioxide NPs, quantum dots, gold NPs and silver NPs.

Research paper thumbnail of Mesoporous Starch Cryoaerogel Material as an Emerging Platform for Oral Drug Delivery: Synthesis and In Vitro Evaluation

Gels

In this study, a starch cryoaerogel formulation was developed as a carrier for poorly water-solub... more In this study, a starch cryoaerogel formulation was developed as a carrier for poorly water-soluble drugs, like atorvastatin. Cryoaerogels were generated through a sol–gel method combined with a freeze-drying technique, and atorvastatin was incorporated into the obtained mesoporous systems during the solvent exchange stage. The formulated drug-loaded polymer structures were characterized in terms of their physicochemical properties, solid-state behavior, and cytotoxicity. They had a pore size of 27.56 nm and a drug loading size of 38.60%. Fourier transform infrared (FTIR) and scanning electron microscopy (SEM) analyses indicated that atorvastatin was successfully incorporated into the cryoaerogel pores. The amorphous nature of the loaded drug was confirmed via X-ray diffraction (XRD). Furthermore, after the atorvastatin incorporation into the cryogel, the volume of nitrogen adsorbed on one gram of cryoaerogel (Vm), as well as the specific surface area (aBET) were reduced. The compar...

Research paper thumbnail of Engineered Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as New Generations of Blood–Brain Barrier Transmitters

ACS Chemical Neuroscience, 2021

The blood-brain barrier (BBB) is considered as the most challenging barrier in brain drug deliver... more The blood-brain barrier (BBB) is considered as the most challenging barrier in brain drug delivery. Indeed, there is a definite link between the BBB integrity defects and central nervous systems (CNS) disorders, such as neurodegenerative diseases and brain cancers, increasing concerns in the contemporary era because of the inability of most therapeutic approaches. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have already been identified as having several advantages in facilitating the transportation of hydrophilic and hydrophobic agents across the BBB. This review first explains BBB functions and its challenges in brain drug delivery, followed by a brief description of nanoparticle-based drug delivery for brain diseases. A detailed presentation of recent progressions in optimizing SLNs and NLCs for controlled release drug delivery, gene therapy, targeted drug delivery, and diagnosis of neurodegenerative diseases and brain cancers is approached. Finally, the problems, challenges, and future perspectives in optimizing these carriers for potential clinical application were described briefly.

Research paper thumbnail of Molecular interaction of fibrinogen with zeolite nanoparticles

Scientific Reports, 2019

Fibrinogen is one of the key proteins that participate in the protein corona composition of many ... more Fibrinogen is one of the key proteins that participate in the protein corona composition of many types of nanoparticles (NPs), and its conformational changes are crucial for activation of immune systems. Recently, we demonstrated that the fibrinogen highly contributed in the protein corona composition at the surface of zeolite nanoparticles. Therefore, understanding the interaction of fibrinogen with zeolite nanoparticles in more details could shed light of their safe applications in medicine. Thus, we probed the molecular interactions between fibrinogen and zeolite nanoparticles using both experimental and simulation approaches. The results indicated that fibrinogen has a strong and thermodynamically favorable interaction with zeolite nanoparticles in a non-cooperative manner. Additionally, fibrinogen experienced a substantial conformational change in the presence of zeolite nanoparticles through a concentration-dependent manner. Simulation results showed that both E- and D-domain ...

Research paper thumbnail of Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions

International Journal of Nanomedicine, 2020

Research paper thumbnail of Antimicrobial activity of carbon-based nanoparticles

Advanced pharmaceutical bulletin, 2015

Due to the vast and inappropriate use of the antibiotics, microorganisms have begun to develop re... more Due to the vast and inappropriate use of the antibiotics, microorganisms have begun to develop resistance to the commonly used antimicrobial agents. So therefore, development of the new and effective antimicrobial agents seems to be necessary. According to some recent reports, carbon-based nanomaterials such as fullerenes, carbon nanotubes (CNTs) (especially single-walled carbon nanotubes (SWCNTs)) and graphene oxide (GO) nanoparticles show potent antimicrobial properties. In present review, we have briefly summarized the antimicrobial activity of carbon-based nanoparticles together with their mechanism of action. Reviewed literature show that the size of carbon nanoparticles plays an important role in the inactivation of the microorganisms. As major mechanism, direct contact of microorganisms with carbon nanostructures seriously affects their cellular membrane integrity, metabolic processes and morphology. The antimicrobial activity of carbon-based nanostructures may interestingly ...

Research paper thumbnail of Biomacromolecule based nanoscaffolds for cell therapy

Journal of Drug Delivery Science and Technology, 2017

Abstract Among stem cells, mesenchymal stromal cells (MSCs) are the most widely used cells in tis... more Abstract Among stem cells, mesenchymal stromal cells (MSCs) are the most widely used cells in tissue engineering because of their easily accessible feature for patients, simple culture and manipulation by viral transduction subsequently the strong expression of transgenes at in vivo / in vitro conditions. In order to support the appropriate proliferation of the MSCs in the implanted site of body tissues, the cells are typically implanted in the target region via biodegradable scaffolds seeded by MSCs. These biomatrixes provide the mechanical support and support the growth factors for the cell attachments and proliferations. This study reviewed comprehensively ideal nanoscaffold properties and their preparation methods based on several attractive biomacromoelecules such as silk, collagen, hyaluronic acid, chitosan, alginate, fibrin in the view of their advantages/disadvantages of using them in the cell therapy/tissue engineering.