Onur Koyuncu | UPTU LKO (original) (raw)

Papers by Onur Koyuncu

Complex regional pain syndrome (CRPS) remains one of the most challenging chronic pain condition.... more Complex regional pain syndrome (CRPS) remains one of the most challenging chronic pain condition. Various therapies have been attempted but with suboptimal clinical improvement. Central sensitization plays a major role in its pathogenesis which involves increased activity of N-methyl-D-aspartate (NMDA) receptors.Therefore, NMDA receptor antagonists, specifically ketamine, is a rationale option for treatment of CRPS. We performed a simple review of current evidence of literature focusing on efficacy and safety related to ketamine use in CRPS. Our aim is to provide published clinical evidence of efficacy of ketamine in treatment of CRPS to aid clinical decision-making. We searched PubMed for articles published after year 2000. After our literature search and careful filtering for relevant articles, we included 12 meta-analysis/systematic reviews, 4 randomized control trials, 4 open-label prospective trials, and 5 retrospective studies. In conclusion, our review suggests that ketamine is a promising treatment option for refractory CRPS patients, although the long-term efficacy is still in question. Ketamine appears to be safe and devoid of major adverse effects. Other aspects such as route of administration, duration of treatment, and optimal dose are less defined and needs further research. Finally, the numbers of high-quality studies are limited and further large, placebo-controlled, randomized trials are needed to evaluate the long-term efficacy and cost-effectiveness of ketamine therapy in CRPS.

Bu calismada, bazi bugday cesitlerinin arasindaki RAPD ve ISSR analizine dayali genetik mesafeler... more Bu calismada, bazi bugday cesitlerinin arasindaki RAPD ve ISSR analizine dayali genetik mesafelerin belirlenerek ayriminin yapilmasi amaclanmistir. Arastirma sonuclarina gore, primerler genotipleri guclendirilmis bantlarin sayisi RAPD’ de 3-10, ISSR’ de 6-10 arasinda degistigi belirlenmis olup, primer/primer kombinasyonlari icerisinde RAPD’de OPBA-03, OPL-15 ve OPY-13’den; ISSR’de UBC810 elde edildigi ortaya konmustur. Dendogram sonuclarina gore cesitler gore uc grup altinda siniflandirilmistir. Yunus, Altay-2000, Naci Bey, Sultan-95, Harmankaya ve Soyer cesitlerinin uzak iliskili; Alpu-01 ve Nacibey cesitlerinin ise yakin iliskili cesitler oldugu tespit edilmistir. Yine RAPD ve ISSR yontemlerinin genetik varyasyonu degerlendirmek, yeni cesitlerin gelistirilmesi ve siniflamasinda kullanilabilir yontemler oldugu belirlenmistir.

In this study the flora of Eskisehir Hekimdag (Bozdag) were investigated. According to Davis'... more In this study the flora of Eskisehir Hekimdag (Bozdag) were investigated. According to Davis's grid system, the research area lies in B3 square. The plant samples collected in this region and determined that there are 59 families, as well as 467 species and subspecies taxa belonging to 219 genera. The phytogeographical distribution is as follows: 49 Mediterranean, 31 Euro-Siberian, 19 Irano- Turanian, 6 Euxin and 362 unknown or other-regional elements. The largest families are Asteraceae (50), Fabaceae (38), Lamiaceae (24), Poaceae (21) and Liliaceae (18) in terms of the number of species and subspecies included. Genera represented by the highest number of species are Centaurea (7), Alyssum (6), Silene, Astragalus, Trifolium, Lathyrus ve Campanula (5) . The number of endemic taxa within the study area is 41 (10.86%). 13 taxa are new records for the B3 squ

Brazilian Journal of Anesthesiology (English Edition)

Artvin Çoruh Üniversitesi Orman Fakültesi Dergisi, 2017

Araştırma alanı Pazaryeri (Bilecik) ve çevresini kapsamakta olup Davis'in kareleme sistemine göre... more Araştırma alanı Pazaryeri (Bilecik) ve çevresini kapsamakta olup Davis'in kareleme sistemine göre A2 ve B2 kareleri içinde yer almaktadır. 2013-2014 yılları arasında araştırma alanından floranın belirlenmesi için 2472 adet bitki örneği toplanmıştır. Toplanan bitki örnekleri herbaryum tekniklerine uygun olarak preslenip kurutulmuştur. Floristik liste APG III sistemi esas alınarak düzenlenmiştir. Yapılan teşhisler sonucunda çalışma bölgesinde; 61 familya, 312 cins, 532 tür ve tür altı damarlı bitki taksonu tespit edilmiştir. Araştırma alanındaki bitki taksonlarının fitocoğrafik bölgelere dağılımı ise şöyledir; %9.09'u İran-Turan, %12.50'i Akdeniz ve %10.79 Avrupa-Sibirya elementi. Çok bölgeli veya fitocoğrafik bölgesi bilinmeyenlerin oranı ise % 67.61'dir. Bölgedeki endemizm oranı %9.19'dur.

Turkiye Klinikleri Journal of Case Reports, 2015

Mustafa Kemal Üniversitesi Tıp Dergisi, 2015

2009 IEEE 17th Signal Processing and Communications Applications Conference, 2009

... Evirmenin büyük olması, en fazla 1530 nmГde kazancı artıracaktır. 1520 nm Y 1530 nm bandı içi... more ... Evirmenin büyük olması, en fazla 1530 nmГde kazancı artıracaktır. 1520 nm Y 1530 nm bandı için de sürekli artan bir kazanç grafiği söz konusudur. ... [6] Sadiku MNO, Optical and Wireless Communications, CRC Press, New York, 2002. ...

Sosyoekonomi, 2014

Test sureci, ozellikle karmasik urunler icin, isletme kaynaklarinin dogru planlanmasini gerektire... more Test sureci, ozellikle karmasik urunler icin, isletme kaynaklarinin dogru planlanmasini gerektiren onemli bir maliyet kapisidir. Cok ozellikli urunlerin testleri ise cikti kalitesini ve ilintili maliyetleri dogrudan etkilemektedir. Literaturde test ve tamir makinesi secimi, bir optimizasyon problemi olarak ele alinmamaktadir. Bu calismada mukemmel olmayan bir test ve tamir dongusu altinda cok ozellikli urunlerin testi icin makine secim optimizasyonu problemini cozecek bir kisit programlama modelinin yapisi aciklanmaktadir. Tamir makineleri icin de genellenebilecek bu model, gercekci bir maliyet hesabi yaklasimiyla ideal test makinesi secimi yapilmasina yardim etmektedir.

Anesthesia & Analgesia, 2008

Bangladesh Journal of Botany, 2013

The present study determines the morphological, anatomical, palynological, karyological, chorolog... more The present study determines the morphological, anatomical, palynological, karyological, chorological features and conservation status of the rediscovered rare endemic Turkish taxon Cota fulvida (Grierson) Holub. (Asteraceae) after ca.110 years. C. fulvida distributes naturally in Gölcük Plateau (Türkmen Mountain), Eski?ehir-Turkey. In the cross-sections of the root of C. fulvida, the pith was found completely covered by xylem cells. As to stem, it was observed that large parenchymatic cells were present in the pith of the stems. Leaves are equifacial and amphistomatious having amaryllis type of stomata. They are mesomorphic. Stomata are anisocytic. The results of the light and scanning electron microscope investigation revealed that the pollen grains of C. fulvida are tricolporatae, amb shape triangular, pollen shape spheroidal. Exine tectatae-echinate. The somatic chromosome number of C. fulvida was found to be 2n =18 without any satellite. It is considered "Critically Endang...

Complex regional pain syndrome (CRPS) remains one of the most challenging chronic pain condition.... more Complex regional pain syndrome (CRPS) remains one of the most challenging chronic pain condition. Various therapies have been attempted but with suboptimal clinical improvement. Central sensitization plays a major role in its pathogenesis which involves increased activity of N-methyl-D-aspartate (NMDA) receptors.Therefore, NMDA receptor antagonists, specifically ketamine, is a rationale option for treatment of CRPS. We performed a simple review of current evidence of literature focusing on efficacy and safety related to ketamine use in CRPS. Our aim is to provide published clinical evidence of efficacy of ketamine in treatment of CRPS to aid clinical decision-making. We searched PubMed for articles published after year 2000. After our literature search and careful filtering for relevant articles, we included 12 meta-analysis/systematic reviews, 4 randomized control trials, 4 open-label prospective trials, and 5 retrospective studies. In conclusion, our review suggests that ketamine is a promising treatment option for refractory CRPS patients, although the long-term efficacy is still in question. Ketamine appears to be safe and devoid of major adverse effects. Other aspects such as route of administration, duration of treatment, and optimal dose are less defined and needs further research. Finally, the numbers of high-quality studies are limited and further large, placebo-controlled, randomized trials are needed to evaluate the long-term efficacy and cost-effectiveness of ketamine therapy in CRPS.

Bu calismada, bazi bugday cesitlerinin arasindaki RAPD ve ISSR analizine dayali genetik mesafeler... more Bu calismada, bazi bugday cesitlerinin arasindaki RAPD ve ISSR analizine dayali genetik mesafelerin belirlenerek ayriminin yapilmasi amaclanmistir. Arastirma sonuclarina gore, primerler genotipleri guclendirilmis bantlarin sayisi RAPD’ de 3-10, ISSR’ de 6-10 arasinda degistigi belirlenmis olup, primer/primer kombinasyonlari icerisinde RAPD’de OPBA-03, OPL-15 ve OPY-13’den; ISSR’de UBC810 elde edildigi ortaya konmustur. Dendogram sonuclarina gore cesitler gore uc grup altinda siniflandirilmistir. Yunus, Altay-2000, Naci Bey, Sultan-95, Harmankaya ve Soyer cesitlerinin uzak iliskili; Alpu-01 ve Nacibey cesitlerinin ise yakin iliskili cesitler oldugu tespit edilmistir. Yine RAPD ve ISSR yontemlerinin genetik varyasyonu degerlendirmek, yeni cesitlerin gelistirilmesi ve siniflamasinda kullanilabilir yontemler oldugu belirlenmistir.

In this study the flora of Eskisehir Hekimdag (Bozdag) were investigated. According to Davis'... more In this study the flora of Eskisehir Hekimdag (Bozdag) were investigated. According to Davis's grid system, the research area lies in B3 square. The plant samples collected in this region and determined that there are 59 families, as well as 467 species and subspecies taxa belonging to 219 genera. The phytogeographical distribution is as follows: 49 Mediterranean, 31 Euro-Siberian, 19 Irano- Turanian, 6 Euxin and 362 unknown or other-regional elements. The largest families are Asteraceae (50), Fabaceae (38), Lamiaceae (24), Poaceae (21) and Liliaceae (18) in terms of the number of species and subspecies included. Genera represented by the highest number of species are Centaurea (7), Alyssum (6), Silene, Astragalus, Trifolium, Lathyrus ve Campanula (5) . The number of endemic taxa within the study area is 41 (10.86%). 13 taxa are new records for the B3 squ

Brazilian Journal of Anesthesiology (English Edition)

Artvin Çoruh Üniversitesi Orman Fakültesi Dergisi, 2017

Araştırma alanı Pazaryeri (Bilecik) ve çevresini kapsamakta olup Davis'in kareleme sistemine göre... more Araştırma alanı Pazaryeri (Bilecik) ve çevresini kapsamakta olup Davis'in kareleme sistemine göre A2 ve B2 kareleri içinde yer almaktadır. 2013-2014 yılları arasında araştırma alanından floranın belirlenmesi için 2472 adet bitki örneği toplanmıştır. Toplanan bitki örnekleri herbaryum tekniklerine uygun olarak preslenip kurutulmuştur. Floristik liste APG III sistemi esas alınarak düzenlenmiştir. Yapılan teşhisler sonucunda çalışma bölgesinde; 61 familya, 312 cins, 532 tür ve tür altı damarlı bitki taksonu tespit edilmiştir. Araştırma alanındaki bitki taksonlarının fitocoğrafik bölgelere dağılımı ise şöyledir; %9.09'u İran-Turan, %12.50'i Akdeniz ve %10.79 Avrupa-Sibirya elementi. Çok bölgeli veya fitocoğrafik bölgesi bilinmeyenlerin oranı ise % 67.61'dir. Bölgedeki endemizm oranı %9.19'dur.

Turkiye Klinikleri Journal of Case Reports, 2015

Mustafa Kemal Üniversitesi Tıp Dergisi, 2015

2009 IEEE 17th Signal Processing and Communications Applications Conference, 2009

... Evirmenin büyük olması, en fazla 1530 nmГde kazancı artıracaktır. 1520 nm Y 1530 nm bandı içi... more ... Evirmenin büyük olması, en fazla 1530 nmГde kazancı artıracaktır. 1520 nm Y 1530 nm bandı için de sürekli artan bir kazanç grafiği söz konusudur. ... [6] Sadiku MNO, Optical and Wireless Communications, CRC Press, New York, 2002. ...

Sosyoekonomi, 2014

Test sureci, ozellikle karmasik urunler icin, isletme kaynaklarinin dogru planlanmasini gerektire... more Test sureci, ozellikle karmasik urunler icin, isletme kaynaklarinin dogru planlanmasini gerektiren onemli bir maliyet kapisidir. Cok ozellikli urunlerin testleri ise cikti kalitesini ve ilintili maliyetleri dogrudan etkilemektedir. Literaturde test ve tamir makinesi secimi, bir optimizasyon problemi olarak ele alinmamaktadir. Bu calismada mukemmel olmayan bir test ve tamir dongusu altinda cok ozellikli urunlerin testi icin makine secim optimizasyonu problemini cozecek bir kisit programlama modelinin yapisi aciklanmaktadir. Tamir makineleri icin de genellenebilecek bu model, gercekci bir maliyet hesabi yaklasimiyla ideal test makinesi secimi yapilmasina yardim etmektedir.

Anesthesia & Analgesia, 2008

Bangladesh Journal of Botany, 2013

The present study determines the morphological, anatomical, palynological, karyological, chorolog... more The present study determines the morphological, anatomical, palynological, karyological, chorological features and conservation status of the rediscovered rare endemic Turkish taxon Cota fulvida (Grierson) Holub. (Asteraceae) after ca.110 years. C. fulvida distributes naturally in Gölcük Plateau (Türkmen Mountain), Eski?ehir-Turkey. In the cross-sections of the root of C. fulvida, the pith was found completely covered by xylem cells. As to stem, it was observed that large parenchymatic cells were present in the pith of the stems. Leaves are equifacial and amphistomatious having amaryllis type of stomata. They are mesomorphic. Stomata are anisocytic. The results of the light and scanning electron microscope investigation revealed that the pollen grains of C. fulvida are tricolporatae, amb shape triangular, pollen shape spheroidal. Exine tectatae-echinate. The somatic chromosome number of C. fulvida was found to be 2n =18 without any satellite. It is considered "Critically Endang...