Innovative Publication | Innovative Publication (original) (raw)
articles by Innovative Publication
IP International Journal of Medical Microbiology and Tropical Diseases, 2023
Abstract Dipodascuscapitatus is a typical inhabitant of humans, especially on the skin, oral cav... more Abstract
Dipodascuscapitatus is a typical inhabitant of humans, especially on the skin, oral cavity, and respiratory tract. Fungi previously considered harmless colonizers (Opportunistic) are emerging as new fungal pathogens, particularly in an immune-compromised state. Infection caused by Dipodascuscapitatus is rare, and the treatment procedures are quite difficult. Here we reported the information on patients with chronic
diabetic conditions. The fungus was isolated from oral washings, the phenotypic identification was based on mycological methods, the molecular marker was based on 18S r RNA sequencing, and the susceptibility test was conducted by micro-dilution technique. The present study mainly focused on quantifying virulence factors, and their activity is expressed in the form of hemolysin protease (1.812 mg/ml). Fungal infections in these patients are often severe, rapid progressive, and challenging to identify, including diagnostic and therapeutic modalities required to provide better patient care.
Keywords: Non albicans Candida, Diabetics, Oral washings, Virulence factors, Drug resistance, Dipodascus capitatus
IP International Journal of Medical Microbiology and Tropical Diseases, 2023
Abstract Background: This study aimed to evaluate the correlation between suspected COVID-19 sym... more Abstract
Background: This study aimed to evaluate the correlation between suspected COVID-19 symptoms and RT-PCR results in the diagnosis of SARS-CoV-2 infection in Burkina Faso.
Materials and Methods: We analyzed SARS-CoV-2 RT-PCR routine diagnostic data in Burkina Faso. Data were collected from March 9, 2020 to September 30, 2020 in the framework of the COVID-19 surveillance. Sensitivity, specificity, predictive values, and Kappa concordance were used to check the correlation between COVID-19 symptoms and the RT-PCR results.
Results: A total of 2217 participants were tested for COVID-19 using RT-PCR, of them 779 COVID-19 positive. The mean age of the participants was 38.7± 17.69 years. Suspected symptoms presented by participants were fever (40.4%), cough (38.6%), asthenia (27.3%), headache (23.6%), dyspnea (20.8%), and odynophagia (16.3%). The sensitivity of presence of at least a clinical sign compared to RT-PCR results was 62.13% and the specificity was 39.85%. The kappa agreement between the presence of COVID-19 suspected symptoms and RT-PCR results was 0.017. The presence of aguesia and/or anosmia in patients induced a positive predictive value of RT-PCR of 91.30%.
Conclusion: The correlation between the COVID-19 symptoms and RT-PCR results in the diagnosis of COVID-19 was very weak. The present study confirms that most clinical signs associated with SARS-CoV-2 infection are not specific to COVID-19, hence the need to always combine RT-PCR or other biological tests with the clinical diagnosis. However, aguesia and anosmia are of interest with a high degree of RT-PCR positivity when present in a COVID-19 suspected patient.
Keywords: Diagnosis, Symptoms, Correlation, COVID-19, SARS-CoV-2, RT-PCR
IP International Journal of Medical Microbiology and Tropical Diseases, 2023
Abstract Candida contains a wide range of organisms, and more than 17 different Candida species ... more Abstract
Candida contains a wide range of organisms, and more than 17 different Candida species have been linked to human infections. Newer species are emerging and Candida albicans and other Species are re-emerging. Isolated strains showing increased antifungal resistance, which necessitates the need for new antifungal drugs. Candida Spp can cause a wide range of mycoses, including invasive candidiasis, which can be deep, widespread, and extremely painful. The majority of the time, it spreads by endogenous Candidaemia. They adhere to host tissues and medical equipment, form biofilms, and release enzymes that break down proteins. Conventional techniques and molecular techniques have made laboratory diagnosis of Candida easy. However, Candida infections are more common in immunocmpromised and hospitalised patients.
Keywords: Candida albicans, Candida auris, Invasive infections, Molecular diagnosis, Antifungal resistance
IP International Journal of Medical Microbiology and Tropical Diseases, 2023
Abstract An ancient disease, Tuberculosis is one of the most challenging infectious disease cont... more Abstract
An ancient disease, Tuberculosis is one of the most challenging infectious disease contributing to mortality and morbidity worldwide. Tuberculosis elimination globally, by 2050, is a mammoth task as Mycobacterial infections have wide range of presentation, from the clinical to the subclinical or latent and pose a diagnostic and therapeutic challenge. The virulence as well as evading property of Mycobacterium tuberculosisMtb) from the host's immune system confers upon it the ability to remain latent in the host cells. This forms the basis of classification of tuberculosis patient as having latent-TBI or active TB.
This review focuses on the role of miRNA as biomarkers of LTBI. The aim is to have an overview of the current knowledge about miRNA, its involvement in TB pathogenesis and its role as a reliable tool for diagnosis of latent tuberculosis.
miRNA are non-encoding endogenous RNAs which regulate gene expression by directing their target RNA for degradation or translational repression. Degraded RNA are released in the extracellular milieu, are present in various body fluids, such as blood, saliva, and urine, and are biomarkers for a number of diseases including cancer, Parkinsons’ disease, CAD, liver diseases, TB and other infectious diseases. miRNAs are differentially expressed during active TB and LTBI, and therefore can be used as biomarkers of disease progression and response to anti-TB therapy. This will further permit more specific therapeutic interventions in TB management.
A thorough search of available literature resources was performed on online databases such as Google Scholar, NCBI, Nature, Research gate, PubMed, Science Direct. It was found that miRNA are promising biomarkers to identify healthy latent TB individuals for further course of action and can be reliable tools for routine use in current clinical practice for specific therapeutic interventions to limit active TB population. They meet the criteria of ideal biomarkers, such as minimally invasive, accessibility, high specificity, and sensitivity.
Keywords: Biomarkers, Latent tuberculosis, miRNA, Pediatric, Diagnosis
Journal of Dental Specialities, 2023
Abstract Lipomas are uncommon oral tumours that make up between 1 and 4 percent of benign oral t... more Abstract
Lipomas are uncommon oral tumours that make up between 1 and 4 percent of benign oral tumours. It often presents as an asymptomatic, soft, smooth-surfaced, nodular, yellowish mass, and most commonly affects the buccal mucosa, tongue, and floor of the mouth. Although there is a lot of conflicting information in the literature on the sensitivity and specificity of ultrasound in detecting lipomas, it has been used as a diagnostic tool for soft-tissue lesions for more than ten years. Understanding the various sites of oral lipomas inside the oral mucosa is crucial for accurate diagnosis and successful therapy. The case report of a 49-year-old man with an oral lipoma that developed in the mandibular buccal vestibule, a rare position, is presented in this article along with ultrasonographic results and a thorough literature analysis. The paper offers insightful analysis for those working in the field of oral healthcare by looking at the clinical presentation, histological traits, and probable differential diagnoses.
Keywords: Oral lipoma, Ultrasonography, Mandibular vestibule, Liposuction
Journal of Dental Specialities, 2023
Abstract Supernumerary teeth is a well recognised phenomenon now a days. Supernumerary teeth are... more Abstract
Supernumerary teeth is a well recognised phenomenon now a days. Supernumerary teeth are those that exceed normal dental formula. Mesiodens is one of the most common examples of supernumerary teeth. It can be associated with syndromes or it can be non syndromic. In this article, the role of genetics in the development of mesiodens is discussed.
Keywords: Genetics, Heredity, Mesiodens, Supernumerary teeth, Non syndromic, Siblings
Journal of Dental Specialities, 2023
Abstract Aim: The aim of this study was to access and compare fracture resistance of tooth resto... more Abstract
Aim: The aim of this study was to access and compare fracture resistance of tooth restored with Cention-N, Zirconomer and Filtek Z350 XT.
Materials and Methods: Seventy five extracted maxillary premolar were divided into five groups; (Group I) Unprepared intact teeth, (Group II) Teeth with class II mesio-occluso-distal (MOD) cavity prepared and unrestored, (Group III) Teeth with class II MOD cavity prepared and restored with Zirconomer (Shofu Inc), (Group IV) Teeth with class II MOD cavity prepared and restored with Cention N, (Group V) Teeth with class II MOD cavity prepared and restored with Universal Composite Restorative Material (Filtek Z350 XT). Specimen was individually tested in a universal testing machine for facture resistance.
Results: Filtek Z350 XT showed statistically significant fracture resistance as compared to Group II, Group III and Group IV (P<0> Conclusion: All the test restorative material showed acceptable fracture resistance under load. Long term clinical evaluation is required to access their behavior intraorally.
Keywords: Tooth fracture, Bicuspid, Dental Cavity Preparation, Filtek Z350, Glass ionomer cement, Alkasite
Journal of Dental Specialities, 2023
Abstract Objectives: Dental caries and periodontal disease are the most common oral diseases. Th... more Abstract
Objectives: Dental caries and periodontal disease are the most common oral diseases. Thus, the aim of this study was to examine the oral health status of adults aged 18 years and above visiting the various outreach camps in the Ghaziabad District.
Materials and Methods: A cross-sectional study was conducted among 336 participants of Ghaziabad District. Dental caries in form of DMFT and periodontal status was recorded based World Health Organization (WHO) criteria-2013. The Statistical analysis was done using the Statistical Package for Social Sciences (SPSS) software.
Results: In total, 336 respondents completed the survey among which 216 (64.3%) were males and 120 (35.7%) were females. Majority of the study subjects belonged to low socioeconomic background. The prevalence of dental caries was found to be 44.34 % and periodontal disease was 81.8% respectively. Individuals belonging to lower socioeconomic status has significantly higher caries prevalence when compared to upper and middle class individuals. (p ? 0.05)
Conclusion: Mounting evidence has demonstrated the essential role of oral health in a long and healthy life. The oral health status of the participants indicates low awareness in majority of the population of Ghaziabad District and only a small number of participants made routine dental visits. The findings can aid planning strategies for oral health care among the population.
Keywords: Oral health, Dental caries, Periodontal disease, Gingival bleeding, Cross-sectional study
Journal of Dental Specialities, 2023
Abstract Background: Periodontitis ranks as the sixth most prevalent global ailment, impacting a... more Abstract
Background: Periodontitis ranks as the sixth most prevalent global ailment, impacting around 750 million individuals and standing as a prominent cause of adult dental loss. This study aims to investigate the dental awareness, viewpoints, and recognition of severe oral ailments with potential systemic health implications among distinct medical specialists: Gynecologists, Diabetologists, and Psychiatrists.
Materials and Methods: A questionnaire based survey among three groups of specialist’s, viz. gynecologists (Group A), diabetologists (Group B), and psychiatrists (Group C) was done to gather insights into the participants' knowledge of periodontal disease and its links to systemic conditions. The collected data were subjected to descriptive statistical analysis using Microsoft excel 2013.
Results: The findings revealed that 100% of diabetologists were cognizant of the correlation between periodontal health and its systemic implications. Among gynecologist’s 67% recognized the relationship between periodontal health, pregnancy, and women's well-being. Meanwhile, the majority of psychiatrists demonstrated appropriate referral practices when necessary. In contrast, only 47% of diabetologists who were aware of the connection initiated referrals for oral health assessments by dentists.
Conclusion: Enhancing awareness and referral rates to dental professionals could potentially foster improved oral health, impacting diverse medical conditions. However, there exists an opportunity to motivate patients to seek dental care independently of their primary healthcare provider's specialization.
Keywords: Dental disease, Diabetologists, Gynecology, Periodontal Diseases, Physicians, Psychiatry
Journal of Dental Specialities, 2023
Abstract Objective: The aim of this study was to compare canal transportation and centering abil... more Abstract
Objective: The aim of this study was to compare canal transportation and centering ability of different nickle titanium systems using Cone beam computed tomography in curved canals.
Materials and Methods: Ninety mandibular molars with angle of curvature ranging from 10°– 40° were randomly allocated into six experimental groups containing 15 teeth in each group. Preinstrumentation scans were taken with CBCT with constant exposure parameters before and after instrumentation. Six grouped specimens were instrumented with Wave One, Twisted File, Hyflex CM, K3XF, ProTaper Next, NeoNiTi file respectively. Post instrumentation the specimens were scanned by CBCT to obtain postoperative images. The amount of root canal transportation and centering ability of the instrument were determined. Statistical analysis on collected data was performed using One way analysis of ANOVA, and post-hoc Tukey test (p<0> Results: K3XF group showed significantly higher transportation values in the apical third (2mm) than TF group (p=0.01) and Hyflex CM group (p=0.03). The coronal transportation values are higher than the apical values but with no significant difference between them (p>0.05). There was no significant difference in centering ratio values between the six groups (p>0.05) at any of the level.
Conclusion: All the file systems can be safely used, showing satisfactory preservation to the original canal shape with preference of TF files.
Keywords: Root Canal, Transportation, Centering, Nickle titanium instruments, Cone beam computed tomography, In vitro study
Journal of Dental Specialities, 2023
Abstract Aim: To inculcate a better understanding and facilitate a better management of separati... more Abstract
Aim: To inculcate a better understanding and facilitate a better management of separation anxiety seen in children in dental clinic.
Conclusion: Separation anxiety is often seen in pediatric patients. Although, not much thought is given to it as parents presume the anxiety to be merely a byproduct of a new environment and unfamiliar faces. It was significant to compile separation anxiety seen in children with a special emphasis on its dental aspect which will aid pedodontists as well as general practitioners in a swift recognition of the symptoms followed by prompt management of pediatric separation anxiety patients in a dental setting.
Keywords: Separation anxiety, Children, Dental Setting, Management, Attachment
Journal of Dental Specialities, 2023
Abstract Thromboembolic events represent a significant healthcare concern, encompassing conditio... more Abstract
Thromboembolic events represent a significant healthcare concern, encompassing conditions such as deep vein thrombosis, pulmonary embolism, stroke, and myocardial infarction. The management of patients with a history of thromboembolic events in the dental setting requires careful consideration and collaboration between dentists and healthcare providers. This review article delves into the intricate relationship between thromboembolic events and dentistry.We explore the importance of patient assessment, emphasizing the need for a comprehensive evaluation of medical history, risk factors, and medication regimens. Special attention is given to anticoagulant therapy, and the role of International Normalized Ratio (INR) monitoring in maintaining safe levels of anticoagulation during dental procedures. We discuss the critical timing of dental interventions and the use of local hemostatic measures to minimize bleeding risk.By elucidating these key aspects, this review article aims to provide dental professionals with a comprehensive understanding of thromboembolic events in dentistry, fostering safe and effective oral healthcare for this patient population.
Keywords: Thromboembolic Events, International Normalized Ratio (INR), Hemostatic Measures, dentistry
Journal of Dental Specialities, 2023
Abstract Cone Beam Computed Tomography (CBCT) is beneficial radiographic diagnostic tool in oral... more Abstract
Cone Beam Computed Tomography (CBCT) is beneficial radiographic diagnostic tool in oral and maxillofacial surgery (OMS). It helps maxillofacial surgeons to develop treatment approach in various conditions. Study of head and neck structures three dimensionally allows surgeon to do planning accurately, as a result enhances operative precision, and assess post-operative result. CBCT imaging have specific indications and limitations. The purpose of this article is to focalize on the advantages, drawbacks, limitations, and clinical applications of CBCT as a headmost CT imaging technique in the OMF region.
Keywords: Cone Beam Computed Tomography (CBCT), 3dimensional, Oral and maxillofacial surgery
Journal of Dental Specialities, 2023
Abstract The definition of anchorage is the opposition a body exhibits to being displaced. In or... more Abstract
The definition of anchorage is the opposition a body exhibits to being displaced. In orthodontics, the body is used to simulate a tooth, and forces that can be either light and continuous or heavy and intermittent are used to propel it around. When natural tooth motions are to be performed in greater amounts, they must be fastened against an anchor that, if feasible, is fairly enduring. This is when anchoring is required in orthodontics.
Keywords: Anchorage, Temporary Skeletal Anchorage Devices (TSADs), Extraalveolar, Infrazygomatic Crest (IZC), Mandibular Buccal Shelf (MBS), Stainless Steel (SS), Titanium Alloys (TiA)
Journal of Dental Specialities, 2023
Abstract This article provides an overview of the application of the intelligent technology in h... more Abstract
This article provides an overview of the application of the intelligent technology in healthcare especially in the various specialities of dentistry and how much it has enhanced the quality of care being provided. Artificial intelligence is widely gaining popularity in various other sectors and is thought to be useful in the healthcare industry for diagnostic purposes and eventually with time programming, the technology to help healthcare personnels to carry out less invasive procedures.
Keywords: Learning, Machine learning, Computer, Dental, Dentistry, Machine intelligence
Journal of Dental Specialities, 2023
Ethics is the study of principles relating to right and wrong conduct. Ethics are the moral princ... more Ethics is the study of principles relating to right and wrong conduct. Ethics are the moral principles that an individual must follow irrespective of time or place. Bioethics is the branch of ethics that studies the implications
of biological and biomedical advances. Primary purpose of dental research is to generate new knowledge. However, this goal can never take precedence over the rights and interests of individual research subjects.
Journal of Dental Specialities, 2023
Abstract The permanent replacement of missing teeth in the maxillary posterior tooth region beco... more Abstract
The permanent replacement of missing teeth in the maxillary posterior tooth region becomes a tedious task when it is confounded with bone atrophies. To overcome this problem and achieve successful rehabilitation, maxillary sinus membrane elevation procedures have been advocated as the most reliable means. The lateral window technique and the crestal approach are two of the most common approaches. These technologically developed procedures have reported high success rates in cases of deficient residual bone. Over time, there have been many advancements in these techniques that led to the development of user-friendly kits like the Lateral approach Sinus (LAS) kit and the Crestal approach Sinus (CAS) kit. In this case series, we have reported two cases, treated with either of these approaches and have compared the same. We aim at highlighting their ease of application in the clinical field and the promising results obtained with their use. Our clinical experience disclosed that maxillary sinus membrane advancement using both the kits have proven to be a reliable technique for implant placement in sites where insufficient bone is available.
Keywords: Crestal approach sinus lift, Hard tissue augmentation, Lateral window approach sinus lift, Platelet rich fibrin membrane, Transalveolar approach sinus lift
Journal of Dental Specialities, 2023
Abstract Introduction: Vertical thickness of the upper lip is an aesthetic determinant in a smil... more Abstract
Introduction: Vertical thickness of the upper lip is an aesthetic determinant in a smiling face for both orthodontists.
Aim and Objectives : To evaluate the vermillion height and lip area in adult patients with various sagittal malocclusion groups following 1 premolar extraction.
Materials and Methods: Pre and post treatment lateral cephalograms of 50 adult patients aged between 17 to 21 years were taken. The sample was divided into 2 groups: Group I (Angles Class I Bidental protrusion) & Group II (Angles Class II div 1) with 25 subjects in each group. 2 angular and 10 linear measurments were recorded for both the groups.
Results: There were no significant differences in the vermilion height and upper lip area changes in group I, except for lower lip area. In group II significant difference were found in upper and lower lip area. When Group I and Group II were compared, only significant difference was found in lower lip area whereas vermillion height and upper lip area were found to be clinically non-significant.
Conclusion: Extraction of four premolars can be extremely successful in improving features of the smile for the patients who have undergone treatment for Class II division 1 malocclusion and Class I Bidental protrusion. This provides a stronger evidence-based rationale for this treatment modality.
Keywords: Vermillion height, Lip area, Bidental protrusion, Class II div 1
Journal of Dental Specialities, 2023
Abstract Introduction: Hyperpigmentation is a medical term used to describe darker patches of sk... more Abstract
Introduction: Hyperpigmentation is a medical term used to describe darker patches of skin from excess melanin production. This can be caused by everything from acne scars and sun damage to hormone fluctuations. The first-line treatment for hyperpigmentation involves topical formulations of conventional agents such as hydroquinone, kojic acid, and glycolic acid followed by oral formulations of therapeutic agents such as transexamic acid, melatonin, and cysteamine hydrochloride. Despite the availability of multiple treatments for the condition, hyperpigmentation continues to present clinical management challenges for dermatologists. The study aims to compare the therapeutic efficacy, to compare the therapeutic efficacy and tolerability of glycolic acid peels and salicylic acid peels for hyperpigmentation treatment.
Materials and Methods: 200 patients were selected and graded on Fitzpatrick scale. A split face peel on right side by Glycolic Acid and left side by Salicylic Acid was done and procedure was repeated after 2 week and then third sitting of PRP was done. Patients were scaled on Fitzpatrick scale at baseline and after 3 sitting (PRP).
Result: Salicylic recorded a mean value of 3.10 at baseline while glycolic acid recorded 2.92 at baseline. After 3 sitting Salicylic Acid recorded a mean reduction value of 0.29 while that of Glycolic Acid mean reduction value was 0.71and this was stastically significant reduction.
Conclusion: Patients with Salicylic Acid peels showed significantly better response than Glycolic Acid peels.
Keywords: Glycolic Acid peels, Salicylic Acid peels, Hyperpigmentation
Journal of Dental Specialities, 2023
Abstract Background: Oral health is an important aspect affecting general health and quality of ... more Abstract
Background: Oral health is an important aspect affecting general health and quality of life. All children have different health considerations including oral health. Children have their own basic nature and this behaviour variability may influence their understanding and acceptability towards maintenance of oral hygiene. Some children may not follow the proper oral hygiene regimes due to variable behaviour which can drastically affect their oral status. Thus, the behaviour of child can act as an obstacle in maintaining oral hygiene.
The present study was aimed at finding the association of child behaviour with dental caries and oral hygiene status.
Materials and Methods : A convenient sample of 100 children aged 6-11 years visiting the Department of Pediatric and Preventive Dentistry were taken for the study. A questionnaire was designed to assess the behaviour of children. Oral hygiene Index and Caries Index of the samples to be studied were recorded. The obtained data was tabulated and subjected to statistical analysis
Result: A statistically significant association was found between child behaviour and dental caries(deft). Also, different types of behaviour pattern showed difference in oral hygiene and caries index. a correlation between oral hygiene and child behaviour was also found.
Conclusion: Oral health status has a multifactorial etiology with child behaviour as an influential factor. Especially in young children, it may directly or indirectly influence caries risk and oral hygiene status. If identified in initial phase, working upon it may help in promoting better oral health of children in the long run.
Keywords: Behaviour pattern, Child behaviour, Dental caries, Oral hygiene, Risk factors
IP International Journal of Medical Microbiology and Tropical Diseases, 2023
Abstract Dipodascuscapitatus is a typical inhabitant of humans, especially on the skin, oral cav... more Abstract
Dipodascuscapitatus is a typical inhabitant of humans, especially on the skin, oral cavity, and respiratory tract. Fungi previously considered harmless colonizers (Opportunistic) are emerging as new fungal pathogens, particularly in an immune-compromised state. Infection caused by Dipodascuscapitatus is rare, and the treatment procedures are quite difficult. Here we reported the information on patients with chronic
diabetic conditions. The fungus was isolated from oral washings, the phenotypic identification was based on mycological methods, the molecular marker was based on 18S r RNA sequencing, and the susceptibility test was conducted by micro-dilution technique. The present study mainly focused on quantifying virulence factors, and their activity is expressed in the form of hemolysin protease (1.812 mg/ml). Fungal infections in these patients are often severe, rapid progressive, and challenging to identify, including diagnostic and therapeutic modalities required to provide better patient care.
Keywords: Non albicans Candida, Diabetics, Oral washings, Virulence factors, Drug resistance, Dipodascus capitatus
IP International Journal of Medical Microbiology and Tropical Diseases, 2023
Abstract Background: This study aimed to evaluate the correlation between suspected COVID-19 sym... more Abstract
Background: This study aimed to evaluate the correlation between suspected COVID-19 symptoms and RT-PCR results in the diagnosis of SARS-CoV-2 infection in Burkina Faso.
Materials and Methods: We analyzed SARS-CoV-2 RT-PCR routine diagnostic data in Burkina Faso. Data were collected from March 9, 2020 to September 30, 2020 in the framework of the COVID-19 surveillance. Sensitivity, specificity, predictive values, and Kappa concordance were used to check the correlation between COVID-19 symptoms and the RT-PCR results.
Results: A total of 2217 participants were tested for COVID-19 using RT-PCR, of them 779 COVID-19 positive. The mean age of the participants was 38.7± 17.69 years. Suspected symptoms presented by participants were fever (40.4%), cough (38.6%), asthenia (27.3%), headache (23.6%), dyspnea (20.8%), and odynophagia (16.3%). The sensitivity of presence of at least a clinical sign compared to RT-PCR results was 62.13% and the specificity was 39.85%. The kappa agreement between the presence of COVID-19 suspected symptoms and RT-PCR results was 0.017. The presence of aguesia and/or anosmia in patients induced a positive predictive value of RT-PCR of 91.30%.
Conclusion: The correlation between the COVID-19 symptoms and RT-PCR results in the diagnosis of COVID-19 was very weak. The present study confirms that most clinical signs associated with SARS-CoV-2 infection are not specific to COVID-19, hence the need to always combine RT-PCR or other biological tests with the clinical diagnosis. However, aguesia and anosmia are of interest with a high degree of RT-PCR positivity when present in a COVID-19 suspected patient.
Keywords: Diagnosis, Symptoms, Correlation, COVID-19, SARS-CoV-2, RT-PCR
IP International Journal of Medical Microbiology and Tropical Diseases, 2023
Abstract Candida contains a wide range of organisms, and more than 17 different Candida species ... more Abstract
Candida contains a wide range of organisms, and more than 17 different Candida species have been linked to human infections. Newer species are emerging and Candida albicans and other Species are re-emerging. Isolated strains showing increased antifungal resistance, which necessitates the need for new antifungal drugs. Candida Spp can cause a wide range of mycoses, including invasive candidiasis, which can be deep, widespread, and extremely painful. The majority of the time, it spreads by endogenous Candidaemia. They adhere to host tissues and medical equipment, form biofilms, and release enzymes that break down proteins. Conventional techniques and molecular techniques have made laboratory diagnosis of Candida easy. However, Candida infections are more common in immunocmpromised and hospitalised patients.
Keywords: Candida albicans, Candida auris, Invasive infections, Molecular diagnosis, Antifungal resistance
IP International Journal of Medical Microbiology and Tropical Diseases, 2023
Abstract An ancient disease, Tuberculosis is one of the most challenging infectious disease cont... more Abstract
An ancient disease, Tuberculosis is one of the most challenging infectious disease contributing to mortality and morbidity worldwide. Tuberculosis elimination globally, by 2050, is a mammoth task as Mycobacterial infections have wide range of presentation, from the clinical to the subclinical or latent and pose a diagnostic and therapeutic challenge. The virulence as well as evading property of Mycobacterium tuberculosisMtb) from the host's immune system confers upon it the ability to remain latent in the host cells. This forms the basis of classification of tuberculosis patient as having latent-TBI or active TB.
This review focuses on the role of miRNA as biomarkers of LTBI. The aim is to have an overview of the current knowledge about miRNA, its involvement in TB pathogenesis and its role as a reliable tool for diagnosis of latent tuberculosis.
miRNA are non-encoding endogenous RNAs which regulate gene expression by directing their target RNA for degradation or translational repression. Degraded RNA are released in the extracellular milieu, are present in various body fluids, such as blood, saliva, and urine, and are biomarkers for a number of diseases including cancer, Parkinsons’ disease, CAD, liver diseases, TB and other infectious diseases. miRNAs are differentially expressed during active TB and LTBI, and therefore can be used as biomarkers of disease progression and response to anti-TB therapy. This will further permit more specific therapeutic interventions in TB management.
A thorough search of available literature resources was performed on online databases such as Google Scholar, NCBI, Nature, Research gate, PubMed, Science Direct. It was found that miRNA are promising biomarkers to identify healthy latent TB individuals for further course of action and can be reliable tools for routine use in current clinical practice for specific therapeutic interventions to limit active TB population. They meet the criteria of ideal biomarkers, such as minimally invasive, accessibility, high specificity, and sensitivity.
Keywords: Biomarkers, Latent tuberculosis, miRNA, Pediatric, Diagnosis
Journal of Dental Specialities, 2023
Abstract Lipomas are uncommon oral tumours that make up between 1 and 4 percent of benign oral t... more Abstract
Lipomas are uncommon oral tumours that make up between 1 and 4 percent of benign oral tumours. It often presents as an asymptomatic, soft, smooth-surfaced, nodular, yellowish mass, and most commonly affects the buccal mucosa, tongue, and floor of the mouth. Although there is a lot of conflicting information in the literature on the sensitivity and specificity of ultrasound in detecting lipomas, it has been used as a diagnostic tool for soft-tissue lesions for more than ten years. Understanding the various sites of oral lipomas inside the oral mucosa is crucial for accurate diagnosis and successful therapy. The case report of a 49-year-old man with an oral lipoma that developed in the mandibular buccal vestibule, a rare position, is presented in this article along with ultrasonographic results and a thorough literature analysis. The paper offers insightful analysis for those working in the field of oral healthcare by looking at the clinical presentation, histological traits, and probable differential diagnoses.
Keywords: Oral lipoma, Ultrasonography, Mandibular vestibule, Liposuction
Journal of Dental Specialities, 2023
Abstract Supernumerary teeth is a well recognised phenomenon now a days. Supernumerary teeth are... more Abstract
Supernumerary teeth is a well recognised phenomenon now a days. Supernumerary teeth are those that exceed normal dental formula. Mesiodens is one of the most common examples of supernumerary teeth. It can be associated with syndromes or it can be non syndromic. In this article, the role of genetics in the development of mesiodens is discussed.
Keywords: Genetics, Heredity, Mesiodens, Supernumerary teeth, Non syndromic, Siblings
Journal of Dental Specialities, 2023
Abstract Aim: The aim of this study was to access and compare fracture resistance of tooth resto... more Abstract
Aim: The aim of this study was to access and compare fracture resistance of tooth restored with Cention-N, Zirconomer and Filtek Z350 XT.
Materials and Methods: Seventy five extracted maxillary premolar were divided into five groups; (Group I) Unprepared intact teeth, (Group II) Teeth with class II mesio-occluso-distal (MOD) cavity prepared and unrestored, (Group III) Teeth with class II MOD cavity prepared and restored with Zirconomer (Shofu Inc), (Group IV) Teeth with class II MOD cavity prepared and restored with Cention N, (Group V) Teeth with class II MOD cavity prepared and restored with Universal Composite Restorative Material (Filtek Z350 XT). Specimen was individually tested in a universal testing machine for facture resistance.
Results: Filtek Z350 XT showed statistically significant fracture resistance as compared to Group II, Group III and Group IV (P<0> Conclusion: All the test restorative material showed acceptable fracture resistance under load. Long term clinical evaluation is required to access their behavior intraorally.
Keywords: Tooth fracture, Bicuspid, Dental Cavity Preparation, Filtek Z350, Glass ionomer cement, Alkasite
Journal of Dental Specialities, 2023
Abstract Objectives: Dental caries and periodontal disease are the most common oral diseases. Th... more Abstract
Objectives: Dental caries and periodontal disease are the most common oral diseases. Thus, the aim of this study was to examine the oral health status of adults aged 18 years and above visiting the various outreach camps in the Ghaziabad District.
Materials and Methods: A cross-sectional study was conducted among 336 participants of Ghaziabad District. Dental caries in form of DMFT and periodontal status was recorded based World Health Organization (WHO) criteria-2013. The Statistical analysis was done using the Statistical Package for Social Sciences (SPSS) software.
Results: In total, 336 respondents completed the survey among which 216 (64.3%) were males and 120 (35.7%) were females. Majority of the study subjects belonged to low socioeconomic background. The prevalence of dental caries was found to be 44.34 % and periodontal disease was 81.8% respectively. Individuals belonging to lower socioeconomic status has significantly higher caries prevalence when compared to upper and middle class individuals. (p ? 0.05)
Conclusion: Mounting evidence has demonstrated the essential role of oral health in a long and healthy life. The oral health status of the participants indicates low awareness in majority of the population of Ghaziabad District and only a small number of participants made routine dental visits. The findings can aid planning strategies for oral health care among the population.
Keywords: Oral health, Dental caries, Periodontal disease, Gingival bleeding, Cross-sectional study
Journal of Dental Specialities, 2023
Abstract Background: Periodontitis ranks as the sixth most prevalent global ailment, impacting a... more Abstract
Background: Periodontitis ranks as the sixth most prevalent global ailment, impacting around 750 million individuals and standing as a prominent cause of adult dental loss. This study aims to investigate the dental awareness, viewpoints, and recognition of severe oral ailments with potential systemic health implications among distinct medical specialists: Gynecologists, Diabetologists, and Psychiatrists.
Materials and Methods: A questionnaire based survey among three groups of specialist’s, viz. gynecologists (Group A), diabetologists (Group B), and psychiatrists (Group C) was done to gather insights into the participants' knowledge of periodontal disease and its links to systemic conditions. The collected data were subjected to descriptive statistical analysis using Microsoft excel 2013.
Results: The findings revealed that 100% of diabetologists were cognizant of the correlation between periodontal health and its systemic implications. Among gynecologist’s 67% recognized the relationship between periodontal health, pregnancy, and women's well-being. Meanwhile, the majority of psychiatrists demonstrated appropriate referral practices when necessary. In contrast, only 47% of diabetologists who were aware of the connection initiated referrals for oral health assessments by dentists.
Conclusion: Enhancing awareness and referral rates to dental professionals could potentially foster improved oral health, impacting diverse medical conditions. However, there exists an opportunity to motivate patients to seek dental care independently of their primary healthcare provider's specialization.
Keywords: Dental disease, Diabetologists, Gynecology, Periodontal Diseases, Physicians, Psychiatry
Journal of Dental Specialities, 2023
Abstract Objective: The aim of this study was to compare canal transportation and centering abil... more Abstract
Objective: The aim of this study was to compare canal transportation and centering ability of different nickle titanium systems using Cone beam computed tomography in curved canals.
Materials and Methods: Ninety mandibular molars with angle of curvature ranging from 10°– 40° were randomly allocated into six experimental groups containing 15 teeth in each group. Preinstrumentation scans were taken with CBCT with constant exposure parameters before and after instrumentation. Six grouped specimens were instrumented with Wave One, Twisted File, Hyflex CM, K3XF, ProTaper Next, NeoNiTi file respectively. Post instrumentation the specimens were scanned by CBCT to obtain postoperative images. The amount of root canal transportation and centering ability of the instrument were determined. Statistical analysis on collected data was performed using One way analysis of ANOVA, and post-hoc Tukey test (p<0> Results: K3XF group showed significantly higher transportation values in the apical third (2mm) than TF group (p=0.01) and Hyflex CM group (p=0.03). The coronal transportation values are higher than the apical values but with no significant difference between them (p>0.05). There was no significant difference in centering ratio values between the six groups (p>0.05) at any of the level.
Conclusion: All the file systems can be safely used, showing satisfactory preservation to the original canal shape with preference of TF files.
Keywords: Root Canal, Transportation, Centering, Nickle titanium instruments, Cone beam computed tomography, In vitro study
Journal of Dental Specialities, 2023
Abstract Aim: To inculcate a better understanding and facilitate a better management of separati... more Abstract
Aim: To inculcate a better understanding and facilitate a better management of separation anxiety seen in children in dental clinic.
Conclusion: Separation anxiety is often seen in pediatric patients. Although, not much thought is given to it as parents presume the anxiety to be merely a byproduct of a new environment and unfamiliar faces. It was significant to compile separation anxiety seen in children with a special emphasis on its dental aspect which will aid pedodontists as well as general practitioners in a swift recognition of the symptoms followed by prompt management of pediatric separation anxiety patients in a dental setting.
Keywords: Separation anxiety, Children, Dental Setting, Management, Attachment
Journal of Dental Specialities, 2023
Abstract Thromboembolic events represent a significant healthcare concern, encompassing conditio... more Abstract
Thromboembolic events represent a significant healthcare concern, encompassing conditions such as deep vein thrombosis, pulmonary embolism, stroke, and myocardial infarction. The management of patients with a history of thromboembolic events in the dental setting requires careful consideration and collaboration between dentists and healthcare providers. This review article delves into the intricate relationship between thromboembolic events and dentistry.We explore the importance of patient assessment, emphasizing the need for a comprehensive evaluation of medical history, risk factors, and medication regimens. Special attention is given to anticoagulant therapy, and the role of International Normalized Ratio (INR) monitoring in maintaining safe levels of anticoagulation during dental procedures. We discuss the critical timing of dental interventions and the use of local hemostatic measures to minimize bleeding risk.By elucidating these key aspects, this review article aims to provide dental professionals with a comprehensive understanding of thromboembolic events in dentistry, fostering safe and effective oral healthcare for this patient population.
Keywords: Thromboembolic Events, International Normalized Ratio (INR), Hemostatic Measures, dentistry
Journal of Dental Specialities, 2023
Abstract Cone Beam Computed Tomography (CBCT) is beneficial radiographic diagnostic tool in oral... more Abstract
Cone Beam Computed Tomography (CBCT) is beneficial radiographic diagnostic tool in oral and maxillofacial surgery (OMS). It helps maxillofacial surgeons to develop treatment approach in various conditions. Study of head and neck structures three dimensionally allows surgeon to do planning accurately, as a result enhances operative precision, and assess post-operative result. CBCT imaging have specific indications and limitations. The purpose of this article is to focalize on the advantages, drawbacks, limitations, and clinical applications of CBCT as a headmost CT imaging technique in the OMF region.
Keywords: Cone Beam Computed Tomography (CBCT), 3dimensional, Oral and maxillofacial surgery
Journal of Dental Specialities, 2023
Abstract The definition of anchorage is the opposition a body exhibits to being displaced. In or... more Abstract
The definition of anchorage is the opposition a body exhibits to being displaced. In orthodontics, the body is used to simulate a tooth, and forces that can be either light and continuous or heavy and intermittent are used to propel it around. When natural tooth motions are to be performed in greater amounts, they must be fastened against an anchor that, if feasible, is fairly enduring. This is when anchoring is required in orthodontics.
Keywords: Anchorage, Temporary Skeletal Anchorage Devices (TSADs), Extraalveolar, Infrazygomatic Crest (IZC), Mandibular Buccal Shelf (MBS), Stainless Steel (SS), Titanium Alloys (TiA)
Journal of Dental Specialities, 2023
Abstract This article provides an overview of the application of the intelligent technology in h... more Abstract
This article provides an overview of the application of the intelligent technology in healthcare especially in the various specialities of dentistry and how much it has enhanced the quality of care being provided. Artificial intelligence is widely gaining popularity in various other sectors and is thought to be useful in the healthcare industry for diagnostic purposes and eventually with time programming, the technology to help healthcare personnels to carry out less invasive procedures.
Keywords: Learning, Machine learning, Computer, Dental, Dentistry, Machine intelligence
Journal of Dental Specialities, 2023
Ethics is the study of principles relating to right and wrong conduct. Ethics are the moral princ... more Ethics is the study of principles relating to right and wrong conduct. Ethics are the moral principles that an individual must follow irrespective of time or place. Bioethics is the branch of ethics that studies the implications
of biological and biomedical advances. Primary purpose of dental research is to generate new knowledge. However, this goal can never take precedence over the rights and interests of individual research subjects.
Journal of Dental Specialities, 2023
Abstract The permanent replacement of missing teeth in the maxillary posterior tooth region beco... more Abstract
The permanent replacement of missing teeth in the maxillary posterior tooth region becomes a tedious task when it is confounded with bone atrophies. To overcome this problem and achieve successful rehabilitation, maxillary sinus membrane elevation procedures have been advocated as the most reliable means. The lateral window technique and the crestal approach are two of the most common approaches. These technologically developed procedures have reported high success rates in cases of deficient residual bone. Over time, there have been many advancements in these techniques that led to the development of user-friendly kits like the Lateral approach Sinus (LAS) kit and the Crestal approach Sinus (CAS) kit. In this case series, we have reported two cases, treated with either of these approaches and have compared the same. We aim at highlighting their ease of application in the clinical field and the promising results obtained with their use. Our clinical experience disclosed that maxillary sinus membrane advancement using both the kits have proven to be a reliable technique for implant placement in sites where insufficient bone is available.
Keywords: Crestal approach sinus lift, Hard tissue augmentation, Lateral window approach sinus lift, Platelet rich fibrin membrane, Transalveolar approach sinus lift
Journal of Dental Specialities, 2023
Abstract Introduction: Vertical thickness of the upper lip is an aesthetic determinant in a smil... more Abstract
Introduction: Vertical thickness of the upper lip is an aesthetic determinant in a smiling face for both orthodontists.
Aim and Objectives : To evaluate the vermillion height and lip area in adult patients with various sagittal malocclusion groups following 1 premolar extraction.
Materials and Methods: Pre and post treatment lateral cephalograms of 50 adult patients aged between 17 to 21 years were taken. The sample was divided into 2 groups: Group I (Angles Class I Bidental protrusion) & Group II (Angles Class II div 1) with 25 subjects in each group. 2 angular and 10 linear measurments were recorded for both the groups.
Results: There were no significant differences in the vermilion height and upper lip area changes in group I, except for lower lip area. In group II significant difference were found in upper and lower lip area. When Group I and Group II were compared, only significant difference was found in lower lip area whereas vermillion height and upper lip area were found to be clinically non-significant.
Conclusion: Extraction of four premolars can be extremely successful in improving features of the smile for the patients who have undergone treatment for Class II division 1 malocclusion and Class I Bidental protrusion. This provides a stronger evidence-based rationale for this treatment modality.
Keywords: Vermillion height, Lip area, Bidental protrusion, Class II div 1
Journal of Dental Specialities, 2023
Abstract Introduction: Hyperpigmentation is a medical term used to describe darker patches of sk... more Abstract
Introduction: Hyperpigmentation is a medical term used to describe darker patches of skin from excess melanin production. This can be caused by everything from acne scars and sun damage to hormone fluctuations. The first-line treatment for hyperpigmentation involves topical formulations of conventional agents such as hydroquinone, kojic acid, and glycolic acid followed by oral formulations of therapeutic agents such as transexamic acid, melatonin, and cysteamine hydrochloride. Despite the availability of multiple treatments for the condition, hyperpigmentation continues to present clinical management challenges for dermatologists. The study aims to compare the therapeutic efficacy, to compare the therapeutic efficacy and tolerability of glycolic acid peels and salicylic acid peels for hyperpigmentation treatment.
Materials and Methods: 200 patients were selected and graded on Fitzpatrick scale. A split face peel on right side by Glycolic Acid and left side by Salicylic Acid was done and procedure was repeated after 2 week and then third sitting of PRP was done. Patients were scaled on Fitzpatrick scale at baseline and after 3 sitting (PRP).
Result: Salicylic recorded a mean value of 3.10 at baseline while glycolic acid recorded 2.92 at baseline. After 3 sitting Salicylic Acid recorded a mean reduction value of 0.29 while that of Glycolic Acid mean reduction value was 0.71and this was stastically significant reduction.
Conclusion: Patients with Salicylic Acid peels showed significantly better response than Glycolic Acid peels.
Keywords: Glycolic Acid peels, Salicylic Acid peels, Hyperpigmentation
Journal of Dental Specialities, 2023
Abstract Background: Oral health is an important aspect affecting general health and quality of ... more Abstract
Background: Oral health is an important aspect affecting general health and quality of life. All children have different health considerations including oral health. Children have their own basic nature and this behaviour variability may influence their understanding and acceptability towards maintenance of oral hygiene. Some children may not follow the proper oral hygiene regimes due to variable behaviour which can drastically affect their oral status. Thus, the behaviour of child can act as an obstacle in maintaining oral hygiene.
The present study was aimed at finding the association of child behaviour with dental caries and oral hygiene status.
Materials and Methods : A convenient sample of 100 children aged 6-11 years visiting the Department of Pediatric and Preventive Dentistry were taken for the study. A questionnaire was designed to assess the behaviour of children. Oral hygiene Index and Caries Index of the samples to be studied were recorded. The obtained data was tabulated and subjected to statistical analysis
Result: A statistically significant association was found between child behaviour and dental caries(deft). Also, different types of behaviour pattern showed difference in oral hygiene and caries index. a correlation between oral hygiene and child behaviour was also found.
Conclusion: Oral health status has a multifactorial etiology with child behaviour as an influential factor. Especially in young children, it may directly or indirectly influence caries risk and oral hygiene status. If identified in initial phase, working upon it may help in promoting better oral health of children in the long run.
Keywords: Behaviour pattern, Child behaviour, Dental caries, Oral hygiene, Risk factors