sayali kapure - Academia.edu (original) (raw)
Papers by sayali kapure
The purpose of the present research was to the effect of camphor as a subliming agent on the mout... more The purpose of the present research was to the effect of camphor as a subliming agent on the mouth dissolving property of famotidine tablets. Method: Orodispersible tablets of famotidine were prepared using camphor as subliming agent and sodium starch glycollate together with crosscarmellose sodium as superdisintegrants. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro and in-vivo dispersion, mouth feel and in vitro dissolution. Result: All the formulations showed low weight variation with dispersion time less than 30 seconds and rapid in vitro dissolution. The results revealed that the tablets containing subliming agent had a good dissolution profile. The drug content of all the formulations was within the acceptable limits of the United States Pharmacopoeia XXVII. The optimized formulation showed good release profile with maximum drug being released at all time intervals. Conclusion: This work helped in understanding the effect of formulation processing variables especially the subliming agent on the drug release profile. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.
The purpose of this investigation was to develop fast dissolving tablets of aceclofenac using cam... more The purpose of this investigation was to develop fast dissolving tablets of aceclofenac using camphor as a subliming agent. Orodispersible tablets of aceclofenac were prepared by wet granulation technique using camphor as subliming agent and sodium starch glycolate together with crosscarmellose sodium as superdisintegrants. Camphor was sublimed from the granules by exposing the granules to vacuum. The porous granules were then compressed in to tablets. Alternatively, tablets were first prepared and later exposed to vacuum. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro and in-vivo dispersion, mouth feel and in vitro dissolution. All the formulations showed low weight variation with dispersion time less than 55 seconds and rapid in vitro dissolution. Sublimation of camphor from tablets resulted in superior tablets as compared with the tablets prepared from granules that were exposed to vacuum. The results revealed that the tablets containing subliming agent had a good dissolution profile. The drug content of all the formulations was within the acceptable limits of the United States Pharmacopoeia XXVII. The optimized formulation showed good release profile with maximum drug being released at all time intervals. It was concluded that fast dissolving tablets with improved aceclofenac dissolution could be prepared by sublimation of tablets containing suitable subliming agent. This work helped in understanding the effect of formulation processing variables especially the subliming agent on the drug release profile. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.
The aim of this investigation was to prepare orodispersible tablets of baclofen using various con... more The aim of this investigation was to prepare orodispersible tablets of baclofen using various concentrations of superdisintegrant agents like Ac-Di-Sol, crospovidone, sodium starch glycolate by direct compression method. Nine formulations having superdisintegrants at different concentration levels were prepared. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and invitro disintegration time. Among the formulations tablets of batch F3 containing Ac-Di-Sol showed superior organoleptic properties along with excellent in-vitro disintegration time and drug release as compere to other formulations. It was concluded that superdisintegrants addition technique is a usuful method for preparing orodispersible tablets by direct compression method.
Aaps Pharmscitech, 2010
Diazepam is one of the most prescribed benzodiazepines. The purpose of the present research was t... more Diazepam is one of the most prescribed benzodiazepines. The purpose of the present research was to optimize the formulation of orodispersible tablets of diazepam. Orodispersible tablets of diazepam were prepared using different types of superdisintegrants (Ac-Di-Sol, sodium starch glycolate, and crospovidone (CP)) and different types of subliming agents (camphor and ammonium bicarbonate (AB)) at different concentrations and two methods of tablets preparations (wet granulation and direct compression methods). The formulations were evaluated for flow properties, wetting time, hardness, friability, content uniformity, in vivo disintegration time (DT), release profiles, and buccal absorption tests. All formulations showed satisfactory mechanical strength except formula F5 which contains camphor and formula F9 which is prepared by direct compression method. The results revealed that the tablets containing CP as a superdisintegrant have good dissolution profile with shortest DT. The optimized formula F7 is prepared using 10% CP as a superdisintegrant and 20% AB as a subliming agent by wet granulation method which shows the shortest DT and good dissolution profile with acceptable stability. This study helps in revealing the effect of formulation processing variables on tablet properties. It can be concluded that the orodispersible tablets of diazepam with better biopharmaceutical properties than conventional tablets could be obtained using formula F7.
In recent days the use of fast mouth dissolving tablets are well accepted by elderly, children an... more In recent days the use of fast mouth dissolving tablets are well accepted by elderly, children and the patients having trouble in swallowing and even by the travelling patients who find it convenient to ingest. Cinnarizine is a piperazine derivative and is widely prescribed for the treatment of vestibular disorders and motion sickness. To enhance the anti-emetic and anti-migraine properties of Cinnarizine it is desirable to develop its fast acting dosage form hence a fast mouth dissolving tablet of Cinnarizine is always a better choice. Chitosan is the best known natural polysaccharide used for its versatile applications in pharmaceutical industry. Superdisintegrant property of chitosan has been utilized to develop a fast mouth dissolving tablet by utilizing a novel method of treatment which can replace any other superdisintegrant. The properties of the rapidly dispersible tablet, such as porosity, hardness, disintegration time, wetting time and dissolution time, were investigated accordingly and the formulation was optimized as per 3 level full factorial design and analysed for response surface methodology to decide the best formulation which further evaluated for in-vitro performances. Fast mouth dissolving or OroDispersible tablets (ODTs) of Cinnarizine with acceptable compression parameters and pleasant mouth feel could be prepared within the optimum region hence Cinnarizine OroDispersible tablets (CODT) can be prepared which upon administration disperse in mouth as soon as in contact with saliva and release the drug content immediately which can be absorbed directly through oral mucosa or can be swallowed without the aid of water hence provide faster and better therapeutic effects.
Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan, 2009
The objective of this investigation was to prepare orodispersible tablets (ODTs) of ondansetron H... more The objective of this investigation was to prepare orodispersible tablets (ODTs) of ondansetron HCl using a direct compression method. A combination of glycine and chitosan was used as a disintegrating system and these tablets were compared for mechanical strength and disintegration time with those containing superdisintegrants. The Plackett-Burman screening design was used to screen the independent variables [concentration of glycine (X 1 ), concentration of chitosan (X 2 ), concentration of ondansetron HCl (X 3 ) and tablet crushing strength (X 4 )] which were found to actively in‰uence the dependent variables [disintegration time in the oral cavity (DT), wetting time (WT), and water absorption ratio (WAR)]. Further, a central composite design was used to formulate additional ODTs of ondansetron HCl for estimating response in the extended spherical domain. The regression analysis (performed using Statistica-7.0) of quad-raticˆt revealed that DT or WT and WAR were 99％ and 98％ correlated with active factors (X 1 , X 2 or X 3 ), respectively. The data showed that disintegration time of optimized ondansetron HCl ODTs was not signiˆcantly diŠerent (p＜ 0.05) from ODTs prepared using Croscarmellose sodium or Crospovidone.
The purpose of the present research was to the effect of camphor as a subliming agent on the mout... more The purpose of the present research was to the effect of camphor as a subliming agent on the mouth dissolving property of famotidine tablets. Method: Orodispersible tablets of famotidine were prepared using camphor as subliming agent and sodium starch glycollate together with crosscarmellose sodium as superdisintegrants. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro and in-vivo dispersion, mouth feel and in vitro dissolution. Result: All the formulations showed low weight variation with dispersion time less than 30 seconds and rapid in vitro dissolution. The results revealed that the tablets containing subliming agent had a good dissolution profile. The drug content of all the formulations was within the acceptable limits of the United States Pharmacopoeia XXVII. The optimized formulation showed good release profile with maximum drug being released at all time intervals. Conclusion: This work helped in understanding the effect of formulation processing variables especially the subliming agent on the drug release profile. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.
The purpose of this investigation was to develop fast dissolving tablets of aceclofenac using cam... more The purpose of this investigation was to develop fast dissolving tablets of aceclofenac using camphor as a subliming agent. Orodispersible tablets of aceclofenac were prepared by wet granulation technique using camphor as subliming agent and sodium starch glycolate together with crosscarmellose sodium as superdisintegrants. Camphor was sublimed from the granules by exposing the granules to vacuum. The porous granules were then compressed in to tablets. Alternatively, tablets were first prepared and later exposed to vacuum. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro and in-vivo dispersion, mouth feel and in vitro dissolution. All the formulations showed low weight variation with dispersion time less than 55 seconds and rapid in vitro dissolution. Sublimation of camphor from tablets resulted in superior tablets as compared with the tablets prepared from granules that were exposed to vacuum. The results revealed that the tablets containing subliming agent had a good dissolution profile. The drug content of all the formulations was within the acceptable limits of the United States Pharmacopoeia XXVII. The optimized formulation showed good release profile with maximum drug being released at all time intervals. It was concluded that fast dissolving tablets with improved aceclofenac dissolution could be prepared by sublimation of tablets containing suitable subliming agent. This work helped in understanding the effect of formulation processing variables especially the subliming agent on the drug release profile. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.
The aim of this investigation was to prepare orodispersible tablets of baclofen using various con... more The aim of this investigation was to prepare orodispersible tablets of baclofen using various concentrations of superdisintegrant agents like Ac-Di-Sol, crospovidone, sodium starch glycolate by direct compression method. Nine formulations having superdisintegrants at different concentration levels were prepared. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and invitro disintegration time. Among the formulations tablets of batch F3 containing Ac-Di-Sol showed superior organoleptic properties along with excellent in-vitro disintegration time and drug release as compere to other formulations. It was concluded that superdisintegrants addition technique is a usuful method for preparing orodispersible tablets by direct compression method.
Aaps Pharmscitech, 2010
Diazepam is one of the most prescribed benzodiazepines. The purpose of the present research was t... more Diazepam is one of the most prescribed benzodiazepines. The purpose of the present research was to optimize the formulation of orodispersible tablets of diazepam. Orodispersible tablets of diazepam were prepared using different types of superdisintegrants (Ac-Di-Sol, sodium starch glycolate, and crospovidone (CP)) and different types of subliming agents (camphor and ammonium bicarbonate (AB)) at different concentrations and two methods of tablets preparations (wet granulation and direct compression methods). The formulations were evaluated for flow properties, wetting time, hardness, friability, content uniformity, in vivo disintegration time (DT), release profiles, and buccal absorption tests. All formulations showed satisfactory mechanical strength except formula F5 which contains camphor and formula F9 which is prepared by direct compression method. The results revealed that the tablets containing CP as a superdisintegrant have good dissolution profile with shortest DT. The optimized formula F7 is prepared using 10% CP as a superdisintegrant and 20% AB as a subliming agent by wet granulation method which shows the shortest DT and good dissolution profile with acceptable stability. This study helps in revealing the effect of formulation processing variables on tablet properties. It can be concluded that the orodispersible tablets of diazepam with better biopharmaceutical properties than conventional tablets could be obtained using formula F7.
In recent days the use of fast mouth dissolving tablets are well accepted by elderly, children an... more In recent days the use of fast mouth dissolving tablets are well accepted by elderly, children and the patients having trouble in swallowing and even by the travelling patients who find it convenient to ingest. Cinnarizine is a piperazine derivative and is widely prescribed for the treatment of vestibular disorders and motion sickness. To enhance the anti-emetic and anti-migraine properties of Cinnarizine it is desirable to develop its fast acting dosage form hence a fast mouth dissolving tablet of Cinnarizine is always a better choice. Chitosan is the best known natural polysaccharide used for its versatile applications in pharmaceutical industry. Superdisintegrant property of chitosan has been utilized to develop a fast mouth dissolving tablet by utilizing a novel method of treatment which can replace any other superdisintegrant. The properties of the rapidly dispersible tablet, such as porosity, hardness, disintegration time, wetting time and dissolution time, were investigated accordingly and the formulation was optimized as per 3 level full factorial design and analysed for response surface methodology to decide the best formulation which further evaluated for in-vitro performances. Fast mouth dissolving or OroDispersible tablets (ODTs) of Cinnarizine with acceptable compression parameters and pleasant mouth feel could be prepared within the optimum region hence Cinnarizine OroDispersible tablets (CODT) can be prepared which upon administration disperse in mouth as soon as in contact with saliva and release the drug content immediately which can be absorbed directly through oral mucosa or can be swallowed without the aid of water hence provide faster and better therapeutic effects.
Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan, 2009
The objective of this investigation was to prepare orodispersible tablets (ODTs) of ondansetron H... more The objective of this investigation was to prepare orodispersible tablets (ODTs) of ondansetron HCl using a direct compression method. A combination of glycine and chitosan was used as a disintegrating system and these tablets were compared for mechanical strength and disintegration time with those containing superdisintegrants. The Plackett-Burman screening design was used to screen the independent variables [concentration of glycine (X 1 ), concentration of chitosan (X 2 ), concentration of ondansetron HCl (X 3 ) and tablet crushing strength (X 4 )] which were found to actively in‰uence the dependent variables [disintegration time in the oral cavity (DT), wetting time (WT), and water absorption ratio (WAR)]. Further, a central composite design was used to formulate additional ODTs of ondansetron HCl for estimating response in the extended spherical domain. The regression analysis (performed using Statistica-7.0) of quad-raticˆt revealed that DT or WT and WAR were 99％ and 98％ correlated with active factors (X 1 , X 2 or X 3 ), respectively. The data showed that disintegration time of optimized ondansetron HCl ODTs was not signiˆcantly diŠerent (p＜ 0.05) from ODTs prepared using Croscarmellose sodium or Crospovidone.