Mohammed Farag | King Saud University (original) (raw)
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Islamic Azad University Isfahan (Khorasgan) Branch
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Diabetes is a global problem and many efforts are being done all over the world searching for new... more Diabetes is a global problem and many efforts are being done all over the world searching for new drugs that can manage it more efficiently. The World Health Organization recommended the natural products to be possible source for antidiabetic compounds. Jatropha curcas plant was employed in Indian traditional medicine for the treatment of several disorders. So, hexane, chloro-form and ethanolic extracts of the aerial part were subjected for evaluation of their hypoglycemic and antidiabetic effects. Oral administration of ethanolic extract at a dose of 400 mg/kg showed hypoglycemic and antidiabetic activities in alloxan induced diabetic mice. Bioassay-guided frac-tionation used to isolate the active fraction. Moreover, the drug was found to be safe up to dose of 5 g/kg. Further fractionation is recommended to find the active compound(s).
Reviewing the current literature for the importance of the plant Albizia lebbeck L. growing world... more Reviewing the current literature for the importance of the plant Albizia lebbeck L. growing worldwide revealed many biological interests. However, the species growing in Saudi Arabia has not received due attention. The present study was undertaken to study antipyretic, analgesic, estrogenic and anti-inflammatory activities of five different fractions from successive extraction of Albizia lebbeck flowers: n hexane, dichloromethane, ethyl acetate, n-butanol as well as the 70% total alcohol. The flowers showed reasonable antipyretic, analgesic, estrogenic and anti-inflammatory activities.
Diabetes mellitus is a hampering and often life-threatening ailment. It has an increasingly frequ... more Diabetes mellitus is a hampering and often life-threatening ailment. It has an increasingly frequency of occurrence throughout the world. Concomitantly, a scientific investigation of traditional herbal remedies for diabetes may provide an exciting opportunity for discovering new leads in order to develop alternative drugs and therapeutic strategiesparticularly in the third-world countries. This review provides information onseveral species of plants reported to have been used to treat diabetes and/or investigated for antidiabetic activity.It also highlights how these natural alternatives overweight the medicines available today in the market.Many traditional plant treatment have been recorded, but only a small number of these have received scientific and medical evaluation to assess their efficacy. Therefore, a big chance for further investigations and isolation of biologically active compound is present.
Five xanthone derivatives and one flavanol were isolated from the dichloromethane extract of Garc... more Five xanthone derivatives and one flavanol were isolated from the dichloromethane extract of Garcinia mangostana. Dichloromethane, ethyl acetate extract and the major xanthone (α-mangostin) were evaluated in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. The major constituent α-mangostin was also checked for antimicrobial potential against Candida albicans, 10600 P. falciparum (IC 50 2.7 μg/mL) and T. brucei (IC 50 0.5 μg/mL) were observed for the dichloromethane extract, however, with only moderate selectivity was seen based on a parallel cytotoxicity evaluation on MRC-5 cells (IC 50 9.4 μg/mL). The ethyl acetate extract was inactive (IC 50 > 30 µg/mL). The major constituent α-mangostin showed rather high cytotoxicity (IC 50 7.5 µM) and a broad but non-selective antiprotozoal and antimicrobial activity profile. This in vitro study endorses that the antiprotozoal and antimicrobial potential of prenylated xanthones is non-conclusive in view of the low level of selectivity.
The principle objective of this review was initially to document the use of medicinal plants thro... more The principle objective of this review was initially to document the use of medicinal plants throughout the history of the humans and the distinct eras during which the so called ―Rationoal ethnopharmacology‖ or the home-remedy based medicine evolved eventionally to become what we currently know as the age of ― high throughout put techneques‖.
A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of ... more A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs' platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β-amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.
Diabetes is a global problem and many efforts are being done all over the world searching for new... more Diabetes is a global problem and many efforts are being done all over the world searching for new drugs that can manage it more efficiently. The World Health Organization recommended the natural products to be possible source for antidiabetic compounds. Jatropha curcas plant was employed in Indian traditional medicine for the treatment of several disorders. So, hexane, chloro-form and ethanolic extracts of the aerial part were subjected for evaluation of their hypoglycemic and antidiabetic effects. Oral administration of ethanolic extract at a dose of 400 mg/kg showed hypoglycemic and antidiabetic activities in alloxan induced diabetic mice. Bioassay-guided frac-tionation used to isolate the active fraction. Moreover, the drug was found to be safe up to dose of 5 g/kg. Further fractionation is recommended to find the active compound(s).
Reviewing the current literature for the importance of the plant Albizia lebbeck L. growing world... more Reviewing the current literature for the importance of the plant Albizia lebbeck L. growing worldwide revealed many biological interests. However, the species growing in Saudi Arabia has not received due attention. The present study was undertaken to study antipyretic, analgesic, estrogenic and anti-inflammatory activities of five different fractions from successive extraction of Albizia lebbeck flowers: n hexane, dichloromethane, ethyl acetate, n-butanol as well as the 70% total alcohol. The flowers showed reasonable antipyretic, analgesic, estrogenic and anti-inflammatory activities.
Diabetes mellitus is a hampering and often life-threatening ailment. It has an increasingly frequ... more Diabetes mellitus is a hampering and often life-threatening ailment. It has an increasingly frequency of occurrence throughout the world. Concomitantly, a scientific investigation of traditional herbal remedies for diabetes may provide an exciting opportunity for discovering new leads in order to develop alternative drugs and therapeutic strategiesparticularly in the third-world countries. This review provides information onseveral species of plants reported to have been used to treat diabetes and/or investigated for antidiabetic activity.It also highlights how these natural alternatives overweight the medicines available today in the market.Many traditional plant treatment have been recorded, but only a small number of these have received scientific and medical evaluation to assess their efficacy. Therefore, a big chance for further investigations and isolation of biologically active compound is present.
Five xanthone derivatives and one flavanol were isolated from the dichloromethane extract of Garc... more Five xanthone derivatives and one flavanol were isolated from the dichloromethane extract of Garcinia mangostana. Dichloromethane, ethyl acetate extract and the major xanthone (α-mangostin) were evaluated in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. The major constituent α-mangostin was also checked for antimicrobial potential against Candida albicans, 10600 P. falciparum (IC 50 2.7 μg/mL) and T. brucei (IC 50 0.5 μg/mL) were observed for the dichloromethane extract, however, with only moderate selectivity was seen based on a parallel cytotoxicity evaluation on MRC-5 cells (IC 50 9.4 μg/mL). The ethyl acetate extract was inactive (IC 50 > 30 µg/mL). The major constituent α-mangostin showed rather high cytotoxicity (IC 50 7.5 µM) and a broad but non-selective antiprotozoal and antimicrobial activity profile. This in vitro study endorses that the antiprotozoal and antimicrobial potential of prenylated xanthones is non-conclusive in view of the low level of selectivity.
The principle objective of this review was initially to document the use of medicinal plants thro... more The principle objective of this review was initially to document the use of medicinal plants throughout the history of the humans and the distinct eras during which the so called ―Rationoal ethnopharmacology‖ or the home-remedy based medicine evolved eventionally to become what we currently know as the age of ― high throughout put techneques‖.
A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of ... more A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs' platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β-amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.