Rajasekhar S | Jawaharlal Nehru Technological University Anantapur (original) (raw)
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Benzimidazole and its derivatives are regarded as an important heterocyclic motif that exhibits a... more Benzimidazole and its derivatives are regarded as an important heterocyclic motif that exhibits a wide range of pharmaceutical applications including anticancers, antihypertensives, antivirals, antifungals, anti-HIVs, anti-convulsants, and anti-diabetics. In view of their wide ranging activities, the synthesis of benzimidazoles and its derivatives remain a primary focus for synthetic chemistry communities. Till date numerous reports especially on the synthesis of 2-arylbenzimidazoles have been published but lack of knowledge on the detailed synthetic reports of two important derivatives such as 2-aminobenzimidazoles, and 2-(alkyl/aryl)thio benzimidazoles still persists. However, owing to fast developing benzimidazole containing new drugs numerous reports have appeared on the synthesis of this privileged scaffold. In this review, efforts have been taken to shed light on the latest informations available on the syntheses and applications of different benzimidazole derivatives. We have also tried to summarize the chemistry involved in the synthesis of various derivatives of benzimidazole for medicinal applications.
In 2014, more than 80% of the marketed drugs in the US contained heterocyclic compounds, which pl... more In 2014, more than 80% of the marketed drugs in the US contained heterocyclic compounds, which play a major role in the drugdiscovery process, as one of the primary components. Benzoxazole, consisting of an oxazole ring fused with a benzene ring, has shown profound impact in drug discovery research owing to its important bioactivity. This moiety has also shown important properties in material science. The synthesis of this privileged scaffold from readily available chemicals remains a primary focus for the synthetic chemistry community. In this review, efforts have been made to focus on the latest information available on the different synthetic strategies such as solution phase, multicomponent, green and solid phase chemistry and applications of different benzoxazole derivatives. Furthermore, the updated synthetic information incorporated in this review article will help to improve future synthesis of this scaffold.
Benzimidazole and its derivatives are regarded as an important heterocyclic motif that exhibits a... more Benzimidazole and its derivatives are regarded as an important heterocyclic motif that exhibits a wide range of pharmaceutical applications including anticancers, antihypertensives, antivirals, antifungals, anti-HIVs, anti-convulsants, and anti-diabetics. In view of their wide ranging activities, the synthesis of benzimidazoles and its derivatives remain a primary focus for synthetic chemistry communities. Till date numerous reports especially on the synthesis of 2-arylbenzimidazoles have been published but lack of knowledge on the detailed synthetic reports of two important derivatives such as 2-aminobenzimidazoles, and 2-(alkyl/aryl)thio benzimidazoles still persists. However, owing to fast developing benzimidazole containing new drugs numerous reports have appeared on the synthesis of this privileged scaffold. In this review, efforts have been taken to shed light on the latest informations available on the syntheses and applications of different benzimidazole derivatives. We have also tried to summarize the chemistry involved in the synthesis of various derivatives of benzimidazole for medicinal applications.
In 2014, more than 80% of the marketed drugs in the US contained heterocyclic compounds, which pl... more In 2014, more than 80% of the marketed drugs in the US contained heterocyclic compounds, which play a major role in the drugdiscovery process, as one of the primary components. Benzoxazole, consisting of an oxazole ring fused with a benzene ring, has shown profound impact in drug discovery research owing to its important bioactivity. This moiety has also shown important properties in material science. The synthesis of this privileged scaffold from readily available chemicals remains a primary focus for the synthetic chemistry community. In this review, efforts have been made to focus on the latest information available on the different synthetic strategies such as solution phase, multicomponent, green and solid phase chemistry and applications of different benzoxazole derivatives. Furthermore, the updated synthetic information incorporated in this review article will help to improve future synthesis of this scaffold.