Salmon WD jr, Daughaday WH (1957) A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med 49: 825–836 CASPubMed Google Scholar
Rinderknecht E, Humbel RE (1978) The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem 253: 2769–2776 CASPubMed Google Scholar
Rinderknecht E, Humbel RE (1978) Primary structure of human insulin-like growth factor II. FEBS Lett 89: 283–286 ArticleCASPubMed Google Scholar
Klapper DG, Svoboda ME, van Wyk JJ (1983) Sequence analysis of somatomedin C: Confirmation of identity with insulin-like growth factor I. Endocrinology 112: 2215–2217 ArticleCASPubMed Google Scholar
Engberg G, Carlquist M, Jörnball H, Hall K (1984) The characterization of somatomedin A, isolated by microcomputer-controlled chromatography, reveals an apparent identity to insulin-like growth factor I. Europ J Biochem 143: 117–124 Article Google Scholar
Froesch ER (1983) From NSILA to IGF: A look back on the major advances and breakthroughs. In: Insulin-like growth factors/ somatomedins. Spencer M (ed) Walter de Gruyter, New York, pp 13–29 Google Scholar
Blundell TL, Bedarkar S, Rinderknecht E, Humbel RE (1978) Insulin-like growth factors: A model for tertiary structure accounting for immunoreactivity and receptor binding. Proc Natl Acad Sci USA 75: 180–184 ArticleCASPubMedPubMed Central Google Scholar
Zapf J, Schoenle E, Froesch ER (1978) Insulin-like growth factors I and II: Some biological actions and receptor binding characteristics of two purified constituents of nonsuppressible insulinlike activity of human serum. Eur J Biochem 87: 285–296 ArticleCASPubMed Google Scholar
Rechler MM, Zapf J, Nissley SP, Froesch ER, Moses AC, Podskalny JM, Schilling EE, Humbel RE (1980) Interactions of insulin-like growth factors I and II and multiplication-stimulating activity with receptors and serum carrier proteins. Endocrinology 107: 1451–1459 ArticleCASPubMed Google Scholar
Brissenden JE, Ullrich A, Francke U (1984) Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor. Nature 310: 781–784 ArticleCASPubMed Google Scholar
Tricoli JV, Rall LB, Scott J, Gell GI, Shows TB (1984) Localization of insulin-like growth factor genes to human chromosomes 11 and 12. Nature 310: 784–786 ArticleCASPubMed Google Scholar
Sakaguchi A, Naylor SL, Shows TB (1983) Human c-Ki-ras2 proto oncogene on chromosome 12. Science 219: 1081–1083 ArticleCASPubMed Google Scholar
O'Brien SJ, Nash GW, Goodwin JL, Lowy DR, Chang EH (1983) Dispersion of the ras family of transforming genes to four different chromosomes in man. Nature 302: 839–842 ArticlePubMed Google Scholar
De Martinville B, Giacalone J, Shih C, Weinberg RA, Francke U (1983) Oncogene from human EJ bladder carcinoma is located on the short arm of chromosome 11. Science 219: 498–501 ArticlePubMed Google Scholar
Janson M, van Schaik FMA, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, van den Brande JL (1983) Sequence of C-DNA encoding human insulin-like growth factor I precursor. Nature 306: 609–611 Article Google Scholar
Widmer U, Zapf J, Froesch ER (1982) Is extrapancreatic tumor hypoglycemia associated with elevated levels of insulin-like growth factor II? J Clin Endocrinol Metab 55: 833–839 ArticleCASPubMed Google Scholar
Zangger I, Zapf J, Froesch ER (1985) Insulin-like growth factor I and II in 13 animal species as determined by three radioligand and two bioassays. Acta Endocrinol (Kbh) (in press)
Kasuga M, Van Obberghen E, Nissley SP, Rechler MM (1981) Demonstration of two subtypes of insulin-like growth factor receptors by affinity crosslinking. J Biol Chem 256/11: 5305–5308 CASPubMed Google Scholar
Van Obberghen E, Rossi B, Kowalski A, Gazzano H, Ponzio G (1983) Receptor mediated phosphorylation of the hepatic insulin receptor: evidence that the 95 K receptor subunit is its own kinase. Proc Natl Acad Sci USA 80: 949 Google Scholar
Howell SL, Tyhurst M (1982) Microtubules, microfilaments and insulin secretion. Diabetologia 22: 301–308 ArticleCASPubMed Google Scholar
Wollheim CB, Sharp GWG (1981) Regulation of insulin release by calcium. Physiol Rev 61: 914–973 CASPubMed Google Scholar
Schwander J, Hauri C, Zapf J, Froesch ER (1983) Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: Dependence on growth hormone status. Endocrinology 113: 297–305 ArticleCASPubMed Google Scholar
Mayer PW, Schalch DS (1983) Somatomedin synthesis by a subclone of Buffalo rat liver cells: Characterization and evidence for immediate secretion of de novo synthesized hormone. Endocrinology 113: 588–595 ArticleCASPubMed Google Scholar
Zapf J, Froesch ER, Humbel RE (1981) The insulin-like growth factors (IGF) of human serum: Chemical and biological characterization and aspects of their possible physiological role. Curr Top Cell Regul 19: 257–309 ArticleCASPubMed Google Scholar
Suzuki F, Kato Y, Hiraki Y, Canalis E, Raisz LG (1983) Action of growth factors on chondrocytes: Discovery of local somatomedins in fetal bovine cartilage. In: Insulin-like growth factors/somatomedins. Spencer M (ed) Walter de Gruyter, New York, pp 431–36 Google Scholar
Stracke H, Schulz A, Moeller D, Rossol S, Schatz H (1984) Effect of growth hormone on osteoblasts and demonstration of somatomedin-C/IGF I in bone organ culture. Acta Endocrinol (Kbh) 107: 16–24 CAS Google Scholar
Zapf J, Waldvogel M, Froesch ER (1975) Binding of nonsuppressible insulin-like activity to human serum: Evidence for a carrier protein. Arch Biochem Biophys 168: 638–645 ArticleCASPubMed Google Scholar
Kaufmann U, Zapf J, Torretti B, Froesch ER (1977) Demonstration of a specific serum carrier protein of nonsuppressible insulinlike activity in vivo. J Clin Endocrinol Metab 44: 160–166 ArticleCASPubMed Google Scholar
Moses AC, Nissley SP, Cohen KL, Rechler MM (1976) Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone. Nature 263: 137–140 ArticleCASPubMed Google Scholar
Zapf J, Schoenle E, Waldvogel M, Sand I, Froesch ER (1981) Effect of trypsin treatment of rat adipocytes on biological effects and binding of insulin-like growth factors. Further evidence for the action of insulin-like growth factors through the insulin receptor. Eur J Biochem 113: 605–609 ArticleCASPubMed Google Scholar
Zapf J, Waldvogel M, Froesch ER (1975) Binding of non-suppressible insulin-like activity to human serum: evidence for a carrier protein. Arch Biochem Biophys 168: 638–645 ArticleCASPubMed Google Scholar
Schlumpf U, Heimann R, Zapf J, Froesch ER (1976) Nonsuppressible insulin-like activity and sulfation activity in serum extracts of normal subjects, acromegalics and pituitary dwarfs. Acta Endocrinol (Kbh) 81: 28–42 CAS Google Scholar
Kaufmann U, Zapf J, Froesch ER (1978) Growth hormone dependence of nonsuppressible insulin-like activity (NSILA) and of NSILA-carrier protein. Acta Endocrinol (Kbh) 87: 716–727 CAS Google Scholar
Froesch ER, Müller WA, Bürgi H, Waldvogel M, Labhart A (1966) Nonsuppressible insulin-like activity of human serum. II Biological properties of plasma extracts with non-suppressible insulinlike activity. Biochim et Biophys Acta 121: 360–374 ArticleCAS Google Scholar
Oelz O, Jakob A, Froesch ER (1970) Nonsuppressible insulin-like activity (NSILA) of human serum. V. Hypoglycemia and preferential metabolic stimulation of muscle by NSILA-S. Eur J Clin Invest 1: 48–53 ArticleCASPubMed Google Scholar
Meuli C, Froesch ER (1975) Effects of insulin and of NSILA on the perfused rat heart: Glucose uptake, lactate production and efflux of 3-O-methylglucose. Eur J Clin Invest 5: 93–99 ArticleCASPubMed Google Scholar
Poggi C, Le Marchand-Brustel Y, Zapf J, Froesch ER, Freychet P (1979) Effects and binding on insulin-like growth factor I (IGFI) in the isolated soleus muscle of lean and obese mice: comparison with insulin. Endocrinology 105: 723–730 ArticleCASPubMed Google Scholar
Morell B, Froesch ER (1973) Fibroblasts as an experimental tool in metabolic and hormone studies. II. Effects of insulin and nonsuppressible insulin-like activity (NSILA-S) on fibroblasts in culture. Eur J Clin Invest 3: 119–123 ArticleCASPubMed Google Scholar
Schmid Ch, Steiner Th, Froesch ER (1984) Insulin-like growth factor I supports differentiation of cultured osteoblast-like cells. Febs Lett 173: 48–52 ArticleCASPubMed Google Scholar
Guenther HL, Guenther HE, Froesch ER, Fleisch H (1982) Effect of insulin-like growth factor on collagen and glycosaminoglycan synthesis by rabbit articular chondrocytes in culture. Experientia 38: 979–980 ArticleCASPubMed Google Scholar
Schmid Ch, Steiner Th, Froesch ER (1983) Preferential enhancement of myoblast differentiation by insulin-like growth factors (IGF I and IGF II) in primary cultures of chicken embryonic cells. FEBS Lett 161: 117–121 ArticleCASPubMed Google Scholar
Schmid C, Steiner Th, Froesch ER (1983) Insulin-like growth factors stimulate synthesis of nucleic acids and glycogen in cultured calvaria cells. Calcif Tissue Int 35: 578–585 ArticleCASPubMed Google Scholar
Kurtz A, Jelkmann W, Bauer Ch (1982) A new candidate for the regulation of erythropoiesis. FEBS Let 149: 105–108 ArticleCAS Google Scholar
Zapf J, Morell B, Walter H, Laron Z, Froesch ER (1980) Serum levels of insulin-like growth factor (IGF) and its carrier protein in various metabolic disorders. Acta Endocrinol (Kbh) 95: 505–517 CAS Google Scholar
Eigenmann JE, Becker M, Kammermann B, Leeman W, Heimann R, Zapf J, Froesch ER (1977) Decrease of non-suppressible insulin-like activity after pancreatectomy and normalization by insulin therapy. Acta Endocrinol 85: 818–822 CASPubMed Google Scholar
Eigenmann JE, de Braijne JJ, Froesch ER (1985) Insulin-like growth factor I and growth hormone in canine starvation. Acta Endocrinol (Kbh) 108: 161–166 CAS Google Scholar
Schoenle E, Zapf J, Humbel RE, FroeschE R (1982) Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature 296: 252–253 ArticleCASPubMed Google Scholar
Schoenle E, Zapf J, Hauri Ch, Steiner Th, Froesch ER (1985) Comparison of in vivo effects of insulin-like growth factors I and II and of growth hormone in hypophysectomized rats. Acta Endocrinol (Kbh) 1808: 167–174 Google Scholar
Merimee TJ, Zapf J, Froesch ER (1981) Dwarfism in the pygmy: An isolated deficiency of insulin-like growth factor I. New Engl J Med 305: 965–968 ArticleCASPubMed Google Scholar
Zapf J, Schmid Ch, Froesch ER (1984) Biological and immunological properties of insulin-like growth factors (IGF) I and II. Clin in Endocrinol Metab 13/1: 3–30 ArticleCAS Google Scholar
Eigenmann JE, Patterson J, Zapf J, Froesch ER (1984) Insulin-like growth factor I in the dog: a study in different dog breeds and in dogs with growth hormone elevation. Acta Endocrinol (Kbh) 105: 294–301 CAS Google Scholar
Eigenmann JE, Patterson DF, Froesch ER (1984) Body size parallels insulin-like growth factor I levels but not growth hormone secretory capacity. Acta Endocrinol (Kbh) 106: 448–453 CAS Google Scholar
Zapf J, Walter H, Froesch ER (1981) Radioimmunological determination of insulin-like growth factor I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia. J Clin Invest 68: 1321–1330 ArticleCASPubMedPubMed Central Google Scholar
Froesch ER (1967) The physiology and pharmacology of adipose tissue lipolysis: its inhibition and implications for the treatment of diabetes. Diabetologia 3: 475–487 ArticleCASPubMed Google Scholar
Randle PJ (1966) Carbohydrate metabolism and lipid storage and breakdown in diabetes. Diabetologia 2: 237–247 ArticleCASPubMed Google Scholar
Sara VR, Hall K (1983) Somatomedin receptors in the human brain throughout life. In: Spencer M (ed) Insulin-like growth factors/somatomedins. Walter de Gruyter, New York, pp 544–548 Google Scholar
Haselbacher G, Humbel R (1982) Evidence for two species of insulin-like growth factor II (IGF II and “big” IGF II) in human spinal fluid. Endocrinology 110: 1822–1824 ArticleCASPubMed Google Scholar