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A liposome is a microscopic vesicle consisting of an aqueous core enclosed in one or more phospho... more A liposome is a microscopic vesicle consisting of an aqueous core enclosed in one or more phospholipid layers, used to convey vaccines, drugs, enzymes, or other substances to target cells or organs. Liposomes are bilayered structures made of amphipathic (both hydrophobic and hydrophilic) phospholipids/cholesterol that spontaneously form closed structures when hydrated in aqueous solutions. Liposomes are acceptable and superior carriers having ability to encapsulate hydrophilic and lipophilic drugs and protect them from degradation. Topical liposomes have similarity to biological membranes they can store water-soluble and lipophilic substances in their different phases. Moreover, they are similar to the epidermis with respect to their lipid composition, which enables them to penetrate the epidermal barrier to a greater extent compared to other dosage forms. According to studies performed so far liposomes are biodegradable and non-toxic. The really new aspect with liposomes is that th...
The demand for fast dissolving tablets of OndansetronHCl has been growing during the last decade ... more The demand for fast dissolving tablets of OndansetronHCl has been growing during the last decade specially for the geriatric and pediatric patients. OndansetronHCl is a recognized as antiemetic drug, so development of an FDT OndansetronHCl and to evaluate the effect of various concentrations of superdisintegrant and binder on its disintegration time and release profile was the prime objective of this research work. Methods: Tablets were prepared by high pressure homogenization followed by direct compression. 22 factorial design was applied in which concentration of superdisintegrant and binder were taken as independentvariables and disintegration time and percentage release were taken as dependent variables. The prepared tablets wereevaluated for weight variation, hardness, friability, disintegration time, content uniformity, and % drug release. Direct compression process was selected for this formulation of ODT tablets, because porous nature is more in direct compression blend than...
A liposome is a microscopic vesicle consisting of an aqueous core enclosed in one or more phospho... more A liposome is a microscopic vesicle consisting of an aqueous core enclosed in one or more phospholipid layers, used to convey vaccines, drugs, enzymes, or other substances to target cells or organs. Liposomes are bilayered structures made of amphipathic (both hydrophobic and hydrophilic) phospholipids/cholesterol that spontaneously form closed structures when hydrated in aqueous solutions. Liposomes are acceptable and superior carriers having ability to encapsulate hydrophilic and lipophilic drugs and protect them from degradation. Topical liposomes have similarity to biological membranes they can store water-soluble and lipophilic substances in their different phases. Moreover, they are similar to the epidermis with respect to their lipid composition, which enables them to penetrate the epidermal barrier to a greater extent compared to other dosage forms. According to studies performed so far liposomes are biodegradable and non-toxic. The really new aspect with liposomes is that th...
The demand for fast dissolving tablets of OndansetronHCl has been growing during the last decade ... more The demand for fast dissolving tablets of OndansetronHCl has been growing during the last decade specially for the geriatric and pediatric patients. OndansetronHCl is a recognized as antiemetic drug, so development of an FDT OndansetronHCl and to evaluate the effect of various concentrations of superdisintegrant and binder on its disintegration time and release profile was the prime objective of this research work. Methods: Tablets were prepared by high pressure homogenization followed by direct compression. 22 factorial design was applied in which concentration of superdisintegrant and binder were taken as independentvariables and disintegration time and percentage release were taken as dependent variables. The prepared tablets wereevaluated for weight variation, hardness, friability, disintegration time, content uniformity, and % drug release. Direct compression process was selected for this formulation of ODT tablets, because porous nature is more in direct compression blend than...