Role Of Immature Myeloid Cells in Mechanisms of Immune Evasion In Cancer (original) (raw)
Almand B, Clark JI, Nikitina E, English NR, Knight SC, Carbone DP and Gabrilovich DI (2001) Increased production of immature myeloid cells in cancer patients A mechanism of immunosuppression in cancer. J Immunol 166:678–689 PubMedCAS Google Scholar
Almand B, Resser J, Lindman B, Nadaf S, Clark J, Kwon E, Carbone D and Gabrilovich D (2000) Clinical significance of defective dendritic cell differentiation in cancer. Clin Cancer Res 6:1755–1766 PubMedCAS Google Scholar
Atochina O, Daly-Angel T, Piskorska D and Harn D (2001) A shistosome expressed immunomodulatory glycoconjugate expand peritoneal Gr1+ macrophages that suppress naïve CD4+ T cell proliferation via an interferon-gamma and nitric oxide dependent mechanism. J Immunol 167:4293–4302 PubMedCAS Google Scholar
Balkwill F and Mantovani A (2001) Inflammation and cancer:back to Virchow? Lancet 357(9255):539–545 ArticlePubMedCAS Google Scholar
Beck C, Schreiber K, Schreiber H and Rowley D (2001) C-kit+ FcR+ myelocytes are increased in cancer and prevent the proliferation of fully cytolytic T cells in the presence of immune serum. Eur J Immunol 33(1):19–28 Article Google Scholar
Boucher JL, Moali C and Tenu JP (1999) Nitric oxyde byosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization. Cell Mol Life Sci 55:1015–1028 ArticlePubMedCAS Google Scholar
Bronte V, Apolloni E, Cabrelle A, Ronca R, Serafini P, Zamboni P, Restifo N and Zanovello P (2000) Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood 96:3838 PubMedCAS Google Scholar
Bronte V, Casic T, Gri G, Gallana K, Borsellino G, Marrigo I, Battistini L, Iafrate M, Prayer-Galletti U, Pagano F and Viola A (2005) Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med 201(8):1257–1268 ArticlePubMedCAS Google Scholar
Bronte V, Chappell DB, Apolloni E, Cabrelle A, Wang M, Hwu P and Restifo NP (1999) Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation. J Immunol 162: 5728–5737 PubMedCAS Google Scholar
Bronte V, Serafini P, Appoloni E and Zanovello P (2001) Tumor-induced immune dysfunctions caused by myeloid suppressor cells. J Immunoth 24:431–446 ArticleCAS Google Scholar
Bronte V, Serafini P, De Santo C, Marigo I, Tosello V, Mazzoni A, Segal DM, Staib C, Lowel M, Sutter G, Colombo MP and Zanovello P (2003) IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice. J Immunol 170(1):270–278 PubMedCAS Google Scholar
Bronte V, Wang M, Overwijk W, Surman D, Pericle F, Rosenberg SA and Restifo NP (1998) Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells. J Immunol 161:5313–5320 PubMedCAS Google Scholar
Cauley L, Miller E, Yen M and Swain S (2000) Superantigen-induced CD4 T cell tolerance mediated by myeloid cells and IFN-gamma. J Immunol 165:6056 PubMedCAS Google Scholar
Cheng F, Wang HW, Cuenca A, Huang M, Ghansah T, Brayer J, Kerr WG, Takeda K, Akira S, Schoenberger SP, Yu H, Jove R and Sotomayor EM (2003) A critical role for Stat3 signaling in immune tolerance. Immunity 19:425–436 ArticlePubMedCAS Google Scholar
De Santo C, Serafini P, Marigo I, Dolcetti L, Bolla M, P DS, Melani C, Guiducci C, Colombo M, Iezzi M, Musiani P, Zanovello P and Bronte V (2005) Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination. Proc Natl Acad Sci U S A 102(11):4185–4190 Google Scholar
Gabrilovich D (2004) The mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat Rev Immunol 4:941–952 ArticlePubMedCAS Google Scholar
Gabrilovich D, Cheng P, Fan Y, Yu B, Nikitina E, Sirotkin A, Shurin M, Oyama T, Adachi Y, Nadaf S, Carbone DP and Skoultchi A (2002) H1o Histone and Differentiation of Dendritic Cells A Molecular Target for Tumor-Derived Factors. J Leuk Biol 72:285–296 CAS Google Scholar
Gabrilovich D, Ishida T, Oyama T, Ran S, Kravtsov V, Nadaf S and Carbone DP (1998) Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92(11):4150–4166 PubMedCAS Google Scholar
Gabrilovich DI, Velders M, Sotomayor E and Kast WM (2001) Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells. J Immunol 166:5398–5406 PubMedCAS Google Scholar
Hengesbach L and Hoag K (2004) Physiological concentrations of retinoic acid favor myeloid dendritic cell development over granulocyte development in cultures of bone marrow cells from mice. J Nutr 134(10): 2653–2659 PubMedCAS Google Scholar
Hestdal K, Ruscetti F, Ihle J, Jacobsen S, Dubois C, Kopp W, Longo D and Keller J (1991) Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. J Immunol 147(1):22–28 PubMedCAS Google Scholar
Kusmartsev S, Cheng F, Yu B, Nefedova Y, Sotomayor E, Lush R and Gabrilovich DI (2003) All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination. Cancer Res 63:4441–4449 PubMedCAS Google Scholar
Kusmartsev S and Gabrilovich D (2005) STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion. J Immunol 174(8): 4880–4891 PubMedCAS Google Scholar
Kusmartsev S and Gabrilovich DI (2003) Inhibition of myeloid cell differentiation in cancer:The role of reactive oxygen species. J Leukoc Biol 74(2):186–196 ArticlePubMedCAS Google Scholar
Kusmartsev S, Li Y and Chen S-H (2000) Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. J Immunol 165:779–785 PubMedCAS Google Scholar
Kusmartsev S, Nefedova Y, Yoder D and Gabrilovich DI (2004) Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. J Immunol 172(2):989–999 PubMedCAS Google Scholar
Kuwata T, Wang I, Tamura T, Ponnamperuma R, Levine R, Holmes K, Morse H, De Luca L and Ozato K (2000) Vitamin A deficiency in mice causes a systemic expansion of myeloid cells. Blood 95(11):3349–3356 PubMedCAS Google Scholar
Lathers D, Clark J, Achille N and Young M (2004) Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3. Cancer Immunol Immunother 53(5):422–430 ArticlePubMedCAS Google Scholar
Li Q, Pan PY, Gu P, Xu D and Chen SH (2004) Role of immature myeloid Gr-1+ cells in the development of antitumor immunity. Cancer Res 64(3):1130–1139 ArticlePubMedCAS Google Scholar
Liu Y, Van Ginderachter J, Brys L, De Baetselier P, Raes G and Geldhof A (2003) Nitric oxide-independent CTL suppression during tumor progression:association with arginase-producing (M2) myeloid cells. J Immunol 170(10):5064–5074 PubMedCAS Google Scholar
Mantovani A, Sozzani S, Locati M, Allavena P and Sica A (2002) Macrophage polarization:tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23(11):549–555 ArticlePubMedCAS Google Scholar
Melani C, Chiodoni C, Forni G and Colombo MP (2003) Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity. Blood 102(6):2138–2145 ArticlePubMedCAS Google Scholar
Mencacci A, Montagnoli C, Bacci A, Cenci E, Pitzurra L, Spreca A, Kopf M, Sharpe A and Romani L (2002) CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. J Immunol 169(6):3180–3190 PubMedCAS Google Scholar
Menetrier-Caux C, Thomachot MC, Alberti L, Montmain G and Blay JY (2001) IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells. Cancer Res 61(7):3096–3104 PubMedCAS Google Scholar
Nefedova Y, Huang M, Kusmartsev S, Bhattacharya R, Cheng P, Salup R, Jove R and Gabrilovich D (2004) Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer. J Immunol 172(1):464–474 PubMedCAS Google Scholar
Ostrand-Rosenberg S, Clements VK, Terabe M, Park JM, Berzofsky JA and Dissanayake SK (2002) Resistance to metastatic disease in STAT6-deficient mice requires hemopoietic and nonhemopoietic cells and is IFN-gamma dependent. J Immunol 169(10):5796–5804 PubMedCAS Google Scholar
Otsuji M, Kimura Y, Aoe T, Okamoto Y and Saito T (1996) Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses. Proc Natl Acad Sci USA 93:13119–13124 ArticlePubMedCAS Google Scholar
Pandit R, Lathers D, Beal N, Garrity T and Young M (2000) CD34+ immune suppressive cells in the peripheral blood of patients with head and neck cancer. Ann Otol Rhinol Laryngol 109:749–754 PubMedCAS Google Scholar
Pelaez B, Campillo J, Lopez-Asenjo J and Subiza J (2001) Cyclophosphamide induces the development of early myeloid cells suppressing tumor growth by a nitric oxide-dependent mechanism. J Immunol 166:6608 PubMedCAS Google Scholar
Pollard J (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4(1):71–78 ArticlePubMedCAS Google Scholar
Rodriguez PC, Quiceno DG, Zabaleta J, Ortiz B, Zea AH, Piazuelo MB, Delgado A, Correa , Brayer J, Sotomayor EM, Antonia S, Ochoa JB and Ochoa AC (2004) Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res 64(16):5839–5849 ArticlePubMedCAS Google Scholar
Rodriguez PC, Zea AH, Culotta KS, Zabaleta J, Ochoa JB and Ochoa AC (2002) Regulation of T cell receptor CD3zeta chain expression by L-arginine. J Biol Chem 277:21123–21129 ArticlePubMedCAS Google Scholar
Rodriguez PC, Zea AH, DeSalvo J, Culotta KS, Zabaleta J, Quiceno DG, Ochoa JB and Ochoa AC (2003) L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes. J Immunol 171(3):1232–1239 PubMedCAS Google Scholar
Saio M, Radoja S, Marino M and Frey AB (2001) Tumor-infiltrating macrophages induce apoptosis in activated CD8(+) T cells by a mechanism requiring cell contact and mediated by both the cell-associated form of TNF and nitric oxide. J Immunol 167(10):5583–5593 PubMedCAS Google Scholar
Salvadori S, Martinelli G and Zier K (2000) Resection of solid tumors reverses T cell defects and restores protective immunity. J Immunol 164:2214 PubMedCAS Google Scholar
Sauer H, Wartenberg M and Hescheler J (2001) Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem 11:173–186 ArticlePubMedCAS Google Scholar
Schmielau J and Finn OJ (2001) Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients. Cancer Res 61:4756–4760 PubMedCAS Google Scholar
Schreck R, Albermann K and Baeuerle PA (1992) Nuclear factor kappa B:an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun 17:221–237 ArticlePubMedCAS Google Scholar
Seung L, Rowley D, Dubeym P and Schreiber H (1995) Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection. Proc Natl Acad Sci U S A 92(14):6254–6258 ArticlePubMedCAS Google Scholar
Shankaran V, Ikeda H, Bruce A, White J, Swanson P, Old L and Schreiber R (2001) IFN-gamma and lymphocytes prevent primary tumor development and shape tumor immunogenicity. Nature 410:1107–1111 ArticlePubMedCAS Google Scholar
Sinha P, Clements V and Ostrand-Rosenberg S (2005) Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease. J Immunol 174(2):636–645 PubMedCAS Google Scholar
Subiza J, Vinuela J, Rodriguez R and De la Concha E (1989) Development of splenic natural suppressor (NS) cells in Ehrlich tumor-bearing mice. Int J Cancer 44:307–314 ArticlePubMedCAS Google Scholar
Terabe M, Matsui S, Park JM, Mamura M, Noben-Trauth N, Donaldson DD, Chen W, Wahl SM, Ledbetter S, Pratt B, Letterio JJ, Paul WE and Berzofsky JA (2003) Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence. J Exp Med 198(11):1741–1752 ArticlePubMedCAS Google Scholar
Walkley C, Yuan Y, Chandraratna R and McArthur G (2002) Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis. Leukemia 16(9):1763–1772 ArticlePubMedCAS Google Scholar
Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, Bhattacharya R, Gabrilovich D, Heller R, Coppola D, Dalton W, Jove R, Pardoll D and Yu H (2004) Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med 10(1):48–54 ArticlePubMed Google Scholar
Wiers K, Lathers D, Wright M and Young M (2000) Vitamin D3 treatment to diminish the levels of immune suppressive CD34+ cells increases the effectiveness of adoptive immunotherapy. J Immunother 23(1):115–124 ArticlePubMedCAS Google Scholar
Wu G and Morris SM (1998) Arginine metabolism:nitric oxide and beyond. Biochem J 336:1–17 PubMedCAS Google Scholar
Yang L, DeBusk L, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, Matrisian L, Carbone D and Lin P (2004) Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 6(4):409–421 ArticlePubMedCAS Google Scholar
Young M (2004) Tumor skewing of CD34+ progenitor cell differentiation into endothelial cells. Int J Cancer 109(4):516–524 ArticlePubMedCAS Google Scholar
Young M, Ihm J, Lozano Y, Wright M and Prechel M (1995) Treating tumor-bearing mice with vitamin D3 diminishes tumor-induced myelopoiesis and associated immunosuppression, and reduces tumor metastasis and recurrence. Cancer Immunol Immunother 41(1):37–45 PubMedCAS Google Scholar
Young MR and Lathers DM (1999) Myeloid progenitor cells mediate immune suppression in patients with head and neck cancers. Int J Immunopharmacol 21:241–252 ArticlePubMedCAS Google Scholar
Young MRI, Wright MA, Matthews JP, Malik I and Pandit R (1996) Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor- b and nitric oxide. J Immunol 156:1916–1921 PubMedCAS Google Scholar
Zea AH, Rodriguez PC, Atkins MB, Hernandez C, Signoretti S, Zabaleta J, McDermott D, Quiceno D, Youmans A, O’Neill A, Mier J and Ochoa AC (2005) Arginase-producing myeloid suppressor cells in renal cell carcinoma patients:a mechanism of tumor evasion. Cancer Res 65(8): 3044–3048 PubMedCAS Google Scholar