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Papers by hamza sule

Dutse Journal of Pure and Applied Sciences, Apr 24, 2024

Malaria poses a significant health challenges globally, disproportionately affecting vulnerable p... more Malaria poses a significant health challenges globally, disproportionately affecting vulnerable population such as children. This study aimed to ascertain the prevalence of asymptomatic malaria among primary school pupils in Dala Local Government Area, Kano State, Nigeria. Utilizing a crosssectional design, blood samples were collected from 107 pupils through finger prick. These samples were then subjected to microscopic examination following the preparation of both thin and thick blood films. The overall prevalence of asymptomatic malaria was found to be 21.5%, with 23 pupils testing positive for the parasite. Gender-wise, male participants exhibited a higher infection rate (73.9%) compared to their female counterparts (26.08%). Age-specific analysis revealed that the 13-16 years age group had the highest prevalence of asymptomatic malaria at 73.9%, whereas the 5-8 years age group had the lowest at 2.38%. These results highlighted the substantial presence of asymptomatic malaria among school-aged children, particularly within the 13-16 years age bracket. The study underscores the need for targeted public health interventions to identify and treat asymptomatic malaria infections in order to mitigate the silent transmission within this vulnerable population.

Dutse Journal of Pure and Applied Sciences, Apr 24, 2024

UMYU Journal of Microbiology Research (UJMR), Jun 29, 2019

Candidiasis as a disease is sometimes synonymous with woman folk and most human immunodeficiency ... more Candidiasis as a disease is sometimes synonymous with woman folk and most human immunodeficiency virus (HIV) infected individuals. But the disease generally has no border, as it affects males, females, old, young and middle age persons. Environmental changes encourage over-growth of the opportunistic pathogens Candida spp. The review aimed to assess different presentations of diseases due to Candida species in some states in Nigeria, covering Northwest, Southwest , South-south and Southeastern parts of the country. Data was obtained through literature search of work from previous researchers. It was observed based on the review that candidiasis is a factor of many different species of the genus Candida but Candida albican is the predominant cause of the illiness, with other non albican Candida, contributing the remaining percentage. It was also discovered that HIV infection, pregnancy, diabetis abuse of antibiotics and generally immunocompromise status are among the predisposing factors of the disease. It was also discovered that age group of 20-30 which is an active age group in women are more prone to candidisis.

Academia Biology

Background to the study: Invasive candidiasis is a critical healthcare-related fungal infection ... more Background to the study: Invasive candidiasis is a critical healthcare-related fungal infection caused by several Candida species. Candida auris is an emerging multidrug-resistant, non-albicans species responsible for nosocomial infections, from skin colonization to invasive candidiasis outbreaks. It causes horizontal transmission, persistent outbreaks, and high mortality rates ranging from 30% to 78% across the affected populations.Objectives and methodological approach: This study aimed to review the data obtained on various virulence and resistance factors of C. auris strains that facilitate their survival. The available published research articles related to C. auris pathogenicity were retrieved and reviewed from four reliable databases, namely ScienceDirect, Google Scholar, PubMed, and Scopus.Results: Common virulent factors of C. auris include host-defense evasion, enzyme production (proteinase, hemolysin, and phospholipase), and adherence ability to host cells. Invasive candidiasis management requires the administration of an appropriate antifungal drug for successful clinical outcomes. Currently, only a few classes of antifungal drugs are available for antifungal therapeutic use. The emergence of resistance to a single class or multidrug greatly impaired effective management. About 90% of C. auris have intrinsic resistance to fluconazole.Conclusions and outcomes: Early, rapid, and sensitive diagnosis is essential for initiation of effective therapy since C. auris strains often produce virulent characteristics and are likely to resist the commonly used antifungal drugs.

AIMS Biophysics

Severe acute respiratory syndrome corona virus2 (SARS-CoV-2) is responsible for the current pande... more Severe acute respiratory syndrome corona virus2 (SARS-CoV-2) is responsible for the current pandemic that led to so many deaths across the globe and still has no effective medication. One attractive target is Papain-like protease (PLpro), which plays a critical role in viral replication. Several important structural features dictate access to the PLpro narrow active site, which includes a series of loops surrounding the area. As such, it is difficult for chemical compounds to fit the SARS-CoV-2 PLpro active site. This work employed a computational study to discover inhibitors that could bind to the SARS-COV-2 PLpro active site, mainly by virtual screening, molecular dynamic simulation, MMPBSA and ADMET analysis. Eight potential inhibitors were identified: carbonoperoxoic acid, Chrysophanol-9-anthrone, Adrenolutin, 1-Dehydroprogesterone, Cholest-22-ene-21-ol, Cis-13-Octadecenoic acid, Hydroxycarbonate and 1-(4-(4-Methylphenyl)-5-phenyl-1,3-oxazol-2-yl) isoquinoline, with binding scor...

Candidiasis as an opportunistic infection that comes up in many different forms, depending on the... more Candidiasis as an opportunistic infection that comes up in many different forms, depending on the part of the body involved and the category of patients affected. Oral candidiasis affects the oral cavity, and is a common phenomenon among HIV patients who are subject to immune depression. This study was to determine the burden of oral candidiasis among HIV patients in the study area. Samples were collected using sterile cotton tipped swabs and processed immediately. In the process, direct gram staining technique and KOH mount was carried out prior to culturing on Sabouraud dextrose agar followed by sub-culturing on chromogenic agar, to help in the phenotypic speciation of the different candida isolates after germ tube test was carried out. A total of 109 Candida species were isolated in this study, that include Candida albicans 72(66.1%), Candida glabrata 13(11.9%) and Candida krusie 24(22.0%). It was also discovered that age limit of 21-30 had the highest infection rate 32(29.4%) wh...

Citation: Hamza Sule., et al. “The Coronavirus Disease Covid-19: A Global Nightmare”. EC Microbio... more Citation: Hamza Sule., et al. “The Coronavirus Disease Covid-19: A Global Nightmare”. EC Microbiology 16.8 (2020): 70-72. The corona virus disease as an emerging pandemics, it affects almost every part of the world and cut across all age groups, but appears to be more serious on certain categories of people (the elderly, the young and those with underline disease conditions like diabetes, heart and liver diseases among others).

As corona virus disease (Covid-19) reaches a pandemic status within short time, it is a call to o... more As corona virus disease (Covid-19) reaches a pandemic status within short time, it is a call to order, to the global health system, because, as at the moment, there is no nation or group of nations spared off the disease. This review aimed to assess, the journey so far, with regards to the search for effective treatment options for covid-19. Relevant data were obtained using various search engines, like Google, Ask.com, Bing and yandex among others. In the course of that, it was discovered based on the previous restudies that, many different agents are candidates for treatment of Covid-19. These include antiviral, antibacterial/antiparasitic as well as anti-inflammatory agents. Due to the significance of the disease to public health, World Health Organization (WHO) initiated a largescale trial called (“Solidarity Trial”), covering many countries and enrolling large number of hospitalized patients at once. This was designed to cut down the normal lengthy period clinical trials and ev...

Urinary Tract infections (UTIs) are one of the most common causes of hospital visit worldwide. Th... more Urinary Tract infections (UTIs) are one of the most common causes of hospital visit worldwide. The study intends to find the prevalence of Escherichia coli in Urinary tract infection cases in Aminu Kano Teaching Hospital (AKTH), Kano. A comprehensive study was conducted on E coli for its prevalence in urine samples, of queried cases of urinary tract infection in patients attending Aminu Kano Teaching Hospital (AKTH), Kano. Two hundred and fourteen urine specimens comprising of 123(57.5%) females and 91(42.5%) males of all age group were screened for bacteria. Of the 214 samples, 68 representing (31.80%) were culture positive with E. coli having 32(47.06%), Klebsiella spp 18(26.47%), Staphylococcus spp 10(14.70%), Proteus spp 6(8.82%) and Pseudomonas spp 2(2.94%). Out of the 32(47.6%) of E. coli isolated, 22 were from female and 10 were from males, the highest prevalence occurred within the age range of 21-30 with females taking the lead. Antibiogram of the isolated E. coli showed a ...

American Journal of Internal Medicine

Bacterial colonies can differ greatly in their morphologies. These differences can help us in ide... more Bacterial colonies can differ greatly in their morphologies. These differences can help us in identifying different species of bacteria. The clinical isolates of Staphylococcus Aureus are subjected to standard biochemical tests, to observe the biochemical characteristics. One hundred and ten (110) pathogenic Staphylococcus Aureus strains were used in this study. Characteristics of these strains were determined by biochemical tests such as catalase, coagulase, DNase test, test for beta haemolysin, fermentation of mannitol and lactose. Staphylococcus Aureus [American Type Culture Collection (ATCC) 25923] was used as a reference control organism. From this study, males were more infected than females, having 60 (61.8%) and 42 (38.2%) respectively. The age group with the highest number of isolates was (0-10) years while blood culture had the highest frequency of Staphylococcus Aureus isolates with a frequency of 42 (38.1%). It was also observed that 100% of Staphylococcus Aureus showed positive results in catalase and tube coagulase, about 101 (91.8%) were positive for slide coagulase production test, 102 (92.7%) strains were positive to DNase test, 63 (57.3%) were positive to beta haemolysin while 79 (71.8%) and 106 (96.4%) strains fermented Mannitol and lactose respectively. This study reveals that no single test that can be used for the identification of Staphylococcus Aureus, hence the need for sequel testing using proper biochemical tests should be used for the identification of Staphylococcus Aureus isolates.

Schistosomiasis is largely a water-snail related disease that mostly affects school aged children... more Schistosomiasis is largely a water-snail related disease that mostly affects school aged children in developing countries. The disease is also related to poverty and lack of health education among other factors. The study focused on the urine associated schistosomiasis in Dawakin Kudu Local Government Area, Kano state. Two hundred and twenty seven (227) urine samples were collected and processed using standard methods, which include macroscopy for colour, turbidity and any blood tinge and microscopy, in which the urine samples were centrifuged and the sediments examined using 10x and 40x objectives with condenser closed sufficiently to give contrast. In the results, overall prevalence rate obtained was 19.4%. According to gender, the result of Schistosoma haematobium infestation in the five villages revealed that, infection was found only among males 44(25.7%) while females had 0(0.00%). Prevalence according to localities indicated, 24(54.5%) for Tsakuwa, 7(15.9%) for Yan Barau, an...

Journal of Microbiology & Experimentation

Universal bottles were used for the collection of the appropriate urine samples for the study. Th... more Universal bottles were used for the collection of the appropriate urine samples for the study. The enrolled patients were educated on the

International Journal of Biomedical Materials Research

Ability of bacteria to withstand antibiotic therapy is often associated with resistance. Certain ... more Ability of bacteria to withstand antibiotic therapy is often associated with resistance. Certain bacteria have the ability to produce some enzymes, like Beta-Lactamase, which confers resistance to some groups of antibiotics like penicillins and cephalosporins. The study focused on producers of these enzymes among uropathogens. A total of one hundred and forteen isolates (114) were screened, out of which seventy one 71 (62.3%) were found positive for the enzymes. Eschericia coli had the highest positivity rate 40 (56.3%). Followed by Klebsiella spp., Staphylococcus aureus, Staphylociccus saprophyticcus, Proteus mirabilis, and Pseudomonas aeruginosa with 15 (21.1%), 7 (10.0%), 5 (7.0%), 3 (4.2%), and 1 (1.4%) respectively. In the same vein, it was discovered that, isolates of females' origin, produced more of the enzymes than those of their males counterpart. This was indicated by the production of the enzyme by at least one isolate in each of the species isolated from female samples while in males, some species did not even produce any of the enzymes. Age-wise distribution of the enzymes showed that, 21-30, and 31-40 age groups had all the isolates producing the enzymes in varying frequencies. Only Pseudomonas aeruginosa that produced its enzyme outside these age groups. Isolates of females origin had more of the enzymes produced in all the species compared to those from males,

American Journal of Biomedical and Life Sciences, 2016

Urinary tract infections (UTIs) are among the most commonly encountered infections, both in the c... more Urinary tract infections (UTIs) are among the most commonly encountered infections, both in the community and in hospitals. The study investigated the Prevalence of Klebsiella species among patients suspected of UTI in Murtala Muhammad Specialist Hospital, Kano, Nigeria. Two hundred urine specimens of patients comparing of 135(67.5%) outpatients and 65(32.5%) inpatients and classified into 125(62.5%) females and 75(37.5%) males were bacteriologically evaluated. A total of 61(30.5%) yielded significant growth on culture of which 50(25%) were from females and 11(5.5%) from males. The age distribution of the patients with significant bacterial growth showed that patients within the age group of 21-30 years had the highest (UTI) cases of 33(16.5%) but those within the age group of less or equal to 10 years and those within the 51 to 60 years age bracket had 3(1.5%) UTI cases each. Of the uropathogens isolated, Escherichia coli was the most frequent organism responsible for UTI with 29((14.5%), followed by Klebsiella species with 16(8.0%). Other organisms isolated were Staphylococcus species 9(4.5%), proteus species 5(2.5%) and Pseudomonas species 2(1.0%) respectively. The speciation of Klebsiella species isolated `showed that 14(7.0%) were Klebsiella pneumoniae and 2(1.0%) were Klebsiella oxytoca. The antibiotic susceptibility testing for Klebsiella species isolates showed Ofloxacin as the best drug of choice with all the 16 isolates susceptible to Ofloxacin but at the same time all were resistant to ampicillin.

Dutse Journal of Pure and Applied Sciences, Apr 24, 2024

Malaria poses a significant health challenges globally, disproportionately affecting vulnerable p... more Malaria poses a significant health challenges globally, disproportionately affecting vulnerable population such as children. This study aimed to ascertain the prevalence of asymptomatic malaria among primary school pupils in Dala Local Government Area, Kano State, Nigeria. Utilizing a crosssectional design, blood samples were collected from 107 pupils through finger prick. These samples were then subjected to microscopic examination following the preparation of both thin and thick blood films. The overall prevalence of asymptomatic malaria was found to be 21.5%, with 23 pupils testing positive for the parasite. Gender-wise, male participants exhibited a higher infection rate (73.9%) compared to their female counterparts (26.08%). Age-specific analysis revealed that the 13-16 years age group had the highest prevalence of asymptomatic malaria at 73.9%, whereas the 5-8 years age group had the lowest at 2.38%. These results highlighted the substantial presence of asymptomatic malaria among school-aged children, particularly within the 13-16 years age bracket. The study underscores the need for targeted public health interventions to identify and treat asymptomatic malaria infections in order to mitigate the silent transmission within this vulnerable population.

Dutse Journal of Pure and Applied Sciences, Apr 24, 2024

UMYU Journal of Microbiology Research (UJMR), Jun 29, 2019

Candidiasis as a disease is sometimes synonymous with woman folk and most human immunodeficiency ... more Candidiasis as a disease is sometimes synonymous with woman folk and most human immunodeficiency virus (HIV) infected individuals. But the disease generally has no border, as it affects males, females, old, young and middle age persons. Environmental changes encourage over-growth of the opportunistic pathogens Candida spp. The review aimed to assess different presentations of diseases due to Candida species in some states in Nigeria, covering Northwest, Southwest , South-south and Southeastern parts of the country. Data was obtained through literature search of work from previous researchers. It was observed based on the review that candidiasis is a factor of many different species of the genus Candida but Candida albican is the predominant cause of the illiness, with other non albican Candida, contributing the remaining percentage. It was also discovered that HIV infection, pregnancy, diabetis abuse of antibiotics and generally immunocompromise status are among the predisposing factors of the disease. It was also discovered that age group of 20-30 which is an active age group in women are more prone to candidisis.

Academia Biology

Background to the study: Invasive candidiasis is a critical healthcare-related fungal infection ... more Background to the study: Invasive candidiasis is a critical healthcare-related fungal infection caused by several Candida species. Candida auris is an emerging multidrug-resistant, non-albicans species responsible for nosocomial infections, from skin colonization to invasive candidiasis outbreaks. It causes horizontal transmission, persistent outbreaks, and high mortality rates ranging from 30% to 78% across the affected populations.Objectives and methodological approach: This study aimed to review the data obtained on various virulence and resistance factors of C. auris strains that facilitate their survival. The available published research articles related to C. auris pathogenicity were retrieved and reviewed from four reliable databases, namely ScienceDirect, Google Scholar, PubMed, and Scopus.Results: Common virulent factors of C. auris include host-defense evasion, enzyme production (proteinase, hemolysin, and phospholipase), and adherence ability to host cells. Invasive candidiasis management requires the administration of an appropriate antifungal drug for successful clinical outcomes. Currently, only a few classes of antifungal drugs are available for antifungal therapeutic use. The emergence of resistance to a single class or multidrug greatly impaired effective management. About 90% of C. auris have intrinsic resistance to fluconazole.Conclusions and outcomes: Early, rapid, and sensitive diagnosis is essential for initiation of effective therapy since C. auris strains often produce virulent characteristics and are likely to resist the commonly used antifungal drugs.

AIMS Biophysics

Severe acute respiratory syndrome corona virus2 (SARS-CoV-2) is responsible for the current pande... more Severe acute respiratory syndrome corona virus2 (SARS-CoV-2) is responsible for the current pandemic that led to so many deaths across the globe and still has no effective medication. One attractive target is Papain-like protease (PLpro), which plays a critical role in viral replication. Several important structural features dictate access to the PLpro narrow active site, which includes a series of loops surrounding the area. As such, it is difficult for chemical compounds to fit the SARS-CoV-2 PLpro active site. This work employed a computational study to discover inhibitors that could bind to the SARS-COV-2 PLpro active site, mainly by virtual screening, molecular dynamic simulation, MMPBSA and ADMET analysis. Eight potential inhibitors were identified: carbonoperoxoic acid, Chrysophanol-9-anthrone, Adrenolutin, 1-Dehydroprogesterone, Cholest-22-ene-21-ol, Cis-13-Octadecenoic acid, Hydroxycarbonate and 1-(4-(4-Methylphenyl)-5-phenyl-1,3-oxazol-2-yl) isoquinoline, with binding scor...

Candidiasis as an opportunistic infection that comes up in many different forms, depending on the... more Candidiasis as an opportunistic infection that comes up in many different forms, depending on the part of the body involved and the category of patients affected. Oral candidiasis affects the oral cavity, and is a common phenomenon among HIV patients who are subject to immune depression. This study was to determine the burden of oral candidiasis among HIV patients in the study area. Samples were collected using sterile cotton tipped swabs and processed immediately. In the process, direct gram staining technique and KOH mount was carried out prior to culturing on Sabouraud dextrose agar followed by sub-culturing on chromogenic agar, to help in the phenotypic speciation of the different candida isolates after germ tube test was carried out. A total of 109 Candida species were isolated in this study, that include Candida albicans 72(66.1%), Candida glabrata 13(11.9%) and Candida krusie 24(22.0%). It was also discovered that age limit of 21-30 had the highest infection rate 32(29.4%) wh...

Citation: Hamza Sule., et al. “The Coronavirus Disease Covid-19: A Global Nightmare”. EC Microbio... more Citation: Hamza Sule., et al. “The Coronavirus Disease Covid-19: A Global Nightmare”. EC Microbiology 16.8 (2020): 70-72. The corona virus disease as an emerging pandemics, it affects almost every part of the world and cut across all age groups, but appears to be more serious on certain categories of people (the elderly, the young and those with underline disease conditions like diabetes, heart and liver diseases among others).

As corona virus disease (Covid-19) reaches a pandemic status within short time, it is a call to o... more As corona virus disease (Covid-19) reaches a pandemic status within short time, it is a call to order, to the global health system, because, as at the moment, there is no nation or group of nations spared off the disease. This review aimed to assess, the journey so far, with regards to the search for effective treatment options for covid-19. Relevant data were obtained using various search engines, like Google, Ask.com, Bing and yandex among others. In the course of that, it was discovered based on the previous restudies that, many different agents are candidates for treatment of Covid-19. These include antiviral, antibacterial/antiparasitic as well as anti-inflammatory agents. Due to the significance of the disease to public health, World Health Organization (WHO) initiated a largescale trial called (“Solidarity Trial”), covering many countries and enrolling large number of hospitalized patients at once. This was designed to cut down the normal lengthy period clinical trials and ev...

Urinary Tract infections (UTIs) are one of the most common causes of hospital visit worldwide. Th... more Urinary Tract infections (UTIs) are one of the most common causes of hospital visit worldwide. The study intends to find the prevalence of Escherichia coli in Urinary tract infection cases in Aminu Kano Teaching Hospital (AKTH), Kano. A comprehensive study was conducted on E coli for its prevalence in urine samples, of queried cases of urinary tract infection in patients attending Aminu Kano Teaching Hospital (AKTH), Kano. Two hundred and fourteen urine specimens comprising of 123(57.5%) females and 91(42.5%) males of all age group were screened for bacteria. Of the 214 samples, 68 representing (31.80%) were culture positive with E. coli having 32(47.06%), Klebsiella spp 18(26.47%), Staphylococcus spp 10(14.70%), Proteus spp 6(8.82%) and Pseudomonas spp 2(2.94%). Out of the 32(47.6%) of E. coli isolated, 22 were from female and 10 were from males, the highest prevalence occurred within the age range of 21-30 with females taking the lead. Antibiogram of the isolated E. coli showed a ...

American Journal of Internal Medicine

Bacterial colonies can differ greatly in their morphologies. These differences can help us in ide... more Bacterial colonies can differ greatly in their morphologies. These differences can help us in identifying different species of bacteria. The clinical isolates of Staphylococcus Aureus are subjected to standard biochemical tests, to observe the biochemical characteristics. One hundred and ten (110) pathogenic Staphylococcus Aureus strains were used in this study. Characteristics of these strains were determined by biochemical tests such as catalase, coagulase, DNase test, test for beta haemolysin, fermentation of mannitol and lactose. Staphylococcus Aureus [American Type Culture Collection (ATCC) 25923] was used as a reference control organism. From this study, males were more infected than females, having 60 (61.8%) and 42 (38.2%) respectively. The age group with the highest number of isolates was (0-10) years while blood culture had the highest frequency of Staphylococcus Aureus isolates with a frequency of 42 (38.1%). It was also observed that 100% of Staphylococcus Aureus showed positive results in catalase and tube coagulase, about 101 (91.8%) were positive for slide coagulase production test, 102 (92.7%) strains were positive to DNase test, 63 (57.3%) were positive to beta haemolysin while 79 (71.8%) and 106 (96.4%) strains fermented Mannitol and lactose respectively. This study reveals that no single test that can be used for the identification of Staphylococcus Aureus, hence the need for sequel testing using proper biochemical tests should be used for the identification of Staphylococcus Aureus isolates.

Schistosomiasis is largely a water-snail related disease that mostly affects school aged children... more Schistosomiasis is largely a water-snail related disease that mostly affects school aged children in developing countries. The disease is also related to poverty and lack of health education among other factors. The study focused on the urine associated schistosomiasis in Dawakin Kudu Local Government Area, Kano state. Two hundred and twenty seven (227) urine samples were collected and processed using standard methods, which include macroscopy for colour, turbidity and any blood tinge and microscopy, in which the urine samples were centrifuged and the sediments examined using 10x and 40x objectives with condenser closed sufficiently to give contrast. In the results, overall prevalence rate obtained was 19.4%. According to gender, the result of Schistosoma haematobium infestation in the five villages revealed that, infection was found only among males 44(25.7%) while females had 0(0.00%). Prevalence according to localities indicated, 24(54.5%) for Tsakuwa, 7(15.9%) for Yan Barau, an...

Journal of Microbiology & Experimentation

Universal bottles were used for the collection of the appropriate urine samples for the study. Th... more Universal bottles were used for the collection of the appropriate urine samples for the study. The enrolled patients were educated on the

International Journal of Biomedical Materials Research

Ability of bacteria to withstand antibiotic therapy is often associated with resistance. Certain ... more Ability of bacteria to withstand antibiotic therapy is often associated with resistance. Certain bacteria have the ability to produce some enzymes, like Beta-Lactamase, which confers resistance to some groups of antibiotics like penicillins and cephalosporins. The study focused on producers of these enzymes among uropathogens. A total of one hundred and forteen isolates (114) were screened, out of which seventy one 71 (62.3%) were found positive for the enzymes. Eschericia coli had the highest positivity rate 40 (56.3%). Followed by Klebsiella spp., Staphylococcus aureus, Staphylociccus saprophyticcus, Proteus mirabilis, and Pseudomonas aeruginosa with 15 (21.1%), 7 (10.0%), 5 (7.0%), 3 (4.2%), and 1 (1.4%) respectively. In the same vein, it was discovered that, isolates of females' origin, produced more of the enzymes than those of their males counterpart. This was indicated by the production of the enzyme by at least one isolate in each of the species isolated from female samples while in males, some species did not even produce any of the enzymes. Age-wise distribution of the enzymes showed that, 21-30, and 31-40 age groups had all the isolates producing the enzymes in varying frequencies. Only Pseudomonas aeruginosa that produced its enzyme outside these age groups. Isolates of females origin had more of the enzymes produced in all the species compared to those from males,

American Journal of Biomedical and Life Sciences, 2016

Urinary tract infections (UTIs) are among the most commonly encountered infections, both in the c... more Urinary tract infections (UTIs) are among the most commonly encountered infections, both in the community and in hospitals. The study investigated the Prevalence of Klebsiella species among patients suspected of UTI in Murtala Muhammad Specialist Hospital, Kano, Nigeria. Two hundred urine specimens of patients comparing of 135(67.5%) outpatients and 65(32.5%) inpatients and classified into 125(62.5%) females and 75(37.5%) males were bacteriologically evaluated. A total of 61(30.5%) yielded significant growth on culture of which 50(25%) were from females and 11(5.5%) from males. The age distribution of the patients with significant bacterial growth showed that patients within the age group of 21-30 years had the highest (UTI) cases of 33(16.5%) but those within the age group of less or equal to 10 years and those within the 51 to 60 years age bracket had 3(1.5%) UTI cases each. Of the uropathogens isolated, Escherichia coli was the most frequent organism responsible for UTI with 29((14.5%), followed by Klebsiella species with 16(8.0%). Other organisms isolated were Staphylococcus species 9(4.5%), proteus species 5(2.5%) and Pseudomonas species 2(1.0%) respectively. The speciation of Klebsiella species isolated `showed that 14(7.0%) were Klebsiella pneumoniae and 2(1.0%) were Klebsiella oxytoca. The antibiotic susceptibility testing for Klebsiella species isolates showed Ofloxacin as the best drug of choice with all the 16 isolates susceptible to Ofloxacin but at the same time all were resistant to ampicillin.