Samran Samran - Academia.edu (original) (raw)
Papers by Samran Samran
World Journal of Pharmacy and Pharmaceutical Sciences, 2015
Orally disintegrating tablets were developed to solve the difficulty of swallowing the convention... more Orally disintegrating tablets were developed to solve the difficulty of swallowing the conventional tablet in pediatrics and geriatrics patients. In administration of orally disintegrating tablets, tablets are placed on the tongue in oral cavity and it will disintegrate rapidly in less than 60 second. Since solid tapai extract is slightly soluble when it puts on the tounge and has sweet taste, it has potential as a natural excipient in Article Received on
International Journal of PharmTech Research, 2016
Solid tapai extract had been applied as excipient in formulating orally disintegrating tablets (O... more Solid tapai extract had been applied as excipient in formulating orally disintegrating tablets (ODTs). Solid tapai extract was used as excipient by combining solid tapai extract with corn starch and avicel. The formula was designed using simplex lattice design method with three component mixture. The optimized formula was determined by in vitro and in vivo study. The objective of this pilot study was to discover in vitro and in vivo correlation of optimized metochlopramide-ODTs. The design of in vivo test designed by using six rabbits. The drug released in the plasma was measured by HPLC instrument using glacial acetic acid 1% in aquabidestilata and metanol-acetonitrile (1:3.7) with ratio 60:40. The result showed that in vitro test on pH 1.2 and 7.4 had correlation to in vivo test with coefficient correlation of 0.996 and 0.975.
JURNAL PENGMAS KESTRA (JPK)
Asam urat sebagai hasil metabolisme senyawa purin atau xanthin, peningkatan konsumsi senyawa puri... more Asam urat sebagai hasil metabolisme senyawa purin atau xanthin, peningkatan konsumsi senyawa purin atau xanthin menyebabkan akumulasi kristal dari senyawa asam urat dengan notabene sukar larut dalam air. Asam urat darah dipengaruhi oleh beberapa faktor, misalnya makanan kaya purin dan xanthin, suku, physic activity, supply alkohol, dan usia. Darah hanya mampu menampung sampai tingkat tertentu, kadar melebihi daya larut, di atas 6,8 mg/dl disebut hiperurisemia, Hiperurisemia bisa berlangsung lama dan sebagian bias menjadi artritis gout. Gout dikenal sebagai penyakit yang dapat menyebabkan penderita mengalami nyeri yang hebat pada sendi. Pengabdian masyarakat dilakukan dengan metode penyuluhan dan pemeriksaan kadar asam urat darah peserta. Masyarakat diharapkan dapat menambah pengetahuan tentang kadar asam urat darah sehingga mengurangi resiko Gout. Serta mengetahui kadar asam urat darah peserta pada saat pengecekan.
BAHASANTODEA, Jan 30, 2017
The idea XA grade students of SMA Negeri 1 Tolitoli Utara can be improved. It was revealed from a... more The idea XA grade students of SMA Negeri 1 Tolitoli Utara can be improved. It was revealed from a study of the problem: (1) how the application of the method of discussion to improve the students express ideas in class XA SMA Negeri 1 Tolitoli Utara? And (2) whether the application of the results of the discussion method can improve the students express ideas in class XA SMA Negeri 1 Tolitoli Utara?. This study aims to (1) describe the application of the method of discussion to improve the students express ideas in class XA SMA Negeri 1 Tolitoli Utara and (2) describe the results of applying the method of discussion to improve the students express ideas in class XA SMA Negeri 1 Tolitoli Utara. Methods of data collection using the oral tests, observation and documentation. Qualitative data analysis techniques and quantitative techniques. The results showed that (1) the application of the method of discussion in several stages, The first researcher to prepare articles that will be distributed to students; two researchers set up research pieces express the idea of learning implementation skills; The third researcher prepares a camera to document the activities of teachers and students during the learning process; After that process, the skills students express ideas increased. The percentage of skill express the idea of students has increased at every meeting of the first cycle and the second cycle. Improved skills of students express the idea in the first cycle of 65.75 from 41.33 the initial conditions. In the second cycle increased by 74.67.
Open Access Macedonian Journal of Medical Sciences, Jan 26, 2022
AIM: This study aimed to make corncobs the basic material for the manufacture of microcrystalline... more AIM: This study aimed to make corncobs the basic material for the manufacture of microcrystalline cellulose. METHODS: Manufacture of corncob cellulose microcrystals (CCMs) by isolating alpha-cellulose from corncobs, then hydrolyzed with HCl 2.5 N. The yield of CCMs of 14.51% can be used as orally disintegrating tablet (ODT) and has similarities with Avicel as standard comparison. RESULTS: Both organoleptic results were pH 5.6 and 6.54; drying shrinkage 3.33% and 4.39%; total ash content 0.17% and 0.02%; and water solubility 0.9% and 0.12%. Furthermore, the real specific gravity is 0.317 and 0.306 g/cm 3 , incompressible density is 0.379 and 0.375 g/cm 3 , the true density is 1.291 and 1.206 g/cm 3 , Hausner index is 1.195 and 1.225, compressibility index is 19.55 and 22.55%, and porosity is 75.5 and 74.6%. CONCLUSION: Captopril ODT tablet preparations with CCM as filler have almost the exact tablet evaluation results compared to Avicel and to meet the requirements.
Amaliah, Oct 26, 2018
Perguruan tinggi memiliki peran untuk memotivasi para mahasiswa dan sarjananya menjadi young entr... more Perguruan tinggi memiliki peran untuk memotivasi para mahasiswa dan sarjananya menjadi young entrepreneurs dan merupakan bagian dari salah satu faktor pendorong pertumbuhan kewirausahaan. Tujuan kegiatan Program Pengembangan Kewirausahaan (PPK) di Universitas Muslim Nusantara (UMN) Al Washliyah untuk menghasilkan wirausaha yang mandiri berbasis iptek dan siap beraktivitas di masyarakat. Metode pendekatan pada program PPK secara Participatory Action Learning System (PALS). Adapun tenant PPK UMN Al Washliyah adalah mahasiswa dan Alumni UMN Al Washliyah. Kegiatan Program Pengembangan Kewirausahaan dengan memberikan bimbingan, motivasi, pelatihan, pendampingan, dan konsultasi kewirausahaan.Kegiatan PPK UMN Al Washliyah telah melakukan kegiatan antara lain, yaitu memperkenalkan tentang kewirausahaan dan memotivasi mahasiswa untuk berwirausaha pada kegiatan kuliah umum kewirausahaan islami, melakukan rekrutmen tenant peserta PPK UMN Al Washliyah, pelatihan kewirausahaan, peningkatan keterampilan berwirausahaan dengan magang, praktek dan kunjungan ke tempat usaha, memberikan modal usaha berupa peralatan penunjang dan bahan habis pakai, pameran produk, dan evaluasi kegiatan kerja tenant. Kegiatan PPK UMN Al Washliyah pada tahun pertama ini telah menghasilkan 5 (lima) orang wirausaha mandiri dan 15 (lima belas) orang sedang merintis berwirausaha.
Open Access Macedonian Journal of Medical Sciences, Jul 7, 2020
BACKGROUND: Bioavailability and bioequivalence studies required by regulations to ensure therapeu... more BACKGROUND: Bioavailability and bioequivalence studies required by regulations to ensure therapeutic equivalence between a pharmaceutically equivalent test product and a reference product. AIM: This study aimed to evaluate the bioavailability performance between the optimum formula of OROS dispersible tablet-metoclopramide dosage forms (FCL-6) and the Primperan ® as the reference product. METHODS: The FCL-6 formula was design by simplex lattice design model with a three components mixture of excipients: Solid tapai extract, corn starch, and Avicel. The optimum formula of OROS dispersible tablet (ODT)metoclopramide consists of solid tapai extract (27.038 mg), corn starch (27.407 mg), and Avicel (53.555 mg), metoclopramide hydrochloric acid (HCl) (10.00 mg), LH-11 (22.50 mg), aspartame (5.00 mg), talcum BP (3.00 mg), and Mg stearate (1.50 mg). The in vivo test was done by cross-over design method using six rabbits. The level of metoclopramide concentration from in vivo test was measured by high-performance liquid chromatography instrument. RESULTS: The study revealed that the t max , C max , and area under curve (AUC) of ODT-metoclopramide FCL-6 were 60 min, 1.95 ± 0.13 µg/mL, and 1118.20 ± 150 µg/mL. min consecutively. The C max and the concentration of the drug absorbed in the blood (AUC) of ODT-metoclopramide were larger than Primperan ® tablets. Statistical data of the optimized ODT-metoclopramide compared with Primperan ® showed that the C max and AUC significance values were <0.05 (p < 0.05). CONCLUSION: The optimized formula of ODT-metoclopramide revealed a better characteristic of C max and AUC concentration compared with Primperan ®. The optimized ODT-metoclopramide with tapai extract was found to be promising to improved bioavailability of metoclopramide.
Syrup is a beverage product resulting from the production of a mixture of water and sugar at a co... more Syrup is a beverage product resulting from the production of a mixture of water and sugar at a content of not less than 65%, whether or not ingredients are in the form of food with or without food additives, which have received permission to use according to the regulations of the Food and Drug Supervisory Agency of the Republic of Indonesia. Fruit syrup is made from fresh fruit juice with sugar and the taste and aroma of the fruit. Fruits used in syrup production must have an attractive color, aroma and distinctive taste. Example the taste and aroma of passion fruit (Passiflora edulis S) and sweet orange (Citrus sinensis L). Sweet orange and passion fruit are used as a source of fruit syrup juice. Sweet oranges are widely grown in Indonesia, including North Sumatra, especially in Gung Pinto Village, Tanah Karo. During the main harvest, there is usually a decrease in the price of oranges so that farmers are reluctant to pick the fruit which has been the foundation of their lives. Th...
Orally disintegrating tablet (ODT) was developed to solve the difficulty of swallowing convention... more Orally disintegrating tablet (ODT) was developed to solve the difficulty of swallowing conventional tablet for paediatric and geriatric patients. In administration of ODT, tablets are placed on the tongue in oral cavity and it will disintegrate rapidly in less than 60 seconds. The solid tapai extract (STE) has sweet taste, is rather sour and slightly soluble when it is put on the tongue. This is the reason why it has potential as a natural excipient in ODT. The objective of the study was to characterise STE as excipient and to use STE as excipient in the formulation of ODT by lyophilisation method. The ingredients were glutinous rice (Oryza sativa L. var. Glutinous) used to form tapai and the liquid extract of tapai which was used to make STE. STE was used as excipient by combining STE with dextrose and avicel. Metoclopramide HCl was used as a drug model. The design of formula used the simplex lattice design (SLD) model with a three components mixture: STE, dextrose and avicel as ex...
Malaysian Journal of Pharmaceutical Sciences, 2014
Orally disintegrating tablet (ODT) was developed to solve the difficulty of swallowing conventio... more Orally disintegrating tablet (ODT) was developed to solve the difficulty of swallowing
conventional tablet for paediatric and geriatric patients. In administration of ODT, tablets are placed on the tongue in oral cavity and it will disintegrate rapidly in less than 60 seconds. The solid tapai extract (STE) has sweet taste, is rather sour and slightly soluble when it is put on the tongue. This is the reason why it has potential as a natural excipient in ODT. The objective of the study was to characterise STE as excipient and to use STE as excipient in the formulation of ODT by lyophilisation method. The ingredients were glutinous rice (Oryza sativa L. var. Glutinous) used to form tapai and the liquid extract of tapai which was used to make STE. STE was used as excipient by combining STE with dextrose and avicel. Metoclopramide HCl was used as a drug model. The design of formula used the simplex lattice design (SLD) model with a three components mixture: STE, dextrose and avicel as excipients. The parameters of lyophilised ODT (LODT) were hardness and friability, wetting time, disintegrating time and dissolution rate. The results showed STE can be used as filler and binder for LODT. STE could also function as disintegrant and formed porosity in the lyophilised method. Based on equation and contour plot of superimposed method, a formula consisting of STE (24.18 mg), dextrose (19.71 mg) and avicel (96.11 mg) was the optimum formula of LODT.
JURNAL FARMASIMED (JFM)
Ikan salah satu dari sekian banyak kekayaan alam bahari Indonesia. Lauk pauk ikan banyak dikonsum... more Ikan salah satu dari sekian banyak kekayaan alam bahari Indonesia. Lauk pauk ikan banyak dikonsumsi masyarakat, mudah diperoleh di pasar dengan harga terjangkau. Namun ikan basah dan ikan kering mudah dan cepat mengalami pembusukan. Mikroba ada sejak ikan masih hidup. Aktivitas mikroba menyebabkan perubahan biokimia dan fisik ikan sehingga bau busuk. Kondisi busuk diketahui setelah bau busuk tersebar dan timbul lendir, warna suram, mata keruh dan sebagainya. Pengawetan ikan basah dan ikan kering dilakukan dengan mengurangi kadar air. Pengawetan merupakan daya upaya peyelamatan hasil tangkapan ikan oleh nelayan. Pembusukan ikan dihambat dengan penambahan garam, sehingga penyimpanan ikan lebih lama tanpa aktivitas bakteri dan enzim. Pesatnya teknik pengolahan pangan, penambahan bahan-bahan aditif pada bahan pangan sulit untuk dihindari, akibatnya keamanan pangan telah menjadi dasar pemilihan suatu produk pangan yang akan dikonsumsi. Bahan aditif berbahaya sulit dihindari, selalu ditem...
International Journal of Applied Pharmaceutics, 2019
Objective: The aim of this work was to formulate and evaluate orally disintegrating tablets of ci... more Objective: The aim of this work was to formulate and evaluate orally disintegrating tablets of cinnarizine that were prepared by direct compression method using different types of diluents and super disintegrants. The rationale behind this work was to accelerate the disintegration of the tablet to provide rapid dissolution, quick action and enhanced bioavailability of the drug.Methods: The tablets were prepared by direct compression method using different types of diluents as mannitol, microcrystalline cellulose (MCC), and lactose. Different super disintegrants were used such as crospovidone (CP), sodium starch glycolate (SSG) and Kyron T-314; Kyron T-314 was used in different concentrations of 5%, 6%, 7%, and 8%. The prepared formulae (F1-F9c) were subjected to flowability studies and post-compression evaluation studies. The optimized formula was selected depending on the time of disintegration and dissolution; then it was subjected to drug-excipient compatibility study and stabili...
Mejuajua: Jurnal Pengabdian pada Masyarakat
Salah satu desa yang berada di wilayah Kabupaten Deli Serdang Provinsi Sumatera Utara, yaitu desa... more Salah satu desa yang berada di wilayah Kabupaten Deli Serdang Provinsi Sumatera Utara, yaitu desa Cinta Rakyat Percut Sei Tuan menjadi objek pengabdian masyarakat oleh Tim Program Kemitraan Masyarakat Progran Studu S1 Farmasi Sekolah Tinggi Ilmu Keshatan Indah Medan. Ibu-ibu di desa ini biasa membantu suami sebagai petani dan nelayan, dan beraktivitas sosial pada kegiatan desa dan keagamaan, belum sampai pada taraf upaya peningkatan ekonomi keluarga. Minuman Sehat Instan Kering adalah sediaan olahan dari bahan baku alami menjadi bentuk serbuk, dan siap disajikan dengan dicampur air hangat. Minuman oalahan tersebut berbahan utama Temulawak, yang biasa dijajakan dalam bentuk sediaan jamu sari Temulawak. Sediaan yang dibuat berpotensi dikembangkan menjadi produk unggulan. Pengabdian dilakukan untuk melatih pembuatan sediaan tersebut dengan bahan baku tumbuhan yang ada di lingkungan sekitar. Pelatihan dilakukan Tim dengan memanggil Ibu-ibu rumah tangga untuk mengikuti pelatihan. Hasil k...
Mejuajua: Jurnal Pengabdian pada Masyarakat, 2021
Lut Tawar dan Pegasing merupakan dua yang ada di Aceh Tengah, Nanggroe Aceh Darussalam (NAD) seba... more Lut Tawar dan Pegasing merupakan dua yang ada di Aceh Tengah, Nanggroe Aceh Darussalam (NAD) sebagai objek Pengabdian oleh Tim PKM Program Studi S1 Farmasi STIKes Indah Medan dan Progran Studi Farmasi SMK Al Razi Sinar Harapan Medan. Ibu anggota TIM PKK utusan Lut Tawar dan Pegasing biasa bersama suami sebagai petani. Ibu yang tergabung dalam TIM PKK berkumpul di Kator Dinas KBP3A untuk dilatih dan dibimbing Tim PKM memproduksi SAOS TOMAT. Tomat salah satu komoditi sayuran asal Aceh Tengah yang saat tertentu panen raya melimpah di Pasar sehingga harga menjadi turun dan berimbas ke kota lain, termasuk Medan, Sumatera Utara; bahkan petani sendiri terkadang tidak lagi memanen karena biaya operasional tidak tercover dari hasil jual panen. Untuk mengatasi ini, alangkah lebih baik bila diolah menjadi SAOS TOMAT sehingga penghasilan petani stabil setiap saat. Ibu-ibu peserta Tim PKK utusan Lut Tawar dan Pegasing mengikuti dengan sangat antusias dan produk SAOS TOMAT sesuai yang diharapkan
The preparation of brewed white sticky rice extract or brem from white glutinous rice had been re... more The preparation of brewed white sticky rice extract or brem from white glutinous rice had been researched by using variation concentration of yeast. The yeasts were bought from traditional market without trade mark. Tape extract obtained by squeezed tape mass using a pressurized equipment, water of tape obtained further filtered using a 60 mesh sieve and the waste is disposed. The variation of yeast influences the pH of liquid tape extract. The optimum concentration of yeast was 1,5%. The research of orally disintegrating tablet (ODT) that using direct compress method was designed by using Simplex Lattice Design (SLD) mixture design programme with two components mixture: brewed white sticky rice extract and corn starch (CS), and metochlopramide as model drug. Brewed white sticky rice extract and CS were formulated become nine designs of formula. Brewed white sticky rice extract was dominant increasing flow and compactability of ODT mass, but decreasing wetting time, disintegrating t...
Amaliah: Jurnal Pengabdian Kepada Masyarakat, 2018
ABSTRAK Perguruan tinggi memiliki peran untuk memotivasi para mahasiswa dan sarjananya menjadi yo... more ABSTRAK Perguruan tinggi memiliki peran untuk memotivasi para mahasiswa dan sarjananya menjadi young entrepreneurs dan merupakan bagian dari salah satu faktor pendorong pertumbuhan kewirausahaan. Tujuan kegiatan Program Pengembangan Kewirausahaan (PPK) di Universitas Muslim Nusantara (UMN) Al Washliyah untuk menghasilkan wirausaha yang mandiri berbasis iptek dan siap beraktivitas di masyarakat. Metode pendekatan pada program PPK secara Participatory Action Learning System (PALS). Adapun tenant PPK UMN Al Washliyah adalah mahasiswa dan Alumni UMN Al Washliyah. Kegiatan Program Pengembangan Kewirausahaan dengan memberikan bimbingan, motivasi, pelatihan, pendampingan, dan konsultasi kewirausahaan.Kegiatan PPK UMN Al Washliyah telah melakukan kegiatan antara lain, yaitu memperkenalkan tentang kewirausahaan dan memotivasi mahasiswa untuk berwirausaha pada kegiatan kuliah umum kewirausahaan islami, melakukan rekrutmen tenant peserta PPK UMN Al Washliyah, pelatihan kewirausahaan, peningkat...
Mejuajua: Jurnal Pengabdian pada Masyarakat, 2021
Kampung Daling Tajuk Dilem ada di wilayah Bebesen, Aceh Tengah, Nanggroe Aceh Darussalam (NAD) se... more Kampung Daling Tajuk Dilem ada di wilayah Bebesen, Aceh Tengah, Nanggroe Aceh Darussalam (NAD) sebagai objek Pengabdian oleh Tim PKM Program Studi S1 Farmasi STIKes Indah Medan dan Progran Studi Farmasi Sekolah Kejuruan Menengah (SMK) Al Razi Sinar Harapan Medan. Ibu anggota PKK Kampung Daling Tajuk Dilem bersama suami sebagai petani, terutama petani kopi. Kopi Arabika merupakan produk Primadona Aceh Tengah, dan Jahe dapat dijadikan pendamping dalam sajian Kopi Arabika yang sudah biasa dijadikan sebagai produk andalan Aceh Tengah dalam menarik wisatawan Domestik maupun Internasional dengan wisata alam Danau Lut Tawar. Minuman Jahe Instan (MJI) adalah sediaan olahan jahe menjadi serbuk siap saji dengan campuran air panas. Pelatihan dilakukan Tim PKM untuk melatih ibu anggota PKK Kampung Daling Tajuk Dilem memproduksi olahan jahe menjadi sediaan instan. Ibu-ibu peserta Tim PKK Kampung Daling Tajuk Dilem mengikuti dengan cukup antusias dan produk MJI Instan sesuai yang diharapkan.
Open Access Macedonian Journal of Medical Sciences
BACKGROUND: Bioavailability and bioequivalence studies required by regulations to ensure therapeu... more BACKGROUND: Bioavailability and bioequivalence studies required by regulations to ensure therapeutic equivalence between a pharmaceutically equivalent test product and a reference product. AIM: This study aimed to evaluate the bioavailability performance between the optimum formula of OROS dispersible tablet-metoclopramide dosage forms (FCL-6) and the Primperan® as the reference product. METHODS: The FCL-6 formula was design by simplex lattice design model with a three components mixture of excipients: Solid tapai extract, corn starch, and Avicel. The optimum formula of OROS dispersible tablet (ODT)-metoclopramide consists of solid tapai extract (27.038 mg), corn starch (27.407 mg), and Avicel (53.555 mg), metoclopramide hydrochloric acid (HCl) (10.00 mg), LH-11 (22.50 mg), aspartame (5.00 mg), talcum BP (3.00 mg), and Mg stearate (1.50 mg). The in vivo test was done by cross-over design method using six rabbits. The level of metoclopramide concentration from in vivo test was measur...
Asian Journal of Pharmaceutical and Clinical Research
Objective: Curcuma xanthorrhiza Roxb. was used as hereditary medicinal plant for prevention of l... more Objective: Curcuma xanthorrhiza Roxb. was used as hereditary medicinal plant for prevention of liver dysfunction, gastrointestinal disease, fever, and hemorrhoid. Curcuma extract was easy to damage because the light exposure, change of pH, weather and a long period of storage time. The problem can be solved by coating the extract with spray wet microencapsulation (SWM) technique. SWM technique is a method of preparing microcapsules in which a solution, suspension, or emulsion with a charged matrix is sprayed into opposing solution. The aim of this research was to formulate the dry Curcuma extract with SWM technique using sodium alginate as matrix.Methods: Brown algae (Sargassum ilicifolium) was a main resource of alginate acid. It was isolated using HCl 5% to make alginate acid and sodium alginate that was obtained by adding Na2CO3 5% to alginate acid solution. The microencapsulation process of Curcuma extract was done by SWM technique. The formula of Curcuma extract microencapsula...
World Journal of Pharmacy and Pharmaceutical Sciences, 2015
Orally disintegrating tablets were developed to solve the difficulty of swallowing the convention... more Orally disintegrating tablets were developed to solve the difficulty of swallowing the conventional tablet in pediatrics and geriatrics patients. In administration of orally disintegrating tablets, tablets are placed on the tongue in oral cavity and it will disintegrate rapidly in less than 60 second. Since solid tapai extract is slightly soluble when it puts on the tounge and has sweet taste, it has potential as a natural excipient in Article Received on
International Journal of PharmTech Research, 2016
Solid tapai extract had been applied as excipient in formulating orally disintegrating tablets (O... more Solid tapai extract had been applied as excipient in formulating orally disintegrating tablets (ODTs). Solid tapai extract was used as excipient by combining solid tapai extract with corn starch and avicel. The formula was designed using simplex lattice design method with three component mixture. The optimized formula was determined by in vitro and in vivo study. The objective of this pilot study was to discover in vitro and in vivo correlation of optimized metochlopramide-ODTs. The design of in vivo test designed by using six rabbits. The drug released in the plasma was measured by HPLC instrument using glacial acetic acid 1% in aquabidestilata and metanol-acetonitrile (1:3.7) with ratio 60:40. The result showed that in vitro test on pH 1.2 and 7.4 had correlation to in vivo test with coefficient correlation of 0.996 and 0.975.
JURNAL PENGMAS KESTRA (JPK)
Asam urat sebagai hasil metabolisme senyawa purin atau xanthin, peningkatan konsumsi senyawa puri... more Asam urat sebagai hasil metabolisme senyawa purin atau xanthin, peningkatan konsumsi senyawa purin atau xanthin menyebabkan akumulasi kristal dari senyawa asam urat dengan notabene sukar larut dalam air. Asam urat darah dipengaruhi oleh beberapa faktor, misalnya makanan kaya purin dan xanthin, suku, physic activity, supply alkohol, dan usia. Darah hanya mampu menampung sampai tingkat tertentu, kadar melebihi daya larut, di atas 6,8 mg/dl disebut hiperurisemia, Hiperurisemia bisa berlangsung lama dan sebagian bias menjadi artritis gout. Gout dikenal sebagai penyakit yang dapat menyebabkan penderita mengalami nyeri yang hebat pada sendi. Pengabdian masyarakat dilakukan dengan metode penyuluhan dan pemeriksaan kadar asam urat darah peserta. Masyarakat diharapkan dapat menambah pengetahuan tentang kadar asam urat darah sehingga mengurangi resiko Gout. Serta mengetahui kadar asam urat darah peserta pada saat pengecekan.
BAHASANTODEA, Jan 30, 2017
The idea XA grade students of SMA Negeri 1 Tolitoli Utara can be improved. It was revealed from a... more The idea XA grade students of SMA Negeri 1 Tolitoli Utara can be improved. It was revealed from a study of the problem: (1) how the application of the method of discussion to improve the students express ideas in class XA SMA Negeri 1 Tolitoli Utara? And (2) whether the application of the results of the discussion method can improve the students express ideas in class XA SMA Negeri 1 Tolitoli Utara?. This study aims to (1) describe the application of the method of discussion to improve the students express ideas in class XA SMA Negeri 1 Tolitoli Utara and (2) describe the results of applying the method of discussion to improve the students express ideas in class XA SMA Negeri 1 Tolitoli Utara. Methods of data collection using the oral tests, observation and documentation. Qualitative data analysis techniques and quantitative techniques. The results showed that (1) the application of the method of discussion in several stages, The first researcher to prepare articles that will be distributed to students; two researchers set up research pieces express the idea of learning implementation skills; The third researcher prepares a camera to document the activities of teachers and students during the learning process; After that process, the skills students express ideas increased. The percentage of skill express the idea of students has increased at every meeting of the first cycle and the second cycle. Improved skills of students express the idea in the first cycle of 65.75 from 41.33 the initial conditions. In the second cycle increased by 74.67.
Open Access Macedonian Journal of Medical Sciences, Jan 26, 2022
AIM: This study aimed to make corncobs the basic material for the manufacture of microcrystalline... more AIM: This study aimed to make corncobs the basic material for the manufacture of microcrystalline cellulose. METHODS: Manufacture of corncob cellulose microcrystals (CCMs) by isolating alpha-cellulose from corncobs, then hydrolyzed with HCl 2.5 N. The yield of CCMs of 14.51% can be used as orally disintegrating tablet (ODT) and has similarities with Avicel as standard comparison. RESULTS: Both organoleptic results were pH 5.6 and 6.54; drying shrinkage 3.33% and 4.39%; total ash content 0.17% and 0.02%; and water solubility 0.9% and 0.12%. Furthermore, the real specific gravity is 0.317 and 0.306 g/cm 3 , incompressible density is 0.379 and 0.375 g/cm 3 , the true density is 1.291 and 1.206 g/cm 3 , Hausner index is 1.195 and 1.225, compressibility index is 19.55 and 22.55%, and porosity is 75.5 and 74.6%. CONCLUSION: Captopril ODT tablet preparations with CCM as filler have almost the exact tablet evaluation results compared to Avicel and to meet the requirements.
Amaliah, Oct 26, 2018
Perguruan tinggi memiliki peran untuk memotivasi para mahasiswa dan sarjananya menjadi young entr... more Perguruan tinggi memiliki peran untuk memotivasi para mahasiswa dan sarjananya menjadi young entrepreneurs dan merupakan bagian dari salah satu faktor pendorong pertumbuhan kewirausahaan. Tujuan kegiatan Program Pengembangan Kewirausahaan (PPK) di Universitas Muslim Nusantara (UMN) Al Washliyah untuk menghasilkan wirausaha yang mandiri berbasis iptek dan siap beraktivitas di masyarakat. Metode pendekatan pada program PPK secara Participatory Action Learning System (PALS). Adapun tenant PPK UMN Al Washliyah adalah mahasiswa dan Alumni UMN Al Washliyah. Kegiatan Program Pengembangan Kewirausahaan dengan memberikan bimbingan, motivasi, pelatihan, pendampingan, dan konsultasi kewirausahaan.Kegiatan PPK UMN Al Washliyah telah melakukan kegiatan antara lain, yaitu memperkenalkan tentang kewirausahaan dan memotivasi mahasiswa untuk berwirausaha pada kegiatan kuliah umum kewirausahaan islami, melakukan rekrutmen tenant peserta PPK UMN Al Washliyah, pelatihan kewirausahaan, peningkatan keterampilan berwirausahaan dengan magang, praktek dan kunjungan ke tempat usaha, memberikan modal usaha berupa peralatan penunjang dan bahan habis pakai, pameran produk, dan evaluasi kegiatan kerja tenant. Kegiatan PPK UMN Al Washliyah pada tahun pertama ini telah menghasilkan 5 (lima) orang wirausaha mandiri dan 15 (lima belas) orang sedang merintis berwirausaha.
Open Access Macedonian Journal of Medical Sciences, Jul 7, 2020
BACKGROUND: Bioavailability and bioequivalence studies required by regulations to ensure therapeu... more BACKGROUND: Bioavailability and bioequivalence studies required by regulations to ensure therapeutic equivalence between a pharmaceutically equivalent test product and a reference product. AIM: This study aimed to evaluate the bioavailability performance between the optimum formula of OROS dispersible tablet-metoclopramide dosage forms (FCL-6) and the Primperan ® as the reference product. METHODS: The FCL-6 formula was design by simplex lattice design model with a three components mixture of excipients: Solid tapai extract, corn starch, and Avicel. The optimum formula of OROS dispersible tablet (ODT)metoclopramide consists of solid tapai extract (27.038 mg), corn starch (27.407 mg), and Avicel (53.555 mg), metoclopramide hydrochloric acid (HCl) (10.00 mg), LH-11 (22.50 mg), aspartame (5.00 mg), talcum BP (3.00 mg), and Mg stearate (1.50 mg). The in vivo test was done by cross-over design method using six rabbits. The level of metoclopramide concentration from in vivo test was measured by high-performance liquid chromatography instrument. RESULTS: The study revealed that the t max , C max , and area under curve (AUC) of ODT-metoclopramide FCL-6 were 60 min, 1.95 ± 0.13 µg/mL, and 1118.20 ± 150 µg/mL. min consecutively. The C max and the concentration of the drug absorbed in the blood (AUC) of ODT-metoclopramide were larger than Primperan ® tablets. Statistical data of the optimized ODT-metoclopramide compared with Primperan ® showed that the C max and AUC significance values were <0.05 (p < 0.05). CONCLUSION: The optimized formula of ODT-metoclopramide revealed a better characteristic of C max and AUC concentration compared with Primperan ®. The optimized ODT-metoclopramide with tapai extract was found to be promising to improved bioavailability of metoclopramide.
Syrup is a beverage product resulting from the production of a mixture of water and sugar at a co... more Syrup is a beverage product resulting from the production of a mixture of water and sugar at a content of not less than 65%, whether or not ingredients are in the form of food with or without food additives, which have received permission to use according to the regulations of the Food and Drug Supervisory Agency of the Republic of Indonesia. Fruit syrup is made from fresh fruit juice with sugar and the taste and aroma of the fruit. Fruits used in syrup production must have an attractive color, aroma and distinctive taste. Example the taste and aroma of passion fruit (Passiflora edulis S) and sweet orange (Citrus sinensis L). Sweet orange and passion fruit are used as a source of fruit syrup juice. Sweet oranges are widely grown in Indonesia, including North Sumatra, especially in Gung Pinto Village, Tanah Karo. During the main harvest, there is usually a decrease in the price of oranges so that farmers are reluctant to pick the fruit which has been the foundation of their lives. Th...
Orally disintegrating tablet (ODT) was developed to solve the difficulty of swallowing convention... more Orally disintegrating tablet (ODT) was developed to solve the difficulty of swallowing conventional tablet for paediatric and geriatric patients. In administration of ODT, tablets are placed on the tongue in oral cavity and it will disintegrate rapidly in less than 60 seconds. The solid tapai extract (STE) has sweet taste, is rather sour and slightly soluble when it is put on the tongue. This is the reason why it has potential as a natural excipient in ODT. The objective of the study was to characterise STE as excipient and to use STE as excipient in the formulation of ODT by lyophilisation method. The ingredients were glutinous rice (Oryza sativa L. var. Glutinous) used to form tapai and the liquid extract of tapai which was used to make STE. STE was used as excipient by combining STE with dextrose and avicel. Metoclopramide HCl was used as a drug model. The design of formula used the simplex lattice design (SLD) model with a three components mixture: STE, dextrose and avicel as ex...
Malaysian Journal of Pharmaceutical Sciences, 2014
Orally disintegrating tablet (ODT) was developed to solve the difficulty of swallowing conventio... more Orally disintegrating tablet (ODT) was developed to solve the difficulty of swallowing
conventional tablet for paediatric and geriatric patients. In administration of ODT, tablets are placed on the tongue in oral cavity and it will disintegrate rapidly in less than 60 seconds. The solid tapai extract (STE) has sweet taste, is rather sour and slightly soluble when it is put on the tongue. This is the reason why it has potential as a natural excipient in ODT. The objective of the study was to characterise STE as excipient and to use STE as excipient in the formulation of ODT by lyophilisation method. The ingredients were glutinous rice (Oryza sativa L. var. Glutinous) used to form tapai and the liquid extract of tapai which was used to make STE. STE was used as excipient by combining STE with dextrose and avicel. Metoclopramide HCl was used as a drug model. The design of formula used the simplex lattice design (SLD) model with a three components mixture: STE, dextrose and avicel as excipients. The parameters of lyophilised ODT (LODT) were hardness and friability, wetting time, disintegrating time and dissolution rate. The results showed STE can be used as filler and binder for LODT. STE could also function as disintegrant and formed porosity in the lyophilised method. Based on equation and contour plot of superimposed method, a formula consisting of STE (24.18 mg), dextrose (19.71 mg) and avicel (96.11 mg) was the optimum formula of LODT.
JURNAL FARMASIMED (JFM)
Ikan salah satu dari sekian banyak kekayaan alam bahari Indonesia. Lauk pauk ikan banyak dikonsum... more Ikan salah satu dari sekian banyak kekayaan alam bahari Indonesia. Lauk pauk ikan banyak dikonsumsi masyarakat, mudah diperoleh di pasar dengan harga terjangkau. Namun ikan basah dan ikan kering mudah dan cepat mengalami pembusukan. Mikroba ada sejak ikan masih hidup. Aktivitas mikroba menyebabkan perubahan biokimia dan fisik ikan sehingga bau busuk. Kondisi busuk diketahui setelah bau busuk tersebar dan timbul lendir, warna suram, mata keruh dan sebagainya. Pengawetan ikan basah dan ikan kering dilakukan dengan mengurangi kadar air. Pengawetan merupakan daya upaya peyelamatan hasil tangkapan ikan oleh nelayan. Pembusukan ikan dihambat dengan penambahan garam, sehingga penyimpanan ikan lebih lama tanpa aktivitas bakteri dan enzim. Pesatnya teknik pengolahan pangan, penambahan bahan-bahan aditif pada bahan pangan sulit untuk dihindari, akibatnya keamanan pangan telah menjadi dasar pemilihan suatu produk pangan yang akan dikonsumsi. Bahan aditif berbahaya sulit dihindari, selalu ditem...
International Journal of Applied Pharmaceutics, 2019
Objective: The aim of this work was to formulate and evaluate orally disintegrating tablets of ci... more Objective: The aim of this work was to formulate and evaluate orally disintegrating tablets of cinnarizine that were prepared by direct compression method using different types of diluents and super disintegrants. The rationale behind this work was to accelerate the disintegration of the tablet to provide rapid dissolution, quick action and enhanced bioavailability of the drug.Methods: The tablets were prepared by direct compression method using different types of diluents as mannitol, microcrystalline cellulose (MCC), and lactose. Different super disintegrants were used such as crospovidone (CP), sodium starch glycolate (SSG) and Kyron T-314; Kyron T-314 was used in different concentrations of 5%, 6%, 7%, and 8%. The prepared formulae (F1-F9c) were subjected to flowability studies and post-compression evaluation studies. The optimized formula was selected depending on the time of disintegration and dissolution; then it was subjected to drug-excipient compatibility study and stabili...
Mejuajua: Jurnal Pengabdian pada Masyarakat
Salah satu desa yang berada di wilayah Kabupaten Deli Serdang Provinsi Sumatera Utara, yaitu desa... more Salah satu desa yang berada di wilayah Kabupaten Deli Serdang Provinsi Sumatera Utara, yaitu desa Cinta Rakyat Percut Sei Tuan menjadi objek pengabdian masyarakat oleh Tim Program Kemitraan Masyarakat Progran Studu S1 Farmasi Sekolah Tinggi Ilmu Keshatan Indah Medan. Ibu-ibu di desa ini biasa membantu suami sebagai petani dan nelayan, dan beraktivitas sosial pada kegiatan desa dan keagamaan, belum sampai pada taraf upaya peningkatan ekonomi keluarga. Minuman Sehat Instan Kering adalah sediaan olahan dari bahan baku alami menjadi bentuk serbuk, dan siap disajikan dengan dicampur air hangat. Minuman oalahan tersebut berbahan utama Temulawak, yang biasa dijajakan dalam bentuk sediaan jamu sari Temulawak. Sediaan yang dibuat berpotensi dikembangkan menjadi produk unggulan. Pengabdian dilakukan untuk melatih pembuatan sediaan tersebut dengan bahan baku tumbuhan yang ada di lingkungan sekitar. Pelatihan dilakukan Tim dengan memanggil Ibu-ibu rumah tangga untuk mengikuti pelatihan. Hasil k...
Mejuajua: Jurnal Pengabdian pada Masyarakat, 2021
Lut Tawar dan Pegasing merupakan dua yang ada di Aceh Tengah, Nanggroe Aceh Darussalam (NAD) seba... more Lut Tawar dan Pegasing merupakan dua yang ada di Aceh Tengah, Nanggroe Aceh Darussalam (NAD) sebagai objek Pengabdian oleh Tim PKM Program Studi S1 Farmasi STIKes Indah Medan dan Progran Studi Farmasi SMK Al Razi Sinar Harapan Medan. Ibu anggota TIM PKK utusan Lut Tawar dan Pegasing biasa bersama suami sebagai petani. Ibu yang tergabung dalam TIM PKK berkumpul di Kator Dinas KBP3A untuk dilatih dan dibimbing Tim PKM memproduksi SAOS TOMAT. Tomat salah satu komoditi sayuran asal Aceh Tengah yang saat tertentu panen raya melimpah di Pasar sehingga harga menjadi turun dan berimbas ke kota lain, termasuk Medan, Sumatera Utara; bahkan petani sendiri terkadang tidak lagi memanen karena biaya operasional tidak tercover dari hasil jual panen. Untuk mengatasi ini, alangkah lebih baik bila diolah menjadi SAOS TOMAT sehingga penghasilan petani stabil setiap saat. Ibu-ibu peserta Tim PKK utusan Lut Tawar dan Pegasing mengikuti dengan sangat antusias dan produk SAOS TOMAT sesuai yang diharapkan
The preparation of brewed white sticky rice extract or brem from white glutinous rice had been re... more The preparation of brewed white sticky rice extract or brem from white glutinous rice had been researched by using variation concentration of yeast. The yeasts were bought from traditional market without trade mark. Tape extract obtained by squeezed tape mass using a pressurized equipment, water of tape obtained further filtered using a 60 mesh sieve and the waste is disposed. The variation of yeast influences the pH of liquid tape extract. The optimum concentration of yeast was 1,5%. The research of orally disintegrating tablet (ODT) that using direct compress method was designed by using Simplex Lattice Design (SLD) mixture design programme with two components mixture: brewed white sticky rice extract and corn starch (CS), and metochlopramide as model drug. Brewed white sticky rice extract and CS were formulated become nine designs of formula. Brewed white sticky rice extract was dominant increasing flow and compactability of ODT mass, but decreasing wetting time, disintegrating t...
Amaliah: Jurnal Pengabdian Kepada Masyarakat, 2018
ABSTRAK Perguruan tinggi memiliki peran untuk memotivasi para mahasiswa dan sarjananya menjadi yo... more ABSTRAK Perguruan tinggi memiliki peran untuk memotivasi para mahasiswa dan sarjananya menjadi young entrepreneurs dan merupakan bagian dari salah satu faktor pendorong pertumbuhan kewirausahaan. Tujuan kegiatan Program Pengembangan Kewirausahaan (PPK) di Universitas Muslim Nusantara (UMN) Al Washliyah untuk menghasilkan wirausaha yang mandiri berbasis iptek dan siap beraktivitas di masyarakat. Metode pendekatan pada program PPK secara Participatory Action Learning System (PALS). Adapun tenant PPK UMN Al Washliyah adalah mahasiswa dan Alumni UMN Al Washliyah. Kegiatan Program Pengembangan Kewirausahaan dengan memberikan bimbingan, motivasi, pelatihan, pendampingan, dan konsultasi kewirausahaan.Kegiatan PPK UMN Al Washliyah telah melakukan kegiatan antara lain, yaitu memperkenalkan tentang kewirausahaan dan memotivasi mahasiswa untuk berwirausaha pada kegiatan kuliah umum kewirausahaan islami, melakukan rekrutmen tenant peserta PPK UMN Al Washliyah, pelatihan kewirausahaan, peningkat...
Mejuajua: Jurnal Pengabdian pada Masyarakat, 2021
Kampung Daling Tajuk Dilem ada di wilayah Bebesen, Aceh Tengah, Nanggroe Aceh Darussalam (NAD) se... more Kampung Daling Tajuk Dilem ada di wilayah Bebesen, Aceh Tengah, Nanggroe Aceh Darussalam (NAD) sebagai objek Pengabdian oleh Tim PKM Program Studi S1 Farmasi STIKes Indah Medan dan Progran Studi Farmasi Sekolah Kejuruan Menengah (SMK) Al Razi Sinar Harapan Medan. Ibu anggota PKK Kampung Daling Tajuk Dilem bersama suami sebagai petani, terutama petani kopi. Kopi Arabika merupakan produk Primadona Aceh Tengah, dan Jahe dapat dijadikan pendamping dalam sajian Kopi Arabika yang sudah biasa dijadikan sebagai produk andalan Aceh Tengah dalam menarik wisatawan Domestik maupun Internasional dengan wisata alam Danau Lut Tawar. Minuman Jahe Instan (MJI) adalah sediaan olahan jahe menjadi serbuk siap saji dengan campuran air panas. Pelatihan dilakukan Tim PKM untuk melatih ibu anggota PKK Kampung Daling Tajuk Dilem memproduksi olahan jahe menjadi sediaan instan. Ibu-ibu peserta Tim PKK Kampung Daling Tajuk Dilem mengikuti dengan cukup antusias dan produk MJI Instan sesuai yang diharapkan.
Open Access Macedonian Journal of Medical Sciences
BACKGROUND: Bioavailability and bioequivalence studies required by regulations to ensure therapeu... more BACKGROUND: Bioavailability and bioequivalence studies required by regulations to ensure therapeutic equivalence between a pharmaceutically equivalent test product and a reference product. AIM: This study aimed to evaluate the bioavailability performance between the optimum formula of OROS dispersible tablet-metoclopramide dosage forms (FCL-6) and the Primperan® as the reference product. METHODS: The FCL-6 formula was design by simplex lattice design model with a three components mixture of excipients: Solid tapai extract, corn starch, and Avicel. The optimum formula of OROS dispersible tablet (ODT)-metoclopramide consists of solid tapai extract (27.038 mg), corn starch (27.407 mg), and Avicel (53.555 mg), metoclopramide hydrochloric acid (HCl) (10.00 mg), LH-11 (22.50 mg), aspartame (5.00 mg), talcum BP (3.00 mg), and Mg stearate (1.50 mg). The in vivo test was done by cross-over design method using six rabbits. The level of metoclopramide concentration from in vivo test was measur...
Asian Journal of Pharmaceutical and Clinical Research
Objective: Curcuma xanthorrhiza Roxb. was used as hereditary medicinal plant for prevention of l... more Objective: Curcuma xanthorrhiza Roxb. was used as hereditary medicinal plant for prevention of liver dysfunction, gastrointestinal disease, fever, and hemorrhoid. Curcuma extract was easy to damage because the light exposure, change of pH, weather and a long period of storage time. The problem can be solved by coating the extract with spray wet microencapsulation (SWM) technique. SWM technique is a method of preparing microcapsules in which a solution, suspension, or emulsion with a charged matrix is sprayed into opposing solution. The aim of this research was to formulate the dry Curcuma extract with SWM technique using sodium alginate as matrix.Methods: Brown algae (Sargassum ilicifolium) was a main resource of alginate acid. It was isolated using HCl 5% to make alginate acid and sodium alginate that was obtained by adding Na2CO3 5% to alginate acid solution. The microencapsulation process of Curcuma extract was done by SWM technique. The formula of Curcuma extract microencapsula...