Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer’s disease (original) (raw)
References
Selkoe DJ (2001) Alzheimer’s disease: genes, proteins, and therapy. Physiol Rev 81:741–766 CASPubMed Google Scholar
Esler WP, Wolfe MS (2001) A portrait of Alzheimer secretases-new features and familiar faces. Science 293:1449–1454 ArticleCASPubMed Google Scholar
LeVine H, 3rd (1993) Thioflavine T interaction with synthetic Alzheimer’s disease beta-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci 2:404–410 CASPubMed Google Scholar
Hsiao KK, Borchelt DR, Olson K, Johannsdottir R, Kitt C, Yunis W, Xu S, Eckman C, Younkin S, Price D et al. (1995) Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 15:1203–1218 ArticleCASPubMed Google Scholar
Nicolau C, Greferath R, Balaban TS, Lazarte JE, Hopkins RJ (2002) A liposome-based therapeutic vaccine against beta-amyloid plaques on the pancreas of transgenic NORBA mice. Proc Natl Acad Sci U S A 99:2332–2337 ArticleCASPubMed Google Scholar
Mohajeri MH, Saini K, Schultz JG, Wollmer MA, Hock C, Nitsch RM (2002) Passive immunization against beta-amyloid peptide protects CNS neurons from increased vulnerability associated with an Alzheimer’s disease-causing mutation. J Biol Chem 14:14 Google Scholar
Dodart JC, Bales KR, Paul SM (2003) Immunotherapy for Alzheimer’s disease: will vaccination work? Trends Mol Med 9:85–87 ArticlePubMed Google Scholar
Monsonego A, Weiner HL (2003) Immunotherapeutic approaches to Alzheimer’s disease. Science 302:834–838 ArticleCASPubMed Google Scholar
Frenkel D, Katz O, Solomon B (2000) Immunization against Alzheimer’s beta-amyloid plaques via EFRH phage administration. Proc Natl Acad Sci USA 97:11455–11459 ArticleCASPubMed Google Scholar
Town T, Tan J, Sansone N, Obregon D, Klein T, Mullan M (2001) Characterization of murine immunoglobulin G antibodies against human amyloid-beta1–42. Neurosci Lett 307:101–104 ArticleCASPubMed Google Scholar
Solomon B, Koppel R, Frankel D, Hanan-Aharon E (1997) Disaggregation of Alzheimer beta-amyloid by site-directed mAb. Proc Natl Acad Sci USA 94:4109–4112 ArticleCASPubMed Google Scholar
O’Nuallain B, Wetzel R (2002) Conformational Abs recognizing a generic amyloid fibril epitope. Proc Natl Acad Sci USA 99:1485–1490 ArticleCASPubMed Google Scholar
DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci USA 98:8850–8855 ArticleCASPubMed Google Scholar
DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM (2002) Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer’s disease. Science 295:2264–2267 ArticleCASPubMed Google Scholar
Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM, Paul SM (2002) Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer’s disease model. Nat Neurosci 8:8 Google Scholar
Solomon B, Koppel R, Hanan E, Katzav T (1996) Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc Natl Acad Sci USA 93:452–455 ArticleCASPubMed Google Scholar
Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock T (2000) Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6:916–919 ArticleCASPubMed Google Scholar
Pirttila T, Kim KS, Mehta PD, Frey H, Wisniewski HM (1994) Soluble amyloid beta-protein in the cerebrospinal fluid from patients with Alzheimer’s disease, vascular dementia and controls. J Neurol Sci 127:90–95 ArticleCASPubMed Google Scholar
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P (1999) Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400:173–177 ArticleCASPubMed Google Scholar
Spooner ET, Desai RV, Mori C, Leverone JF, Lemere CA (2002) The generation and characterization of potentially therapeutic Abeta antibodies in mice: differences according to strain and immunization protocol. Vaccine 21:290–297 ArticleCASPubMed Google Scholar
Check E (2002) Nerve inflammation halts trial for Alzheimer’s drug. Nature 415:462 ArticleCAS Google Scholar
Wolchok JD, Gregor PD, Nordquist LT, Slovin SF, Scher HI (2003) DNA vaccines: an active immunization strategy for prostate cancer. Semin Oncol 30:659–666 CASPubMed Google Scholar
Ramshaw IA, Ramsay AJ (2000) The prime-boost strategy: exciting prospects for improved vaccination. Immunol Today 21:163–165 ArticleCASPubMed Google Scholar
Schultz J, Dollenmaier G, Molling K (2000) Update on antiviral DNA vaccine research (1998–2000). Intervirology 43:197–217 ArticleCASPubMed Google Scholar
Robinson HL, Montefiori DC, Johnson RP, Kalish ML, Lydy SL, McClure HM (2000) DNA priming and recombinant pox virus boosters for an AIDS vaccine. Dev Biol 104:93–100 CAS Google Scholar
McCluskie MJ, Brazolot Millan CL, Gramzinski RA, Robinson HL, Santoro JC, Fuller JT, Widera G, Haynes JR, Purcell RH, Davis HL (1999) Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates. Mol Med 5:287–300 ArticleCASPubMed Google Scholar
Montgomery DL, Shiver JW, Leander KR, Perry HC, Friedman A, Martinez D, Ulmer JB, Donnelly JJ, Liu MA (1993) Heterologous and homologous protection against influenza A by DNA vaccination: optimization of DNA vectors. DNA Cell Biol 12:777–783 CASPubMed Google Scholar
Schultz J, Pavlovic J, Strack B, Nawrath M, Moelling K (1999) Long-lasting anti-metastatic efficiency of interleukin 12-encoding plasmid DNA. Hum Gene Ther 10:407–417 ArticleCASPubMed Google Scholar
Chen CA, Okayama H (1988) Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA. Biotechniques 6:632–638 CASPubMed Google Scholar
Hock C, Konietzko U, Papassotiropoulos A, Wollmer A, Streffer J, Von Rotz RC, Davey G, Moritz E, Nitsch RM (2002) Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease. Nat Med 8:1270–1275 ArticleCASPubMed Google Scholar
Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495–497 CASPubMed Google Scholar
Wenschuh H, Volkmer-Engert R, Schmidt M, Schulz M, Schneider-Mergener J, Reineke U (2000) Coherent membrane supports for parallel microsynthesis and screening of bioactive peptides. Biopolymers 55:188–206 ArticleCASPubMed Google Scholar
Kramer A, Volkmer-Engert R, Malin R, Reineke U, Schneider-Mergener J (1993) Simultaneous synthesis of peptide libraries on single resin and continuous cellulose membrane supports: examples for the identification of protein, metal and DNA binding peptide mixtures. Pept Res 6:314–319 CASPubMed Google Scholar
Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546–549 ArticleCASPubMed Google Scholar
Moelling K (2000) Viral DNA Vaccines. Intervirology 43:2–10 Google Scholar
Weber R, Bossart W, Cone R, Luethy R, Moelling K (2001) Phase I clinical trial with HIV-1 gp160 plasmid vaccine in HIV-1-infected asymptomatic subjects. Eur J Clin Microbiol Infect Dis 20:800–803 ArticleCASPubMed Google Scholar
Schenk D (2002) Opinion: amyloid-beta immunotherapy for Alzheimer’s disease: the end of the beginning. Nat Rev Neurosci 3:824–828 ArticleCASPubMed Google Scholar
Peretz D, Williamson RA, Kaneko K, Vergara J, Leclerc E, Schmitt-Ulms G, Mehlhorn IR, Legname G, Wormald MR, Rudd PM, Dwek RA, Burton DR, Prusiner SB (2001) Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature 412:739–743 ArticleCASPubMed Google Scholar
Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, Mathews PM, Jucker M (2002) Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science 298:1379 ArticleCASPubMed Google Scholar